Article
Food Science & Technology
Javad Sharifi-Rad, Cristina Quispe, Mary Angelia Alfred, Nanjangud Venaktesh Anil Kumar, Niccolo Lombardi, Lucrezia Cinquanta, Marcello Iriti, Elena M. Varoni, Gaurav Gupta, Dinesh Kumar Chellappan, Kamal Dua, Susana M. Cardoso, Gregorio Peron, Abhijit Dey, Natalia Cruz-Martins, Celia F. Rodrigues
Summary: Periodontitis is a prevalent inflammatory disease causing severe infection in the gum, while resveratrol, a plant polyphenol, has shown promising potential in effectively treating periodontitis with its antimicrobial, antioxidant, and anti-inflammatory properties. Further comprehensive studies are needed to fully understand its mechanism of action and structure-activity relationship for successful implementation as a mainstream drug against periodontitis.
Article
Pharmacology & Pharmacy
Julia Solnier, Yiming Zhang, Yun Chai Kuo, Min Du, Kyle Roh, Roland Gahler, Simon Wood, Chuck Chang
Summary: This study investigated the in vitro solubility and Caco-2 cell permeability of a new food-grade berberine delivery system, as well as its pharmacokinetic profiling in healthy volunteers. The results showed that the new delivery system exhibited higher bioavailability and absorption compared to the standard formulation, potentially improving the therapeutic efficacy of berberine.
Article
Biochemistry & Molecular Biology
Bernhard Blank-Landeshammer, Gerald Klanert, Lisa Mitter, Sophia Turisser, Nicolas Nusser, Alice Koenig, Marcus Iken, Julian Weghuber
Summary: Intestinal absorption of lipophilic micronutrients and phytochemicals is usually low, but plant extracts can enhance their bioavailability. This study investigated the effects of extracts from curcuma, ginger, and black pepper on the uptake and transport rates of lutein, zeaxanthin, and soy isoflavones. It was found that curcuma extract increased lutein uptake, while curcuma and ginger extracts enhanced isoflavone transport rates.
Article
Pharmacology & Pharmacy
Xiao-Hang Liu, Xin-Rong Li, Xiao-Ming Gao, Mei Wang, Zhan-Ying Chang, Xiao-Li Gao
Summary: The study investigated the permeability of Conjugated Estrogens (CEs) as a potential drug using rat intestinal perfusion and cell monolayer models. The results showed that CEs had similar permeability to a reference drug and that their permeability was time- and concentration-dependent. P-gp was found to be involved in the transport of CEs. Overall, CEs can be considered as a drug with moderate permeability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kazuyoshi Michiba, Kazuya Maeda, Ko Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda, Hiroyuki Kusuhara
Summary: This study characterized the functions of major intestinal uptake/efflux drug transporters in freshly isolated human jejunum sections using the Ussing chamber system. The findings showed a good correlation between the mucosal-to-serosal apparent permeability coefficient of various drugs and reported human FaFg values, highlighting the importance of intestinal uptake transporters in facilitating drug absorption in humans.
DRUG METABOLISM AND DISPOSITION
(2021)
Article
Pharmacology & Pharmacy
Yun Kuang, Sai-Ying Wang, Meng-Na Wang, Guo-Ping Yang, Can Guo, Shuang Yang, Xing-Fei Zhang, Xiao-Yan Yang, Qi Pei, Chan Zou, Yan-Hong He, Ying-Yong Zhou, Kai-Ming Duan, Jie Huang
Summary: The present study evaluated the safety and pharmacokinetics/pharmacodynamics of Dex nasal spray in healthy adults and its potential use in children. The results showed that the optimized nasal spray method greatly improved the bioavailability of Dex nasal spray.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Christine M. Madla, Yujia Qin, Francesca K. H. Gavins, Jing Liu, Liu Dou, Mine Orlu, Sudaxshina Murdan, Yang Mai, Abdul W. Basit
Summary: The study demonstrates that Wistar and Sprague Dawley rats have differences in gastrointestinal factors that influence oral drug absorption, particularly in relation to the expression of P-glycoprotein (P-gp). Significant sex differences in P-gp expression were observed in Wistar rats, while Sprague Dawley rats showed no sex differences. In light of these findings, Wistar rats may be a better pre-clinical animal model for studying oral drug absorption of P-gp substrates in both male and female subjects.
Article
Pharmacology & Pharmacy
Nimishraj Panse, Phillip M. Gerk
Summary: The Caco-2 cell model is widely used to assess drug permeability, providing a reliable estimation of oral drug permeability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biology
Weiyin Huang, Shuang Chen, Lin Sun, Hubin Wwang, Hongqun Qiao
Summary: The study investigated the intestinal permeability of lamivudine using Caco-2 cells monolayer and single-pass intestinal perfusion, revealing a passive diffusion absorption mechanism possibly related to efflux transporters. Lamivudine was classified as a moderate-permeability drug in the Biopharmaceutics Classification System.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Like Xie, Zhipeng Diao, Jing Xia, Jing Zhang, Yao Xu, Yapeng Wu, Zihou Liu, Chengwen Jiang, Ying Peng, Zhe Song, Guangji Wang, Junrong Zhu, Jianguo Sun
Summary: A new HPLC-Q-TOF method was developed to analyze and identify the prototype and metabolites of glabridin in rats. A total of 63 compounds were identified, including 43 new metabolites. The oral bioavailability of glabridin was found to be 6.63 +/- 2.29% in rats. Additionally, the study revealed a hepatic first-pass effect of 62.12 +/- 15.7% for glabridin.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xi Tang, Hui Feng, Jie Gao, Ruohong Bi, Lin Pan, Yi Shi, Yunfeng Han, Xianrong Lai
Summary: This study investigated the intestinal absorption characteristics of berberine hydrochloride (BBH) under different perfusion conditions in rats. The results showed that BBH is absorbed through passive diffusion in a neutral environment of pH 7.4, and the jejunum is the most efficient segment for absorption.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Oceanography
Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua
Summary: This study investigated the pharmacokinetics, bioavailability, and in vitro absorption of chito-oligosaccharide (COS) with different degrees of polymerization (DPs). It was found that COS could be absorbed by the intestinal tract both in vitro and in vivo. However, the low permeability of COS resulted in very low oral bioavailability. The bioavailability of COS2-7 decreased with increasing DPs.
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2022)
Review
Medicine, Research & Experimental
Bart Hens, Isabel Gonzalez-Alvarez, Marival Bermejo
Summary: This review presents the applications and future perspectives of the in situ perfusion technique for studying drug absorption mechanisms. The differences in gastrointestinal anatomy and physiology between rats and humans are thoroughly discussed.
MOLECULAR PHARMACEUTICS
(2022)
Review
Cardiac & Cardiovascular Systems
Peter E. Wu, David N. Juurlink
Summary: Loperamide, a nonprescription medication used for treating diarrhea, is an opioid with low absorption and good tolerance at standard doses. However, in recent years, misuse of loperamide has increased due to its euphoric effects and concomitant use with other medications.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Antonio Portoles-Perez, Ana Belen Rivas Paterna, Andres Sanchez Pernaute, Antonio Jose Torres Garcia, Carmen Moreno Lopera, Luis M. Chicharro, Fernando Bandres, Amanda Lopez-Picado, Miguel A. Rubio, Emilio Vargas Castrillon
Summary: This study found that the bioavailability of omeprazole is reduced in patients undergoing gastric bypass surgery, but the pharmacokinetic parameters of omeprazole 6 months after surgery are similar to those of control subjects, indicating that no dose correction is required after gastric bypass surgery for a given indication.
Article
Pharmacology & Pharmacy
P. K. Patel, B. A. Vyas, S. V. Joshi, T. R. Gandhi
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2016)
Article
Chemistry, Multidisciplinary
Furqan A. Maulvi, Dhara H. Lakdawala, Anjum A. Shaikh, Ankita R. Desai, Harsh H. Choksi, Rutvi J. Vaidya, Ketan M. Ranch, Akshay R. Koli, Bhavin A. Vyas, Dinesh O. Shah
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Pharmacology & Pharmacy
Furqan A. Maulvi, Ankita R. Desai, Harsh H. Choksi, Rahul J. Patil, Ketan M. Ranch, Bhavin A. Vyas, Dinesh O. Shah
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Pharmacology & Pharmacy
Furqan A. Mauvi, Sulabh S. Singhania, Ankita R. Desai, Manish R. Shukla, Aniruddha S. Tannk, Ketan M. Ranch, Bhavin A. Vyas, Dinesh O. Shah
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Materials Science, Biomaterials
Ankita R. Desai, Furqan A. Maulvi, Mihir M. Pandya, Ketan M. Ranch, Bhavin A. Vyas, Shailesh A. Shah, Dinesh O. Shah
BIOMATERIALS SCIENCE
(2018)
Article
Pharmacology & Pharmacy
Bhavin A. Vyas, Niket Y. Desai, Paras K. Patel, Shrikant V. Joshi, Dinesh R. Shah
INDIAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Plant Sciences
Paras K. Patel, Manish A. Patel, Bhavin A. Vyas, Dinesh R. Shah, Tejal R. Gandhi
JOURNAL OF ETHNOPHARMACOLOGY
(2012)
Article
Engineering, Biomedical
Furqan A. Maulvi, Rahul J. Patil, Ankita R. Desai, Manish R. Shukla, Rutvi J. Vaidya, Ketan M. Ranch, Bhavin A. Vyas, Shailesh A. Shah, Dinesh O. Shah
ACTA BIOMATERIALIA
(2019)
Article
Pharmacology & Pharmacy
Shrikant Joshi, Ekta P. Patel, Bhavin A. Vyas, Sandesh R. Lodha, Gajanan G. Kalyankar
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Materials Science, Biomaterials
Ankita R. Desai, Furqan A. Maulvi, Ditixa M. Desai, Manish R. Shukla, Ketan M. Ranch, Bhavin A. Vyas, Shailesh A. Shah, Susan Sandeman, Dinesh O. Shah
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Pharmacology & Pharmacy
Avinash Khadela, Bhavin Vyas
DRUGS & THERAPY PERSPECTIVES
(2020)
Article
Biophysics
Furqan A. Maulvi, Harsh H. Choksi, Ankita R. Desai, Akanksha S. Patel, Ketan M. Ranch, Bhavin A. Vyas, Dinesh O. Shah
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Engineering, Biomedical
Furgan A. Maulvi, Anjum A. Shaikh, Dhara H. Lakdawala, Ankita R. Desai, Mihir M. Pandya, Sulabh S. Singhania, Rutvi J. Vaidya, Ketan M. Ranch, Bhavin A. Vyas, Dinesh O. Shah
ACTA BIOMATERIALIA
(2017)
Letter
Pharmacology & Pharmacy
Arti Gupta, N. R. Sheth, Sonia Pandey, Jitendra S. Yadav, D. R. Shah, B. Vyas, S. Joshi
JOURNAL OF PHARMACOLOGY & PHARMACOTHERAPEUTICS
(2012)