Lipid-Based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/Absorption Pathway

Intestinal Bile Secretion Promotes Drug Absorption from Lipid Colloidal Phases via Induction of Supersaturation

(2013) Yan Yan Yeap et al.   MOLECULAR PHARMACEUTICS

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the In Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-Based Formulations

(2013) Hywel D. Williams et al.   PHARMACEUTICAL RESEARCH

Lipid Absorption Triggers Drug Supersaturation at the Intestinal Unstirred Water Layer and Promotes Drug Absorption from Mixed Micelles

(2013) Yan Yan Yeap et al.   PHARMACEUTICAL RESEARCH

Characterizing the Impact of Hydroxypropylmethyl Cellulose on the Growth and Nucleation Kinetics of Felodipine from Supersaturated Solutions

(2012) David E. Alonzo et al.   CRYSTAL GROWTH & DESIGN

Inhibition of solution crystal growth of ritonavir by cellulose polymers – factors influencing polymer effectiveness

(2012) Grace A. Ilevbare et al.   CRYSTENGCOMM

Drug precipitation–permeation interplay: Supersaturation in an absorptive environment

(2012) Jan Bevernage et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)

(2012) N. Thomas et al.   JOURNAL OF CONTROLLED RELEASE

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 1: Method Parameterization and Comparison of In Vitro Digestion Profiles Across a Range of Representative Formulations

(2012) Hywel D. Williams et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Lipid Digestion as a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery Systems

(2012) Mette U. Anby et al.   MOLECULAR PHARMACEUTICS

Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

(2012) Hywel D. Williams et al.   MOLECULAR PHARMACEUTICS

A Win–Win Solution in Oral Delivery of Lipophilic Drugs: Supersaturation via Amorphous Solid Dispersions Increases Apparent Solubility without Sacrifice of Intestinal Membrane Permeability

(2012) Jonathan M. Miller et al.   MOLECULAR PHARMACEUTICS

Enhanced oral bioavailability of silybin by a supersaturatable self-emulsifying drug delivery system (S-SEDDS)

(2011) Yinghui Wei et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

A formulation‐enabled preclinical efficacy assessment of a farnesoid X receptor agonist, GW4064, in hamsters and cynomolgus monkeys

(2011) Po‐Chang Chiang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Supersaturation–Nucleation Behavior of Poorly Soluble Drugs and its Impact on the Oral Absorption of Drugs in Thermodynamically High-Energy Forms

(2011) Shunsuke Ozaki et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

(2011) Jan Bevernage et al.   MOLECULAR PHARMACEUTICS

Application of Dissolution/Permeation System for Evaluation of Formulation Effect on Oral Absorption of Poorly Water-Soluble Drugs in Drug Development

(2011) Makoto Kataoka et al.   PHARMACEUTICAL RESEARCH

Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility

(2010) Dallas B. Warren et al.   JOURNAL OF DRUG TARGETING

Biorelevant Media Simulating Fed State Intestinal Fluids: Colloid Phase Characterization and Impact on Solubilization Capacity

(2010) Karen Kleberg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Application of a Biphasic Test for Characterization of In Vitro Drug Release of Immediate Release Formulations of Celecoxib and Its Relevance to In Vivo Absorption

(2010) Yi Shi et al.   MOLECULAR PHARMACEUTICS

Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: Effects of lipid composition and formulation

(2009) Si-fei Han et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drugs: Precipitation of Drug after Dispersion of Formulations in Aqueous Solution

(2009) Kazi Mohsin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Supersaturating Drug Delivery Systems: The Answer to Solubility-Limited Oral Bioavailability?

(2009) Joachim Brouwers et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Enhanced In Vivo Absorption of Itraconazole via Stabilization of Supersaturation Following Acidic-to-Neutral pH Transition

(2008) Dave A. Miller et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Characterization and Optimization of AMG 517 Supersaturatable Self‐Emulsifying Drug Delivery System (S‐SEDDS) for Improved Oral Absorption

(2008) Ping Gao et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Enhancing intestinal drug solubilisation using lipid-based delivery systems

(2007) Christopher J.H. Porter et al.   ADVANCED DRUG DELIVERY REVIEWS

Evaluation of the Impact of Surfactant Digestion on the Bioavailability of Danazol after Oral Administration of Lipidic Self-Emulsifying Formulations to Dogs

(2007) Jean F. Cuiné et al.   JOURNAL OF PHARMACEUTICAL SCIENCES