Article
Neurosciences
Anton Tokariev, Victoria C. Oberlander, Mari Videman, Sampsa Vanhatalo
Summary: The effects of maternal SRI medication on infants' early neurodevelopment, specifically cortical frequency-specific and cross-frequency interactions, were studied. The study found that the sleep-related dynamics of PPC networks were affected by in utero SRI exposure, but these alterations did not correlate to later neurocognitive development. Phase-amplitude coupling was found to be suppressed in SRI infants and was linked to their neurocognitive outcomes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Eduardo Gutierrez-Abejon, M. Aranzazu Pedrosa-Naudin, Diego Fernandez-Lazaro, F. Javier Alvarez
Summary: Non-adherence to antidepressants is associated with worse disease outcomes and economic burden. This study found that nearly 20% of patients were non-adherent to antidepressant treatment in 2021. Different types of antidepressants varied in terms of non-adherence rates and costs. Reducing non-adherence to antidepressants is critical for improving clinical and economic outcomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jaena Han, Valentine Andreu, Cory Langreck, Elizabeth A. Pekarskaya, Steven G. Grinnell, Florence Allain, Valerie Magalong, John Pintar, Brigitte L. Kieffer, Alexander Z. Harris, Jonathan A. Javitch, Rene Hen, Katherine M. Nautiyal
Summary: Research has shown that tianeptine can rapidly induce antidepressant-like effects in mice after just one week of treatment. Its mechanism of action differs from fluoxetine in two key aspects, including the requirement for MORs for its chronic antidepressant-like effect and the lack of promotion of hippocampal neurogenesis compared to fluoxetine.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Lin Lin, Lin Yu, Shuying Zhang, Jing Liu, Ying Xiong
Summary: This study aimed to observe the influence of MPIM on infantile eczema, quality of life, growth, and maternal mental state. The results showed that MPIM could effectively promote the remission of infantile eczema and reduce its relapse, along with relieving maternal anxiety and depression mood.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Allergy
Kjell Erik Julius Hakansson, Martino Renzi-Lomholt, Vibeke Backer, Charlotte Suppli Ulrik
Summary: The purpose of this study was to investigate the prevalence and risk factors for antidepressant use in asthma patients compared to the background population. The results revealed a significantly higher use of antidepressant drugs in asthma patients, even after adjusting for known risk factors. Female sex, higher age, being divorced or never married, having lower education level and lower income were associated with higher odds of antidepressant use. The study suggests that living with asthma carries a psychological burden, leading to increased use of antidepressants.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Medicine, General & Internal
Christine Sandheimer, Cecilia Bjorkelund, Gunnel Hensing, Kirsten Mehlig, Tove Hedenrud
Summary: The study evaluated the implementation of a care manager organisation for common mental disorders in primary care centres in Region Vastra Gotaland, Sweden, and its association with antidepressant medication patterns. PCCs with a care manager organisation had a significantly lower proportion of inadequate medication users in 2016 compared to those without the organisation. Private PCCs had higher proportions of inadequate medication users, while PCCs that shifted to a care manager organisation showed a significant decrease in inadequate medication users over time.
Article
Clinical Neurology
Ayesha C. Sujan, Nerissa Nance, Charles Quesenberry, Kathryn Ridout, Mibhali Bhalala, Lyndsay A. Avalos
Summary: This study found racial and ethnic differences in perinatal depression and anxiety. Asian individuals had a lower risk of perinatal depression and anxiety but a higher risk of severe depression during pregnancy. Non-Hispanic Black individuals had a higher risk of perinatal depression and anxiety. Hispanic individuals had a lower risk of depression during pregnancy but a higher risk of postpartum depression and severe depression during and after pregnancy. Targeted prevention, intervention, and destigmatization efforts should be implemented for different racial and ethnic groups.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
David P. Herzog, Diego Pascual Cuadrado, Giulia Treccani, Tanja Jene, Verena Opitz, Annika Hasch, Beat Lutz, Klaus Lieb, Inge Sillaber, Michael A. Van der Kooij, Vijay K. Tiwari, Marianne B. Mueller
Summary: The study revealed differentially expressed genes associated with paroxetine treatment and candidate mechanisms related to good treatment response, such as neuropeptide signaling and synaptic transmission. The results suggest that general paroxetine effects can be distinguished from treatment response-associated molecular signatures, offering potential new targets for future antidepressant treatments.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Megan M. Hare, Aimee Kroll-Desrosiers, Kristina M. Deligiannidis
Summary: The study found that women at risk for peripartum depression and those with peripartum depression experience worse mother-infant bonding. Peripartum anxiety should also be assessed as it may indicate later postpartum depression.
DEPRESSION AND ANXIETY
(2021)
Article
Obstetrics & Gynecology
Emelie Wolgast, Caroline Lilliecreutz, Gunilla Sydsjo, Marie Bladh, Ann Josefsson
Summary: The study found that women with major depressive disorder (MDD) diagnosed before pregnancy and who had used antidepressants before or during pregnancy were at increased risk for adverse obstetric and neonatal outcomes compared to women without MDD. These risks included operative childbirth, neonatal intensive care unit (NICU) admissions, preterm birth, and low birthweight. Women who continued antidepressant medication during pregnancy had somewhat higher risks for adverse outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shaopu Wang, Shuqin Zeng, Muireann Egan, Paul Cherry, Conall Strain, Emilene Morais, Patrick Boyaval, C. Anthony Ryan, Eugene M. Dempsey, R. Paul Ross, Catherine Stanton
Summary: The study analyzed 376 mother-infant dyads and found that maternal gut microbiota has higher diversity at species and strain levels, with many shared species showing more metabolic functions in mother-sourced species. Predictive models showed moderate performance accuracy for shared species and strains occurrences in infants.
Article
Multidisciplinary Sciences
Natalie Hesselgrave, Timothy A. Troppoli, Andreas B. Wulff, Anthony B. Cole, Scott M. Thompson
Summary: Psilocybin has shown promising rapid and persistent antidepressant effects in mice, possibly through enhancing excitatory synapses in the hippocampus, independent of 5-HT2A receptor activation. Further research is needed to explore the potential combination of psychedelic compounds and 5-HT2AR antagonists for clinical utility in human depression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Gastroenterology & Hepatology
Nishani Jayasooriya, Jonathan Blackwell, Sonia Saxena, Alex Bottle, Irene Petersen, Hanna Creese, Matthew Hotopf, Richard C. G. Pollok
Summary: This study found that the use of antidepressants among individuals diagnosed with inflammatory bowel disease (IBD) has been increasing over the years. However, a majority of patients did not adhere to the recommended treatment duration according to international guidelines. Younger patients were more likely to discontinue antidepressant treatment earlier.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Philip Boyce, Rebecca Anglin, Elizabeth McKinnon, Andrew J. Lewis
Summary: The study found that women with untreated depression during pregnancy had higher intake of unhealthy takeaway food throughout the postpartum period, while higher depressive symptoms in the postpartum were also associated with higher takeaway intake. However, there was no difference in fruit and vegetable intake among the three groups, and intake was highest for all women late in pregnancy and declined in the postpartum period.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Sarah M. Hutchison, Steven L. Rathgeber, Astrid M. De Souza, Tom Blydt-Hansen, Louise C. Masse, Kathryn R. Armstrong, Tim F. Oberlander
Summary: The study examines the agreement between parent and adolescent ratings of executive function in adolescents with solid organ transplant. The results show moderate to excellent agreement between parents and adolescents, with higher agreement in males than females. Both parents and adolescents report higher levels of executive dysfunction compared to their peers.
APPLIED NEUROPSYCHOLOGY-CHILD
(2022)
Review
Health Care Sciences & Services
Enav Z. Zusman, Alekhya Lavu, Colleen Pawliuk, Jodi Pawluski, Sarah M. Hutchison, Robert W. Platt, Tim F. Oberlander
Summary: This study aims to assess the impact of prenatal exposure to serotonergic antidepressants on stress regulation in children. Various physiological indices, such as cortisol levels and heart rate variability, will be evaluated to determine the effects of these drugs on children. The results of this assessment will inform decisions about using these medications during pregnancy.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Psychiatry
Sarah M. Hutchison, Ursula Brain, Ruth E. Grunau, Boris Kuzeljevic, Mike Irvine, Louise C. Masse, Tim F. Oberlander
Summary: Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with increased internalising and anxious behaviours in young children, but it is unclear whether this association persists into early adolescence. Furthermore, the contribution of in utero SSRI exposure versus underlying maternal mood to these associations is not well established.
Article
Clinical Neurology
Ella Weik, Regula Neuenschwander, Brinn Edgington, Karin Jensen, Christine M. Tipper, Tim F. Oberlander
Summary: Previous studies have provided inconsistent results on whether adolescents show similar, weaker, or non-significant conditioned placebo and nocebo effects compared to adults. In this current study, the researchers used novel neutral 3D visual cues to implicitly induce conditioned placebo-like and nocebo-like effects in adolescents and adults. The results showed that adults were more influenced by the conditioning cues compared to adolescents, suggesting that thermal perception in adolescents is less influenced by conditioning.
BRITISH JOURNAL OF PAIN
(2023)
Review
Clinical Neurology
Aurore Curie, Tim F. F. Oberlander, Karin B. Jensen
Summary: Placebo responses are frequently observed in research studies and clinical contexts, yet there is limited knowledge about the placebo effect among children with neurodevelopmental disorders. In this review, the authors discuss the placebo effect in autism spectrum disorder (ASD) and how it can be influenced by caregivers or clinicians indirectly shaping patient outcomes. Understanding placebo effects in ASD may help differentiate genuine treatment effects from contextual factors in clinical trials and improve research designs and treatments for ASD symptoms. Furthermore, deeper knowledge about placebo and nocebo effects may optimize care delivery for individuals with ASD in the future.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Behavioral Sciences
Katelynn E. Boerner, Leora Pearl-Dowler, Liisa Holsti, Marie-Noelle Wharton, Harold Siden, Tim F. Oberlander
Summary: Quality child health research requires multimodal, multi-informant, longitudinal tools for data collection to ensure a holistic description of real-world health, function, and well-being. However, the design of these tools has not typically included community input from families with children whose function spans the developmental spectrum.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Jodi L. Pawluski, Pauline Murail, Florine Grudet, Lena Bys, Anna V. Golubeva, Thomaz Bastiaanssen, Tim F. Oberlander, John F. Cryan, Siobhain M. O'Mahony, Thierry D. Charlier
Summary: This study aimed to determine how peripartum SSRI treatment may prevent the effects of gestational stress on plasticity in the maternal hippocampus, plasticity in the neonatal brain, and related changes in gut microbiota. The findings show significant changes to the maternal microbiome-gut-brain axis that may mediate plasticity in the maternal hippocampus. Additionally, gestational stress has a significant impact on neonatal gut microbiota and brain microglia density, while the effects of SSRIs are limited. This is the first study to explore the impact of gestational stress and SSRIs on the microbiome-gut-brain axis in the mother and neonate.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Neurosciences
Tanvi A. Puri, Jennifer E. Richard, Liisa A. M. Galea
Summary: Growing attention is given to the inclusion of females in neuroscience studies and studying sex as a biological variable. However, there is limited research on how female-specific factors like menopause and pregnancy affect the brain. This review focuses on pregnancy as a unique female experience that can impact neuroplasticity, neuroinflammation, and cognition, highlighting studies in humans and rodents.
TRENDS IN NEUROSCIENCES
(2023)
Article
Endocrinology & Metabolism
Tori N. Stranges, Amanda B. Namchuk, Tallinn F. L. Splinter, Katherine N. Moore, Liisa A. M. Galea
Summary: Sex and gender play a significant role in health outcomes, yet the health of women and 2S/LGBTQ+ individuals is often compromised. The CIHR implemented a framework to incorporate sex and gender analysis into grant proposals, but only a small percentage of funded grants mentioned sex or gender. There is a need for greater emphasis on sex, gender, and health equity populations in research.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Psychiatry
Grace A. Thiele, Deirdre M. Ryan, Tim F. Oberlander, Gillian E. Hanley
Summary: The study used population-based data to build complex, longitudinal mental health histories, finding that preconception to postpartum depression and anxiety play a significant role in predicting adverse pregnancy and birth outcomes.
Editorial Material
Endocrinology & Metabolism
Jodi L. Pawluski, Paula J. Brunton, Oliver J. Bosch
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
A. Khan, A. M. Inkster, M. S. Penaherrera, S. King, S. Kildea, T. F. Oberlander, D. M. Olson, C. Vaillancourt, U. Brain, E. O. Beraldo, A. G. Beristain, V. L. Clifton, G. F. Del Gobbo, W. L. Lam, G. A. S. Metz, J. W. Y. Ng, E. M. Price, J. M. Schuetz, V. Yuan, E. Portales-Casamar, W. P. Robinson
Summary: This study analyzed DNAme data from 204 placentas from three cohorts to estimate epiphenotypes including gestational age, ancestry, and cell composition. The results showed that epigenetic gestational age was estimated accurately within 4 days of reported gestational age, and cell composition estimates varied within and between cohorts as well as over long placental processing times. The study also found that the ratio of cytotrophoblast to syncytiotrophoblast proportion decreased with increasing gestational age, and differed slightly by maternal ethnicity and genetic ancestry. The cohort of origin and cytotrophoblast proportion were the largest drivers of DNAme variation in the dataset.
EPIGENETICS & CHROMATIN
(2023)
Article
Pediatrics
Katelynn E. Boerner, Unma Desai, Jessica Luu, Karon E. Maclean, Tamara Munzner, Haley Foladare, Jane Shen, Javed Gill, Tim F. Oberlander
Summary: Data tracking is a common feature in pain e-health applications, but its potential as an intervention through data visualization has not been investigated. A feasibility trial was conducted with youth aged 12-18 years, using Ecological Momentary Assessment (EMA) data collection and a data visualization platform. Technical issues affected participant experience and data analysis, and only 48% of participants viewed the visualizations. Patient feedback is crucial for modifying the platform and addressing technical issues before a larger trial.
Article
Psychology, Developmental
Dianne Semeniuk, Katelynn E. Boerner, Ursula Brain, Deirdre Ryan, Tim F. Oberlander
Summary: This study examined the relationship between mood symptoms in birthing parents at 3 months postpartum and their child's internalizing behavior at 3 and 6 years old, and found that parenting stress at 6 months postpartum mediated this relationship. The association between higher postpartum mood symptoms at 3 months and increased internalizing behavior at 3 years old was influenced by increased reports of parenting stress at 6 months. However, this association was not evident at 6 years. Early parenting stress may be a target for reducing the impact of perinatal depression on early child behavior.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Medicine, Research & Experimental
Katelynn E. Boerner, Unma Desai, Karon E. MacLean, Tamara Munzner, Haley Foladare, Javed Gill, Tim F. Oberlander
Summary: This study aims to explore the feasibility and acceptability of using a data visualization platform to track and monitor chronic pain in youth. The randomized controlled trial will recruit 50 participants and examine the effects of using the intervention on symptom appraisal and functional recovery. The results will provide valuable insights for conducting larger-scale trials and supporting clinical care for youth with chronic pain.
PILOT AND FEASIBILITY STUDIES
(2022)
