Article
Endocrinology & Metabolism
Christine W. Hockett, Kylie K. Harrall, Deborah H. Glueck, Dana M. Dabelea
Summary: This study investigates the differences in body mass index (BMI) trajectories among adolescents exposed or not exposed to maternal gestational diabetes mellitus (GDM) and whether these associations differ across different life stages. The results show that children exposed to GDM have higher BMI trajectories during middle childhood and adolescence, but not during early childhood. These findings suggest that efforts to prevent childhood obesity among those exposed to maternal GDM should start before puberty.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Furkan Erdogan, Ayla Guven
Summary: This study retrospectively analyzed the pubertal development of children with Down syndrome (DS) and found that girls with DS have an earlier age of menarche compared to their healthy peers, while boys with DS have a longer duration of puberty. Additionally, there is a tendency towards obesity in the whole DS population.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Mayako Saito-Abe, Minaho Nishizato, Kiwako Yamamoto-Hanada, Liming Yang, Maki Fukami, Yoshiya Ito, Kenji Ihara, Atsushi Iwabuchi, Shingo Okamoto, Yasuhiro Naiki, Yukihiro Ohya, Reiko Horikawa
Summary: This study aimed to assess the reliability of judging pubertal onset in Japanese children using a self-assessment sheet. The results showed good agreement between self-assessment and physician's assessment for girls, but poor agreement for boys, especially those in the early pubertal stage. Therefore, conducting large-scale epidemiological studies for early pubertal boys is challenging.
FRONTIERS IN PEDIATRICS
(2023)
Editorial Material
Multidisciplinary Sciences
Adam Kucharski
Summary: To address the vicious cycle of incomplete understanding and ineffective virus control, it is necessary to have a conversation about privacy.
Article
Endocrinology & Metabolism
Xinyi Liang, Ke Huang, Guangping Dong, Ruimin Chen, Shaoke Chen, Rongxiu Zheng, Chunlin Wang, Haiyan Wei, Bingyan Cao, Yan Liang, Hui Yao, Zhe Su, Mireguli Maimaiti, Feihong Luo, Pin Li, Min Zhu, Hongwei Du, Yu Yang, Lanwei Cui, Shuting Si, Guannan Bai, Yunxian Yu, Er-Gang Wang, Paul L. Hofman, Junfen Fu
Summary: Over the past decade, pubertal development has been occurring earlier in Chinese children. The age for breast development in girls is 9.65 years and for testicular volume ≥ 4 mL in boys is 10.65 years. Obesity and overweight are associated with a higher risk for early puberty onset.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Iana Markevych, Thomas Astell-Burt, Hicran Altug, Kai Triebner, Marie Standl, Claudia Flexeder, Joachim Heinrich, Tamara Schikowski, Sibylle Koletzko, Gunda Herberth, Carl-Peter Bauer, Andrea von Berg, Dietrich Berdel, Xiaoqi Feng
Summary: Residential green space was not found to be associated with the age at menarche, but urban residents were more likely to have earlier menarche. Researchers should further explore environmental risk factors of early menarche.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Medicine, General & Internal
Charlotte Floersheim, Sandrine Musso, August Eubanks, Maylis Douine, Bruno Spire, Luis Sagaon-Teyssier, Marie Claire Parriault, Gabriel Girard, Emilie Mosnier
Summary: This study identifies three key factors contributing to late HIV diagnosis among illegal gold miners at French Guiana's border with Brazil: economic and political structural factors, representations of the body and health, and gender roles shaping masculinity and heterosexuality. These factors reduce access to HIV testing and healthcare for migrant workers in an illegal gold mining area.
Article
Environmental Sciences
Nathalia Ribeiro dos Santos, Juliana Lima Gomes Rodrigues, Matheus de Jesus Bandeira, Ana Laura dos Santos Anjos, Cecilia Freitas da Silva Araujo, Luis Fernando Fernandes Adan, Jose Antonio Menezes-Filho
Summary: This study evaluated the exposure to manganese and lead in school-aged children living near a ferromanganese alloy plant in Brazil and their potential effects on early puberty. The findings suggest that manganese exposure is not associated with early puberty, while lead exposure is associated with the onset of pubic hair development in boys and early pubarche in girls. Manganese and lead may have different effects on the regulation of the neuroendocrine system.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Wenxin Lu, Ronnie Levin, Joel Schwartz
Summary: This study examines the association between community water lead levels and academic performances of students. The results show that an increase in water lead levels is associated with a decrease in math test scores, but not with English Language Arts. This suggests that even at relatively low levels, lead has a significant impact on academic performance.
Article
Environmental Sciences
Yabin Hu, Juan Li, Tao Yuan, Tingting Yu, Yao Chen, Huijun Kong, Cuilan Lin, Zhemin Shen, Ying Tian, Shilu Tong, Xiaodan Yu, Shijian Liu
Summary: Foods and water in China may be contaminated with antibiotics, potentially affecting children's health. This study found an association between antibiotic exposure and precocious puberty, especially with fluoroquinolones and tetracyclines.
ENVIRONMENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Sommayya Aftab, Jaida Manzoor, Qaiser Mahmood, Tahir Shaheen
Summary: This retrospective study investigated children with precocious puberty at a children's hospital in Lahore and found both central and peripheral precocious puberty cases, with congenital adrenal hyperplasia being the most common underlying cause.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Pediatrics
Kyu Hee Choi, Seung Chan Park
Summary: This study investigates the current status and treatment costs of precocious puberty (PP) in Korea from 2016 to 2021, finding an increasing number of diagnosed cases and medical expenses. The study also reveals a rising incidence of PP in males, possibly due to the impact of the COVID-19 pandemic and increased awareness. Further research is needed to determine the causes of the increasing prevalence of PP.
FRONTIERS IN PEDIATRICS
(2022)
Article
Environmental Sciences
Shaoyi Wang, Jiawei Wu, Jianqun Jiang, Shakil Masum, Haijian Xie
Summary: Lead (Pb) is a highly toxic pollutant found in landfill leachate, and loess-amended soil buffers have been proven effective in reducing its migration. This study investigated the mechanisms and capacity of loess to adsorb Pb under high NH4+ concentration, showing that adsorption capacity increases with temperature. The adsorption process is endothermic and non-spontaneous, driven by both membrane and intraparticle diffusions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pediatrics
Yan Dong, Lili Dai, Yang Dong, Na Wang, Jing Zhang, Chao Liu, Zhifang Li, Limin Chu, Sisi Chen
Summary: This study aimed to explore the related factors of precocious puberty in children. Through analyzing the data of 1239 children, it was found that factors such as gender, bone age, exercise habits, hormone levels, mother's menarche time, living environment, dietary habits, and sleep time were associated with precocious puberty in children.
Article
Medicine, Research & Experimental
Xiao-Xu Han, Fu-Ying Zhao, Kan-Ru Gu, Guo-Ping Wang, Jing Zhang, Rui Tao, Jiao Yuan, Jie Gu, Jian-Qiang Yu
Summary: Precocious puberty in children is a common endocrine disease, and its prevalence has increased globally. It negatively affects children's physical and mental health and may increase the risk of various diseases in adulthood. Traditional medicinal plants, especially in Asian traditional Chinese medicine, have been used to treat and delay the onset of precocious puberty. However, the safety of these treatments still requires long-term evaluation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Genetics & Heredity
J. Richard Pilsner, Alex Shershebnev, Haotian Wu, Chelsea Marcho, Olga Dribnokhodova, Victoria Shtratnikova, Oleg Sergeyev, Alexander Suvorov
Summary: Paternal age is closely associated with changes in sperm methylome, and environmental xenobiotics may interfere with this process.
Article
Environmental Sciences
Bora Plaku-Alakbarova, Oleg Sergeyev, Paige L. Williams, Jane S. Burns, Mary M. Lee, Russ Hauser, Susan A. Korrick
Summary: The study found that in a group of 8-9 year old Russian boys, serum dioxins, furans and PCBs clustered by chlorination pattern, with Sigma NDL-PCBs representing 4,4'-chlorinated PCBs most effectively. This may reflect shared persistence, metabolism or source of exposure of these chemicals in the human body.
Editorial Material
Pharmacology & Pharmacy
Kelsey J. Cook, Benjamin Q. Duong, Nathan D. Seligson, Pamela Arn, Vicky L. Funanage, Karen W. Gripp, Susan M. Kirwin, Stephen T. Lawless, Mary M. Lee, Katherine M. Robbins, David West, Kathryn V. Blake
Summary: Clinical implementation of pharmacogenomics relies on integrating PGx results into EHR and CDS systems. Institutions often struggle to develop their own PGx CDS and may turn to external genomic support vendors for assistance, but there is limited information available on this process. Sharing experiences can help guide other institutions in choosing a suitable genomic support vendor for PGx implementation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Obstetrics & Gynecology
Paige L. Williams, Lidia Minguez-Alarcon, Susan A. Korrick, Mary M. Lee, Bora Plaku-Alakbarova, Jane S. Burns, Luidmila Smigulina, Yury Dikov, Ramy Abou Ghayda, Russ Hauser, Oleg Sergeyev
Summary: This study aimed to investigate the association between peripubertal blood lead levels (BLLs) and semen parameters and serum reproductive hormones among young Russian men. The findings suggest a possible link between higher peripubertal BLLs and lower ejaculate volume, but no associations were found between BLLs and reproductive hormones or other sperm parameters. Further research is warranted to explore this potential link and confirm the lack of associations among youth exposed to environmental BLLs.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Mikhail Polzikov, Dmitry Blinov, Zarema Barakhoeva, Lyudmila Vovk, Yulia Fetisova, Maria Ovchinnikova, Marina Tischenko, Irina Zorina, Vasily Yurasov, Tatyana Ushakova, Oleg Sergeyev
Summary: This study aimed to investigate the association of serum folate, magnesium, and calcium levels before ovarian stimulation with assisted reproductive technology (ART) outcomes in normogonadotropic women. The study found that high serum folate concentration and a lower calcium/magnesium ratio were associated with worse ART outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Lidia Minguez Alarcon, Jane Burns, Paige L. Williams, Susan A. Korrick, Mary M. Lee, Jemar R. Bather, Sergey V. Kovalev, Sergey A. Sokolov, Albert T. Lebedev, Luidmila Smigulina, Ramy Abou Ghayda, Holger M. Koch, Oleg Sergeyev, Russ Hauser
Summary: This study aimed to investigate the associations between urinary phthalate metabolite concentrations measured during pubertal development and semen parameters in Russian men. The results showed that higher urinary concentrations of EDiNP metabolites during late puberty were related to poorer semen quality. Additionally, young men with higher urinary concentrations of MiBP metabolites in early puberty tended to have poorer semen quality.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Jane S. Burns, Oleg Sergeyev, Mary M. Lee, Paige L. Williams, Lidia Minguez-Alarcon, Bora Plaku-Alakbarova, Sergey Sokolov, Sergey Kovalev, Holger M. Koch, Albert T. Lebedev, Russ Hauser, Susan A. Korrick
Summary: This study examined the association between phthalate metabolite concentrations in prepubertal urine and age at pubertal onset in Russian boys. The results showed that boys with higher concentrations of phthalate metabolites had later pubertal onset, possibly due to disruption of androgen-dependent biological pathways.
ENVIRONMENTAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
Vasily Ashapkin, Alexander Suvorov, J. Richard Pilsner, Stephen A. Krawetz, Oleg Sergeyev
Summary: This article reviews age-related epigenetic changes in sperm in mammals and humans, including DNA methylation, histone modifications, and non-coding RNAs. Age affects all known epigenetic mechanisms in sperm, which may have implications for embryonic and offspring epigenetic and phenotypic events. Chemical and lifestyle exposures, as well as assisted reproductive technologies, can influence the epigenetic aging of sperm. The age-related changes in the sperm epigenome may compromise reproductive health of fathers and transfer altered epigenetic information to subsequent generations.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Biochemistry & Molecular Biology
Olatunbosun Arowolo, J. Richard Pilsner, Oleg Sergeyev, Alexander Suvorov
Summary: Polybrominated diphenyl ethers (PBDEs) are flame retardants used in artificial materials. They persist in the environment and human tissues, causing male reproductive toxicity, including genital malformations and decreased sperm quality. Mechanisms of toxicity include oxidative stress, hormone signaling disruption, and metabolic signaling disruption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Vitalik Bezuglov, Alexey Stupnikov, Ivan Skakov, Victoria Shtratnikova, J. Richard Pilsner, Alexander Suvorov, Oleg Sergeyev
Summary: Expression analysis of small noncoding RNA (sRNA), including microRNA, piwi-interacting RNA, small rRNA-derived RNA, and tRNA-derived small RNA, is a challenging task due to the need for selecting and adapting an optimal pipeline. This paper focuses on identifying the best pipeline configurations for each step of human sRNA analysis, including trimming, filtering, mapping, quantification, and differential expression analysis. Based on the study, parameters for human sRNA analysis with two groups of biosamples are suggested, such as trimming with specific length bounds, mapping with bowtie aligner allowing one mismatch, filtering by mean threshold, and using DESeq2 or limma for differential expression analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alexey Stupnikov, Vitaly Bezuglov, Ivan Skakov, Victoria Shtratnikova, J. Richard Pilsner, Alexander Suvorov, Oleg Sergeyev
Summary: This article introduces ITAS, an integrated transcript annotation tool for small RNA, which provides filtered, corrected and integrated information on various types of small RNAs. It is applicable for most bioinformatics transcriptomics analysis.
Article
Andrology
Victoria Shtratnikova, Vladimir Naumov, Vitaly Bezuglov, Anna Zheludkevich, Luidmila Smigulina, Yury Dikov, Tatiana Denisova, Alexander Suvorov, J. Richard Pilsner, Russ Hauser, Stephen A. Krawetz, Oleg Sergeyev
Summary: This study aimed to optimize methods for isolating small RNAs from sperm and preparing libraries for sequencing, using 67 samples from the Russian Children's Study biobank. Despite using the same amount of miRNA input, NEBNext libraries had significantly higher DNA concentration compared to NEXTFlex libraries. In high input situations, NEXTFlex Small RNA-Seq kit detected more microRNAs, while NEBNext proved more effective in low input scenarios.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2021)