Article
Rheumatology
Jelena Vojinovic, Ivan Foeldvari, Joke Dehoorne, Violeta Panaviene, Gordana Susic, Gerd Horneff, Valda Stanevicha, Katarzyna Kobusinska, Zbigniew Zuber, Bogna Dobrzyniecka, Jonathan Akikusa, Tadej Avcin, Cecilia Borlenghi, Edmund Arthur, Svitlana Y. Tatulych, Chuanbo Zang, Vassilis Tsekouras, Bonnie Vlahos, Alberto Martini, Nicolino Ruperto
Summary: CLIPPER2 is an 8-year study on the safety and efficacy of etanercept in patients with juvenile idiopathic arthritis (JIA). The study found that etanercept treatment was well tolerated and effective in these patients.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Franz Thiele, Ariane Klein, Jens Klotsche, Daniel Windschall, Frank Dressler, Jasmin Kuemmerle-Deschner, Kirsten Minden, Ivan Foeldvari, Dirk Foell, Sonja Mrusek, Prasad Thomas Oommen, Gerd Horneff
Summary: This study investigated the impact of additionally given MTX on the effectiveness, safety, and drug survival of biologic treatment in polyarticular JIA. The results showed that additionally given MTX improves the effectiveness of biologic treatment, especially for patients receiving TNFi, without seriously compromising treatment safety. Patients treated with TNFi gained more benefits from additionally given MTX compared to patients treated with tocilizumab.
Review
Rheumatology
Claas H. Hinze, Dirk Foell, Christoph Kessel
Summary: Systemic juvenile idiopathic arthritis (sJIA) is a disease characterized by severe systemic inflammation and arthritis. It poses challenges to rheumatologists treating pediatric and adult patients worldwide. Although treatment plans exist for classic sJIA, there is still a lack of clear treatment approaches for early sJIA without arthritis and complicated sJIA.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Immunology
L. Nijhuis, J. F. Swart, B. J. Prakken, J. van Loosdregt, S. J. Vastert
Summary: This review discusses the unresolved clinical challenges in juvenile idiopathic arthritis (JIA) and explores how an increased understanding of the disease's biology can lead to future treatment strategies at various stages of the disease. The most relevant disease subtypes, nonsystemic (OA and PA) JIA and systemic (SJ) JIA, are examined, along with their proposed mechanisms and current therapeutic modalities. Current treatment strategies in JIA, such as the "Step-up" and "Treat to Target" approaches, are discussed, and the potential for more targeted strategies in the future is explored.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Immunology
Stephanie Py, Florine Maylie, Anne-Laure Parmentier, Chrystelle Vidal, Benjamin Cuinet, Frederic Mauny, Anne Lohse, Eric Toussirot, Sagawa Yoshimasa, Nicolas Tordi, Delphine Binda, Claire Ballot-Schmit
Summary: The ATHLETIQUE project aims to evaluate the impact of an Adapted Physical Activities (APA) program integrated with the use of a pedometer watch on disease activity in patients with Juvenile Idiopathic Arthritis (JIA). The study will be a randomized, multicenter, open-label, controlled clinical trial with 2 parallel arms, involving children and adolescents with JIA aged 6 to 17 years. The expected results may contribute to promoting an active lifestyle and improving physical and mental well-being in children with JIA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Renata Puppin Zandonadi
Summary: Nutrition plays a crucial role in the treatment, health, and life of patients with juvenile idiopathic arthritis (JIA). Suboptimal nutrition can adversely affect the long-term outcome of JIA patients, while correct nutritional status helps with recovery and inflammation reduction.
Article
Rheumatology
Martijn J. H. Doeleman, Sytze de Roock, Mohsin El Amrani, Erik M. van Maarseveen, Nico M. Wulffraat, Joost F. Swart
Summary: The objective of this study was to assess the relationship between adalimumab trough concentrations and treatment response in paediatric patients with JIA. The results showed that adalimumab trough concentrations were significantly lower in patients with secondary failure compared to patients with primary failure or an adequate response. This suggests that trough concentration measurements could identify JIA patients who require increased adalimumab doses.
Article
Medicine, General & Internal
Monika Ostrowska, Piotr Gietka, Malgorzata Manczak, Emil Michalski, Iwona Sudol-Szopinska
Summary: The study aimed to differentiate between hip arthritis in JIA and hip arthralgia of unknown etiology using MRI. MRI is effective in distinguishing between the two conditions, with good specificity in confirming a diagnosis of JIA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Saverio La Bella, Marta Rinaldi, Armando Di Ludovico, Giulia Di Donato, Giulio Di Donato, Vincenzo Salpietro, Francesco Chiarelli, Luciana Breda
Summary: This review evaluates the current understanding of the pathogenesis of JIA subtypes by examining the most relevant and up-to-date evidence. Despite significant improvements over the past decade, the exact cause and molecular mechanisms of JIA remain unclear. Complex interactions between genetic background and environmental factors, as well as the involvement of HLA haplotypes and non-HLA genes, contribute to the abnormal activation of immune cells and the inflammatory process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Celine Klein, Vincent Barbier, Christophe Glorion, Richard Gouron
Summary: Juvenile idiopathic arthritis (JIA) is a common chronic rheumatic disease in children and significantly affects their daily life. The introduction of new drug treatments has reduced the need for surgery, but personalized surgical management is still required for patients who do not respond to drug therapy. This article provides an overview of the surgical indications and outcomes for various interventions in JIA, such as intra-articular corticosteroid injections, synovectomy, soft tissue release, surgery for growth disorders, and arthroplasty.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pediatrics
Emil Carlsson, Michael W. Beresford, Athimalaipet Ramanan, Andrew D. Dick, Christian M. Hedrich
Summary: Early treatment and frequent screening are crucial for controlling JIA-associated uveitis, which poses a significant risk for serious complications. The identification of specific risk factors for JIA-associated uveitis is a key focus of research as our understanding of pathogenic drivers is still incomplete. Genomic, transcriptomic, and proteomic factors have been identified as potential risk factors, and therapeutic strategies are being discussed.
Article
Medicine, General & Internal
Alberto Martini, Daniel J. Lovell, Salvatore Albania, Hermine Brunner, Kimme L. Hyrich, Susan D. Thompson, Nicolino Ruperto
Summary: Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory rheumatic condition of childhood, classified into seven categories. The pathogenesis of JIA involves autoimmune and autoinflammatory mechanisms, and the availability of new drugs has significantly improved treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Review
Nutrition & Dietetics
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jing-Long Huang, Jenn-Haung Lai
Summary: Vitamin D plays an important role in bone health and immune regulation. Juvenile idiopathic arthritis is a chronic inflammatory joint disease, and vitamin D may have potential effects on its manifestations and outcomes.
Article
Rheumatology
Mirkamal Tolend, Thitiporn Junhasavasdikul, Randy Q. Cron, Emilio J. Inarejos Clemente, Thekla von Kalle, Christian J. Kellenberger, Bernd Koos, Elka Miller, Marion A. van Rossum, Rotraud K. Saurenmann, Lynn Spiegel, Jennifer Stimec, Marinka Twilt, Nikolay Tzaribachev, Shelly Abramowicz, Simone Appenzeller, Linda Z. Arvidsson, Saurabh Guleria, Jacob L. Jaremko, Eva Kirkhus, Tore A. Larheim, Arthur B. Meyers, Jyoti Panwar, Cory M. Resnick, Susan C. Shelmerdine, Brian M. Feldman, Andrea S. Doria
Summary: A DCE survey was used to determine the relative importance weights of items and grades of the JAMRIS-TMJ, showing high convergent validity with an unrestricted, holistic vignette ranking method.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Daniel D. Reiff, Randy Q. Cron
Summary: This review provides an in-depth analysis of multisystem inflammatory disease in children (MIS-C) following COVID-19. It discusses the clinical findings, pathophysiology, imaging and laboratory studies, treatment algorithms, and disease outcomes. MIS-C can be challenging to diagnose due to its non-specific presentation, but accurate diagnosis can be achieved through common laboratory features, imaging findings, and historical clues, enabling appropriate treatment with therapies such as IVIG. Aggressive treatment leads to good outcomes, and longitudinal studies shed light on long-term cardiac sequelae and recovery.
CURRENT RHEUMATOLOGY REPORTS
(2022)
Article
Biology
Daniel D. Reiff, Mingce Zhang, Emily A. Smitherman, Melissa L. Mannion, Matthew L. Stoll, Peter Weiser, Randy Q. Cron
Summary: This study found decreased NK cell function and features of sHLH in a severe COVID-19 patient, and identified a mutation in the patient's genetic makeup. The mutation resulted in significantly decreased NK cell degranulation and cytolysis. These findings are important for understanding the pathophysiology, diagnosis, and treatment of severe COVID-19 cases.
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. The guideline emphasizes the importance of improving patient quality of life and involving patients and caregivers in decision-making. However, the evidence quality for all recommendations is low.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on specific types of JIA and treatment options. The recommendations are based on low-quality evidence and are conditional in nature.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This guideline provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Recommendations include physical therapy and occupational therapy interventions, a healthy diet, medication monitoring, immunizations, and shared decision-making with patients/caregivers.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Matthew Gibson, Randy Q. Cron, Matthew L. Stoll, Brian E. Kinard, Tessa Patterson, Chung How Kau
Summary: This study found significant differences in airway dimensions, particularly in the nasopharyngeal airway volume and the most constricted cross-sectional area, between juvenile idiopathic arthritis (JIA) patients and healthy controls. Additionally, there may be an impact on posterior facial dimensions in JIA patients.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Anshul Vagrecha, Mingce Zhang, Suchitra Acharya, Shannon Lozinsky, Aaron Singer, Chana Levine, Maha Al-Ghafry, Carolyn Fein Levy, Randy Q. Cron
Summary: Children with COVID-19 have the potential to develop a novel syndrome known as MIS-C, characterized by high levels of inflammation. This study discovered that a small number of children with MIS-C carried genetic mutations, including a variant called DOCK8, which may be a risk factor for the development of this syndrome. These findings contribute to a better understanding of the mechanisms underlying MIS-C.
Editorial Material
Rheumatology
Melissa L. Mannion, Randy Q. Cron
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Immunology
Randy Q. Cron
Summary: In addition to the acute phase, a significant percentage of SARS-CoV-2 patients experience prolonged illness with varying symptoms. Longitudinal data collection on immunologic, inflammatory, and metabolic factors has allowed the development of a composite signature that can predict recovery.
Article
Biology
Daniel D. Reiff, Mingce Zhang, Randy Q. Cron
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by uncontrolled inflammation and immune system activation. Primary HLH (pHLH) is caused by genetic mutations that lead to organ failure and can be fatal. Secondary HLH (sHLH) can be triggered by genetic mutations in certain genes. This study focused on the significance of a DOCK2 mutation in the pathogenesis of sHLH and its implications for diagnosis and treatment.
Review
Immunology
Pui Y. Lee, Randy Q. Cron
Summary: Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states characterized by persistent immune cell activation and excessive cytokine production. CSSs can be caused by genetic errors of immunity, infections, chronic inflammatory diseases, or malignancies. This review explores the biology of different types of CSSs, the involvement of immune pathways, the contribution of host genetics, and discusses treatment approaches.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Pediatrics
Daniel D. Reiff, Randy Q. Cron
Summary: Cytokine storm syndrome (CSS) is a serious condition caused by severe systemic inflammation and immune activation. The use of cytokine-directed therapies, such as interleukin-1 receptor antagonist, has shown promising results in treating CSS in ECMO patients.
Editorial Material
Rheumatology
Daniel D. Reiff, Randy Q. Cron