Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Utility of Physiologically Based Modeling and Preclinical In Vitro/In Vivo Data to Mitigate Positive Food Effect in a BCS Class 2 Compound

(2013) Binfeng Xia et al.   AAPS PHARMSCITECH

Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling

(2013) Zoe E. Barter et al.   CLINICAL PHARMACOKINETICS

Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics

(2013) Marilyn N. Martinez et al.   DRUG METABOLISM REVIEWS

Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state

(2013) Marcel Arndt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Targeted Quantitative Proteomics for the Analysis of 14 UGT1As and -2Bs in Human Liver Using NanoUPLC–MS/MS with Selected Reaction Monitoring

(2013) John K. Fallon et al.   JOURNAL OF PROTEOME RESEARCH

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

(2013) Aki T. Heikkinen et al.   MOLECULAR PHARMACEUTICS

A high throughput assay for the glucuronidation of 7-hydroxy-4-trifluoromethylcoumarin by recombinant human UDP-glucuronosyltransferases and liver microsomes

(2013) Tuomas Rahikainen et al.   XENOBIOTICA

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanisticin vitro-in vivoextrapolation of oral drug absorption

(2012) M. D. Harwood et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™

(2012) Aki T. Heikkinen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Peptide Production and Decay Rates Affect the Quantitative Accuracy of Protein Cleavage Isotope Dilution Mass Spectrometry (PC-IDMS)

(2012) Christopher M. Shuford et al.   MOLECULAR & CELLULAR PROTEOMICS

A Computational Tool to Detect and Avoid Redundancy in Selected Reaction Monitoring

(2012) Hannes Röst et al.   MOLECULAR & CELLULAR PROTEOMICS

Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

(2012) Aki T. Heikkinen et al.   PHARMACEUTICAL RESEARCH

The glycosidation of xenobiotics and endogenous compounds: Versatility and redundancy in the UDP glycosyltransferase superfamily

(2012) Robyn Meech et al.   PHARMACOLOGY & THERAPEUTICS

Quantification of Human Uridine-Diphosphate Glucuronosyl Transferase 1A Isoforms in Liver, Intestine, and Kidney Using Nanobore Liquid Chromatography–Tandem Mass Spectrometry

(2011) David E. Harbourt et al.   ANALYTICAL CHEMISTRY

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Development of a Highly Sensitive Method Using Liquid Chromatography-Multiple Reaction Monitoring to Quantify Membrane P-Glycoprotein in Biological Matrices and Relationship to Transport Function

(2011) T. Miliotis et al.   DRUG METABOLISM AND DISPOSITION

Prediction of the Intestinal First-pass Metabolism of CYP3A and UGT Substrates in Humans from in vitro Data

(2011) Haruka Nishimuta et al.   Drug Metabolism and Pharmacokinetics

Reliability and Robustness of Simultaneous Absolute Quantification of Drug Transporters, Cytochrome P450 Enzymes, and Udp-Glucuronosyltransferases in Human Liver Tissue by Multiplexed MRM/Selected Reaction Monitoring Mode Tandem Mass Spectrometry with Nano-Liquid Chromatography

(2011) Atsushi Sakamoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of absolute peptide quantitation strategies using selected reaction monitoring

(2011) James Campbell et al.   PROTEOMICS

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

(2011) Helen E. Cubitt et al.   XENOBIOTICA

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450

(2010) Y. Chen et al.   DRUG METABOLISM AND DISPOSITION

Expression and Characterization of Dog Cytochrome P450 2A13 and 2A25 in Baculovirus-Infected Insect Cells

(2010) D. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data

(2010) M. Gertz et al.   DRUG METABOLISM AND DISPOSITION

Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection

(2010) Hirotaka Kawakami et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cytochrome P450 and the Biological Clock in Mammals

(2009) Oren Froy   CURRENT DRUG METABOLISM

Bioavailability of generic ritonavir and lopinavir/ritonavir tablet products in a dog model

(2009) Kevin W. Garren et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

(2009) Elmar Langenfeld et al.   PROTEOMICS

Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase

(2008) C. W. Locuson et al.   DRUG METABOLISM AND DISPOSITION

Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction

(2008) S. Ohno et al.   DRUG METABOLISM AND DISPOSITION

Factors Influencing the Gastric Residence of Dosage Forms in Dogs

(2008) Marilyn N. Martinez et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Selected reaction monitoring for quantitative proteomics: a tutorial

(2008) Vinzenz Lange et al.   Molecular Systems Biology

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

(2008) Junichi Kamiie et al.   PHARMACEUTICAL RESEARCH

Differential expression ofCYP3A12andCYP3A26mRNAs in canine liver and intestine

(2008) K. L. Mealey et al.   XENOBIOTICA

Determination of microsome and hepatocyte scaling factors forin vitro/in vivoextrapolation in the rat and dog

(2008) R. Smith et al.   XENOBIOTICA