Article
Pharmacology & Pharmacy
Aoife B. Kilgallen, Frederieke van den Akker, Dries A. M. Feyen, Sandra Crnko, Christian J. B. Snijders Blok, Hendrik Gremmels, Bastiaan C. du Pre, Robin Reijers, Pieter A. Doevendans, Saskia C. A. de Jager, Joost P. G. Sluijter, Vasco Sampaio-Pinto, Linda W. van Laake
Summary: Circadian rhythms play a crucial role in the hyperacute immune response after a myocardial infarction (MI). The levels of immune cells and cardiac damage vary throughout the day, indicating the circadian influence on the immune response. These findings align with the clinical observation that patients who experience an MI early in the morning have worse outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zaida Abad-Jimenez, Sandra Lopez-Domenech, Celia Garcia-Gargallo, Teresa Vezza, Segundo Angel Gomez-Abril, Carlos Morillas, Pedro Diaz-Pozo, Rosa Falcon, Celia Banuls, Victor M. Victor, Milagros Rocha
Summary: This cohort study explored the molecular mechanisms involved in energy homeostasis in leukocytes of obese subjects one year after Roux-en-Y gastric bypass (RYGB) surgery. The surgery resulted in improved metabolic outcomes, reduced systemic inflammation, altered intracellular inflammatory pathways, enhanced autophagy/mitophagy markers, and decreased mitochondrial membrane potential.
Article
Engineering, Biomedical
Emma R. Brannon, William J. Kelley, Michael W. Newstead, Alison L. Banka, Kathryn E. Uhrich, Colleen E. O'Connor, Theodore J. Standiford, Omolola Eniola-Adefeso
Summary: A technology using Poly-Aspirin (Poly-A) polymer microparticles has been developed to intervene in acute respiratory distress syndrome (ARDS), reducing neutrophil-mediated lung injury and inflammation, and enhancing survival rates.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Immunology
Suzanne H. Bongers, Na Chen, Erinke van Grinsven, Selma van Staveren, Marwan Hassani, Roy Spijkerman, Lilian Hesselink, Adele T. Lo Tam Loi, Corneli van Aalst, Guus P. Leijte, Matthijs Kox, Peter Pickkers, Falco Hietbrink, Luke P. H. Leenen, Leo Koenderman, Nienke Vrisekoop
Summary: Neutrophil phenotypes exhibit changes in disease states, with acute inflammation showing more heterogeneity and chronic inflammation not leading to increases in specific neutrophil subsets. The dynamics of neutrophil subsets in various inflammatory conditions contribute to our understanding of the role of neutrophils in health and disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Amro M. Soliman, Daniel R. Barreda
Summary: Acute inflammation plays a crucial role in the immune responses of fish, protecting the host from infection and promoting tissue repair. Inflammatory signals and mediators drive leukocyte recruitment, antimicrobial mechanisms, and resolution of inflammation. Understanding the kinetics and unique characteristics of fish inflammation is important for studying fish diseases and potential treatments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Novi Khila Firani, Khoirunisah Dwi Hartanti, Putri Purnamasari
Summary: This study evaluated predictors of in-hospital mortality in patients with acute myocardial infarction (AMI). The results showed that leukocyte count, neutrophil count, eosinophil count, and eosinophil/leukocyte ratio can help predict in-hospital mortality of AMI patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sarah Thompson, Chong Yun Pang, Krishna Mohan Sepuru, Seppe Cambier, Thomas P. Hellyer, Jonathan Scott, A. John Simpson, Paul Proost, John A. Kirby, Krishna Rajarathnam, Neil S. Sheerin, Simi Ali
Summary: Chemokine CXCL8 plays a crucial role in human immune response by mediating neutrophil migration and activation at sites of infection and injury. This study demonstrates that peroxynitrite can nitrate CXCL8, leading to impaired neutrophil migration and activation. The nitrated chemokine showed reduced ability to induce neutrophil migration in vitro and failed to promote leukocyte recruitment in vivo due to impaired receptor signaling and binding to glycosaminoglycans. The presence of nitrated CXCL8 was detected in bronchoalveolar lavage samples from patients with pneumonia, providing the first direct evidence of chemokine nitration in human pathophysiology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Medicine, General & Internal
Maria Dulfary Sanchez-Pino, William S. Richardson, Jovanny Zabaleta, Ramesh Thylur Puttalingaiah, Andrew G. Chapple, Jiao Liu, Yonghyan Kim, Michelle Ponder, Randi DeArmitt, Lyndsey Buckner Baiamonte, Dorota Wyczechowska, Liqin Zheng, Amir A. Al-Khami, Jone Garai, Rachel Martini, Melissa Davis, Jessica Koller Gorham, James B. Wooldridge, Paulo C. Rodriguez, Lucio Miele, Augusto C. Ochoa
Summary: The number of LDN in the circulation is increased in obese patients and is associated with an inflammatory gene signature. Bariatric surgery significantly reduces LDN levels and improves metabolic parameters.
Article
Immunology
Chanchal Sur Chowdhury, Elizabeth Wareham, Juying Xu, Sachin Kumar, Matthew Kofron, Sribalaji Lakshmikanthan, Magdalena Chrzanowska, Marie-Dominique Filippi
Summary: This study discovers that neutrophil acidity plays a critical role in their function, and acidification leads to abnormal behavior, increased invasiveness, transcellular migration, and vascular leakage. Inhibiting acidity can selectively suppress the infiltration and inflammatory response of pathogenic neutrophils.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Bochra Tourki, Laurence M. Black, Vasundhara Kain, Ganesh Halade
Summary: The persistent increase in 12/15 lipoxygenase enzyme activity is associated with uncontrolled inflammation, which can lead to organ dysfunction. The use of the ML351 antagonist to inhibit lipoxygenases can suppress inflammation initiation but may also disrupt the acute immune response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Psychiatry
Caleb Mclachlan, Richard Shelton, Li Li
Summary: There is a bidirectional relationship between adolescent depression and obesity, with inflammation playing a role in both disorders. This study aims to investigate the impact of inflammation on the association between obesity and depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Microbiology
Tucker J. Piergallini, Julia M. Scordo, Paula A. Pino, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner
Summary: The study demonstrates that an early and transient inflammatory environment induced by lipopolysaccharide treatment enhances protection against Mycobacterium tuberculosis infection in mice for up to 6 months postinfection. Neutrophils from lipopolysaccharide-treated mice exhibited increased association with M. tuberculosis and had a greater innate capacity for killing the bacteria. The results suggest that acute inflammation at the time of M. tuberculosis infection can positively alter disease outcome by potentially improving immune responses.
MICROBIOLOGY SPECTRUM
(2021)
Article
Immunology
Lanjing Tang, Nannan Cai, Yao Zhou, Yi Liu, Jingxia Hu, Yalin Li, Shuying Yi, Wengang Song, Li Kang, Hao He
Summary: Psychological stress can affect the immune system and regulate the disease process. This study found that acute stress leads to up-regulation of immune genes related to inflammatory response, defense response, wound healing, complement activation, and pro-inflammatory cytokine production. Additionally, acute stress increases the number of neutrophils and decreases the number of T cells and B cells. Moreover, acute stress results in an inflammatory state dominated by the innate immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amro M. M. Soliman, Daniel R. R. Barreda
Summary: There are well-established connections between acute inflammation and successful tissue repair. Innate immune reactions play a significant role in pathogen clearance and activation of subsequent reparative events. A network of molecular and cellular regulators supports antimicrobial and tissue repair functions throughout the healing process. A balance must be achieved between protection and the potential for collateral tissue damage associated with overt inflammation. This review summarizes the contributions of key cellular and molecular components to the acute inflammatory process and the timely transition towards activation of tissue repair mechanisms. Furthermore, it discusses how the disruption of inflammatory responses ultimately leads to chronic non-healing injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Robinson Ramirez-Velez, Antonio Garcia-Hermoso, Maria Correa-Rodriguez, Joaquin Fernandez-Irigoyen, Sara Palomino-Echeverria, Enrique Santamaria, Jorge Enrique Correa-Bautista, Katherine Gonzalez-Ruiz, Mikel Izquierdo
Summary: Obesity-related metabolic risk factors in overweight/obese adolescents may be associated with systemic low-grade inflammation. Implementing a 6-month exercise program can significantly change inflammatory levels and prevent obesity-related metabolic diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Psychology, Clinical
Patricia L. East, Jenalee R. Doom, Estela Blanco, Raquel Burrows, Betsy Lozoff, Sheila Gahagan
Summary: This study examines the association between iron deficiency in infancy and sluggish cognitive tempo (SCT) or attention-deficit/hyperactive-impulsive (AD-HI) symptoms in childhood and adolescence, as well as the impact of these behaviors on verbal and mathematical abilities. The results suggest that greater severity of iron deficiency in infancy is associated with more frequent SCT and AD-HI symptoms at all ages studied. Additionally, the effects of iron deficiency on children's verbal and math skills are mediated through AD-HI behaviors.
JOURNAL OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY
(2023)
Article
Neurosciences
Patricia L. East, Brie Reid, Estela Blanco, Raquel Burrows, Betsy Lozoff, Sheila Gahagan
Summary: This study found that high levels of iron supplementation in nonanemic infants may have negative effects on neurocognitive functioning, particularly in visual-motor integration, quantitative reasoning, and neurocognitive tasks. It suggests that the balance between the physiological need for iron during rapid brain development in young infants and the risks associated with supplementing nonanemic infants with high levels of iron should be considered.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Environmental Sciences
Maria Elisa Quinteros, Estela Blanco, Janeet Sanabria, Felipe Rosas-Diaz, Carola A. Blazquez, Salvador Ayala, Juan Pablo Cardenas-R, Elizabeth A. Stone, Keely Sybesma, Juana Maria Delgado-Saborit, Roy M. Harrison, Pablo Ruiz-Rudolph
Summary: This study investigates the air pollution problem caused by residential wood heating in Temuco, a city in Southern Chile. The concentrations of PM2.5, levoglucosan, and K-sol were found to be particularly high in winter. The ratios of levoglucosan and K-sol to PM2.5 were lower in summer. Spatial clustering analysis revealed that some neighborhoods with higher ratios were associated with lower socioeconomic status and possibly lower quality stoves.
ATMOSPHERIC ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Sofia Sanhueza, Layla Simon, Mariana Cifuentes, Andrew F. G. Quest
Summary: Obesity, with a worldwide prevalence of 39% as of 2021, is a major public health concern. It is strongly associated with chronic low-grade systemic inflammation and has become a significant risk factor for the development of various chronic diseases, such as diabetes, cardiovascular problems, and cancer. Dysfunctional components in adipose tissue, particularly adipocytes and macrophages, play a central role in understanding how obesity leads to these diseases. This review focuses on the endocrine signals generated by excess fat accumulation in adipose tissue that promote cancer development, as well as the paracrine communication between cancer cells, macrophages, and adipocytes in the tumor microenvironment that supports cancer progression. Additionally, the involvement of reactive oxygen species in these signaling pathways and the potential of antioxidants to mitigate the effects of dysfunctional adipose tissue in obesity will be discussed.
Article
Nutrition & Dietetics
Camila Zancheta Ricardo, Ana Clara Duran, Mariana Fagundes Grilo, Natalia Rebolledo, Ximena Diaz-Torrente, Marcela Reyes, Camila Corvalan
Summary: This study compared the frequency and share of ultra-processed foods (UPF) in the diets of Chilean preschoolers using three different methods of identification. The results showed that searching for UPF markers in the ingredients list increased the proportion of identified UPF products and affected the caloric share of UPF in the children's diets.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Lautaro Briones-Suarez, Mariana Cifuentes, Roberto Bravo-Sagua
Summary: Obesity-induced inflammation in adipose tissue has harmful effects on organs like the liver. The activation of the calcium-sensing receptor in pre-adipocytes results in the secretion of pro-inflammatory cytokines, TNF-alpha, and IL-1 beta. These cytokines promote cell senescence and mitochondrial dysfunction in HepG2 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Daphne Yvette LaCoursiere, Lisa Kane Low, Sara Putnam, Jean. F. F. Wyman, Diane. K. K. Newman, Shayna Cunningham, Leslie Rickey, Amanda Berry, Sheila Gahagan, Camille. P. P. Vaughan, Oluwateniola Brown, Sonya. S. S. Brady
Summary: The Prevention of Lower Urinary Tract Symptoms (PLUS) research consortium developed a bladder health knowledge, attitudes, and beliefs (BH-KAB) instrument to assess women's knowledge, attitudes, and beliefs related to bladder health. The 18-item instrument evaluates self-reported bladder knowledge, perceptions of bladder function and related medical conditions, attitudes toward fluid intake and urinary habits, and the impact of pregnancy and pelvic muscle exercises on bladder health.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Social Sciences, Interdisciplinary
Erin Delker, Sheila Gahagan, Raquel Burrows, Paulina Burrows-Correa, Patricia East, Betsy Lozoff, Estela Blanco
Summary: This study aims to understand how socioeconomic position (SEP) across development relates to executive functioning. The results indicate that experiencing cumulatively low socioeconomic position from infancy to adolescence can have a negative impact on cognitive functioning in young adulthood. Furthermore, the findings provide evidence in support of adolescence as a key developmental period during which SEP can most strongly impact cognitive functioning.
ADVANCES IN LIFE COURSE RESEARCH
(2023)
Article
Nutrition & Dietetics
Estela Blanco, Suzanna M. Martinez, Patricia East, Raquel Burrows, Paulina Correa-Burrows, Betsy Lozoff, Sheila Gahagan
Summary: This study examined the association between breastfeeding duration and body mass index (BMI) from childhood to young adulthood and found that longer breastfeeding was associated with lower BMI in early childhood, but had no significant effect on later BMI.
Article
Engineering, Environmental
Maria Elisa Quinteros, Carola Blazquez, Salvador Ayala, Dylan Kilby, Juan Pablo Cardenas-R, Ximena Ossa, Felipe Rosas-Diaz, Elizabeth A. Stone, Estela Blanco, Juana-Maria Delgado-Saborit, Roy M. Harrison, Pablo Ruiz-Rudolph
Summary: Air pollution caused by biomass burning is a significant public health issue. This study developed spatial-temporal land use regression models to predict the concentrations of fine particulate matter and wood-burning tracers. The models were used to estimate exposure for an epidemiological study.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)