The molecular mechanism of SLC34 proteins: insights from two decades of transport assays and structure-function studies

Gating currents

(2018) Francisco Bezanilla   JOURNAL OF GENERAL PHYSIOLOGY

A general method for determining secondary active transporter substrate stoichiometry

(2017) Gabriel A Fitzgerald et al.   eLife

Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters

(2016) Andreas Werner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Cation Interactions and Membrane Potential Induce Conformational Changes in NaPi-IIb

(2016) Monica Patti et al.   BIOPHYSICAL JOURNAL

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism

(2016) Christopher Mulligan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loss of function of NaPiIIa causes nephrocalcinosis and possibly kidney insufficiency

(2016) Dganit Dinour et al.   PEDIATRIC NEPHROLOGY

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism

(2016) Christopher Mulligan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of the First Sodium Binding Site of the Phosphate Cotransporter NaPi-IIa (SLC34A1)

(2015) Cristina Fenollar-Ferrer et al.   BIOPHYSICAL JOURNAL

Family resemblances: A common fold for some dimeric ion-coupled secondary transporters

(2015) Ariela Vergara-Jaque et al.   JOURNAL OF GENERAL PHYSIOLOGY

Repeat-swap homology modeling of secondary active transporters: updated protocol and prediction of elevator-type mechanisms

(2015) Ariela Vergara-Jaque et al.   Frontiers in Pharmacology

Structural Fold and Binding Sites of the Human Na+-Phosphate Cotransporter NaPi-II

(2014) Cristina Fenollar-Ferrer et al.   BIOPHYSICAL JOURNAL

Shedding Light on Conformational Dynamics of Na+-Coupled Transporters

(2014) Christof Grewer   BIOPHYSICAL JOURNAL

Functional characterization of a Na+-dependent dicarboxylate transporter fromVibrio cholerae

(2014) Christopher Mulligan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Sodium-phosphate cotransporter mediates reabsorption of lithium in rat kidney

(2014) Yuichi Uwai et al.   PHARMACOLOGICAL RESEARCH

Phosphate Transporters and Their Function

(2013) Jürg Biber et al.   Annual Review of Physiology

Phosphate transporters of the SLC20 and SLC34 families

(2013) Ian C. Forster et al.   MOLECULAR ASPECTS OF MEDICINE

Conferring electrogenicity to the electroneutral phosphate cotransporter NaPi-IIc (SLC34A3) reveals an internal cation release step

(2013) Monica Patti et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Functional identification and characterization of sodium binding sites in Na symporters

(2013) D. D. F. Loo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using lithium to probe sequential cation interactions with GAT1

(2012) Anne-Kristine Meinild et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Simulated annealing reveals the kinetic activity of SGLT1, a member of the LeuT structural family

(2012) Jean-Philippe Longpré et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter

(2012) Romina Mancusso et al.   NATURE

Lithium interactions with Na+-coupled inorganic phosphate cotransporters: insights into the mechanism of sequential cation binding

(2011) Olga Andrini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Voltage- and substrate-dependent interactions between sites in putative re-entrant domains of a Na+-coupled phosphate cotransporter

(2011) Chiara Ghezzi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The leak mode of type II Na+-Pi cotransporters

(2010) Olga Andrini et al.   Channels

Remarkable commonalities of electrogenic and electroneutral Na+-phosphate cotransporters

(2009) Sepehr Eskandari   JOURNAL OF PHYSIOLOGY-LONDON

Substrate interactions of the electroneutral Na+-coupled inorganic phosphate cotransporter (NaPi-IIc)

(2009) Chiara Ghezzi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unlocking the molecular secrets of sodium-coupled transporters

(2009) Harini Krishnamurthy et al.   NATURE

Monitoring Protein-Protein Interactions between the Mammalian Integral Membrane Transporters and PDZ-interacting Partners Using a Modified Split-ubiquitin Membrane Yeast Two-hybrid System

(2008) Serge M. Gisler et al.   MOLECULAR & CELLULAR PROTEOMICS

How membrane proteins sense voltage

(2008) Francisco Bezanilla   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na+/Sugar Symport

(2008) S. Faham et al.   SCIENCE