Article
Biochemistry & Molecular Biology
Christopher Spankovich, Bradley J. Walters
Summary: Sensorineural hearing loss significantly impacts quality of life and risk for comorbidities, with noise and ototoxic drugs being common preventable risk factors. Recent advances in utilizing mild therapeutic hypothermia (TH) for otoprotection show promise for various forms of acquired hearing loss, but further research is needed to understand its mechanisms for different forms of hearing loss.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Behavioral Sciences
Elena Pala, Anna Penalba, Alejandro Bustamante, Teresa Garcia-Berrocoso, Marcel Lamana-Vallverdu, Christian Meisel, Andreas Meisel, H. Bart van der Worp, Malcolm R. Macleod, Bernd Kallmuenzer, Stefan Schwab, Joan Montaner
Summary: Blood biomarkers, including MMP-3, FABP, and IL-8, showed increased levels over time in relation to therapeutic hypothermia in stroke patients. These changes could serve as surrogate markers to evaluate the efficacy and safety of hypothermia treatment.
BRAIN AND BEHAVIOR
(2023)
Editorial Material
Endocrinology & Metabolism
Di Wu, Jian Chen, Xuxiang Zhang, Roxanne Ilagan, Yuchuan Ding, Xunming Ji
Summary: Selective therapeutic cooling is a promising technique for reducing final infarct volume and improving outcomes in ischemic stroke. However, more targeted induction of brain hypothermia and mitigating potential side effects related to inducing hypothermia may be necessary to enhance the benefits of this method.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Maria E. E. Bernis, Margit Zweyer, Elke Maes, Yvonne Schleehuber, Hemmen Sabir
Summary: The peripheral immune system plays a critical role in neuroinflammation of the central nervous system after an insult. In this study, a neonatal model of experimental hypoxic-ischemic (HI) brain injury was used to investigate the activation of neutrophils and the formation of neutrophil extracellular traps (NETs). The results suggest the important pathological functions of early arriving neutrophils and NETosis following neonatal HI, particularly after therapeutic hypothermia (TH) treatment, which could serve as a potential therapeutic target for neonatal hypoxic-ischemic encephalopathy (HIE).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Biruk Beletew Abate, Melaku Bimerew, Bereket Gebremichael, Ayelign Mengesha Kassie, MesfinWudu Kassaw, Teshome Gebremeskel, Wubet Alebachew Bayih
Summary: Therapeutic hypothermia reduces the risk of death in neonates with moderate to severe hypoxic-ischemic encephalopathy, with both selective head cooling and whole-body cooling method being effective. Low income countries benefit the most from this treatment.
Article
Engineering, Biomedical
Ming Li, Yuan Gao, Miaowen Jiang, Hongkang Zhang, Yang Zhang, Yan Wu, Wenhao Zhou, Di Wu, Chuanjie Wu, Longfei Wu, Luzi Bao, Xiaoxiao Ge, Zhengfei Qi, Ming Wei, Ang Li, Yuchuan Ding, Jicheng Zhang, Guangzhen Pan, Yu Wu, Yan Cheng, Yufeng Zheng, Xunming Ji
Summary: Researchers have developed a catheter with a thermally-insulated coating, which improves cooling efficiency and provides neuroprotection for patients with acute ischemic stroke.
BIOACTIVE MATERIALS
(2023)
Article
Pediatrics
Lucia Lanciotti, Rossella Sica, Laura Penta, Francesca Parisi, Alberto Argentiero, Maurizio Radicioni, Giuseppe Di Cara, Francesca Di Genova, Alberto Verrotti, Stefania Troiani, Susanna Maria Roberta Esposito
Summary: The aim of this study is to evaluate whether minipuberty occurs in patients with hypoxic ischemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH). The results showed that minipuberty occurred in the case group patients, with no significant differences reported from the control group and with hormonal serum levels comparable to healthy infants of the control group.
FRONTIERS IN PEDIATRICS
(2023)
Article
Emergency Medicine
Jia-Yu Chen, Chien-Hua Huang, Wen-Jone Chen, Wei-Ting Chen, Hooi-Nee Ong, Wei-Tien Chang, Min-Shan Tsai
Summary: This study found that QRS durations at ROSC and after rewarming were associated with survival rates in cardiac arrest survivors undergoing therapeutic hypothermia. The wide-wide group had the lowest survival rate, followed by the narrow-wide group and the wide-narrow group.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Panzao Yang, Joanne O. O. Davidson, Kelly Q. Q. Zhou, Rani Wilson, Guido Wassink, Jaya D. D. Prasad, Laura Bennet, Alistair J. J. Gunn, Justin M. M. Dean
Summary: Therapeutic hypothermia improves outcomes after neonatal hypoxic-ischemic encephalopathy, but its protective effects are limited. Loss of cortical inhibitory interneurons may contribute to long-term neurological dysfunction in these infants, and the duration of hypothermia has differential effects on interneuron survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
C. Autilio, M. Echaide, A. Cruz, C. Mouton, A. Hidalgo, E. Da Silva, D. De Luca, B. Sorli Jorid, J. Perez-Gil
Summary: Therapeutic hypothermia improves pulmonary surfactant performance by enhancing its resistance to plasma inhibition and more effectively restoring surface tension at 33 degrees Celsius.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas Scherz, Thomas M. Hofbauer, Anna S. Ondracek, Daniel Simon, Fritz Sterz, Christoph Testori, Irene M. Lang, Andreas Mangold
Summary: The study revealed that in STEMI patients treated with MTH, there were longer clotting times and higher platelet reactivity, but these changes did not correlate with clinical bleeding events or larger infarct size.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
GianPietro Sechi, M. Margherita Sechi
Summary: In neonatal hypoxic-ischemic encephalopathy (HIE), therapeutic hypothermia (TH) is the standard care in developed countries, but it may not be beneficial or suitable in developing nations. Moreover, hypothermic neuroprotection is often incomplete, with infants still experiencing death or significant neurological issues. Therefore, there is a need to find innovative neuroprotective compounds for HIE, such as ketone bodies and thiamine, which may provide additional neuroprotection in conjunction with TH and improve treatment strategies in low-middle-income countries.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Bowen Weng, Chongbing Yan, Yihuan Chen, Xiaohui Gong, Cheng Cai
Summary: Therapeutic hypothermia in neonates with moderate to severe HIE was found to significantly improve neurological outcomes and reduce the incidence of death and disabilities associated with major neuron development.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Kylie A. Corry, Olivia R. White, AnnaMarie E. Shearlock, Daniel H. Moralejo, Janessa B. Law, Jessica M. Snyder, Sandra E. Juul, Thomas R. Wood
Summary: In a ferret model of inflammation-sensitized hypoxic-ischemic brain injury, uridine monophosphate and therapeutic hypothermia did not provide meaningful neuroprotection, with uridine monophosphate appearing to worsen outcomes. In contrast, erythropoietin showed significant neuroprotection in this model, although not complete.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Marlotte A. A. van der Veer, Timo R. de Haan, Linda G. W. Franken, Caspar J. Hodiamont, Floris Groenendaal, Peter H. Dijk, Willem P. de Boode, Sinno Simons, Koen P. Dijkman, Henrica L. M. van Straaten, Monique Rijken, Filip Cools, Debbie H. G. M. Nuytemans, Anton H. van Kaam, Yuma A. Bijleveld, Ron A. A. Mathot
Summary: This study investigated the pharmacokinetics (PK) of ceftazidime in asphyxiated neonates during hypothermia, rewarming, and normothermia and proposed a population-based rational dosing regimen. The results showed that the probability of the concentration in the blood exceeding the minimum inhibitory concentration (MIC) for 100% of the time (T->MIC) during hypothermia and normothermia was 99.7% and 87.7%, respectively. Therefore, a dosing regimen of 100 mg/kg/day in 2 doses during hypothermia and rewarming and 150 mg/kg/day in 3 doses during the following normothermic phase is advised.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)