Article
Immunology
Tiitus Lamponen, Iivo Hetemaki, Heikki J. Niemi, Hanna Jarva, Eliisa Kekalainen, Satu Makela, Jukka Mustonen, Antti Vaheri, T. Petteri Arstila
Summary: The study found that during acute Puumala hantavirus infection, tetanus- and pertussis-specific IgG concentrations elevate and are associated with proliferation of heterologous T cells. A year after the infection, tetanus-specific IgG levels remained elevated while pertussis-specific IgG declined rapidly.
Article
Biophysics
Quan-Quan Zhuang, Rui-Ting Chen, Yi-Jing Zheng, Kai-Yuan Huang, Hua-Ping Peng, Zhen Lin, Xing-Hua Xia, Wei Chen, Hao-Hua Deng
Summary: The development of Tet-IgG-AuNCs through a facile biomineralization process for detecting tetanus toxoid has shown promising results. The immunochromatography test strip utilizing fluorescent Tet-IgG-AuNCs demonstrated good sensitivity with a detection limit of 0.03μg/mL.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Immunology
Daniel Amoak, Nancy Osei Kye, Florence Wullo Anfaara, Yujiro Sano, Roger Antabe
Summary: Poverty and low education levels are among the main reasons for low maternal tetanus toxoid vaccination rates in Benin.
Article
Veterinary Sciences
Megumi Murata, Anastasiia Kovba, Akihisa Kaneko, Mayumi Morimoto, Akiyo Ishigami, Takayoshi Natsume, Ayaka Washizaki, Takako Miyabe-Nishiwaki, Juri Suzuki, Hirofumi Akari
Summary: There was a tetanus outbreak in a facility rearing rhesus macaques during 2014-2015. To protect the macaques from further tetanus infection, a tetanus toxoid vaccination was recommended. The vaccination developed effective antibody responses in animals of all age groups.
EXPERIMENTAL ANIMALS
(2023)
Article
Public, Environmental & Occupational Health
Ummay Nayeema Islam, Kanchan Kumar Sen, Wasimul Bari
Summary: Disparities in tetanus toxoid immunization coverage among women in Bangladesh were found, indicating the need for immunization campaigns to improve utilization of healthcare and immunization services among disadvantaged populations.
Article
Biochemical Research Methods
Zhen Long, Chen Wei, Robert Ross, Xi Luo, Xiao Ma, Yingzi Qi, Ruiping Chai, Jianming Cao, Min Huang, Tao Bo
Summary: This study investigated the effects of formaldehyde on industrial TTd and DTd, revealing the detoxification process and structural changes of toxoids. The results showed that TTd and DTd obtained from mild detoxification conditions had higher glycosylation and less impact on foreign proteins. Thus, it is suggested to use mild detoxification conditions when preparing TTd and DTd.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Immunology
Essie Komla, Oscar B. Torres, Rashmi Jalah, Agnieszka Sulima, Zoltan Beck, Carl R. Alving, Arthur E. Jacobson, Kenner C. Rice, Gary R. Matyas
Summary: Opioid use disorder is a serious health issue that has been increasing significantly in the past decade. Developing a conjugate vaccine to generate high affinity antibodies and neutralize opioids before they reach the brain is a complementary strategy to combat the crisis. The vaccine components include an opioid hapten conjugated to a carrier protein with adjuvants, and preexisting immunity to the carrier protein does not affect the immunogenicity and efficacy of the vaccine.
Article
Multidisciplinary Sciences
Bony Amin, Nitai Roy, Amatul Elah Meem, Ekhtear Hossain, Aktarujjaman
Summary: The study found a gradual decline in tetanus toxoid immunization coverage in Bangladesh from 2006 to 2019, with disparities between regions and socioeconomic groups. It highlights the importance of strengthening public health programs to ensure adequate immunization coverage, particularly among high-risk populations.
Article
Immunology
Mikhail Petrovich Kostinov, Nelli Kimovna Akhmatova, Olga Olegovna Magarshak, Anna Egorovna Vlasenko, Valentina Borisovna Polishchuk, Aristitsa Mikhailovna Kostinova, Kirill Vadimovich Mashilov
Summary: In this study, revaccination with DT toxoid in children with glomerulonephritis did not lead to undesirable changes in the immune cell system, but had an immunomodulatory effect, which contributed to the favorable maintenance of the remission period of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nadine Peart Akindele, Lisa Pieterse, San Suwanmanee, Diane E. Griffin
Summary: This study compared the immune responses in children with COVID-19 and MIS-C. MIS-C patients had higher antibody levels early in the disease and the avidity of virus-specific antibodies did not mature further during follow-up. Both groups had decreasing proportions of B cells in circulation but sustained production of virus-specific antibodies.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Firdausi Qadri, Farhana Khanam, Xinxue Liu, Katherine Theiss-Nyland, Prasanta Kumar Biswas, Amirul Islam Bhuiyan, Faisal Ahmmed, Rachel Colin-Jones, Nicola Smith, Susan Tonks, Merryn Voysey, Yama F. Mujadidi, Olga Mazur, Nazmul Hasan Rajib, Md Ismail Hossen, Shams Uddin Ahmed, Arifuzzaman Khan, Nazia Rahman, Golap Babu, Melanie Greenland, Sarah Kelly, Mahzabeen Ireen, Kamrul Islam, Peter O'Reilly, Karin Sofia Scherrer, Virginia E. Pitzer, Kathleen M. Neuzil, K. Zaman, Andrew J. Pollard, John D. Clemens
Summary: The Vi-tetanus toxoid conjugate vaccine (Vi-TT) provided protection against typhoid fever to children aged 9 months to less than 16 years, with a total vaccine protection of 85%. Longer-term follow-up is needed to assess the duration of protection and potential need for booster doses. The vaccines were well tolerated and no serious adverse events related to the vaccines were observed.
Review
Biochemistry & Molecular Biology
Victor Araujo Correa, Thais Sousa Rodrigues, Amanda Izeli Portilho, Gabriela Trzewikoswki de Lima, Elizabeth De Gaspari
Summary: Antibody avidity is a crucial parameter for evaluating immune response and distinguishing different infection statuses, with the most common method being a modified ELISA. The use of commercial kits or in-house methods to assess antibody avidity is increasing, but the lack of standardization between different assays can lead to variability in results.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Marta Prygiel, Ewa Mosiej, Karol Wdowiak, Daniel Rabczenko, Aleksandra Anna Zasada
Summary: There is a growing interest in developing new-generation purified antigen vaccines with higher safety profiles. Subunit vaccines have lower immunogenicity and induce weaker and shorter-lasting immune responses compared to whole-cell vaccines.
Article
Cell Biology
Benson Chellakkan Selvanesan, Dinesh Chandra, Wilber Quispe-Tintaya, Arthee Jahangir, Ankur Patel, Kiran Meena, Rodrigo Alberto Alves Da Silva, Madeline Friedman, Lisa Gabor, Olivia Khouri, Steven K. Libutti, Ziqiang Yuan, Jenny Li, Sarah Siddiqui, Amanda Beck, Lydia Tesfa, Wade Koba, Jennifer Chuy, John C. McAuliffe, Rojin Jafari, David Entenberg, Yarong Wang, John Condeelis, Vera DesMarais, Vinod Balachandran, Xusheng Zhang, Ken Lin, Claudia Gravekamp
Summary: This study introduces a microbial-based immunotherapeutic treatment that utilizes attenuated Listeria monocytogenes to deliver an immunogenic protein into pancreatic ductal adenocarcinoma (PDAC) tumor cells. By reactivating TT-specific memory T cells, this treatment effectively kills infected tumor cells and reduces tumor burden. Additionally, low doses of gemcitabine enhance the immune effects, promoting an immune response against the cold tumors.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Chao Zhang, Weijun Hu, Yu Ma, Li Li, Yuan Si, Shaobai Zhang
Summary: The study aims to determine the seroprevalence of tetanus antibodies among healthy people in Shaanxi province aged 1-59 years old. The results showed significant differences in antibody levels among different age groups, regions, immunization histories, and doses of tetanus-toxoid-containing vaccines. Additionally, the study found that the full protection rate and antibody levels decreased with the interval following immunization and the interval since the last dose of vaccines.
Article
Immunology
Lisanne M. A. Janssen, Michiel Heron, Jean-Luc Murk, Alexander C. A. P. Leenders, Ger T. Rijkers, Esther de Vries
Summary: For patients suspected of primary immunodeficiency, the assessment of immunocompetence still requires serotype-specific PnPS IgG testing, and the additional measurement of anti-PnPS IgA and IgM does not reduce the need for serotype-specific IgG testing. Future studies are needed to investigate the clinical relevance of potential 'specific IgA or IgM antibody deficiency' in patients with recurrent airway infections without a diagnosed PAD.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Infectious Diseases
Barbara J. M. Bergmans, Chantal B. E. M. Reusken, Anne J. G. van Oudheusden, Gert-Jan Godeke, Axel A. Bonacic Marinovic, Esther de Vries, Yvette C. M. Kluiters-de Hingh, Ralf Vingerhoets, Marvin A. H. Berrevoets, Jaco J. Verweij, An-Emmie Nieman, Johan Reimerink, Jean-Luc. Murk, Arno Swart
Summary: Real-time reverse transcription-polymerase chain reaction (RT-PCR) plays a key role in diagnosing and guiding SARS-CoV-2 infections, with sensitivity varying based on disease severity and duration. Bayesian statistical modeling is utilized to determine infection sensitivity, especially in the context of changing sensitivity in COVID-19 cases.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Allergy
Matthias Haimel, Julia Pazmandi, Raul Jimenez Heredia, Jasmin Dmytrus, Sevgi Koestel Bal, Samaneh Zoghi, Paul van Daele, Tracy A. Briggs, Carine Wouters, Brigitte Bader-Meunier, Florence A. Aeschlimann, Roberta Caorsi, Despina Eleftheriou, Esther Hoppenreijs, Elisabeth Salzer, Shahrzad Bakhtiar, Beata Derfalvi, Francesco Saettini, Maaike A. A. Kusters, Reem Elfeky, Johannes Truck, Jacques G. Riviere, Mirjam van der Burg, Marco Gattorno, Markus G. Seidel, Siobhan Burns, Klaus Warnatz, Fabian Hauck, Paul Brogan, Kimberly C. Gilmour, Catharina Schuetz, Anna Simon, Christoph Bock, Sophie Hambleton, Esther de Vries, Peter N. Robinson, Marielle van Gijn, Kaan Boztug
Summary: This study aims to expand the Human Phenotype Ontology (HPO) for the depiction of inborn errors of immunity (IEIs) and reannotate IEIs with HPO terms, providing accurate and standardized phenotypic descriptions. By expert review and machine learning, the branches of HPO were expanded and IEI diseases were reannotated with HPO terms. This allows for improved computational matching of IEI cases to their known diagnosis and enhanced phenotype-driven disease classification.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Lisanne M. A. Janssen, Michiel van der Flier, Esther de Vries
Summary: Diagnostic delay in common variable immunodeficiency disorders (CVID) is considerable. No generally accepted symptom-recognition framework for its early detection exists. This study systematically reviewed existing data on the clinical presentation of CVID. The study found a bimodal sex distribution, with male predominance in children and female predominance in adults. The shift in sex distribution suggests differences in genetic and environmental etiology in CVID, with implications for pathophysiologic studies. Early detection of CVID may be improved by screening for antibody deficiency in patients with specific manifestations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Lisanne M. A. Janssen, Kim van den Akker, Mohamed A. Boussihmad, Esther de Vries
Summary: This study analyzed how PAD patients appraised their symptoms and what factors were involved in seeking medical care. Patients often attributed their symptoms to common illnesses, rather than specific conditions, and had issues with doctor-patient communication.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Immunology
Martin Stocker, Imant Daunhawer, Wendy van Herk, Salhab el Helou, Sourabh Dutta, Frank A. B. A. Schuerman, Rita K. van den Tooren-de Groot, Jantien W. Wieringa, Jan Janota, Laura H. van der Meer-Kappelle, Rob Moonen, Sintha D. Sie, Esther de Vries, Albertine E. Donker, Urs Zimmerman, Luregn J. Schlapbach, Amerik C. de Mol, Angelique Hoffmann-Haringsma, Madan Roy, Maren Tomaske, Rene F. Kornelisse, Juliette van Gijsel, Frans B. Ploetz, Sven Wellmann, Niek B. Achten, Dirk Lehnick, Annemarie M. C. van Rossum, Julia E. Vogt
Summary: This study used machine learning to analyze the diagnostic accuracy of risk factors, clinical signs, and biomarkers for neonatal early-onset sepsis. Biomarkers were found to be superior to clinical signs and risk factors in predicting culture-proven sepsis. A prediction model combining a screening tool for all neonates with a higher risk population could potentially reduce unnecessary antibiotic use.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Lisanne M. A. Janssen, Ineke C. G. M. Reijnen, Cinzia Milito, David Edgar, Helen Chapel, Esther de Vries
Summary: This study aims to investigate the characteristics and treatment methods of patients with primary antibody deficiencies. Unclassified primary antibody deficiencies, which lack identification and classification, form a large and heterogeneous group. This study will reduce the number of missed and unidentified patients by describing the characteristics and conducting follow-ups, and provide personalized treatment plans for high-risk patients.
Article
Immunology
Bianca M. M. Streng, Marin Bont, Eveline M. Delemarre, Rob S. Binnendijk, Gaby Smit, Gerco den Hartog, Antonia M. W. Coppus, Esther de Vries, Michel E. Weijerman, Regina Lamberts, Gert de Graaf, Fiona R. van der Klis, Gestur Vidarsson, Neele Rave, Louis J. Bont, Joanne G. Wildenbeest
Summary: Adults with Down syndrome have an increased risk of severe course and mortality from SARS-CoV-2 infection, and this risk persists after vaccination. This study compared the antibody responses to routine SARS-CoV-2 vaccination in adults with Down syndrome and healthy controls, finding lower antibody concentrations in adults with Down syndrome, especially with increasing age.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Allergy
Lamia Dahdah, Mieke Roelofs, Karen Knipping, Esther de Vries, Anneke Rijnierse, Johan Garssen, Paul L. P. Brand, Alessandro Fiocchi
Summary: This study evaluated the hypoallergenicity, growth, and gastrointestinal tolerability of a new extensively hydrolyzed whey-protein formula in children with cow's milk allergy. The results showed that all subjects tolerated the formula, and it was associated with normal growth and gastrointestinal tolerability.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Dirk H. van Dalen, Angele P. M. Kerckhoffs, Esther de Vries
Summary: Frailty is an increasing problem with the aging population, and it is associated with adverse health outcomes and higher healthcare costs. This study aims to develop an automated tool using routine hospital electronic health records data to estimate the probability of being frail, by identifying potential predictors and incorporating them into modeling algorithms.
Article
Environmental Sciences
Sascha Naomi Jansz, Mark Mobach, Terry van Dijk, Esther de Vries, Roeland van Hout
Summary: The survey on three Dutch campuses identified characteristics of successful meeting places for academic staff and companies, with principal component analysis revealing PC factors for services and locations. Personal characteristics had minimal effects, indicating that campus design can be effective for all users.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Management
Monique M. A. Penturij-Kloks, Simon T. de Gans, Mandy van Liempt, Esther de Vries, Fedde Scheele, Carolina J. P. W. Keijsers
Summary: The aim of this study was to measure the development of nurses' work engagement during the first three waves of COVID-19 and compare it with pre-outbreak data. The study found that each assessment showed a significant decrease in work engagement, although it stabilized in the last two assessments. Therefore, nurse leaders should facilitate nurses' self-regulation processes and encourage them to develop resources in order to maintain high levels of work engagement.
JOURNAL OF NURSING MANAGEMENT
(2023)
Article
Pediatrics
Noortje B. Eijsvoogel, Ruud H. J. Verstegen, Gijs Th J. van Well, Roeland W. N. M. van Hout, Esther de Vries
Summary: The study found that children with Down syndrome are more likely to experience respiratory symptoms compared to children from the general population, and the symptoms last for a longer duration. Respiratory consequences are also more significant in children with Down syndrome, with higher rates of doctor's visits, antibiotic prescriptions, and absenteeism from school and work.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Critical Care Medicine
A. J. L. M. Geraerds, Wendy van Herk, Martin Stocker, Salhab el Helou, Sourabh Dutta, Matteo S. Fontana, Frank A. B. A. Schuerman, Rita K. van den Tooren-de Groot, Jantien Wieringa, Jan Janota, Laura H. van der Meer-Kappelle, Rob Moonen, Sintha D. Sie, Esther de Vries, Albertine E. Donker, Urs Zimmerman, Luregn J. Schlapbach, Amerik C. de Mol, Angelique Hoffman-Haringsma, Madan Roy, Maren Tomaske, Rene F. Kornelisse, Juliette van Gijsel, Eline G. Visser, Annemarie M. C. van Rossum, Suzanne Polinder
Summary: This study conducted a cost-minimization analysis of the NeoPInS trial, comparing health care costs of PCT-guided decision making and standard care. The results showed that PCT-guided decision making can significantly reduce health care costs in neonates with 'infection unlikely' risk category and gestational age >= 37 weeks in certain countries.
