Article
Rheumatology
Edoardo Conticini, Paolo Falsetti, Suhel Gabriele Al Khayyat, Caterina Baldi, Francesca Bellisai, Marco Bardelli, Jurgen Sota, Luca Cantarini, Bruno Frediani
Summary: The study found that edema and power Doppler signal are closely related to early active myositis, while muscle atrophy is more related to the patient's age and the severity of the disease.
Article
Rheumatology
Anne W. Walter, Johan Lim, Joost Raaphorst, Frank F. Smithuis, J. Michiel den Harder, Filip Eftimov, Wouter Potters, Christiaan G. J. Saris, Marianne de Visser, Ivo N. van Schaik, Rob J. de Haan, Anneke J. van der Kooi, Camiel Verhamme
Summary: This study compared the sensitivity of ultrasound and whole-body MRI in detecting muscle abnormalities associated with IIM. The results showed that MRI was more sensitive in detecting these abnormalities. Semi-quantitative and qualitative ultrasound were able to detect abnormalities in most patients, while evaluating fewer muscles compared to MRI. These ultrasound methods also showed changes over time after nine weeks of treatment.
Review
Radiology, Nuclear Medicine & Medical Imaging
Shaobo Fang, Yanyu Yang, Nan Xu, Yun Tu, Zhenzhen Yin, Yu Zhang, Yajie Liu, Zhiqing Duan, Wenyu Liu, Shaowu Wang
Summary: In the past two decades, efforts have been made to develop non-invasive methods and new imaging tools such as diffusion-weighted imaging, perfusion imaging, magnetic resonance spectroscopy, and the use of artificial intelligence technology to aid in predicting tumor grade, aiding in early treatment decisions, and providing prognostic information. These advancements offer leverage in characterizing the spatial heterogeneity of tumor tissues.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Review
Clinical Neurology
Claus Z. Simonsen, Thabele M. Leslie-Mazwi, Gotz Thomalla
Summary: Reperfusion therapy has been shown to be effective for stroke with unknown time of onset, but challenges in clinical practice exist due to variability in data and different imaging paradigms. Physicians need to consider which imaging approach to use when guiding reperfusion treatment for these patients.
Article
Chemistry, Applied
Kathryn E. Anderssen, Mathias Kranz, Shaheen Syed, Svein Kristian Stormo
Summary: This study investigates the use of diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) as a quantitative method to describe the structure of muscle tissue in meat and seafood. The results show that DTI can effectively distinguish between different sample qualities and detect changes caused by freezing and thawing damage.
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paolo Spinnato, Anna Maria Chiesa, Pauline Ledoux, Michele Kind, Giuseppe Bianchi, Gianmarco Tuzzato, Alberto Righi, Amandine Crombe
Summary: In this study, the researchers investigated whether conventional MRI could differentiate extra-nodal soft-tissue lymphomas from other soft-tissue tumors. The results showed that MRI features such as signal intensity, enhancement pattern, presence of blood or fibrotic signal, and abnormal vasculature were independent predictors of lymphomas. The findings suggest that MRI can be a useful tool in suggesting the diagnosis of lymphomas and expediting histopathological analysis.
ACADEMIC RADIOLOGY
(2023)
Article
Medicine, General & Internal
Kevin Chevalier, Benjamin Thoreau, Marc Michel, Bertrand Godeau, Christian Agard, Thomas Papo, Karim Sacre, Raphaele Seror, Xavier Mariette, Patrice Cacoub, Ygal Benhamou, Herve Levesque, Cecile Goujard, Olivier Lambotte, Bernard Bonnotte, Maxime Samson, Felix Ackermann, Jean Schmidt, Pierre Duhaut, Jean-Emmanuel Kahn, Thomas Hanslik, Nathalie Costedoat-Chalumeau, Benjamin Terrier, Alexis Regent, Bertrand Dunogue, Pascal Cohen, Veronique Le Guern, Eric Hachulla, Benjamin Chaigne, Luc Mouthon
Summary: This study aims to better characterize the features and outcomes of a large population of patients with mixed connective tissue disease (MCTD). An observational retrospective multicenter cohort study was conducted in France, including patients who fulfilled at least one MCTD diagnostic criterion and none of the criteria for other differentiated CTD.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Grant Sprow, Joshua Dan, Joseph F. Merola, Victoria P. Werth
Summary: Cutaneous lupus erythematosus (CLE) is an autoimmune disease that can greatly impact patient's quality of life. New therapies are needed to effectively treat CLE. Anifrolumab and belimumab have shown efficacy in treating CLE, while other therapies targeting specific cells and pathways are currently being developed.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Nina Schweighofer, Mitja Rupreht, Natasa Marcun Varda, Primoz Caf, Petra Povalej Brzan, Vojko Kanic
Summary: The study found that epicardial adipose tissue (EAT) is associated with essential arterial hypertension (AH) in children and adolescents. Hypertensive patients have a higher volume and thickness of EAT compared to their healthy peers. The volume of EAT may be a potential predictor of AH in children.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ziying Yin, Xin Lu, Salomon Cohen Cohen, Yi Sui, Armando Manduca, Jamie J. Van Gompel, Richard L. Ehman, John Huston
Summary: The study developed an objective quantitative method based on MRE to characterize and visualize meningioma-brain adhesion. The entropy of Delta NOSSbdy was found to be significantly different between adherent and non-adherent tumors, with high accuracy for classification. The reconstructed 3D Delta NOSSbdy surface map is a useful tool for clinicians to identify meningiomas with a high risk of adhesion.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Rebecca R. Baker, Christopher Payne, Yichao Yu, Matin Mohseni, John J. Connell, Fangyu Lin, Ian F. Harrison, Paul Southern, Umesh S. Rudrapatna, Daniel J. Stuckey, Tammy L. Kalber, Bernard Siow, Lewis Thorne, Shonit Punwani, Derek K. Jones, Mark Emberton, Quentin A. Pankhurst, Mark F. Lythgoe
Summary: Magnetic resonance navigation is an emergent technique that allows for remote control of magnetically labeled therapies and devices using an MRI system. The MINIMA technique, a novel MRI-guided ablation technique, has the potential to avoid traditional toxicities and offers precise control over the ablation volume.
Article
Cardiac & Cardiovascular Systems
Conor P. O'Halloran, Joshua D. Robinson, Kae Watanabe, Katelyn B. Zumpf, Lucia C. Petito, Bradley S. Marino, Joyce T. Johnson
Summary: This study investigated the use of cardiac magnetic resonance (CMR) in children with myocarditis and examined the association between CMR use, hospital cost, and clinical outcomes. The study found that the use of CMR in pediatric myocarditis has increased over the past 15 years. For most children, CMR use is associated with higher hospitalization costs and similar length of stay, but for the sickest children, CMR use is associated with lower costs. The use of CMR in specific patients may improve clinical outcomes at a lower cost.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongxi Zhang, Xingwang Yong, Xiaohui Ma, Jianjiang Zhao, Zhipeng Shen, Xinchun Chen, Fengyu Tian, Weibo Chen, Dan Wu, Yi Zhang
Summary: APT imaging can differentiate high-grade and low-grade gliomas in pediatric patients, and provides additional value beyond quantitative relaxation times.
EUROPEAN RADIOLOGY
(2021)
Review
Immunology
Margherita Giannini, Benjamin Ellezam, Valerie Leclair, Frederic Lefebvre, Yves Troyanov, Marie Hudson, Jean-Luc Senecal, Bernard Geny, Oceane Landon-Cardinal, Alain Meyer
Summary: Systemic sclerosis and autoimmune myositis are associated with decreased quality of life and increased mortality. Recent findings have identified a new disease subset, called scleromyositis, within both diseases, which has important implications for patient management and understanding of the disease pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Mirkamal Tolend, Thitiporn Junhasavasdikul, Randy Q. Cron, Emilio J. Inarejos Clemente, Thekla von Kalle, Christian J. Kellenberger, Bernd Koos, Elka Miller, Marion A. van Rossum, Rotraud K. Saurenmann, Lynn Spiegel, Jennifer Stimec, Marinka Twilt, Nikolay Tzaribachev, Shelly Abramowicz, Simone Appenzeller, Linda Z. Arvidsson, Saurabh Guleria, Jacob L. Jaremko, Eva Kirkhus, Tore A. Larheim, Arthur B. Meyers, Jyoti Panwar, Cory M. Resnick, Susan C. Shelmerdine, Brian M. Feldman, Andrea S. Doria
Summary: A DCE survey was used to determine the relative importance weights of items and grades of the JAMRIS-TMJ, showing high convergent validity with an unrestricted, holistic vignette ranking method.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Daniel D. Reiff, Randy Q. Cron
Summary: This review provides an in-depth analysis of multisystem inflammatory disease in children (MIS-C) following COVID-19. It discusses the clinical findings, pathophysiology, imaging and laboratory studies, treatment algorithms, and disease outcomes. MIS-C can be challenging to diagnose due to its non-specific presentation, but accurate diagnosis can be achieved through common laboratory features, imaging findings, and historical clues, enabling appropriate treatment with therapies such as IVIG. Aggressive treatment leads to good outcomes, and longitudinal studies shed light on long-term cardiac sequelae and recovery.
CURRENT RHEUMATOLOGY REPORTS
(2022)
Article
Biology
Daniel D. Reiff, Mingce Zhang, Emily A. Smitherman, Melissa L. Mannion, Matthew L. Stoll, Peter Weiser, Randy Q. Cron
Summary: This study found decreased NK cell function and features of sHLH in a severe COVID-19 patient, and identified a mutation in the patient's genetic makeup. The mutation resulted in significantly decreased NK cell degranulation and cytolysis. These findings are important for understanding the pathophysiology, diagnosis, and treatment of severe COVID-19 cases.
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. The guideline emphasizes the importance of improving patient quality of life and involving patients and caregivers in decision-making. However, the evidence quality for all recommendations is low.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This study provides updated guidelines for pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on specific types of JIA and treatment options. The recommendations are based on low-quality evidence and are conditional in nature.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This guideline provides recommendations for the management of juvenile idiopathic arthritis, focusing on nonpharmacologic therapies, medication monitoring, immunizations, and imaging. Recommendations include physical therapy and occupational therapy interventions, a healthy diet, medication monitoring, immunizations, and shared decision-making with patients/caregivers.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Karen B. Onel, Daniel B. Horton, Daniel J. Lovell, Susan Shenoi, Carlos A. Cuello, Sheila T. Angeles-Han, Mara L. Becker, Randy Q. Cron, Brian M. Feldman, Polly J. Ferguson, Harry Gewanter, Jaime Guzman, Yukiko Kimura, Tzielan Lee, Katherine Murphy, Peter A. Nigrovic, Michael J. Ombrello, C. Egla Rabinovich, Melissa Tesher, Marinka Twilt, Marisa Klein-Gitelman, Fatima Barbar-Smiley, Ashley M. Cooper, Barbara Edelheit, Miriah Gillispie-Taylor, Kimberly Hays, Melissa L. Mannion, Rosemary Peterson, Elaine Flanagan, Nadine Saad, Nancy Sullivan, Ann Marie Szymanski, Rebecca Trachtman, Marat Turgunbaev, Keila Veiga, Amy S. Turner, James T. Reston
Summary: This article provides updated guidelines for the pharmacologic management of juvenile idiopathic arthritis (JIA), focusing on different forms of JIA and providing recommendations for treatment and tapering of medications. The evidence for these recommendations is generally low quality, but the inclusion of patients and caregivers in the decision-making process strengthens the relevance and applicability of the guideline.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Matthew Gibson, Randy Q. Cron, Matthew L. Stoll, Brian E. Kinard, Tessa Patterson, Chung How Kau
Summary: This study found significant differences in airway dimensions, particularly in the nasopharyngeal airway volume and the most constricted cross-sectional area, between juvenile idiopathic arthritis (JIA) patients and healthy controls. Additionally, there may be an impact on posterior facial dimensions in JIA patients.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Anshul Vagrecha, Mingce Zhang, Suchitra Acharya, Shannon Lozinsky, Aaron Singer, Chana Levine, Maha Al-Ghafry, Carolyn Fein Levy, Randy Q. Cron
Summary: Children with COVID-19 have the potential to develop a novel syndrome known as MIS-C, characterized by high levels of inflammation. This study discovered that a small number of children with MIS-C carried genetic mutations, including a variant called DOCK8, which may be a risk factor for the development of this syndrome. These findings contribute to a better understanding of the mechanisms underlying MIS-C.
Editorial Material
Rheumatology
Melissa L. Mannion, Randy Q. Cron
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Immunology
Randy Q. Cron
Summary: In addition to the acute phase, a significant percentage of SARS-CoV-2 patients experience prolonged illness with varying symptoms. Longitudinal data collection on immunologic, inflammatory, and metabolic factors has allowed the development of a composite signature that can predict recovery.
Article
Biology
Daniel D. Reiff, Mingce Zhang, Randy Q. Cron
Summary: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by uncontrolled inflammation and immune system activation. Primary HLH (pHLH) is caused by genetic mutations that lead to organ failure and can be fatal. Secondary HLH (sHLH) can be triggered by genetic mutations in certain genes. This study focused on the significance of a DOCK2 mutation in the pathogenesis of sHLH and its implications for diagnosis and treatment.
Review
Immunology
Pui Y. Lee, Randy Q. Cron
Summary: Cytokine storm syndromes (CSSs) are potentially fatal hyperinflammatory states characterized by persistent immune cell activation and excessive cytokine production. CSSs can be caused by genetic errors of immunity, infections, chronic inflammatory diseases, or malignancies. This review explores the biology of different types of CSSs, the involvement of immune pathways, the contribution of host genetics, and discusses treatment approaches.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Pediatrics
Daniel D. Reiff, Randy Q. Cron
Summary: Cytokine storm syndrome (CSS) is a serious condition caused by severe systemic inflammation and immune activation. The use of cytokine-directed therapies, such as interleukin-1 receptor antagonist, has shown promising results in treating CSS in ECMO patients.
Editorial Material
Rheumatology
Daniel D. Reiff, Randy Q. Cron
