Review
Pediatrics
Melissa Borrelli, Giuliana Ponte, Erasmo Miele, Marco Maglione, Carlo Caffarelli, Francesca Santamaria
Summary: Gastroesophageal reflux (GER) and wheeze are common conditions in children, with a debated causal relationship. More research is needed to confirm or rule out the association between preschool wheezing and GER.
Article
Respiratory System
Jin-soo Park, Leticia Burton, Hans Van der Wall, Gregory Leighton Falk
Summary: The study revealed frequent early scintigraphic reflux in the pharynx and proximal esophagus in severe reflux patients. A high rate of reflux-related pulmonary aspiration was also observed.
Article
Multidisciplinary Sciences
Matthew Xu, John D. Brannan, Vincent Ho, Jerry Zhou
Summary: This study investigates the mechanisms of gastro-esophageal reflux induced by spirometry and finds that spirometry can cause an elevation in impedance values and a reduction in resting pressure of the lower esophageal sphincter. The study also observes a decline in spirometric parameters during the second spirometry session when compared to the first session, providing compelling evidence for the association between spirometry maneuvers and gastro-esophageal reflux.
Article
Surgery
Yazmin Johari, Gillian Lim, Anagi Wickremasinghe, Helen Yue, Jarrel Seah, Geraldine Ooi, Julie Playfair, Cheryl Laurie, Paul Beech, Kenneth Yap, Geoff Hebbard, Wendy Brown, Paul Burton
Summary: The study evaluated the mechanisms associated with reflux events after sleeve gastrectomy (SG). The results showed a strong association between reflux and SG, and identified three unique categories of reflux. The study also found that elevated gastro-esophageal pressure gradient was the main mechanism of reflux.
Article
Surgery
Jun Liang Teh, Hui Yu Tham, Alex Yu Sen Soh, Corrisa Chee, Guowei Kim, Asim Shabbir, Reuben Kong Min Wong, Jimmy Bok Yan So
Summary: This study focused on reflux after POEM, finding that 43.1% of patients had symptomatic reflux, 60% had endoscopic evidence of esophagitis, and 56% had increased acid exposure on pH-impedance test.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Vanda F. Torous, Debra Basler, Caroline McEnery, Todd Astor, Amy Ly
Summary: This study observed that clinical evaluation for aspiration relied more heavily on transbronchial biopsy findings. Although LLMI may retain clinical utility in some scenarios, reevaluation of the clinical value of ORO testing would be prudent.
CANCER CYTOPATHOLOGY
(2023)
Article
Biology
Mariana Floria, Diana-Elena Iov, Daniela Maria Tanase, Oana Bogdana Barboi, Genoveva Livia Baroi, Alexandru Burlacu, Mihaela Grecu, Radu Andy Sascau, Cristian Statescu, Catalina Mihai, Vasile Liviu Drug
Summary: Patients undergoing atrial fibrillation ablation may not be at a higher risk of developing symptomatic gastroesophageal reflux disease three months after the procedure, according to a small prospective study.
Article
Medicine, General & Internal
Haydar Adanir, Bilge Bas, Betul Pakoz, Suleyman Gunay, Hakan Camyar, Muge Ustaoglu
Summary: This study compared the clinical features and endoscopic findings of GERD in elderly and younger patients, revealing that elderly patients had milder typical symptoms but more severe endoscopic findings compared to younger patients.
FRONTIERS IN MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Leonardo Frazzoni, Lorenzo Fuccio, Rocco Maurizio Zagari
Summary: Gastro-esophageal reflux disease (GERD) is a common condition that primary care physicians and gastroenterologists frequently encounter. Improving the management of GERD is vital for optimizing patient care and resource utilization. This review aims to provide a comprehensive update on the clinical management of GERD patients through a literature review on diagnosis and treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pharmacology & Pharmacy
Melina Simon, Elvira Ingrid Levy, Yvan Vandenplas
Summary: GERD is increasingly diagnosed in infants worldwide, leading to more infants being treated. Non-pharmacological treatments are effective and safe, while acid-suppressive medications may have adverse effects. In infants, GERD is often nonacid related.
EXPERT OPINION ON DRUG SAFETY
(2021)
Review
Public, Environmental & Occupational Health
Hsiang-Tai Chen, Hung-Yi Chuang, Tsung-Yu Hsieh, Pei-Shan Wu, Fang-Jiun Lin, Huan-Chih Huang, Chen-Cheng Yang, Chao-Hung Kuo
Summary: This study demonstrates a positive association between shift work and possible GERD symptoms through meta-analysis. Subgroup analysis reveals positive associations between possible GERD and night shifts, rotating shifts, shift work in men, and shift work in both genders.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Surgery
Gillian Lim, Yazmin Johari, Geraldine Ooi, Julie Playfair, Cheryl Laurie, Geoffrey Hebbard, Wendy Brown, Paul Burton
Summary: This study aimed to determine the discriminant factors of symptomatic reflux and establish diagnostic thresholds for GERD following SG. The results indicated that reflux score and supine acid exposure were the strongest discriminant factors for symptomatic reflux. The symptomatic cohort typically showed higher levels of acid exposure.
Article
Surgery
Louise Montalva, Aurora Mariani, Francoise Schmitt, Cecile O. Muller, Khalid Alzahrani, Jerome Viala, Alexis Mosca, Matthieu Peycelon, Arnaud Bonnard
Summary: The study found that concurrent GT insertion and LNF is a common practice in children with GERD and failure to thrive. Children born preterm or with esophageal atresia are at high-risk for LNF failure after LNF/GT. Prospective, multicentric studies are needed to evaluate the best GT technique in children undergoing LNF.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Pharmacology & Pharmacy
Ilaria Ardoino, Manuela Casula, Giulia Molari, Sara Mucherino, Valentina Orlando, Enrica Menditto, Carlotta Franchi
Summary: This study evaluated the appropriateness of drug prescription for GERD in older people and found that only 41.2% of patients received appropriate prescriptions. Therefore, educational interventions should be implemented for physicians to improve prescription quality and prevent unnecessary health risks and costs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Lisa S. E. Shim, Meng C. Ngu, Yunki Yau, Robert Russo
Summary: This study found that reflux scintigraphy has limited role in diagnosing GERD when compared to 24 h combined pH-impedance monitoring.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Dermatology
Lisa M. Arkin, John J. Moon, Jennifer M. Tran, Samira Asgan, Cliona O'Farrelly, Jean-Laurent Casanova, Edward W. Cowen, Jacqueline W. Mays, Anne Marie Singh, Beth A. Drolet
Summary: Despite the large number of patients with pandemic-associated pernio, establishing a causal link to SARS-CoV-2 remains a challenge. Pathophysiological studies suggest that some children with pernio may have abnormalities in IFN-1 immunity, while excessive immune responses to SARS-CoV-2 are seen in the skin of pernio patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Andrew J. McArdle, Ortensia Vito, Harsita Patel, Eleanor G. Seaby, Priyen Shah, Clare Wilson, Claire Broderick, Ruud Nijman, Adriana H. Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J. Carter, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A. Herberg, Myrsini Kaforou, Aubrey J. Cunnington, Michael Levin
Summary: This international observational cohort study found no significant difference in the recovery from MIS-C after primary treatment with IVIG alone, IVIG plus glucocorticoids, or glucocorticoids alone, although significant differences may emerge as more data accrue.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, Filomeen Haerynck, Tom Taghon
Summary: SCID is a primary deficiency of the immune system caused by genetic defects, leading to fatal infections. Next-generation sequencing has enabled the identification of novel variants in SCID genes, improving diagnostic accuracy and therapy implementation.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Rheumatology
Jens T. Van Praet, Pascale De Paepe, Levi Hoste, Filomeen Haerynck
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Multidisciplinary Sciences
Qian Zhang, Paul Bastard, Aurelie Cobat, Jean-Laurent Casanova
Summary: SARS-CoV-2 infection is generally mild, but in around 10% of cases, it can lead to severe pneumonia and potentially death. Genetic factors, such as inborn errors of type I interferons, and pre-existing auto-antibodies can increase the risk of critical illness. The production of type I interferons is essential for host defense against the virus.
Article
Immunology
Evangelos Andreakos, Laurent Abel, Donald C. Vinh, Elzbieta Kaja, Beth A. Drolet, Qian Zhang, Cliona O'Farrelly, Giuseppe Novelli, Carlos Rodriguez-Gallego, Filomeen Haerynck, Carolina Prando, Aurora Pujol, Helen C. Su, Jean-Laurent Casanova, Andras N. Spaan, Paul Bastard, Catherine M. Biggs, Benedetta Bigio, Bertrand Boisson, Alexandre Bolze, Anastasiia Bondarenko, Petter Brodin, Samya Chakravorty, John Christodoulou, Aurelie Cobat, Antonio Condino-Neto, Stefan N. Constantinescu, Hagit Baris Feldman, Jacques Fellay, Rabih Halwani, Emmanuelle Jouanguy, Yu-Lung Lau, Isabelle Meyts, Trine H. Mogensen, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarstrom, Anna M. Planas, Anne Puel, Lluis Quintana-Murci, Laurent Renia, Igor Resnick, Anna Sediva, Anna Shcherbina, Ondrej Slaby, Ivan Tancevski, Stuart E. Turvey, K. M. Furkan Uddin, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Shen-Ying Zhang
Summary: SARS-CoV-2 infections can vary greatly between individuals, with some being asymptomatic while others experience life-threatening disease. While 20% of critical COVID-19 cases are due to inborn errors or autoantibodies, the genetic and immunological factors for resistance to infection itself remain unknown. Studies have shown that autosomal recessive deficiencies in certain genes or enzymes can confer resistance to diseases, suggesting a potential strategy for identifying individuals naturally resistant to SARS-CoV-2 infection.
Correction
Immunology
Evangelos Andreakos, Laurent Abel, Donald C. Vinh, Elzbieta Kaja, Beth A. Drolet, Qian Zhang, Cliona O'Farrelly, Giuseppe Novelli, Carlos Rodriguez-Gallego, Filomeen Haerynck, Carolina Prando, Aurora Pujol, Helen C. Su, Jean-Laurent Casanova, Andras N. Spaan
Article
Psychology, Developmental
Aline Wauters, Tine Vervoort, Karlien Dhondt, Bart Soenens, Maarten Vansteenkiste, Sofie Morbee, Joachim Waterschoot, Filomeen Haerynck, Kristof Vandekerckhove, Helene Verhelst, Sara Van Aken, Ann Raes, Petra Schelstraete, Johan Vande Walle, Eline Van Hoecke
Summary: Findings of the study showed that parents of children with chronic diseases experienced higher levels of anxiety, with COVID-19-specific stressors and parental psychological experiences being associated with increased anxiety, depression, and sleep problems. Moreover, parental burn-out was identified as a mediator for the impact of COVID-19-specific stressors on the well-being outcomes. This highlights the importance of interventions targeting parental burn-out in this vulnerable group.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2022)
Article
Immunology
Leslie Naesens, Josephine Nemegeer, Filip Roelens, Lore Vallaeys, Marije Meuwissen, Katrien Janssens, Patrick Verloo, Benson Ogunjimi, Dimitri Hemelsoet, Levi Hoste, Lisa Roels, Marieke De Bruyne, Elfride De Baere, Jo Van Dorpe, Amelie Dendooven, Anne Sieben, Gillian Rice, Tessa Kerre, Rudi Beyaert, Carolina Uggenti, Yanick J. Crow, Simon J. Tavernier, Jonathan Maelfait, Filomeen Haerynck
Summary: This study analyzed the clinical, genetic, and immunological characteristics of 3 patients with uncharacterized AGS. RNU7-1 gene mutations were found to impair the processing of RDH pre-mRNA. A distinct IFN-I signature was observed in peripheral blood, and MCP-1 (CCL2) and CXCL10 were upregulated in cerebrospinal fluid. Histopathological analysis showed thrombotic microangiopathy in kidney tissue. Dysregulated STAT phosphorylation was observed upon cytokine stimulation.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Petter Brodin, Giorgio Casari, Liam Townsend, Cliona O'Farrelly, Ivan Tancevski, Judith Loeffler-Ragg, Trine H. Mogensen, Jean Laurent Casanova
Article
Genetics & Heredity
Nika Schuermans, Dimitri Hemelsoet, Wim Terryn, Sanne Steyaert, Rudy Van Coster, Paul J. Coucke, Wouter Steyaert, Bert Callewaert, Elke Bogaert, Patrick Verloo, Arnaud V. Vanlander, Elke Debackere, Jody Ghijsels, Pontus LeBlanc, Hannah Verdin, Leslie Naesens, Filomeen Haerynck, Steven Callens, Bart Dermaut, Bruce Poppe
Summary: UD-PrOZA is an innovative interdisciplinary platform for diagnosing rare diseases in adults and supporting translational research. It combines a multidisciplinary clinical approach with state-of-the-art genomic technologies, working in collaboration with research facilities to diagnose patients.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Letter
Allergy
Delfien Bogaert, Ruth De Bruyne, Arnaud V. Vanlander, Lara Garabedian, Yves Louis, Filomeen Haerynck, Victoria Bordon, Barbara De Moerloose
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Immunology
Matthijs Oyaert, Marie-Angelique De Scheerder, Sophie Van Herrewege, Guy Laureys, Sofie Van Assche, Melissa Cambron, Leslie Naesens, Levi Hoste, Karlien Claes, Filomeen Haerynck, Tessa Kerre, Steven Van Laecke, Wim Van Biesen, Peggy Jacques, Bruno Verhasselt, Elizaveta Padalko
Summary: Immunocompromised patients may show variable immune responses to the BNT162b2 mRNA vaccine against SARS-CoV-2, and the delay in humoral or cellular immune responses depends on the patient group, therapy, and individual risk factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
L. Kestens, L. Van Acker, A. Hoorens, E. O. Kreps, F. Haerynck, A. Debrock, V Catry, S. Weyers, K. Roelens, E. Van Braeckel
Summary: This case report highlights tuberculosis as a potential cause of infertility even in low-incidence countries. It also emphasizes that the peripartum period is a major risk factor for drug-induced liver injury.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
D. G. Ebo, M. M. van der Poorten, A. L. Van Gasse, R. Schrijvers, C. Hermans, M. Bartiaux, F. Haerynck, J. Willekens, H. Lapeere, M. Moutschen, O. Michel, V. Sabato
Summary: This paper assessed the alignment of Belgian clinical practice in hereditary angioedema (HAE) with the updated international guideline and identified opportunities for optimization. The main action points to further optimize the Belgian clinical practice of HAE include working towards total disease control, informing patients about new long-term prophylactic therapies, ensuring availability of on-demand therapy, implementing a more comprehensive assessment in daily clinical practice, and expanding the existing patient registry.
ACTA CLINICA BELGICA
(2023)
