Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program

588 A First-in-patient Phase I Study of the Novel Gamma Secretase Inhibitor PF-03084014 in Patients with Advanced Solid Tumor Malignancies

(2012) W.A. Messersmith et al.   EUROPEAN JOURNAL OF CANCER

Preclinical Analysis of the  -Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

(2012) J. B. Samon et al.   MOLECULAR CANCER THERAPEUTICS

The double-edged sword of Notch signaling in cancer

(2012) Andrew P. South et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling

(2011) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014

(2010) Michael A. Brodney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Notch Pathway Inhibition Significantly Reduces Rhabdomyosarcoma Invasiveness and Mobility In Vitro

(2010) J. Roma et al.   CLINICAL CANCER RESEARCH

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

(2010) Jon C Aster et al.   JOURNAL OF PATHOLOGY

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

(2010) P Zhang et al.   ONCOGENE

National Cancer Institute pediatric preclinical testing program: Model description for in vitro cytotoxicity testing

(2010) Min H. Kang et al.   PEDIATRIC BLOOD & CANCER

Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation

(2009) M Tanaka et al.   BRITISH JOURNAL OF CANCER

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

Candidate Genes on Chromosome 9q33-34 Involved in the Progression of Childhood Ependymomas

(2009) Stéphanie Puget et al.   JOURNAL OF CLINICAL ONCOLOGY

Initial testing of VNP40101M (Cloretazine®) by the pediatric preclinical testing program

(2008) Stephen T. Keir et al.   PEDIATRIC BLOOD & CANCER