Review
Cell Biology
Peng Xu, Yeling Ma, Hongyu Wu, Yan-Ling Wang
Summary: Disorders in placental cells are closely associated with adverse pregnancy outcomes, and microRNAs in the placenta play important roles in regulating placental cell behaviors. Placental exosome miRNAs can potentially target maternal cells for intercellular communication between the mother and fetus, serving as novel biomarkers for predicting diseases such as preeclampsia. The transfer of placental miRNAs through exosomes may offer targeted strategies for diagnosing, prognosing, or treating preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Review
Immunology
Xiaoqi Wei, Xiuhua Yang
Summary: Preeclampsia (PE) is a unique pregnancy-related disease that can cause maternal and perinatal mortality. Research suggests that natural killer (NK) cells play a central role in immune communication between the fetus and mother, and changes in their count or function may be the cause of PE. This review provides obstetricians with an updated report on the immunological roles of NK cells in PE and suggests that therapeutic measures targeting NK cells are necessary to maintain immune equilibrium.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xiaoqi Wei, Xiuhua Yang
Summary: This study found that the expression of KIR2DS5 was significantly lower in preeclampsia patients. Overexpression of KIR2DS5 facilitated the proliferation, migration, and invasion of trophoblasts. Mechanistic study demonstrated a positive relationship between KIR2DS5 and GM-CSF. A decrease in KIR2DS5 could reduce the expression of GM-CSF via the JAK2/STAT5 pathway, resulting in the occurrence of preeclampsia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Oceane Pecheux, Ana Correia-Branco, Marie Cohen, Begona Martinez de Tejada
Summary: The apelinergic system is a highly conserved pleiotropic system that plays important roles in pregnancy and placenta-related complications. It is involved in the regulation of the adipoinsular axis, cardiovascular and central nervous systems, carcinogenesis, and embryo cardiogenesis and vasculogenesis during pregnancy. However, there are inconsistencies in the expression and circulating levels of its components in human placenta-associated preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Cell Biology
Margarita L. Martinez-Fierro, Idalia Garza-Veloz
Summary: The study evaluated serum microRNA expression profiling and identified multiple microRNAs involved in preeclampsia development, affecting various signaling pathways. Specific microRNAs were differentially expressed in the serum of pregnant women before the development of preeclampsia.
Article
Biochemistry & Molecular Biology
Reinaldo Marin, Flor H. Pujol, Deliana Rojas, Luis Sobrevia
Summary: SARS-CoV-2 infection in pregnant women leads to alterations in maternal and placental function, increasing the risk of preterm birth and caesarean delivery. Placentas of infected mothers show signs of vasculopathy and inflammation. The impact of maternal infection on the fetus and postnatal health is still unclear.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Nadja Kupper, Berthold Huppertz
Summary: This article discusses the importance of the placental exposome on maternal health and normal pregnancy development, as well as the role and interaction of placenta-derived extracellular vesicles in this process.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Svetlana Trifunovic, Branka Sosic Jurjevic, Natasa Ristic, Natasa Nestorovic, Branko Filipovic, Ivana Stevanovic, Vesna Begovic-Kupresanin, Milica Manojlovic-Stojanoski
Summary: The placenta plays an important role in providing a suitable environment for fetal growth. This study found that there are sex differences in the placenta's morphological features and antioxidant status after exposure to dexamethasone (Dx). Female placentas showed a greater decrease in volume and antioxidant enzyme activities, and an increase in lipid peroxides and nitric oxide concentration compared to male placentas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Jessica Milano-Foster, Laura C. Schulz
Summary: Researching preeclampsia is challenging due to the unique characteristics of the human placenta. The mouse model, commonly used for studying diseases, is not ideal due to differences in placental structure. Human placental tissues from affected pregnancies can assess the damage caused by preeclampsia, but cannot determine its onset. Although various animal and cell culture models can partially replicate preeclampsia, none can fully capture its complexity.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Lingli Li, Luping Liu, YuYue Xu
Summary: A meta-analysis explored the potential relationship between hypertensive disease during pregnancy and placenta accreta, finding that hypertensive disease during pregnancy was associated with a lower prevalence of placenta accreta.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Michalina Bralewska, Lidia Biesiada, Mariusz Grzesiak, Magda Rybak-Krzyszkowska, Hubert Huras, Agnieszka Gach, Tadeusz Pietrucha, Agata Sakowicz
Summary: This study reveals that chromogranin A gene expression level is associated with preeclampsia for the first time. The depletion in catestatin level might be a marker of developing preeclampsia. Further studies may unravel the role of Chromogranin A in the discussed disease.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Physiology
Rinaldo Rodrigues dos Passos Junior, Raiany Alves de Freitas, Julieta Reppetti, Yollyseth Medina, Vanessa Dela Justina, Camila Werle Bach, Gisele Facholi Bomfim, Victor Vitorino Lima, Alicia E. Damiano, Fernanda R. Giachini
Summary: The study showed that elevated TNF-alpha levels negatively impact AQP3 expression and cell migration in placental tissues affected by hypertension.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Manju Kandel, Teresa M. MacDonald, Susan P. Walker, Catherine Cluver, Lina Bergman, Jenny Myers, Roxanne Hastie, Emerson Keenan, Natalie J. Hannan, Ping Cannon, Tuong-Vi Nguyen, Natasha Pritchard, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: This study found that the expression of PSG7 and PSG9 significantly increases before the onset of preeclampsia. These changes have been validated in different populations and are associated with the severity of the disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)