Finding Promiscuous Old Drugs for New Uses

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma

(2010) Jinesh S. Gheeya et al.   CANCER BIOLOGY & THERAPY

When pharmaceutical companies publish large datasets: an abundance of riches or fool's gold?

(2010) Sean Ekins et al.   DRUG DISCOVERY TODAY

Drug screening to identify suppressors of GFAP expression

(2010) Woosung Cho et al.   HUMAN MOLECULAR GENETICS

Polypharmacology Directed Compound Data Mining: Identification of Promiscuous Chemotypes with Different Activity Profiles and Comparison to Approved Drugs

(2010) Ye Hu et al.   Journal of Chemical Information and Modeling

Analysis and hit filtering of a very large library of compounds screened against Mycobacterium tuberculosis

(2010) Sean Ekins et al.   Molecular BioSystems

A collaborative database and computational models for tuberculosis drug discovery

(2010) Sean Ekins et al.   Molecular BioSystems

Repositioning of an existing drug for the neglected tropical disease Onchocerciasis

(2010) Christian Gloeckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-analysis of molecular property patterns and filtering of public datasets of antimalarial “hits” and drugs

(2010) Sean Ekins et al.   MedChemComm

Novel web-based tools combining chemistry informatics, biology and social networks for drug discovery

(2009) Moses Hohman et al.   DRUG DISCOVERY TODAY

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computational Models for Drug Inhibition of the Human Apical Sodium-Dependent Bile Acid Transporter

(2009) Xiaowan Zheng et al.   MOLECULAR PHARMACEUTICS

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Novel Inhibitors of Human Organic Cation/Carnitine Transporter (hOCTN2) via Computational Modeling and In Vitro Testing

(2009) Lei Diao et al.   PHARMACEUTICAL RESEARCH

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

(2009) A. N. Gerber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The importance of discerning shape in molecular pharmacology

(2009) Sandhya Kortagere et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

New anti-tuberculosis agents amongst known drugs

(2009) Kathryn E.A. Lougheed et al.   TUBERCULOSIS

Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model

(2008) A. S. Downey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: A report from the Children's Oncology Group

(2008) Steven G. DuBois et al.   PEDIATRIC BLOOD & CANCER

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Biosensor of S100A4 Metastasis Factor Activation:  Inhibitor Screening and Cellular Activation Dynamics†

(2007) Sarah C. Garrett et al.   BIOCHEMISTRY