Article
Clinical Neurology
Till S. Zimmer, Anatoly Korotkov, Susan Zwakenberg, Floor E. Jansen, Fried J. T. Zwartkruis, Nicholas R. Rensing, Michael Wong, Angelika Muhlebner, Erwin A. van Vliet, Eleonora Aronica, James D. Mills
Summary: This study identified a novel transcription factor, SPI1/PU.1, which is involved in the pro-inflammatory gene expression in malformed cells in TSC and FCD 2b. The expression of SPI1/PU.1 is associated with mTOR activation, oxidative stress, and seizure development, providing potential therapeutic targets for genetic epilepsies.
Article
Clinical Neurology
Victoria-Elisabeth Gruber, Mark J. Luinenburg, Katrin Colleselli, Verena Endmayr, Jasper J. Anink, Till S. Zimmer, Floor Jansen, Peter Gosselaar, Roland Coras, Theresa Scholl, Ingmar Blumcke, Jose Pimentel, Johannes A. Hainfellner, Romana Hoeftberger, Karl Roessler, Martha Feucht, Jackelien Scheppingen, Eleonora Aronica, Angelika Muehlebner
Summary: This study found that C3 protein expression was significantly upregulated in white and gray matter lesions of TSC and FCD2B, while synaptophysin showed a remarkable increase in the white matter of both diseases. Confocal imaging revealed colocalization of complement factors with various cell types, suggesting that complement pathway overactivation may play a role in the pathogenesis of TSC and FCD2B.
Article
Clinical Neurology
Hannah Spitzer, Mathilde Ripart, Kirstie Whitaker, Felice D'Arco, Kshitij Mankad, Andrew A. Chen, Antonio Napolitano, Luca De Palma, Alessandro De Benedictis, Stephen Foldes, Zachary Humphreys, Kai Zhang, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Christopher Guttler, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefania Conde-Blanco, Jose Carlos Pariente, Saul Pascual-Diaz, Ignacio Delgado-Martinez, Carmen Perez-Enriquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Eugenia Caligiuri, Ben Sinclair, Lucy Vivash, Anna Willard, Jothy Kandasamy, Ailsa McLellan, Drahoslav Sokol, Mira Semmelroch, Ane G. Kloster, Giske Opheim, Leticia Ribeiro, Clarissa Yasuda, Camilla Rossi-Espagnet, Khalid Hamandi, Anna Tietze, Carmen Barba, Renzo Guerrini, William Davis Gaillard, Xiaozhen You, Irene Wang, Sofia Gonzalez-Ortiz, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Reetta Kalviainen, Antonio Gambardella, Angelo Labate, Patricia Desmond, Elaine Lui, Terence O'Brien, Jay Shetty, Graeme Jackson, John S. Duncan, Gavin P. Winston, Lars H. Pinborg, Fernando Cendes, Fabian J. Theis, Russell T. Shinohara, J. Helen Cross, Torsten Baldeweg, Sophie Adler, Konrad Wagstyl
Summary: One of the challenges in applying machine learning to diagnostic biomedical imaging is the interpretability of algorithms. This study developed an open-source and interpretable machine-learning algorithm to automatically identify FCDs from structural MRI data, improving the confidence of physicians in identifying subtle MRI lesions in individuals with epilepsy.
Review
Biochemistry & Molecular Biology
Ekaterina Bychkova, Marina Dorofeeva, Aleksandr Levov, Alexey Kislyakov, Kristina Karandasheva, Vladimir Strelnikov, Kirill Anoshkin
Summary: Patients with tuberous sclerosis complex display cognitive, behavioral, and psychiatric impairments linked to cortical tubers. These tubers are caused by mutations in TSC1 or TSC2 genes, resulting in overactivation of the mTOR pathway. However, the formation of cortical tubers may involve more complex molecular mechanisms that require further investigation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Clinical Neurology
Konrad Wagstyl, Kirstie Whitaker, Armin Raznahan, Jakob Seidlitz, Petra E. Vertes, Stephen Foldes, Zachary Humphreys, Wenhan Hu, Jiajie Mo, Marcus Likeman, Shirin Davies, Matteo Lenge, Nathan T. Cohen, Yingying Tang, Shan Wang, Mathilde Ripart, Aswin Chari, Martin Tisdall, Nuria Bargallo, Estefania Conde-Blanco, Jose Carlos Pariente, Saul Pascual-Diaz, Ignacio Delgado-Martinez, Carmen Perez-Enriquez, Ilaria Lagorio, Eugenio Abela, Nandini Mullatti, Jonathan O'Muircheartaigh, Katy Vecchiato, Yawu Liu, Maria Caligiuri, Ben Sinclair, Lucy Vivash, Anna Willard, Jothy Kandasamy, Ailsa McLellan, Drahoslav Sokol, Mira Semmelroch, Ane Kloster, Giske Opheim, Clarissa Yasuda, Kai Zhang, Khalid Hamandi, Carmen Barba, Renzo Guerrini, William Davis Gaillard, Xiaozhen You, Irene Wang, Sofia Gonzalez-Ortiz, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Reetta Kalviainen, Antonio Gambardella, Angelo Labate, Patricia Desmond, Elaine Lui, Terry O'Brien, Jay Shetty, Graeme Jackson, John S. Duncan, Gavin P. Winston, Lars Pinborg, Fernando Cendes, Judith Helen Cross, Torsten Baldeweg, Sophie Adler
Summary: The study revealed that FCDs are unevenly distributed across the cerebral cortex and different lesion locations have significant impact on surgical outcomes. Lesions in the temporal and occipital lobes tend to be larger than frontal lobe lesions, leading to varying rates of seizure freedom post surgery.
Review
Clinical Neurology
Horst Urbach, Elias Kellner, Nico Kremers, Ingmar Bluemcke, Theo Demerath
Summary: FCD is classified into different types, with only FCD II showing distinctive MRI and molecular genetic alterations. Subtle FCD located in the depth of sulci are often overlooked and require the use of specialized sequences and postprocessing methods for diagnosis. The added value of 7 Tesla MRI has yet to be proven.
Article
Clinical Neurology
Hyo M. Lee, Seok-Jun Hong, Ravnoor Gill, Benoit Caldairou, Irene Wang, Jian-guo Zhang, Francesco Deleo, Dewi Schrader, Fabrice Bartolomei, Maxime Guye, Kyoo Ho Cho, Carmen Barba, Sanjay Sisodiya, Graeme Jackson, R. Edward Hogan, Lily Wong-Kisiel, Gregory D. Cascino, Andreas Schulze-Bonhage, Iscia Lopes-Cendes, Fernando Cendes, Renzo Guerrini, Boris Bernhardt, Neda Bernasconi, Andrea Bernasconi
Summary: This study explores the associations between Focal cortical dysplasia (FCD) and cytoarchitecture, gene expression, and axes of cortical organization. The findings suggest that the vulnerability of the frontal lobe to FCD may be due to early termination of prenatal neurogenesis and aberrant postnatal synaptogenesis.
Article
Medicine, Research & Experimental
Kakeru Hosomoto, Tatsuya Sasaki, Koji Kawai, Yosuke Okazaki, Yuki Hyodo, Takashi Shibata, Susumu Sasada, Takao Yasuhara, Katsuhiro Kobayashi, Hiroyuki Yanai, Isao Date
Summary: We report a case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case.
ACTA MEDICA OKAYAMA
(2022)
Article
Clinical Neurology
Yao-Feng Li, Fatma Scerif, Simon R. Picker, Thomas J. Stone, Jessica C. Pickles, Dale A. Moulding, Aimee Avery, Alex Virasami, Amy R. Fairchild, Martin Tisdall, William Harkness, J. Helen Cross, Darren Hargrave, Francois Guillemot, Simon M. Paine, Shireena A. Yasin, Thomas S. Jacques
Summary: This study identified previously uncharacterised small cell populations in FCD and TS, highlighting a new level of diversity and cellular interactions in cortical malformations. The findings provide a generalisable approach to understanding cell-cell interactions and cellular heterogeneity in developmental neuropathology.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O'Gorman Tuura, Georgia Ramantani
Summary: This study investigated the potential of diffusion tensor imaging (DTI) in paediatric structural epilepsy associated with focal cortical dysplasia (FCD). The results showed that DTI indices can differentiate between FCD and contralateral brain parenchyma (CBP), and that clinical features have an impact on these indices.
INSIGHTS INTO IMAGING
(2023)
Article
Immunology
Kaixuan Huang, Zhongke Wang, Zeng He, Yang Li, Shujing Li, Kaifeng Shen, Gang Zhu, Zhonghong Liu, Shengqing Lv, Chunqing Zhang, Hui Yang, Xiaolin Yang, Shiyong Liu
Summary: This study found that the expression of FPR2 was decreased in patients with FCDIIb and TSC, and FPR2 immunoreactivity was low in DNs, BCs, and GCs. Additionally, the NF-κB signaling pathway was significantly activated, and the protein level of FPR2 was negatively correlated with seizure frequency. These results suggest that FPR2 may play an important role in epilepsy caused by FCDIIb and TSC.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Neurosciences
Qiyuan Zhu, Zichun Yan, Zhuowei Shi, Dan Luo, Shuang Ding, Xiaoya Chen, Yongmei Li
Summary: Specific biomarkers for cortical gray matter (cGM) pathology in multiple sclerosis (MS) are needed to understand the disease progression. Our study evaluated the association between different types of cortical lesions and cGM damage using diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI). We found that kurtosis fractional anisotropy (KFA) was the most sensitive in characterizing cGM damage, and leukocortical lesion (LCL) volume was more related to cGM damage.
Article
Psychology, Developmental
Banu Ahtam, Hyuk Jin Yun, Rutvi Vyas, Rudolph Pienaar, Josephine H. Wilson, Caroline P. Goswami, Laura F. Berto, Simon K. Warfield, Mustafa Sahin, P. Ellen Grant, Jurriaan M. Peters, Kiho Im
Summary: A significant number of individuals with Tuberous Sclerosis Complex (TSC) experience language difficulties. This study examined the brain morphometry related to language in different groups, including TSC with and without Autism Spectrum Disorder (ASD), ASD-only, and typically developing controls. The results show that both ASD and TSC-ASD groups have differences in cortical thickness and curvature in multiple language regions compared to other groups. These findings suggest that comorbid ASD in TSC and tuber load in TSC may contribute to changes in the morphometry of language regions. Larger sample sizes are needed to confirm these preliminary findings.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Clinical Neurology
Roland Coras, Hans Holthausen, Harvey B. Sarnat
Summary: The ILAE classification of Focal Cortical Dysplasia (FCD) from 2011 has been widely accepted and used, particularly focusing on three subtypes where FCD Type 2 has been validated extensively compared to Type 1 and Type 3. Further research is needed to provide comprehensive clinico-pathological specifications for FCD Type 1B and 1C as well as to establish a valid animal model for FCD Type 1.
Article
Clinical Neurology
Hanna M. Hulshof, Barbora Benova, Pavel Krsek, Martin Kyncl, Maarten H. Lequin, Anezka Belohlavkova, Petr Jezdik, Kees P. J. Braun, Floor E. Jansen
Summary: Patients with TSC often present drug-resistant epilepsy, with evaluation for epilepsy surgery being necessary. Pre-surgical delineation of the EZ among multiple dysplastic lesions in MRI is challenging. Features such as increased cortical thickness, gray-white matter blurring, and calcifications are more frequently observed in the EZ, aiding in pre-surgical MRI evaluation for epilepsy surgery candidates with TSC.
Article
Clinical Neurology
Dilek Cebeci, Ebru Arhan, Tugba Hirfanoglu, Zeynep Selen Karalok, Hakan Ercelebi, Ozge Dedeoglu, Lutfiye Ozlem Atay, Murat Ucar, Ayse Serdaroglu
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2020)
Article
Endocrinology & Metabolism
Cengiz Havali, Sevil Dorum, Yilmaz Akbas, Orhan Gorukmez, Tugba Hirfanoglu
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2020)
Article
Behavioral Sciences
Ebru Arhan, Habibe Koc Ucar, Kursad Aydin, Tugba Hirfanoglu, Ayse Serdaroglu
Summary: The study aimed to assess sleep architecture and problems among different groups of children with epilepsy. Results showed that children with drug-resistant epilepsy experienced the most severe sleep disturbances, while those with newly diagnosed epilepsy also had significant sleep issues compared to healthy children.
EPILEPSY & BEHAVIOR
(2021)
Letter
Behavioral Sciences
Ebru Arhan, Habibe Koc Ucar, Kursad Aydin, Tugba Hirfanoglu, Ayse Serdaroglu
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Hossein Shahabi, Kenneth Taylor, Tugba Hirfanoglu, Shreekanth Koneru, William Bingaman, Katsuya Kobayashi, Masako Kobayashi, Anand Joshi, Richard M. Leahy, John C. Mosher, Juan Bulacio, Dileep Nair
Summary: This study compared brain connectivity differences between FCD types I and II, revealing that type I patients exhibit greater cortical hyperexcitability while type II patients display a more restricted zone of hyperexcitability. These differences may contribute to different post-surgical seizure outcomes between the two pathological substrates.
Article
Clinical Neurology
Hakan Ercelebi, Pinar Ozbudak, Tugba Hirfanoglu, Ayse Serdaroglu, Unsal Yilmaz, Ebru Arhan
Summary: The study examined the semiological features of Psychogenic Nonepileptic Seizures (PNES) in children and evaluated the interobserver reliability of two different classifications. The results showed that ictal eye closure was the most common seizure semiology, and the new classification system had higher interobserver reliability compared to the old classification system.
Meeting Abstract
Clinical Neurology
D. Menderes, E. Serdaroglu, E. Arhan, T. Hirfanoglu, A. Serdaroglu
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
H. K. Ucar, E. Arhan, K. Aydin, T. Hirfanoglu, A. Serdaroglu
Summary: The study aims to evaluate epilepsy classification in children before and after monitoring, comparing the ILAE and SSC systems. The results show that parents can generally describe seizures well, and both systems can be applied in daily practice.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Habibe Ucar, Ebru Arhan, Kuersad Aydin, Tugba Hirfanoglu, Ayse Serdaroglu
Summary: This study aimed to determine the significance of SWI calculation during electrical status epilepticus during slow sleep (ESES). The evaluation of EEG findings revealed a strong positive correlation between the short method and long conventional method, and the SWI short method was found to predict typical ESES. Therefore, utilizing measurements such as SWP and SF allows for the comparison of epileptiform activities among different patient groups.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
H. K. Ucar, E. Arhan, K. Aydin, T. Hirfanoglu, A. Serdaroglu
Summary: This study examined the development and resolution of ESES in children with BCECTS and evaluated the clinical and EEG parameters associated with prognosis. The results showed that the resolution rate of ESES was 87.9%, with a median time to resolution of 10.5 months. Age at ESES diagnosis, the time between BCECTS diagnosis and the onset of ESES, time to resolution of ESES, ESES remission, and seizure freedom after ESES were found to be significantly associated with prognosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Irem Yildirim, Asli Akyol Gurses, Esra Erkoc Ataoglu, Gokhan Kurt, Umit Ozgur Akdemir, Ali Yusuf Oner, Tugba Hirfanoglu, Lutfiye Ozlem Atay, Ayse Serdaroglu, Erhan Bilir
Summary: The study demonstrated the effectiveness of epilepsy surgery for refractory temporal lobe epilepsy and identified potential prognostic factors influencing postoperative seizure remission. The results suggested that surgical treatment provides long-term seizure control and that factors such as history of febrile seizures, unilateral interictal epileptiform discharges, and unilateral findings of temporal hypometabolism on FDG-PET were independent predictors of seizure remission in patients.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Kenneth N. Taylor, Anand A. Joshi, Tugba Hirfanoglu, Olesya Grinenko, Ping Liu, Xiaofeng Wang, Jorge A. Gonzalez-Martinez, Richard M. Leahy, John C. Mosher, Dileep R. Nair
Summary: The agreement in anatomical labeling between the two methods for over 17,000 SEEG contacts was 82%, consistent across patients with and without previous surgery. Expert review of contacts in disagreement between the two methods showed that 48% were in agreement with atlas-based labels, 36% with manual labels, and 16% were disagreements with both methods. The method described here for semi-automated atlas-based anatomical labeling has the potential to reduce analysis time and likelihood of gross anatomical error, as well as standardize anatomical labels for intersubject analysis.
Article
Clinical Neurology
Tugba Hirfanoglu, Zeynep Ozturk, Guntulu Sahin Gokdogan, Ibrahim Murat Hirfanoglu, Eray Esra Onal, Canan Turkyilmaz, Ebru Ergenekon, Esin Koc
JOURNAL OF PEDIATRIC NEUROSCIENCES
(2020)
Article
Pediatrics
Ozge Vural, Ayse Serdaroglu, Aysegul Nese Citak Kurt, Tugba Hirfanoglu, Gokhan Kurt
GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS
(2019)
Article
Clinical Neurology
Zeynep Ozturk, Tugba Hirfanoglu, Asli Inci, Ilyas Okur, Esin Koc, Leyla Tumer, Ebru Arhan, Kursad Aydin, Ayse Serdaroglu
JOURNAL OF PEDIATRIC NEUROSCIENCES
(2018)
Article
Clinical Neurology
Ani Gok, Seha Kamil Saygili, Sebuh Kurugoglu, Sema Saltik, Nur Canpolat
Summary: This study examines the occurrence of nephrolithiasis in children with type 1 SMA and identifies hypercalciuria and high urine specific gravity as common risk factors. The study suggests that children with SMA type 1 may have an increased risk of nephrolithiasis compared to the general population.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Glenn S. Rivera, Jesse A. Stokum, Janet Dean, Cristina L. Sadowsky, Allan J. Belzberg, Matthew J. Elrick
Summary: This study evaluated the surgical efficacy of nerve transfer surgery in patients with acute flaccid myelitis (AFM) and found that preoperative clinical and neurophysiological data play a valuable role in preoperative planning and patient selection. The postoperative outcomes demonstrated that nerve transfer surgery is an effective strategy to restore strength.
PEDIATRIC NEUROLOGY
(2024)
Review
Clinical Neurology
Tristan T. Sands, Jennifer N. Gelinas
Summary: This review explores the concept of epileptic encephalopathy (EE) in pediatric epilepsy, discussing the potential impact of epileptic activity on normal brain development and mechanisms underlying cognitive and behavioral impairments. The findings highlight the threat of epileptic activity to normal brain physiology and development.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Grace Gombolay, Melissa A. Walker
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Salman Rashid, Monisha Goyal, Kathryn Lalor, Khaled Al-Robaidi, Vivek Shukla, Fazlur Rahman, Manimaran Ramani
Summary: This study investigated the seizure risk in asymptomatic preterm infants with high-grade intraventricular hemorrhage who underwent long-term video electroencephalographic monitoring. The findings showed that approximately 16% of these infants had seizures, and those with seizures were younger and more likely to be remonitored.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Bernadeta Zabielska, Natalia Rzewuska, Sergiusz Jozwiak
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Kelly C. Burk, Maki Kaneko, Catherine Quindipan, My H. Vu, Maritza Feliz Cepin, Jonathan D. Santoro, Michele Van Hirtum-Das, Deborah Holder, Gordana Raca
Summary: This study compared the diagnostic yields of chromosomal microarray (CMA) and epilepsy-genes sequencing (EGS) for genetic epilepsy etiologies. It found that EGS had a significantly higher diagnostic yield than CMA, especially for patients with infantile seizure onset and additional neurological findings.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Ursula Thome, Larissa A. Batista, Renata P. Rocha, Vera C. Terra, Ana Paula A. Hamad, Americo C. Sakamoto, Antonio C. Santos, Marcelo Santos, Helio R. Machado
Summary: Rasmussen encephalitis (RE) is a characterized by pharmacoresistant epilepsy and progressive neurological deficits. Surgical disconnection of the affected hemisphere is considered the treatment of choice, although the precise etiology is still unknown. This study reports the clinical, electrographic, and neuroimaging features of children and adolescents who underwent hemispheric surgery (HS) for the treatment of RE.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Michal Tzadok, Rotem Gur-Pollack, Hadar Florh, Yael Michaeli, Tal Gilboa, Mirit Lezinger, Eli Heyman, Veronika Chernuha, Irina Gudis, Andreea Nissenkorn, Tally Lerman-Sagie, Bruria Ben Zeev, Shimrit Uliel-Sibony
Summary: Purified CBD is well-tolerated and effective in reducing seizure frequency in children and young adults with drug-resistant epilepsy.
PEDIATRIC NEUROLOGY
(2024)
Editorial Material
Clinical Neurology
Zimeng Ye, Sufang Lin, Xia Zhao, Mathew Wallis, Xinyi Gao, Li Sun, Jiarui Wu, Jing Duan, Yi Yao, Lin Li, Li Chen, Dezhi Cao, Zhanqi Hu, Victor W. Zhang, Samuel F. Berkovic, Ingrid E. Scheffer, Jianxiang Liao, Michael S. Hildebrand
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Nicolas J. Abreu, Madeline Chiujdea, Shanshan Liu, Bo Zhang, Sarah J. Spence
Summary: This study found a low completion rate of chromosomal microarray (CMA) testing for patients with autism spectrum disorder (ASD). Provider recommendation and more follow-up visits were associated with CMA completion. Age, intellectual disability or global developmental delay, first-degree relative with ASD, and public insurance were all related to CMA completion. Parental concern and cost/insurance coverage were the most frequently documented barriers.
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Wafa Bouchaala, Sirine Laroussi, Yosra Mzid, Imen Maaloul, Olfa Jallouli, Salma Zouari, Sihem Ben Nsir, Zeineb Mnif, Fatma Kammoun, Chahnez Triki
Summary: Moyamoya angiopathy is a rare but serious cerebrovascular disease in children, which may result in arterial ischemic stroke. The clinical and radiological presentations can vary and are often overlooked. Early diagnosis and treatment are crucial.
PEDIATRIC NEUROLOGY
(2024)
Letter
Clinical Neurology
Eline M. C. Hamilton, Pinar Topaloglu, Jigyasha Sinha, Francesco Nicita, Genevieve Bernard, S. Ali Fatemi, Marjo S. van der Knaap
PEDIATRIC NEUROLOGY
(2024)
Article
Clinical Neurology
Muhamad Azamin Anuar, Muhammad'Adil Zainal Abidin, Soo Hong Tan, Cai Fong Yeap, Nor Azni Yahaya
Summary: This study conducted in Malaysia found that most infants with epilepsy can achieve seizure remission. However, poor seizure control and developmental delay are associated with abnormal EEG background and neuroimaging abnormalities.
PEDIATRIC NEUROLOGY
(2024)