Article
Oncology
Paul Workman
Summary: The NCI-60 screen, which involved screening of 10,000 diverse compounds against 60 human tumor cell lines, marked a major technological advance in cancer research and development. It provided the foundation for subsequent larger-scale human cancer cell panel screens with detailed molecular annotation and sophisticated informatics, enabling the implementation of modern molecular target-based drug discovery and precision oncology.
Article
Cell Biology
Zi-Ning Lei, Qiu-Xu Teng, Pranav Gupta, Wei Zhang, Silpa Narayanan, Dong-Hua Yang, John N. D. Wurpel, Ying-Fang Fan, Zhe-Sheng Chen
Summary: The study demonstrates that CBZ can inhibit the ABCG2 transporter and resensitize drug-resistant cancer cells to specific drugs, showing promising reversal effects in an in vivo xenograft model.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hari Sankaran, Simarjeet Negi, Lisa M. McShane, Yingdong Zhao, Julia Krushkal
Summary: This study analyzed the activity of Indian natural products in the NCI-60 cell line panel and identified associations with gene expression and mutations related to cancer treatment. The findings are important for understanding the mechanisms of these Indian natural products.
Article
Nanoscience & Nanotechnology
Gerard Rubi-Sans, Agata Nyga, Elena Rebollo, Soledad Perez-Amodio, Jorge Otero, Daniel Navajas, Miguel A. Mateos-Timoneda, Elisabeth Engel
Summary: The study introduced a novel method to produce mesenchymal cell-derived matrices (CDMs) aimed at mimicking the fibrotic tumor microenvironment, showing that they closely mimic the composition, structure, and mechanical properties of human fibrotic ECM. CDMs have highly reproducible composition and tunable mechanical properties, and exhibit increased doxorubicin resistance in cancer cells following chemotherapeutic treatment in comparison to 3D culture in collagen hydrogels.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Medicine, Research & Experimental
Shaymaa Fadhel Abbas Albaayit, Mariam Ashfaq Khan, Rasedee Abdullah, Mohd Hezmee Mohd Noor
Summary: The study demonstrated that ethyl acetate C. excavata leaf extract exhibits cytotoxic effects on the non-small lung cancer cell line NCI-H460, inducing apoptosis and increasing ROS production. Through modulation of apoptotic gene expressions, it reveals the potential of EACE as an anti-lung cancer agent.
JOURNAL OF APPLIED BIOMEDICINE
(2021)
Article
Polymer Science
S. Arockia Anushya, S. Prabhu, Vilwanathan Ravikumar, A. Philominal
Summary: The present study investigated the cytotoxicity and apoptosis on lung cancer cell lines by including bismuth oxide (Bi2O3) with reduced graphene oxide (rGO). The synthesized materials were confirmed by various characterizations. The results showed that the rGO-Bi2O3 nanocomposite had enhanced anticancer properties compared to GO and rGO.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Oncology
Julia Krushkal, Simarjeet Negi, Laura M. Yee, Jason R. Evans, Tanja Grkovic, Alida Palmisano, Jianwen Fang, Hari Sankaran, Lisa M. McShane, Yingdong Zhao, Barry R. O'Keefe
Summary: Investigation revealed associations between gene expression and the response of cancer cells to specific categories of natural products, suggesting potential mechanisms of action and paving the way for future targeted cancer chemotherapy agent discovery and design.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luis R. Raposo, Ana Silva, Dario Silva, Catarina Roma-Rodrigues, Margarida Espadinha, Pedro Baptista, Maria M. M. Santos, Alexandra R. Fernandes
Summary: This study assessed the antiproliferative activity of five spiropyrazoline oxindoles in ovarian cancer cells and identified a compound with the highest effectiveness and selectivity. The compound induced cell death through mitochondria-mediated apoptosis and autophagy, with interaction with DNA by groove-binding without genotoxicity. Proteomic studies revealed the compound's role in promoting ER stress and triggering cell death in ovarian cancer cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wagner da S. Terra, Erika S. Bull, Samila R. Morcelli, Rafaela R. Moreira, Leide Laura F. Maciel, Joao Carlos de A. Almeida, Milton M. Kanashiro, Christiane Fernandes, Adolfo Horn Jr
Summary: This study reported the cytotoxicity of three water-soluble copper(II) coordination compounds on five human tumor cell lines, with one complex showing the best antiproliferative effect and selectivity against lung cancer cell line NCI-H460. The mechanism of cell death promoted by this complex was found to be apoptosis, leading to damage of mitochondrial membrane potential and other organelles.
Article
Immunology
Karsten M. Warwas, Marten Meyer, Marcia Goncalves, Gerhard Moldenhauer, Nadja Bulbuc, Susanne Knabe, Claudia Luckner-Minden, Claudia Ziegelmeier, Claus Peter Heussel, Inka Zoernig, Dirk Jaeger, Frank Momburg
Summary: This study demonstrates that co-stimulation significantly enhances the tumoricidal activity of T cell-activating BiMAb, while reducing the required dose for T cell activation and overcoming immune-suppressive effects. Co-stimulation could provide a more localized and effective activation of the immune system against tumor cells, showing promise for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Juthamart Maneenet, Ahmed M. Tawila, Ashraf M. Omar, Nguyen Duy Phan, Chiharu Ojima, Masahiro Kuroda, Mao Sato, Mio Mizoguchi, Ikue Takahashi, Suresh Awale
Summary: An n-hexane extract from Callistemon subulatus exhibited potent cytotoxicity against PANC-1 human pancreatic cancer cells, particularly under nutrition starvation conditions. Among the isolated compounds, myrtucommulone A (2) demonstrated highly preferential cytotoxicity against the cancer cells and induced cell death through inhibition of cell migration and downregulation of signaling pathways.
Article
Biochemistry & Molecular Biology
Blake R. Rushing
Summary: This study used a multi-omics approach to explore the molecular determinants affecting the response of cancer cells to alkylating agents. Through integrated pathway analysis, key metabolic pathways were identified, and potential druggable targets were revealed. Copy number variant analysis also identified notable differences in genes associated with metabolic changes, protein trafficking, and miRNAs between drug-sensitive and drug-resistant cells. These findings provide a comprehensive view of the molecular landscape underlying the response to alkylating agents and can contribute to the development of personalized treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Tao Wang, Joaquim Rovira, Jordi Sierra, Jordi Blanco, She-Jun Chen, Bi- Xian Mai, Marta Schuhmacher, Jose L. Domingo
Summary: This study investigated the concentrations and composition of airborne particles in industrial/commercial sites of Guangzhou, China. The research focused on major and trace elements, ions, carbonaceous fraction, and cytotoxicity of these particles on human lung cancer cell lines. The results showed varying levels of toxicity based on particle size, and identified industrial activities and coal combustion as major sources of pollution.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Claire Xin Sun, Paul Daniel, Gabrielle Bradshaw, Hui Shi, Melissa Loi, Nicole Chew, Sarah Parackal, Vanessa Tsui, Yuqing Liang, Mateusz Koptyra, Shazia Adjumain, Christie Sun, Wai Chin Chong, Dasun Fernando, Caroline Drinkwater, Motahhareh Tourchi, Dilru Habarakada, Dhanya Sooraj, Diana Carvalho, Phillip B. Storm, Valerie Baubet, Leanne C. Sayles, Elisabet Fernandez, Thy Nguyen, Mia Poerksen, Anh Doan, Duncan E. Crombie, Monty Panday, Nataliya Zhukova, Matthew D. Dun, Louise E. Ludlow, Bryan Day, Brett W. Stringer, Naama Neeman, Jeffrey A. Rubens, Eric H. Raabe, Maria Vinci, Vanessa Tyrrell, Jamie I. Fletcher, Paul G. Ekert, Biljana Dumevska, David S. Ziegler, Maria Tsoli, Nur Farhana Syed Sulaiman, Amos Hong Pheng Loh, Sharon Yin Yee Low, E. Alejandro Sweet-Cordero, Michelle Monje, Adam Resnick, Chris Jones, Peter Downie, Bryan Williams, Joseph Rosenbluh, Daniel Gough, Jason E. Cain, Ron Firestein
Summary: The study establishes a pediatric cancer model resource with 261 cell lines, including 224 representing childhood tumor types. Through multi-omics analysis and genetic screening, specific treatment opportunities and biomarkers in pediatric tumor classes are identified. The findings are of great significance in improving the clinical relevance of pediatric cancer treatment.
Article
Biochemistry & Molecular Biology
Evangelia Sereti, Chrisiida Tsimplouli, Elisavet Kalaitsidou, Nikos Sakellaridis, Konstantinos Dimas
Summary: This study aimed to investigate the expression levels of both sigma receptor subtypes in several human cancer cell lines and study their relationship with the activity of sigma ligands. Through in vitro experiments and the NCI60 COMPARE algorithm, the cytotoxic mechanism of action of the selected sigma ligands studied herein was further elucidated.
Article
Oncology
Michael M. Song, Monish R. Makena, Ashly Hindle, Balakrishna Koneru, Thinh H Nguyen, Dattesh U. Verlekar, Hwangeui Cho, Barry J. Maurer, Min H. Kang, C. Patrick Reynolds
Article
Oncology
Monish R. Makena, Hwang Eui Cho, Thinh H. Nguyen, Balakrishna Koneru, Dattesh U. Verlekar, Ashly Hindle, Min H. Kang, C. Patrick Reynolds
PEDIATRIC BLOOD & CANCER
(2018)
Article
Oncology
Caitlin D. Lowery, Michele Dowless, Matthew Renschler, Wayne Blosser, Alle B. VanWye, Jennifer R. Stephens, Philip W. Iversen, Aimee Bence Lin, Richard P. Beckmann, Kateryna Krytska, Kristina A. Cole, John M. Maris, Douglas S. Hawkins, Brian P. Rubin, Raushan T. Kurmasheva, Peter J. Houghton, Richard Gorlick, E. Anders Kolb, Min H. Kang, C. Patrick Reynolds, Stephen W. Erickson, Beverly A. Teicher, Malcolm A. Smith, Louis F. Stancato
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Ismail S. Mohiuddin, Sung-Jen Wei, Min H. Kang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Biochemical Research Methods
Hwang Eui Cho, Barry J. Maurer, C. Patrick Reynolds, Min H. Kang
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2019)
Review
Oncology
Ismail S. Mohiuddin, Min H. Kang
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Thinh H. Nguyen, Balakrishna Koneru, Sung-Jen Wei, Wan Hsi Chen, Monish Ram Makena, Eduardo Urias, Min H. Kang, C. Patrick Reynolds
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Cell Biology
Sung-Jen Wei, Thinh H. Nguyen, In-Hyoung Yang, Dustin G. Mook, Monish Ram Makena, Dattesh Verlekar, Ashly Hindle, Gloria M. Martinez, Shengping Yang, Hiroyuki Shimada, C. Patrick Reynolds, Min H. Kang
CELL DEATH & DISEASE
(2020)
Review
Oncology
Alexander Kroll, Hwang Eui Cho, Min H. Kang
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Jacob S. Thomas, Anthony B. El-Khoueiry, Barry J. Maurer, Susan Groshen, Jacek K. Pinski, Everardo Cobos, David R. Gandara, Heinz J. Lenz, Min H. Kang, C. Patrick Reynolds, Edward M. Newman
Summary: The study aimed to investigate the tolerability, efficacy, and pharmacokinetics of intravenous lipid emulsion fenretinide in patients with advanced solid tumors. The results showed that the formulation had a manageable safety profile and achieved higher plasma steady-state concentrations of the active metabolite compared to previous capsule formulations.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Maggie H. Chasse, Benjamin K. Johnson, Elissa A. Boguslawski, Katie M. Sorensen, Jessica E. Rosien, Min H. Kang, C. Patrick Reynolds, Lyong Heo, Zachary B. Madaj, Ian Beddows, Gabrielle E. Foxa, Susan M. Kitchen-Goosen, Bart O. Williams, Timothy J. Triche, Patrick J. Grohar
Summary: The study found that rhabdoid tumors are more sensitive to mithramycin and EC8042, with their sensitivity superior to traditional DNA damaging agents and linked to the causative mutation of SMARCB1 deletion in the tumor. Mithramycin can block the activity of SMARCB1-deficient SWI/SNF complex, leading to chromatin remodeling and restoration of cellular differentiation.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ismail S. Mohiuddin, Sung-Jen Wei, In-Hyoung Yang, Gloria M. Martinez, Shengping Yang, Eun J. Cho, Kevin N. Dalby, Min H. Kang
Summary: A novel cell-based luminescence assay was developed to identify inhibitors targeting c-MYC transcriptional activation, leading to the discovery of five potential lead compounds with significant ability to kill cancer cells. Two candidate compounds from the DNA-PKcs assay and three from the MK2 assay were identified through a two-step validation method.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Public, Environmental & Occupational Health
Abdurrahman Kharbat, Habib Abla, Mahmud Alkul, Ranger Kile, Justin White, Cynthia Reinoso Webb, Steven M. Presley, Min H. Kang
Summary: This article describes a system using a hydrogen peroxide vaporization method to decontaminate and reuse N95 respirators, providing support for healthcare institutions in West Texas by decontaminating over 12,000 units of PPE.
INFECTION PREVENTION IN PRACTICE
(2021)
Review
Medicine, Research & Experimental
Michelle E. Keyel, C. Patrick Reynolds
BIOLOGICS-TARGETS & THERAPY
(2019)