Article
Medicine, Research & Experimental
Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos
Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.
EMBO MOLECULAR MEDICINE
(2022)
Article
Critical Care Medicine
Dean A. Fennell, Amy King, Seid Mohammed, Amy Branson, Cassandra Brookes, Liz Darlison, Alan G. Dawson, Aarti Gaba, Margaret Hutka, Bruno Morgan, Adrian Nicholson, Cathy Richards, Peter Wells-Jordan, Gavin James Murphy, Anne Thomas
Summary: This study tested the sensitivity of BAP1-deficient or BRCA1-deficient mesotheliomas to rucaparib, showing promising activity with manageable toxicity; further investigation of homologous recombination deficiency mutations is planned to refine the identification of predictive biomarkers for PARP inhibition in mesothelioma.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Oncology
Pietro Gino Barbieri, Dario Consonni, Anna Somigliana
Summary: The study found no significant relationship between asbestos lung burden and survival, with histologic subtype being the strongest prognostic determinant.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Pauliina Repo, Aleksandra Staskiewicz, Eva Sutinen, Mikko Ronty, Tero T. Kivela, Marjukka Myllarniemi, Joni A. Turunen
Summary: The frequency of pathogenic germline BAP1 variants in Finnish patients with MM is 1.8%, comparable to the frequency in Finnish patients with UM. Further study should be conducted on the frequency of recurring BINs in patients with BAP1-TPDS, and genetic testing for BAP1 variants should be considered for patients with >= 2 BAP1-TPDS core tumors, including BINs.
Article
Environmental Sciences
C. Airoldi, C. Magnani, F. Lazzarato, D. Mirabelli, S. Tunesi, D. Ferrante
Summary: This study found an increasing pattern of mesothelioma risk in the area around a big AC factory, with secondary clusters of cases detected due to local exposure points, possibly associated with the use of asbestos materials.
ENVIRONMENTAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Gabriella Serio, Federica Pezzuto, Francesco Fortarezza, Andrea Marzullo, Maria Celeste Delfino, Antonio d'Amati, Daniele Egidio Romano, Sonia Maniglio, Concetta Caporusso, Teresa Lettini, Domenica Cavone, Luigi Vimercati
Summary: There is evidence suggesting that asbestos may play a role in the carcinogenesis of digestive cancers, although the mechanism is still unclear. This study reports four unusual cases of colorectal cancers in patients with long-term asbestos exposure who also developed mesothelioma. The evaluation of certain proteins supports the hypothesis that they are tumor suppressor genes involved in disease progression in both digestive cancers and mesothelioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Min-Sung Kang, Sung-Soo Lee, Soon-Chan Kwon, Da-An Huh, Yong-Jin Lee
Summary: This study aimed to identify the epidemiologic characteristics and prognostic factors for malignant pleural mesothelioma in Korea. The results showed that a combination of surgery and chemotherapy was a significant predictor of survival, while factors like sex, age, smoking history, occupational asbestos exposure, and histological subtype had no significant impact on prognosis. The study also found that non-occupational exposure had a similar prognosis to occupational asbestos exposure, and there was no sex difference in survival rates.
APPLIED SCIENCES-BASEL
(2021)
Article
Multidisciplinary Sciences
Flavia Novelli, Angela Bononi, Qian Wang, Fang Bai, Simone Patergnani, Franz Kricek, Ellinor Haglund, Joelle S. Suarez, Mika Tanji, Ronghui Xu, Yasutaka Takanishi, Michael Minaai, Sandra Pastorino, Paul Morris, Greg Sakamoto, Harvey Pass, Haithem Barbour, Giovanni Gaudino, Carlotta Giorgi, Paolo Pinton, Jose N. Onuchic, Haining Yang, Michele Carbone
Summary: Carriers of heterozygous germline BAP1 mutations are more susceptible to asbestos carcinogenesis and mesothelioma, possibly due to increased secretion of HMGB1 and acetylated HMGB1 levels. The study also found that BAP1 forms a trimeric protein complex with HMGB1 and HDAC1, which modulates HMGB1 acetylation and its release, ultimately promoting mesothelial cell transformation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W. Menges, Anna-Mariya Kukuyan, Ting Zhang, Vladimir Khazak, Lauren A. Fox, Eric A. Ross, Suresh Ramanathan, Suresh C. Jhanwar, Raja M. Flores, Siddharth Balachandran, Joseph R. Testa
Summary: The study revealed that RIPK3 loss in malignant mesothelioma is associated with epigenetic silencing through DNA methylation, impairing necroptosis and contributing to chemoresistance and poor survival outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Environmental Sciences
Yuhe Gao, Jacek M. Mazurek, Yaming Li, David Blackley, David N. Weissman, Shirley V. Burton, Waqas Amin, Douglas Landsittel, Michael J. Becich, Ye Ye
Summary: This study examines the work histories and survival time of patients with suspected exposure to asbestos. The most frequent cases of mesothelioma occurred in patients working in manufacturing, construction, and education services. Males or individuals over 40 tended to work in traditionally asbestos-associated industries, while females or individuals aged 20-40 tended to work in non-traditionally associated industries. The results highlight the importance of considering all potential sources of asbestos exposure when evaluating mesothelioma patients.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
A. Scarselli, A. Marinaccio, S. Iavicoli
Summary: The study aimed to estimate the potential health impact of naturally occurring asbestos from ophiolitic outcrops in certain areas of Calabria, southern Italy. By analyzing employment, compensation, and mortality data, statistically significant excess risks were observed in several municipalities, some of which were located in areas where asbestos outcrops had been identified.
Article
Biochemistry & Molecular Biology
Shu Luo, Junzuo Gong, Shiqiao Zhao, Menqin Li, Ruixiu Li
Summary: This study investigates the role of Breast cancer susceptibility protein 1-associated protein 1 (BAP1) in sepsis-induced acute kidney injury (AKI). The findings suggest that BAP1 can protect against AKI by enhancing the stability of BRCA1 protein and inactivating the NF-xB signaling pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Cell Biology
Ze Gao, Junxiu Chen, Yiran Tao, Qiong Wang, Shirong Peng, Shunli Yu, Jianwen Zeng, Kaiwen Li, Zhongqiu Xie, Hai Huang
Summary: By analyzing the TME and gene mutations of ccRCC patients, a prognostic immune score model was established to identify suitable patients for immunotherapy and select more appropriate drug combinations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Zishuo Hu, Markku Miettinen, Martha Quezado, Alexandra P. Lebensohn, Kenneth Aldape, Maria Agra, Cathy Wagner, Yvonne Mallory, Raffit Hassan, Azam Ghafoor
Summary: This study reports the co-occurrence of pleural mesotheliomas and meningiomas in patients with germline BAP1 mutations. The authors describe the cancer history, family pedigrees, clinical management, and outcomes of four BAP1 germline mutation carrier families with a history of malignant mesothelioma and meningioma.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Karen Walker-Bone, Geza Benke, Ewan MacFarlane, S. Klebe, Ken Takahashi, Fraser Brims, Malcolm Ross Sim, Tim R. Driscoll
Summary: Mesothelioma, a rare and deadly cancer associated with asbestos exposure, continues to be diagnosed in Australia despite the ban on asbestos since 2003. The Australian Mesothelioma Registry was established to gather comprehensive data on incidence, mortality, and asbestos exposure. Results show a decline in incidence and mortality rates due to effective control of occupational asbestos use, but the rates among women remain stable, suggesting other sources of exposure.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Hematology
C. Robier, O. Amouzadeh-Ghadikolai, C. Bregant, J. Diez, K. Melinz, F. Quehenberger, S. Quasthoff
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas Wimmer, Juergen Steiner, Emina Talakic, Rudolf Stauber, Franz Quehenberger, Rupert Horst Portugaller, Helmut Schoellnast
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Juergen Wallner, Knut Reinbacher, Matthias Feichtinger, Mauro Pau, Georg Feigl, Franz Quehenberger, Katja Schwenzer-Zimmerer, Wolfgang Zemann
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2017)
Meeting Abstract
Dermatology
C. Painsi, A. Hirtenfelder, B. Lange-Asschenfeldt, F. Quehenberger, P. Wolf
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2017)
Article
Dermatology
C. I. Busard, A. D. Cohen, P. Wolf, S. Gkalpakiotis, S. Cazzaniga, R. S. Stern, B. A. Hutten, I. Feldhamer, F. Quehenberger, R. Lichem, M. Kojanova, E. Adenubiova, A. Addis, L. Naldi, P. I. Spuls
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2018)
Article
Endocrinology & Metabolism
Sharon Li Ting Pek, Chee Fang Sum, Lee Ying Yeoh, Simon Biing Ming Lee, Wern Ee Tang, Su Chi Lim, Subramaniam Tavintharan
METABOLISM-CLINICAL AND EXPERIMENTAL
(2017)
Article
Medical Laboratory Technology
Luka Brcic, Gregor Vlacic, Franz Quehenberger, Izidor Kern
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2018)
Article
Medical Laboratory Technology
Christoph Robier, Carolin Koerber, Franz Quehenberger, Manfred Neubauer, Albert Woelfler
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Article
Pathology
Luka Brcic, Stefanie Stanzer, Dagmar Krenbek, Ulrike Gruber-Moesenbacher, Gudrun Absenger, Franz Quehenberger, Arschang Valipour, Joerg Lindenmann, Herbert Stoeger, Mohamed Al Effah, Melanie Fediuk, Marija Balic, Helmut H. Popper
Article
Cell Biology
Paul Wurzer, Raimund Winter, Sebastian O. Stemmer, Josipa Ivancic, Patricia B. Lebo, Gabriel Hundeshagen, Janos Cambiaso-Daniel, Franz Quehenberger, Lars-Peter Kamolz, David B. Lumenta
WOUND REPAIR AND REGENERATION
(2018)
Article
Dermatology
Peter Wolf, Wolfgang Weger, Franz Legat, Clemens Painsi, Werner Saxinger, Robert Muellegger, Paul Sator, Gudrun Ratzinger, Sylvia Selhofer, Leo Richter, Wolfgang Salmhofer, Bernhard Lange-Asschenfeldt, Franz Trautinger, Alexander Mlynek, Robert Strohal, Matthias Augustin, Franz Quehenberger
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2018)
Meeting Abstract
Oncology
S. Hatzl, S. Ebner, B. Perfler, F. Quehenberger, J. Troppmair, A. Reinisch, A. Woelfler, H. Sill, A. Zebisch
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
Martin Benesch, Petra Neumayer, Karolina Nemes, Torsten Pietsch, Beate Timmermann, Brigitte Bison, Monika Warmuth-Metz, Pablo Hernaiz Driever, Georg Ebetsberger-Dachs, Franck Bourdeaut, Christelle Dufour, Fanny Fouyssac, Martin Hasselblatt, Veronica Biassoni, Andres Morales La Madrid, Natasha Entz-Werle, Veronique Laithier, Franz Quehenberger, Michael C. Fruehwald
Letter
Hematology
Eduard Schulz, Karin Lind, Wilfried Renner, Britt-Sabina Petersen, Franz Quehenberger, Claudia Dill, Sybille Hofer, Ridhima Lal, Gerald Hoefler, Peter Schlenke, Gerhard Ehninger, Johannes Schetelig, Jan M. Middeke, Friedrich Stoelzel, Heinz Sill
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Hematology
Lukas Gaksch, Karl Kashofer, Ellen Heitzer, Franz Quehenberger, Shruti Daga, Sybille Hofer, Iris Halbwedl, Ricarda Graf, Nina Krisper, Gerald Hoefler, Armin Zebisch, Heinz Sill, Albert Woelfler
AMERICAN JOURNAL OF HEMATOLOGY
(2018)
