Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Medicine, Research & Experimental
Wenya Bai, Siying Huo, Guilin Zhou, Junjie Li, Yuan Yang, Jianlin Shao
Summary: This study investigated the potential of Biliverdin to alleviate cerebral ischemia reperfusion injury (CIRI) by inhibiting pyroptosis. Biliverdin was found to significantly alleviate CIRI both in vivo and in vitro by activating the Nrf2/A20/eEF1A2 axis, which in turn inhibited the NF-KB pathway. The findings of this study provide insights into novel therapeutic targets for the treatment of CIRI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenqiang Tao, Fen Liu, Jianguo Zhang, Shangmiao Fu, Hui Zhan, Kejian Qian
Summary: This study investigated the miRNA-mRNA regulatory networks involved in ferroptosis following renal ischemia-reperfusion injury. The results showed that inhibition of miR-3587 promotes upregulation of HO-1, thereby protecting renal tissues from IR-induced ferroptosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Immunology
Jonathan M. Harnoss, Jun Cai, Sascha Hinterkopf, Praveen Radhakrishnan, Annabelle Schmitt, Mareen Dupovac, Lisa K. Nees, Moritz J. Strowitzki, Cormac T. Taylor, Martin Schneider
Summary: This study investigates the activation of the HIF pathway through inhibition of PHDs as a potential strategy to reduce primary graft dysfunction (PGD) after liver transplantation (LT). The results show that the administration of the small-molecule inhibitor EDHB induces HIF-1 signaling and increases the expression of its downstream target genes. In vivo experiments demonstrate that pretreatment with EDHB can mitigate hepatic ischemia and reperfusion injury and allograft injury after LT in animal models. The findings suggest that targeting PHDs with small-molecule inhibitors could be a promising therapeutic approach to reduce PGD after LT.
Review
Pharmacology & Pharmacy
Hyeongseop Keum, Dohyun Yoo, Sangyong Jon
Summary: Photoimaging and phototherapy are important platforms for the diagnosis and treatment of health complications. Heme-derived compounds have unique photoproperties and show potential for biomedical imaging and phototherapy applications.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Nora A. Spraakman, Annemieke M. Coester, Arno R. Bourgonje, Vincent B. Nieuwenhuijs, Jan-Stephan F. Sanders, Henri G. D. Leuvenink, Harry van Goor, Gertrude J. Nieuwenhuijs-Moeke
Summary: In this study, the researchers investigated the changes in R-SH levels during kidney transplantation and found that renal ischemia-reperfusion injury can result in trans-renal oxidative stress. The levels of R-SH in systemic and renal samples of transplant recipients were found to reflect the graft function changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
So Hye Yoon, Hye Bin Kang, Jongwan Kim, Keunje Yoo, Sang Jun Han
Summary: This study found that diminazene aceturate (DIZE) can protect the liver from ischemia/reperfusion (I/R) injury by attenuating inflammation and oxidative damage. DIZE treatment reduces liver failure and histologically-apparent liver damage, as well as milder inflammatory responses, reactive oxidative damage, and apoptosis following hepatic I/R.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ying-Da Feng, Wen Ye, Wen Tian, Jing-Ru Meng, Meng Zhang, Yang Sun, Hui-Nan Zhang, Shou-Jia Wang, Ke-Han Wu, Chen-Xu Liu, Shao-Yuan Liu, Wei Cao, Xiao-Qiang Li
Summary: This study investigated the effects of APG on intestinal ischemia/reperfusion injury (IIRI). The results showed that APG could improve intestinal edema and increase Chiu's score. It was found that APG specifically bound to heme oxygenase 1 (HO-1) and monoamine oxidase b (MAO-B), and could attenuate ROS generation and Fe2+ accumulation, maintain mitochondria function, and inhibit ferroptosis in a dose-dependent manner. In addition, knocking down HO-1 and MAO-B, as well as using their inhibitors, also had positive effects on intestine and vascular endothelial cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Xiudi Zhou, Qiang Chen, Chunjing Guo, Yanguo Su, Huimin Guo, Min Cao, Zhongxin Liu, Dandan Zhang, Ningning Diao, Huaying Fan, Daquan Chen
Summary: A novel drug delivery system has been developed to precisely deliver drugs to pathological renal tissue for attenuating renal ischemia-reperfusion injury. The system exhibits responsive properties to reactive oxygen species, biocompatibility, and cell penetration. The intracellular concentration of hydrogen sulfide released by the system is threefold higher than that in the control group, and it demonstrates anti-inflammatory effects by blocking the NF-KB signaling pathway. This research provides a promising strategy for pharmaceutical treatment of renal ischemia-reperfusion injury.
Article
Multidisciplinary Sciences
Wenjun Li, Yuriko Terada, Yulia Y. Tyurina, Vladimir A. Tyurin, Amit Bery, Jason M. Gauthier, Ryuji Higashikubo, Alice Y. Tong, Dequan Zhou, Felix Nunez-Santana, Emilia Lecuona, Adil Hassan, Kohei Hashimoto, Davide Scozzi, Varun Puri, Ruben G. Nava, Alexander S. Krupnick, Kory J. Lavine, Andrew E. Gelman, Mark J. Miller, Valerian E. Kagan, Ankit Bharat, Daniel Kreisel
Summary: Ischemia reperfusion injury is a common pathological condition triggered by the release of endogenous ligands. In this study, the researchers discovered that necroptosis, a nonapoptotic form of cell death, triggers the recruitment of neutrophils in injured lungs. Initially, neutrophils traffic predominantly to subpleural vessels, guided by chemoattractants produced by nonclassical monocytes. The disruption of pulmonary capillaries by neutrophils leads to vascular leakage and impaired graft function. The study also found that TLR4 signaling and NADPH oxidase 4 expression mediate the arrest of neutrophils, preventing their extravasation. The formation of neutrophil extracellular traps in injured lungs can be disrupted with DNase to prevent vascular leakage and improve graft dysfunction. These findings could have important implications for the development of therapeutics to protect lungs from ischemia reperfusion injury.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Jia-Ning Jin, Xian Liu, Ming-Juan Li, Xin-Ling Bai, An-Mu Xie
Summary: This meta-analysis study suggests that PD patients have higher levels of total bilirubin and direct bilirubin, with no significant relationship found between indirect bilirubin and PD. Subgroup analysis based on ethnicity indicates that Caucasians with PD have higher serum total bilirubin levels. These findings suggest that bilirubin may play a role in the pathogenesis of PD and could potentially be used as a biochemical marker for diagnosis and treatment.
CHINESE MEDICAL JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Serena Del Turco, Valentina Cappello, Christos Tapeinos, Aldo Moscardini, Laura Sabatino, Matteo Battaglini, Fabio Melandro, Francesco Torri, Caterina Martinelli, Serena Babboni, Beatrice Silvestrini, Riccardo Morganti, Mauro Gemmi, Paolo De Simone, Paulo N. Martins, Laura Crocetti, Adriano Peris, Daniela Campani, Giuseppina Basta, Gianni Ciofani, Davide Ghinolfi
Summary: The combination of ex situ normothermic machine perfusion (NMP) and nanotechnology, specifically the use of antioxidant cerium oxide nanoparticles, shows potential in mitigating ischemia/reperfusion injury in liver transplantation. This study evaluated the uptake, distribution, and efficacy of cerium oxide nanoparticles during NMP of discarded human livers. Results showed that the nanoparticles were taken up by the liver cells, improved antioxidant defenses, and reduced oxidative stress. This approach could be a valuable tool in improving the quality of grafts and protecting them against reperfusion injury.
LIVER TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Darren M. Gordon, Stephen H. Hong, Zachary A. Kipp, Terry D. Hinds
Summary: This study revealed that bilirubin interacts with threonine 283 (T283) and alanine 333 (A333) in the ligand-binding pocket of PPAR alpha. Mutational analysis showed significantly reduced bilirubin binding with T283 and A333 mutations. Bilirubin did not show any interaction with PPAR gamma.
Article
Biotechnology & Applied Microbiology
Longlong Wu, Xuan Tian, Huaiwen Zuo, Weiping Zheng, Xiang Li, Mengshu Yuan, Xiaorong Tian, Hongli Song
Summary: This study found that ferroptosis is involved in the ischemia-reperfusion injury (IRI) during liver transplantation (LT) using severe steatotic donor livers. The researchers also discovered that miR-124-3p in HO-1/BMMSCs-derived exosomes (HM-exos) can downregulate Steap3 expression to inhibit ferroptosis, thereby reducing graft IRI. This suggests that targeting miR-124-3p could be a promising strategy for treating IRI in steatotic grafts.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adam Doyle, Andre Gorgen, Hala Muaddi, Aloysious D. Aravinthan, Assaf Issachar, Oleg Mironov, Wei Zhang, John Kachura, Robert Beecroft, Sean P. Cleary, Anand Ghanekar, Paul D. Greig, Ian D. McGilvray, Markus Selzner, Mark S. Cattral, David R. Grant, Leslie B. Lilly, Nazia Selzner, Eberhard L. Renner, Morris Sherman, Gonzalo Sapisochin
JOURNAL OF HEPATOLOGY
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Ravikiran Sindhuvalada Karnam, Nicholas Mitsakakis, Lilly Leslie, Nazia Selzner, Zita Galvin, Mamtha Bhat
JOURNAL OF HEPATOLOGY
(2019)
Editorial Material
Immunology
Deepali Kumar, Nazia Selzner
Article
Immunology
Arnaud G. L'huillier, Victor H. Ferreira, Cedric Hirzel, Yoichiro Natori, Jaclyn Slomovic, Terrance Ku, Katja Hoschler, Matthew Ierullo, Nazia Selzner, Jeffrey Schiff, Lianne G. Singer, Atul Humar, Deepali Kumar
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Immunology
Yoichiro Natori, Ali Alghamdi, Shahid Husain, Coleman Rotstein, Nazia Selzner, Jussi Tikkanen, Jeffrey Schiff, Atul Humar, Deepali Kumar
TRANSPLANT INFECTIOUS DISEASE
(2020)
Article
Immunology
Timucin Taner, Paulo N. Martins, Qi Ling, Kevin T. Ng, Kuang-Tzu Huang, Corey Eymard, Mamatha Bhat, Eliano Bonaccorsi-Riani, Valeria R. Mas, Markus Selzner, Burcin Ekser
Editorial Material
Surgery
Toru Goto, Markus Selzner
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Meeting Abstract
Surgery
Peter Urbanellis, Caitriona McEvoy, Moritz Kaths, Matyas Hamar, Laura Mazilescu, Ivan Linares, Dagmar Kollmann, Toru Goto, Yuki Noguchi, Sujani Ganesh, Rohan John, Istvan Mucsi, Anand Ghanekar, Darius Bagli, Ana Konvalinka, Lisa Robinson, Markus Selzner
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Meeting Abstract
Surgery
Peter Urbanellis, Laura Mazilescu, Matyas Hamar, Caitriona McEvoy, Ivan Linares, Dagmar Kollmann, Toru Goto, Yuki Noguchi, Sujani Ganesh, Rohan John, Istvan Mucsi, Anand Ghanekar, Darius Bagli, Ana Konvalinka, Lisa Robinson, Markus Selzner
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Meeting Abstract
Immunology
A. Chruscinski, H. Atkins, M. Macarthur, A. M. Clement, D. Grant, C. Bredsen, E. Renner, L. Lilly, N. Selzner, O. Adeyi, M. Epstein, R. Smith, S. Moshkelgosha, A. Humar, S. Juvet, G. Levy
Meeting Abstract
Immunology
A. Chruscinski, V Rojas-Luengas, S. Moshkelgosha, M. Macarthur, A. Issacher, J. Luo, H. Yowanto, L. Lilly, R. Smith, E. Renner, J. Zhang, D. Grant, O. Adeyi, H. Atkins, Z. Galvin, P. Juni, S. Juvet, N. Selzner, G. Levy
Meeting Abstract
Surgery
L. I. Mazilescu, M. J. Kaths, P. Urbanellis, M. Hamar, I. Linares, T. Goto, D. Bagli, L. A. Robinson, M. Selzner
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Ravi Kiran, Nicholas Mitsakakis, Zita Galvin, Nazia Selzner, Les Lilly, Sumeet K. Asrani, Mamatha Bhat
Meeting Abstract
Gastroenterology & Hepatology
Toru Goto, Ivan Linares, Paul D. Greig, Trevor Reichman, Gonzalo Sapisochin, Ian D. McGilvray, David R. Grant, Markus Selzner, Anand Ghanekar, Mark Cattral, Nazia Selzner
