Article
Chemistry, Multidisciplinary
Maximilian Regenold, Kan Kaneko, Xuehan Wang, H. Benson Peng, James C. Evans, Pauric Bannigan, Christine Allen
Summary: Triggered drug delivery strategies, such as thermosensitive liposomes, have shown improved targetability for chemotherapeutics. However, most studies have focused on doxorubicin encapsulation, while other drugs could also benefit from this targeted delivery approach.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Hanmei Li, Qi Tang, Yao Wang, Mao Li, Yannan Wang, Hong Zhu, Fang Geng, Di Wu, Lianxin Peng, Gang Zhao, Liang Zou, Sanjun Shi
Summary: By encapsulating ropivacaine into liposomes and loading them into Poloxamer 407-based thermosensitive hydrogels, a system has been developed to prolong local anesthesia after a single injection. This system shows promising results in in vitro and in vivo studies, demonstrating small initial burst release, long-term nerve blockade, and good biocompatibility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biophysics
Weiwei Tang, Jiapeng Kang, Lu Yang, Jialin Lin, Jing Song, Dan Zhou, Feng Ye
Summary: A composite nanomaterial for combined photothermal and photodynamic therapies was designed and developed. The material showed improved spectral response range, photothermal conversion efficiency and light absorption performance through modification and addition of photosensitizers. The nanocomposite induced cell apoptosis, inhibited tumor growth and showed favorable effects on liver cancer phototherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Kento Koga, Tatsuaki Tagami, Tetsuya Ozeki
Summary: The study developed gold nanoparticle-coated liposome/doxorubicin for controlled drug release and photothermal effect, showing synergistic therapeutic efficacy on lung cancer cells compared to monotherapy. This approach holds promise for cancer treatment with the use of near-infrared laser irradiation.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemistry & Molecular Biology
Franco Furlani, Arianna Rossi, Maria Aurora Grimaudo, Giada Bassi, Elena Giusto, Filippo Molinari, Florigio Lista, Monica Montesi, Silvia Panseri
Summary: This work presents the development of an injectable nanocomposite system for regenerative medicine, combining chitosan thermosensitive hydrogel and liposomes. The system allows controlled release, enhances cellular uptake, and can form a hydrogel at physiological temperature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Hui Ye, Xiaoying Chu, Zhensheng Cao, Xuanxuan Hu, Zihan Wang, Meiqi Li, Leyu Wan, Yongping Li, Yongge Cao, Zhanqiu Diao, Fengting Peng, Jinsong Liu, Lihua Xu
Summary: A novel magnetic thermosensitive cationic liposome drug carrier for the codelivery of OXA and MDC1-AS was prepared and shown to have desirable targeted delivery efficacy, OXA thermosensitive release, and MDC1-AS regulating MDC1. The codelivery of OXA and MDC1-AS enhanced the inhibition of cervical cancer cell growth in vitro and in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Sijie Wu, Gaodan Liu, Ping Shao, Xingyu Lin, Jiahao Yu, Hanchi Chen, Huiliang Li, Simin Feng
Summary: This study developed a carboxymethyl-modified chitosan/hyaluronic acid thermosensitive hydrogel for sustained transdermal delivery of liposomes. The hydrogel exhibited suitable gel properties and structure, resulting in delayed liposomes release and improved skin retention. The liposome-hydrogel system more efficiently promoted the effects of anti-aging agents on the skin.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Souri, Farshad Moradi Kashkooli, M. Soltani
Summary: A mathematical model was used to investigate the therapeutic response of drug-loaded thermosensitive liposome following intravascular release. The study found that continuous or pulsed hyperthermia can affect drug concentration levels, with a slightly higher concentration for pulsed mode. However, there was no significant difference in onset time of tumor growth.
PHARMACEUTICAL RESEARCH
(2022)
Article
Materials Science, Biomaterials
Zhiqiang Zhang, Anning Li, Xingqi Min, Qunqun Zhang, Jun Yang, Guo Chen, Meijuan Zou, Wei Sun, Gang Cheng
Summary: Researchers prepared a biomimetic and thermosensitive hydrogel encapsulating reactive oxygen species (ROS)-sensitive tegafur (TF)-protoporphyrin IX (PpIX) heterodimers (TTP) to synergize chemotherapy and photodynamic therapy for breast cancer treatment. This innovative approach overcame major obstacles in breast cancer treatment and opened up new paths for treatment.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Isabela P. Gomes, Angelo Malachias, Ana Luiza Chaves Maia, Eduardo B. Lages, Felipe Alves Ferreira, Ricardo J. Alves, Cristiane S. Giuberti, Andre Luis B. de Barros, Elaine A. Leite
Summary: This study developed a thermosensitive liposomal formulation functionalized with hyaluronic acid to encapsulate cisplatin. The results showed that the functionalization resulted in homogeneous formulations with high coating efficiency. The thermal and physicochemical characteristics were also investigated.
JOURNAL OF NANOPARTICLE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Xinxin Li, Chunsheng Yang, Yingkai Tao, Xiaoyang Hou, Yanqun Liu, Hong Sang, Guan Jiang
Summary: A novel targeted drug delivery system for melanoma combining chemo and photothermal therapy was developed, showing efficient photothermal conversion and drug release performance. The liposomes exhibited concentration-dependent uptake by melanoma cells, entering cells via endocytosis and storing in lysosomes. Exposure to NIR laser resulted in a significant reduction in cell viability, indicating a promising chemo/photothermal effect.
ONCOTARGETS AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Wouter J. M. Lokerse, Artur Lazarian, Alisa Kleinhempel, Matteo Petrini, Patricia Schwarz, Martin Hossann, Lesca M. Holdt, Volker Mailaender, Lars H. Lindner
Summary: Various thermosensitive liposome formulations have been described, and it remains unclear which is optimal for solid tumor treatment. Most liposomes achieve sufficient circulation half-life through polyethylene glycol surface modification, while DPPG(2) has been identified as a promising alternative. In vitro and in vivo studies suggest that higher mol% DPPG(2) increases Apolipoprotein E adsorption, decreases complement activation, and does not exhibit accelerated blood clearance, potentially offering advantages over PEG-TSL. Additionally, low complement activation for 20-30 mol% DPPG(2)-TSL presents a unique attribute for clinical evaluation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Martin E. Villanueva, Francesca Giudice, Ernesto Ambroggio, Raquel V. Vico
Summary: Membrane fusion plays a crucial role in various scientific fields and biotechnological processes. In this study, hydrophobic oleic acid-coated magnetite nanoparticles were used to induce the fusion of liposomes, showing a direct dependence on the nanoparticle concentration. The application of a low-intensity magnetic field enhanced the fusogenic activity of the nanoparticles, highlighting their potential for biotechnological applications.
Article
Pharmacology & Pharmacy
Ana Luiza C. Maia, Aline T. M. E. Silva, Aina L. A. Cesar, Cristiane S. Giuberti, Fernanda C. G. Evangelista, Janaina de A. Lemos, Adriano P. Sabino, Angelo Malachias, Christian Fernandes, Andre L. B. de Barros, Daniel C. F. Soares, Gilson A. Ramaldes
Summary: This study developed thermosensitive liposomes containing Gd-DTPA-BMA and demonstrated their high cytotoxicity against breast cancer cells and minimal toxicity in normal cells. This nanocarrier system may represent a promising new direction for breast cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Environmental Sciences
Ye -Lim Han, Hye-Ran Kim, Hyun-Kyung Kim, Jae -Woo Park
Summary: A series of thermosensitive and magneto-responsive dendrimers were synthesized and their properties at different temperatures were studied. The results showed that PNIPAM-g-MCD could encapsulate and fix benzene molecules below the critical solution temperature, while it could disrupt oil-water emulsions above the critical solution temperature.
