Article
Cell & Tissue Engineering
Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang
Summary: This study found that adding an unrelated umbilical cord blood unit to haploidentical hematopoietic stem cell transplantation can improve the prognosis and enhance the graft versus leukemia effect without increasing the incidence of graft versus host disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Fan Lin, Tingting Han, Yuanyuan Zhang, Yifei Cheng, Zhengli Xu, Xiaodong Mo, Fengrong Wang, Chenhua Yan, Yuqian Sun, Jingzhi Wang, Feifei Tang, Wei Han, Yuhong Chen, Yu Wang, Xiaohui Zhang, Kaiyan Liu, Xiaojun Huang, Lanping Xu
Summary: Secondary poor graft function (sPGF) after haploidentical hematopoietic stem cell transplantation (HSCT) in patients with acquired aplastic anemia (AA) has a cumulative incidence of 4.62% and is associated with lower 2-year overall survival. Later neutrophil engraftment and a history of refractory cytomegalovirus viremia are risk factors for sPGF.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Hideki Sano, Kazuhiro Mochizuki, Shogo Kobayashi, Yoshihiro Ohara, Nobuhisa Takahashi, Shingo Kudo, Tomoko Waragai, Kazuhiko Ikeda, Hitoshi Ohto, Atsushi Kikuta
Summary: This study evaluated the efficacy of T-cell replete HLA haploidentical hematopoietic stem cell transplantation (TCR-haplo-HSCT) in pediatric refractory/relapsed B-cell precursor acute lymphoblastic leukemia. The results suggest that this transplantation approach has the potential to improve outcomes in some patients with RR-BCP-ALL, but it also carries certain risks.
FRONTIERS IN PEDIATRICS
(2021)
Article
Engineering, Multidisciplinary
Xiao-Dong Mo, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu, Xiao-Jun Huang
Summary: The development of Disease Risk Comorbidity Index (DRCI) based on Disease Risk Index (DRI) and Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) allows for effective risk stratification of patients receiving haploidentical hematopoietic stem cell transplantation. The DRCI accurately predicts disease-free survival, particularly in disease-specific subgroups such as acute leukemia patients. This index also shows predictive value for relapse, non-relapse mortality, overall survival, and can aid in identifying patients who will benefit most from the transplantation procedure.
Article
Pediatrics
Yong Wang, Yongzhi Zheng, Jingjing Wen, Jinhua Ren, Xiaohong Yuan, Ting Yang, Jianda Hu
Summary: The incidence of CSA-related neurotoxicity in children undergoing HID-HSCT for hematopathy is relatively high, with hypertension being a common prodrome. Some patients continue to exhibit persistent neurological abnormalities even at the 5-year follow-up.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Ran Zhang, Xuan Lu, Liang V. Tang, Huafang Wang, Han Yan, Yong You, Zhaodong Zhong, Wei Shi, Linghui Xia
Summary: This study examined the influence of graft composition in haploidentical hematopoietic stem cell transplantation. The results showed that using G-CSF-primed bone marrow and peripheral blood stem cells had comparable outcomes to using only G-CSF-mobilized peripheral blood stem cells. Furthermore, patients with a certain range of nucleated cell transfusion had lower transplant-related mortality and slightly improved survival rates. These findings suggest that adjusting the composition and ratio of graft cells can enhance the efficacy of haploidentical hematopoietic stem cell transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biophysics
Michael H. Albert, Mehtap Sirin, Manfred Hoenig, Fabian Hauck, Catharina Schuetz, Rajat Bhattacharyya, Polina Stepensky, Elad Jacoby, Tayfun Gungor, Rita Beier, Ansgar Schulz
Summary: The study found that a post-transplantation cyclophosphamide-based HLA-haploidentical salvage HSCT after irradiation-free conditioning resulted in excellent engraftment and overall survival in children with non-malignant diseases.
BONE MARROW TRANSPLANTATION
(2021)
Review
Immunology
Motoko Koyama, Geoffrey R. Hill
Summary: Allogeneic stem cell transplantation is an effective therapy for hematopoietic malignancies, relying on donor T cells and NK cells for the graft-versus-leukemia effect. However, graft-versus-host disease remains a major complication, highlighting the importance of understanding alloantigen presentation to separate beneficial effects from detrimental ones. Mouse models and tools play a key role in quantifying alloantigen presentation post-alloSCT.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Siddika Songul Yalcin, Tekin Aksu, Baris Kuskonmaz, Namik Yasar Ozbek, Vicente Perez-Brocal, Melda Celik, Duygu Uckan Cetinkaya, Andres Moya, Ener Cagri Dinleyici
Summary: This study evaluated the mycobiota composition pre- and post-HSCT in children with thalassemia, revealing a decrease in diversity following transplantation. Particularly, there was a predominance of Malassezia in children with GVHD. Further research is needed to understand this phenomenon in children with GVHD.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Medicine, General & Internal
Adetola A. Kassim, Alexis Leonard
Summary: Hematopoietic stem cell transplantation is an effective treatment for SCD, but limited by the availability of matched sibling donors. Haploidentical HSCT and gene therapy show potential as alternative options, with expanded donor pool and improved outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Jiao-Yu Zhao, Si-Ning Liu, Lan-Ping Xu, Xiao-Hui Zhang, Yu Wang, Yu-Hong Chen, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Dong Mo
Summary: The study demonstrates that ruxolitinib is an effective salvage treatment for patients with multidrug-resistant graft-versus-host disease in haploidentical hematopoietic stem cell transplantation recipients, showing significant improvements in patient conditions and increased survival rates.
ANNALS OF HEMATOLOGY
(2021)
Article
Immunology
Qin Zhang, Yujia Huo, Qinggang Sun, Nan Liu, Hongchuan Shi, Minghui Wang, Jinming Xiao, Hanzi Yuan, Xiangfeng Tang
Summary: Unstable hemoglobinopathies are rare diseases that disrupt hemoglobin stability, causing chronic hemolysis and anemia. Hematopoietic stem cell transplantation has been reported as a curative approach for transfusion-dependent patients with unstable hemoglobinopathies. This case report describes the successful haploidentical HSCT treatment of Hb Bristol-Alesha variant in a 6-year-old boy with severe anemia. Two years post-transplantation, the patient achieved near normal hemoglobin levels without signs of hemolysis, confirming full engraftment with normal erythropoiesis through DNA analysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ashley D. Hadjis, Natalia S. Nunes, Shanzay M. Khan, Rochelle E. Fletcher, Alessandra de Paula Pohl, David J. Venzon, Michael A. Eckhaus, Christopher G. Kanakry
Summary: Post-transplantation cyclophosphamide (PTCy) is a drug used to treat graft-versus-host disease (GVHD) following hematopoietic cell transplantation (HCT). It works by impairing and suppressing antigen-specific T cells. In this study, reduced proliferation of CD4(+) T cells at day +7 and preferential recovery of CD4(+)CD25(+)Foxp3(+) regulatory T cells (T-regs) at day +21 were identified as potential biomarkers associated with optimal PTCy dosing and timing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Wen-Jing Yu, Yu-Qian Sun, Ting-Ting Han, Pei-Pei Ye, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Chen-Hua Yan, Xiao-Jun Huang, Yu Wang
Summary: This retrospective study on 14 myeloid sarcoma patients who underwent haploidentical hematopoietic stem cell transplantation (haplo-HSCT) found that it is a feasible treatment option for those without matched sibling or unrelated donors, but comes with risks of complications.
ANNALS OF HEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Riccardo Masetti, Daniele Zama, Davide Leardini, Edoardo Muratore, Silvia Turroni, Patrizia Brigidi, Andrea Pession
Summary: The gut microbiome plays a significant role in hematopoietic stem cell transplantation, with its metabolites mediating interactions between intestinal microbial communities and the host. New data offer a fresh perspective on the role of microbiome-derived metabolites in transplant settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Li Liang, Xin Li, Lin Nong, Weijing Cai, Jixin Zhang, Ping Liu, Ting Li
Summary: A new method called MASE-CE has been developed for genotyping analysis in patients with colorectal cancer. It can simultaneously detect KRAS/NRAS/BRAF gene mutations and microsatellite instability (MSI) status. The method showed high consistency with NGS and PCR-CE, and had superior sensitivity in mutation and MSI detection. This time-saving and specimen-saving method can provide timely clinical decision support.
Article
Chemistry, Multidisciplinary
Zhengfeng Guo, Honggang Gu, Yali Yu, Zhongming Wei, Shiyuan Liu
Summary: Optical anisotropy in SnSe is utilized to design broadband and incident-angle-modulation near-infrared polarizers, with high modulation efficiency and no energy consumption. The broadband polarizer has a bandwidth of 324 nm and an average extinction ratio above 23 dB, while the incident-angle-modulation polarizer dynamically and reversibly modulates its working wavelength with a maximum extinction ratio of 71 dB. The proposed design opens up possibilities for mass-production and integration of polarizing optical components based on low-symmetry materials.
Article
Immunology
Sen Li, Ke Li, Fei Tian, Hongle Li, Qingxin Xia, Tiepeng Li, Bing Dong, Danyang Li, Juan Yu, Junli Zhang, Li Wang, Chengjuan Zhang, Shuning Xu, Yuzhou Zhao, Ying Liu
Summary: Single-cell RNA sequencing revealed that a high baseline interferon gamma (IFN-gamma) signature in CD8(+) T cells predicts better responses to neoadjuvant immunotherapy plus chemotherapy in gastric cancer (GC). The therapy also leads to a significant decrease in the IFN-gamma signature in multiple cell types and suppresses the exhausted signature of CD8(+) T cells during treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ziqi Zhou, Tao Shen, Pan Wang, Quanlin Guo, Qinghe Wang, Chenjun Ma, Kaiyao Xin, Kai Zhao, Yali Yu, Biao Qin, Yue-Yang Liu, Juehan Yang, Hao Hong, Kaihui Liu, Can Liu, Hui-Xiong Deng, Zhongming Wei
Summary: Polarization-sensitive photodetectors have unique advantages in national security, medical diagnosis, and aerospace. By designing a sub-wavelength array structure, the anisotropic sensitivity of germanium selenium can be improved, resulting in enhanced polarized photocurrent ratio. This study provides a feasible guideline to improve the polarization sensitivity of 2D materials and greatly benefits the development of polarized imaging sensors.
Article
Rheumatology
Hui Jin, Shihang Zhou, Yangyiyi Yu, Ming Zhao, Haijing Wu, Hai Long, Siqi Fu, Ruifang Wu, Heng Yin, Jieyue Liao, Shuangyan Luo, Yu Liu, Qing Zhang, Peng Zhang, Yixin Tan, Shuaihantian Luo, Xin Huang, Fen Li, Guanghui Ling, Qianjin Lu
Summary: This study compared the demographic and clinical differences among different subtypes of lupus. The findings suggest that cutaneous lupus erythematosus and systemic lupus erythematosus are distinct disease states, and different types of skin lesions and autoantibodies are associated with varying clinical characteristics and disease severity.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Engineering, Electrical & Electronic
Zifeng Song, Shuangxi Li, Xiaozhu Chen, Zhiyuan Liu, Tan Zhao, Baiqi Huang
Summary: In this study, a two-stage floating-ring isolation seal with a non-slotted main sealing surface was designed and its leakage characteristics were calculated. The effect of the inlet on the seal's performance was taken into account, and a reliability analysis was conducted on a self-constructed test bench. The results provide guidance for designing floating-ring isolation seals for turbine pumps.
Article
Management
Yingying Yao, Lianying Zhang, Hui Sun
Summary: This study examines the role of leader-leader exchange (LLX), psychological empowerment, and organizational identification in enhancing project managers' commitment to strategy. The results suggest that both LLX and psychological empowerment contribute to strategy commitment, and organizational identification moderates this relationship.
INTERNATIONAL JOURNAL OF PROJECT MANAGEMENT
(2023)
Article
Materials Science, Multidisciplinary
Xin Xie, Lei Sheng, Xingxu Gao, Hao Gong, Ling Yang, Min Cao, Datuan Li, Yaozong Bai, Gaojun Liu, Haoyu Dong, Tao Wang, Xianli Huang, Jianping He
Summary: A lithiated molecular sieve (LMS) ceramic particles were designed as a functional separator coating to inhibit lithium dendrites, showing improved ionic conductivity and lithium-ion transfer efficiency. The composite separator successfully achieved dendrite-free lithium deposition morphology and enhanced coulombic efficiency in Li//Cu half-cells. The strategy of using this functional composite separator is expected to improve the electrochemical performance of lithium metal batteries.
ACS APPLIED POLYMER MATERIALS
(2023)
Meeting Abstract
Oncology
Shu (Sophie) Lin, Hongbin Liu, Rui Tan, Weipeng Zhang, Chengxi He, Yue Rong, Zhuo Huang, Jinhua Yu, Yunling Wang, Yangli Qi, Xingdong Zhao, Lihua Jiang, Yanxin Liu, Xilei Wang, Zongyao Zou, Jing Sun, Yuwei Gao, Weibo Wang, Xiaohui Guan, Yifang Wu
Article
Engineering, Electrical & Electronic
Xuesong Han, Xuezhi Yang, Shuai Fang, Rencheng Song, Longwei Li, Jie Zhang
Summary: The article introduces a new method for estimating blood pressure based on the iPPG pulse signals, which captures the tiny change of skin color caused by a heartbeat using consumer-level cameras. It incorporates cardiovascular characteristics such as heart rate, stroke volume, the elasticity of vessel walls, and peripheral vascular resistance. Bayesian neural network models are constructed for the estimation of systolic and diastolic blood pressure, and the machine learning uncertainty is evaluated. The uncalibrated method has been tested on 220 patients with a history of cardiovascular diseases, demonstrating its reliability with low estimation errors.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Multidisciplinary
Qianying Li, Shaoke Fu, Xiaochuan Li, Huilin Chen, Wencong He, Qianxi Yang, Xuemei Zhang, Huake Yang, Dahu Ren, Yi Xi
Summary: The ternary direct-current TENG (T-DC-TENG) is a promising new technology that disrupts the traditional energy production model by harvesting sustainable energy from the natural environment. By combining the charge leakage effect and the ternary dielectric triboelectrification effect, it improves the performance of direct-current TENGs. The optimized T-DC-TENG achieves an ultra-high average power density of 6.15 W m(-2) Hz(-1) and a historically low crest factor (1.0043), surpassing previous reports.
ENERGY & ENVIRONMENTAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Hongbo Wu, Fengxian Ma, Zhixue Tian, Ying Liu, Yalong Jiao, Aijun Du
Summary: Using first-principles calculations, we predict that two ferromagnetic monolayers, BiXO3 (X = Ru, Os), have direct band gaps and high Curie temperatures. Monte Carlo simulations show that the monolayers exhibit high Tc beyond 400 K. Both monolayers demonstrate out-of-plane magnetic anisotropy, with significant magnetic anisotropy energies. The electronic and magnetic properties of BiXO3 monolayers make them promising candidates for nanoscale electronics and spintronics.
Article
Anesthesiology
Mengyao Qi, Wei Xiao, Shuyi Yang, Shijun Wang, Liane Zhou, Anxia Wan, Shuai Feng, Dongxu Yao, Chunxiu Wang, Tianlong Wang
Summary: This study aimed to evaluate the effect of preventive precise multimodal analgesia (PPMA) on the duration of acute postoperative pain after total laparoscopic hysterectomy (TLH). The results showed that PPMA can shorten the duration of incisional and visceral pain at rest and during coughing, reduce postoperative opioid consumption, and decrease the incidence of postoperative nausea and vomiting.
Review
Obstetrics & Gynecology
Meng Wu, Qingqing Zhu, Yibao Huang, Weicheng Tang, Jun Dai, Yican Guo, Jiaqiang Xiong, Jinjin Zhang, Su Zhou, Fangfang Fu, Mingfu Wu, Shixuan Wang
Summary: Our study reveals that cancer itself may affect ovarian function in reproductive-aged patients even before any gonadotoxic treatment.
HUMAN REPRODUCTION OPEN
(2023)
Article
Computer Science, Artificial Intelligence
Han Jiang, Shucai Zhang, Wenyu Yang, Xin Peng, Weimin Zhong
Summary: Forecasting NOx concentration in FCC regeneration flue gas can guide real-time adjustment of treatment devices and prevent excessive pollutant emissions. The proposed method, TSE-TCN, combines encoding-decoding and temporal predicting procedures using a single optimizer, resulting in improved accuracy compared to state-of-art methods.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
