Article
Oncology
Rebecca A. Harrison, Noha Sharafeldin, Jennie L. Rexer, Brennan Streck, Melissa Petersen, Ashley M. Henneghan, Shelli R. Kesler
Summary: Hematopoietic stem cell transplant (HSCT) is crucial in treating hematologic cancers, but can lead to cognitive impairment and other challenges for survivors. Understanding the impact on brain health is essential for clinicians working with HSCT survivors, as it can affect various aspects of their lives. Efforts to identify and manage cognitive dysfunction and related symptoms are important for managing the long-term effects of HSCT.
Article
Cell & Tissue Engineering
Rakefet Sidlik Muskatel, Bar Nathansohn-Levi, Shlomit Reich-Zeliger, Michal Mark, Liat Stoler-Barak, Chava Rosen, Irit Milman-Krentsis, Esther Bachar Lustig, Robert Pete Gale, Nir Friedman, Yair Reisner
Summary: Partial tolerance toward pancreatic autoantigens in the treatment of type 1 diabetes mellitus can be achieved by autologous or allogeneic hematopoietic stem cell transplantation, but both have limitations. In this study, a non-myeloablative conditioning approach using donor-derived anti-3rd party central memory CD8 veto T cells was found to effectively eliminate autoimmune T-cell clones and prevent diabetes in a mouse model. This approach shows promise as a treatment strategy for individuals at risk of developing type 1 diabetes or for preventing beta cell destruction after allogenic beta cell transplantation.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Kristine Doney, Wendy Leisenring, Hannah Linden
Summary: This study compared the outcomes of allogeneic stem cell transplantation in breast cancer survivors to a control group. The results showed that a history of breast cancer did not significantly affect the transplant outcomes, indicating that breast cancer survivors should not be excluded from consideration for this treatment.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Pharmacology & Pharmacy
Shaza S. Issa, Alisa A. Shaimardanova, Victor V. Valiullin, Albert A. Rizvanov, Valeriya V. Solovyeva
Summary: Lysosomal storage diseases (LSDs) are a group of genetic disorders caused by mutations in genes involved in cell degradation and lipid transfer. Accumulation of lipids and other macromolecules in lysosomes leads to cell destruction. Treatment options for LSDs are limited, and innovative therapeutic approaches, such as stem cell therapy, show promise in preclinical studies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chenyu Lin, Mitchell E. Horwitz, Lindsay A. M. Rein
Summary: Numerous recent advancements in T-cell based immunotherapies have revolutionized the treatment of hematologic malignancies. Allogeneic NK cell therapies are now being actively explored in the setting of hematopoietic stem cell transplantation and adoptive transfer. This review will discuss the recent clinical advancements in NK cell therapies in hematologic malignancies as well as promising avenues of future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aneta Sevcikova, Ivana Fridrichova, Nataliia Nikolaieva, Lenka Kalinkova, Radoslav Omelka, Monika Martiniakova, Sona Ciernikova
Summary: Hematologic malignancies can arise at any stage of hematopoiesis and miRNAs play a key role in their development by regulating gene expression. This review summarizes the current knowledge of dysregulated miRNA expression in hematological malignancies and discusses their clinical utility as biomarkers for diagnosis, prognosis, and treatment response. The potential role of miRNAs in hematopoietic stem cell transplantation and post-transplant complications is also explored. The therapeutical potential of miRNA-based approaches, including antagomiRs, mimetics, and circRNAs, is outlined. Overall, miRNAs have the potential to improve the diagnosis and outcomes of hematologic malignancies.
Review
Biochemistry & Molecular Biology
Kaneyasu Nishimura, Kazuyuki Takata
Summary: Cell transplantation therapy using pluripotent/multipotent stem cells shows promise as a novel strategy for treating neurodegenerative diseases. Drug repurposing can enhance cell engraftments and improve treatment outcomes, making it a beneficial approach for enhancing cell transplantation therapies for neurological diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Nobuaki Nakano, Hideki Nakasone, Shigeo Fuji, Akihito Shinohara, Ritsuro Suzuki, Atae Utsunomiya, Tetsuya Eto, Satoko Morishima, Kazuhiro Ikegame, Yasutaka Kakinoki, Ken-ichi Matsuoka, Yasuo Mori, Youko Suehiro, Naoyuki Uchida, Ayumu Ito, Noriko Doki, Yukiyasu Ozawa, Junya Kanda, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Masao Ogata
Summary: This study analyzed the survival and mortality rates of HTLV-1 carriers and non-carriers who underwent hematopoietic stem cell transplantation. The results showed that HTLV-1 positivity was associated with poor prognosis in adult patients and an increase in transplant-related mortality in pediatric patients.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Review
Immunology
Junhong Li, Zhaoxian Yu, Yingyi Jiang, Suihua Lao, Dexian Li
Summary: This is the first successful case of post-HSCT TB patients treated with contezolid-containing antibiotic management strategies, which exhibited remarkable efficacy and good safety in this deadly disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Cong Zeng, Yan Chen, Juan Hua, Yi Liu, Ting-ting Cheng, Xia Ma, Xu Chen, Shi-yu Wang, Ya-jing Xu
Summary: This retrospective study analyzed the outcomes of 80 patients with hematologic malignancies who received haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) combined with unrelated cord blood (UCB). Satisfactory results were obtained with high engraftment rates and relatively low rates of transplant-related complications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Liping Dou, Lu Wang, Xin Li, Yvchen Liu, Fei Li, Lijun Wang, Xiaoning Gao, Wenrong Huang, Shuhong Wang, Chunji Gao, Li Yu, Daihong Liu
Summary: The study found that using ATG as part of GVHD prophylaxis in MSD-PBSCT patients can significantly reduce the incidence of chronic GVHD without increasing the risk of relapse and nonrelapse mortality.
Review
Hematology
Federica R. Achini-Gutzwiller, John A. Snowden, Selim Corbacioglu, Raffaella Greco
Summary: Although modern clinical management strategies have improved the outcome of paediatric patients with severe autoimmune and inflammatory diseases, a proportion will still experience ongoing or recurrent/relapsing disease activity. Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been successfully used to induce disease control and cure in children with severe treatment-refractory autoimmune diseases. However, the long-term outcomes and balancing risks of HSCT against other non-transplant options are challenging. Further research is needed to establish the position of HSCT in paediatric autoimmune diseases.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Review
Oncology
Shanshan Li, Yanzhen Bi, Zhongping Duan, Yongkai Chang, Feng Hong, Yu Chen
Summary: Recent research has shown the important role of various stem cells in liver recovery, indicating their potential as effective treatments for liver diseases. Studies have focused on the classification, culture, transplantation, tracking, and therapies related to stem cells in liver diseases.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Tobias Alexander, John A. Snowden, Joachim Burman, Hyun-Dong Chang, Nicoletta Del Papa, Dominique Farge, James O. Lindsay, Florent Malard, Paolo A. Muraro, Rosamaria Nitti, Azucena Salas, Basil Sharrack, Mohamad Mohty, Raffaella Greco
Summary: Hematopoietic stem cell transplantation (HSCT) has been evolving as a specific treatment for severe and refractory autoimmune diseases, with studies showing the important role of intestinal microbiota in shaping immune response and predicting treatment outcomes. Therapeutic interventions such as fecal microbiota transplant have emerged as promising approaches for restoring intestinal microbiota integrity post-transplantation.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Mariana Nassif Kerbauy, Leonardo Javier Arcuri, Sergio Leonardo Favareto, Ana Carolina Pires de Rezende, Nelson Hamerschlak
Summary: Total body irradiation (TBI) is an important part of the conditioning regimen in hematopoietic cell transplantation. However, higher doses of TBI can result in more significant toxicities. To overcome this, total marrow irradiation and total marrow and lymphoid irradiation have been developed to deliver targeted radiotherapy while sparing organs. Studies have shown that these techniques can be safely administered with different chemotherapy conditioning regimens, especially in situations such as multiple myeloma, high-risk hematologic malignancies, relapsed or refractory leukemias, and elderly or frail patients, with low transplant-related mortality rates.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Sung-Yong Kim, Won-Sik Lee, Sung Yong Oh, Deok-Hwan Yang, Hyo Jung Kim, Seong Kyu Park, Jae Wook Yang, Suk-Woo Yang, Seok-Goo Cho
Summary: In this study, the long-term efficacy of rituximab, cyclophosphamide, doxorubicin, and prednisolone (R-CVP) chemoimmunotherapy in limited-stage ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) patients was investigated. The results showed a high response rate and a significant risk of late relapse. The study suggests that clinical trials for limited-stage OAML patients should have a long-term observation period and consider sequential or combination treatment to reduce the risk of delayed relapse.
Article
Biology
Issam I. Raad, Ray Hachem, Nigo Masayuki, Tarcila Datoguia, Hiba Dagher, Ying Jiang, Vivek Subbiah, Bilal Siddiqui, Arnaud Bayle, Robert Somer, Ana Fernandez Cruz, Edward Gorak, Arvinder Bhinder, Nobuyoshi Mori, Nelson Hamerschlak, Samuel Shelanski, Tomislav Dragovich, Yee Elise Vong Kiat, Suha Fakhreddine, Abi Hanna Pierre, Roy F. Chemaly, Victor Mulanovich, Javier Adachi, Jovan Borjan, Fareed Khawaja, Bruno Granwehr, Teny John, Eduardo Yepez Yepez, Harrys A. Torres, Natraj Reddy Ammakkanavar, Marcel Yibirin, Cielito C. Reyes-Gibby, Mala Pande, Noman Ali, Raniv Dawey Rojo, Shahnoor M. Ali, Rita E. Deeba, Patrick Chaftari, Takahiro Matsuo, Kazuhiro Ishikawa, Ryo Hasegawa, Ramon Aguado-Noya, Alvaro Garcia Garcia, Cristina Traseira Puchol, Dong Gun Lee, Monica Slavin, Benjamin Teh, Cesar A. Arias, Dimitrios P. Kontoyiannis, Alexandre E. Malek, Anne-Marie Chaftari
Summary: This international multicenter study aimed to identify independent risk factors for increased 30-day mortality in COVID-19 patients with and without cancer. The study analyzed data from 16 international centers and found that cancer itself was not an independent risk factor for increased mortality. Older age and lymphopenia were the main predictors of 30-day mortality in all patients, and remdesivir was the only therapeutic agent associated with decreased mortality.
Article
Oncology
Gi-June Min, Tong Yoon Kim, Young-Woo Jeon, Joo O. Hyun, Byung-Ock Choi, Gyeongsin Park, Young-Hoon Park, Seok-Goo Cho
Summary: This study aimed to identify factors indicative of PIOL, describe treatment outcomes, and determine modalities to prevent relapse. The study found that ophthalmologic and central nervous system relapse were common in PIOL patients regardless of the treatment modalities. Therefore, diagnosis should be based on clinical signs and assisted by vitrectomy, cytologic, molecular, and cytokine studies.
Article
Hematology
Gi-June Min, Donghoon Kang, Han Hee Lee, Seung-Jun Kim, Tong Yoon Kim, Young-Woo Jeon, Joo Hyun, Byung-Ock Choi, Gyeongsin Park, Seok-Goo Cho
Summary: This study evaluated the real-world clinical outcomes of different therapeutic modalities for gastric MALT lymphoma and analyzed factors affecting survival outcomes. Helicobacter pylori eradication was found to be effective in achieving complete remission in localized HPI-positive patients. Poor response to eradication was associated with lesions in specific locations and invasion depth, while HPI negativity correlated with poor progression-free survival. HPI eradication should be the first-line treatment for localized HPI-positive gastric MALT lymphoma, while radiotherapy is recommended for HPI-negative patients or when eradication fails.
ANNALS OF HEMATOLOGY
(2023)
Article
Chemistry, Physical
Jitendra Bahadur, Jun Ryu, Dong-Gun Lee, Jongin Hong, Shuzi Hayase, Jung Sang Cho, Sang Mun Jeong, Dong-Won Kang
Summary: In this study, small carbon chain molecules were introduced as liquid additives to improve the crystal growth and surface processing of CsPbI2Br perovskite. The additives could passivate surface defects by conducting with halide ions, leading to improved performance and stability of the photovoltaic devices. The addition of diiodo-methane was found to significantly enhance the power conversion efficiency of perovskite solar cells, reaching a record high of 16.42%.
APPLIED SURFACE SCIENCE
(2023)
Article
Medicine, General & Internal
Alberto Papi, Michael G. Ison, Joanne M. Langley, Dong-Gun Lee, Isabel Leroux-Roels, Federico Martinon-Torres, Tino F. Schwarz, Richard N. van Zyl-Smit, Laura Campora, Nancy Dezutter, Nathalie de Schrevel, Laurence Fissette, Marie-Pierre David, Marie Van der Wielen, Lusine Kostanyan, Veronica Hulstrom
Summary: A phase 3 clinical trial showed that a candidate vaccine for respiratory syncytial virus (RSV) infection has a high efficacy in preventing RSV-related respiratory infection and lower respiratory tract disease in older adults. The vaccine was effective against both RSV subtypes and in individuals with underlying conditions.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Chemistry, Analytical
Ae Sol Lee, Su Min Kim, Kyeong Rok Kim, Chulmin Park, Dong-Gun Lee, Hyung Joon Cha, Hye Ryoung Heo, Chang Sup Kim
Summary: To control SARS-CoV-2, early diagnosis of infected individuals is crucial. A colorimetric lateral flow immunoassay (LFIA) was developed in this study, enabling sensitive detection of cultured SARS-CoV-2 in 15 minutes with a detection limit of 5 x 10^4 copies/mL. Clinical evaluation showed that the LFIA accurately detected all positive and negative samples, achieving 100% accuracy.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Virology
Seungwan Chae, Hoon Seok Kim, Sung-Yeon Cho, Dukhee Nho, Raeseok Lee, Dong-Gun Lee, Myungshin Kim, Yonggoo Kim
Summary: This study aimed to identify variants associated with CMV drug resistance in HCT recipients and assess their clinical significance. The study found that 8.1% of patients had resistance variants, and 39.0% of patients had variants of uncertain significance. Patients with resistance variants had higher CMV viral load and higher risks of severe graft-versus-host disease and lower one-year survival rates.
Article
Biophysics
Juhwan Park, Minjun Park, Junbeom Kim, Youhee Heo, Bo Hoon Han, Nakwon Choi, Chulmin Park, Raeseok Lee, Dong-Gun Lee, Seok Chung, Ji Yoon Kang
Summary: Digital enzyme linked immunosorbent assays (ELISA) can detect SARS-CoV-2 antigens with higher sensitivity compared to conventional antigen tests. To improve detection sensitivity, researchers developed an oil-and bead-free single molecule counting assay with rolling circle amplification (RCA) on a substrate. This method showed more than 100-fold improvement in detecting the N protein of SARS-CoV-2 compared to conventional ELISA.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Immunology
Geon Young Ko, Jihyun Lee, Hyunjoo Bae, Ji Hyeong Ryu, Hye-Sun Park, Hyunhye Kang, Jin Jung, Ae-Ran Choi, Raeseok Lee, Dong-Gun Lee, Eun-Jee Oh
Summary: This prospective study evaluated immune responses and breakthrough infections in 235 infection-naive healthcare workers. The study found that both vaccine groups exhibited peak responses one to two months after the second or third dose, followed by gradual declines. The ChAd group showed a gradual increase in ELISPOT results, but their antibody levels declined more rapidly than the BNT group. Six months after the third dose, both groups had substantial cellular responses, with superior humoral responses in the BNT group.
Article
Pediatrics
Jeong Min Kim, Hyun Mi Kang, In Hyuk Yoo, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho
Summary: Gastrointestinal bleeding is a rare adverse event of dasatinib, which can be caused by dasatinib-induced colitis, severe thrombocytopenia, and platelet dysfunction. We report two cases of pediatric patients who developed hematochezia during treatment with dasatinib after hematopoietic stem cell transplantation (HSCT). A colonic tissue biopsy was performed to differentiate the cause of GI bleeding. Both patients were diagnosed with proven cytomegalovirus (CMV) colitis, but only one received ganciclovir treatment. The patient who did not receive antiviral therapy experienced recurrent GI bleeding during dasatinib administration, leading to multiple treatment interruptions. Patients with GI bleeding and confirmed CMV colitis during dasatinib therapy after HSCT may benefit from antiviral therapy to reduce interruptions in dasatinib therapy.
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jongmin Lee, Raeseok Lee, Kyongmin Sarah Beck, Dae Hee Han, Gi June Min, Suyon Chang, Jung Im Jung, Dong-Gun Lee
Summary: This study reported the clinical and radiological characteristics of patients with B-cell lymphoma and COVID-19, showing migratory airspace opacities on serial chest CT. The results showed that these patients exhibited multifocal patchy peripheral ground glass opacities (GGOs) with basal predominance in the baseline CTs, and clearance of previous opacities with the development of new peripheral and peribronchial GGO and consolidation in different locations. All patients demonstrated prolonged COVID-19 symptoms accompanied by positive polymerase chain reaction results throughout the follow-up period.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Infectious Diseases
Jing Chen, Ju-Young Shin, Sumitra Shantakumar, Sungho Bea, Byong Duk Ye, Dong-Gun Lee, Hyungwoo Kim, Won Suk Choi, Iain Kaan
Summary: The incidence rate of herpes zoster (HZ) is higher in individuals with immunocompromised conditions and autoimmune diseases (IC/AID) in the Republic of Korea (ROK), especially in women, those aged 50 years and above, and those who have undergone transplants and hemato-oncology treatment. HZ in IC/AID patients leads to higher medical costs.
INFECTIOUS DISEASES AND THERAPY
(2023)
Letter
Medical Laboratory Technology
Hyunhye Kang, Seok-Goo Cho, Eun-Jee Oh
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Infectious Diseases
Hyeah Choi, Hyojin Ahn, Raeseok Lee, Sung-Yeon Cho, Dong-Gun Lee
Summary: This study analyzed the clinical features and microorganism distributions in patients with hematologic diseases at a tertiary care university-affiliated hospital in Korea. The results showed that Gram-negative bacteria remained dominant pathogens in bloodstream infections. The prevalence of ESBL-producing Enterobacteriaceae decreased, but enterococcal BSIs and vancomycin-resistant Enterococcus isolates increased.
INFECTION AND CHEMOTHERAPY
(2022)
