Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 626, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2021.127038
Keywords
Gold nanoparticle; Liposome; Photothermal effect; Thermosensitive liposome; Triggered release
Categories
Funding
- Japan Society for the Promotion of Science [16K18952, 17K08456]
- Hori Sciences and Arts Foundation
- Grants-in-Aid for Scientific Research [17K08456, 16K18952] Funding Source: KAKEN
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The study developed gold nanoparticle-coated liposome/doxorubicin for controlled drug release and photothermal effect, showing synergistic therapeutic efficacy on lung cancer cells compared to monotherapy. This approach holds promise for cancer treatment with the use of near-infrared laser irradiation.
We constructed gold nanoparticle-coated liposome/doxorubicin (GCL/DOX) for the purpose of combination therapy and focused on 1) controlled drug release from the thermosensitive liposomes triggered by near-infrared laser (NIR-laser) irradiation and 2) the photothermal effect of the gold nanoshell-like structures upon absorbing laser light. GCL/DOX was prepared using thiol-group-spiked liposomes containing glutathione conjugated to gold nanoparticles under reducing conditions. The absorption peak of GCL was dependent on the amount of added HAuCl4 and shifted from 636 to 795 nm, appropriate for the absorption of NIR laser light (660 nm) by GCL/DOX. Most of the encapsulated drug was released from GCL/DOX within 1 min (>80%) under NIR laser irradiation. GCL/DOX exhibited a synergistic effect compared to monotherapy (photothermal effect alone or free-DOX treatment alone) on A549 cells. GCL is thus an effective liposome carrier, and in conjunction with NIR laser irradiation its therapeutic modality holds promise for cancer treatment.
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