Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells

The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent

(2015) Chen Li et al.   CANCER BIOLOGY & THERAPY

C6 ceramide dramatically enhances docetaxel-induced growth inhibition and apoptosis in cultured breast cancer cells: A mechanism study

(2015) Lan Yang et al.   EXPERIMENTAL CELL RESEARCH

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

Curcumin-induced melanoma cell death is associated with mitochondrial permeability transition pore (mPTP) opening

(2014) Ying Qiu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gemcitabine-induced pancreatic cancer cell death is associated with MST1/Cyclophilin D mitochondrial complexation

(2014) Shao-Hua Chen et al.   BIOCHIMIE

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

P53 Dependent Mitochondrial Permeability Transition Pore Opening Is Required for Dexamethasone-Induced Death of Osteoblasts

(2014) Yun-fang Zhen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Towards improved drugs, combinations and patient selection

(2014) Hans-Joachim Schmoll et al.   Nature Reviews Clinical Oncology

The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death

(2014) Massimo Bonora et al.   Frontiers in Oncology

Cisplatin-induced non-apoptotic death of pancreatic cancer cells requires mitochondrial cyclophilin-D-p53 signaling

(2013) Bo Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effects of selenium and the GPx-1 selenoprotein on the phosphorylation of H2AX

(2013) A. Jerome-Morais et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

(2013) John W. Elrod et al.   CIRCULATION JOURNAL

The mitochondrial cyclophilin D/p53 complexation mediates doxorubicin-induced non-apoptotic death of A549 lung cancer cells

(2013) Jia-huan Lu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The short chain cell-permeable ceramide (C6) restores cell apoptosis and perifosine sensitivity in cultured glioblastoma cells

(2013) Li-sen Qin et al.   MOLECULAR BIOLOGY REPORTS

Colorectal cancer screening—optimizing current strategies and new directions

(2013) Ernst J. Kuipers et al.   Nature Reviews Clinical Oncology

Metastatic colorectal cancer outcome and fatty liver disease

(2013) Antoine Brouquet et al.   Nature Reviews Gastroenterology & Hepatology

Ginsenoside Rg-1 Protects Retinal Pigment Epithelium (RPE) Cells from Cobalt Chloride (CoCl2) and Hypoxia Assaults

(2013) Ke-ran Li et al.   PLoS One

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis—An In Vitro Efficacy Study

(2012) Dong Yao et al.   PLoS One

An anticancer agent icaritin induces sustained activation of the extracellular signal-regulated kinase (ERK) pathway and inhibits growth of breast cancer cells

(2011) YuMing Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Icaritin Causes Sustained ERK1/2 Activation and Induces Apoptosis in Human Endometrial Cancer Cells

(2011) Jing-Shan Tong et al.   PLoS One

C6 ceramide potentiates curcumin-induced cell death and apoptosis in melanoma cell lines in vitro

(2010) Teng Yu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning

(2010) D. J. Hausenloy et al.   CARDIOVASCULAR RESEARCH

WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts

(2010) Alma Zecevic et al.   CELL CYCLE

Icaritin Induces Apoptosis of HepG2 Cells via the JNK1 Signaling Pathway Independent of the Estrogen Receptor

(2010) Jun He et al.   PLANTA MEDICA

The molecular composition of the mitochondrial permeability transition pore

(2009) Christopher P. Baines   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY