Review
Biochemistry & Molecular Biology
Andrea T. Nguyen, Christopher Szeto, Stephanie Gras
Summary: Human leukocyte antigens (HLA) are cell-surface proteins that present peptides to T cells. The binding specificity of pockets B and F are strong determinants of peptide binding and have been used to classify HLA into supertypes. Peptide binding prediction has become more reliable over the years by using binding affinity and mass spectrometry data.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biology
Eli Olson, Theadora Ceccarelli, Malini Raghavan
Summary: The extreme polymorphisms of HLA class I proteins enable diverse peptide presentation, and the endo-lysosomes in moDCs play a role in the presentation of HLA class I molecules. HLA-B allotypes display varying responses to disruption of the endo-lysosomal pH, with HLA-B*08:01 being more resistant and HLA-B*35:01 being more sensitive. The degree of endo-lysosomal assembly dictates constitutive HLA class I expression and affects the efficiency of cross-presentation.
Review
Immunology
Simon Jasinski-Bergner, Dominik Schmiedel, Ofer Mandelboim, Barbara Seliger
Summary: This review provides a summary of the expression, regulation, function, and impact of HLA-G in the context of different viral infections, including virus-associated cancers. It emphasizes the potential use of HLA-G as a novel diagnostic and prognostic biomarker for viral infections, as well as a therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Ourlad Alzeus G. Tantengco, Lauren Richardson, Alan Lee, Ananthkumar Kammala, Mariana de Castro Silva, Hend Shahin, Samantha Sheller-Miller, Ramkumar Menon
Summary: This systematic review examined the expression and function of HLA-G in reproductive tissues during pregnancy. The research found that HLA-G is mainly studied in placental tissue and peripheral blood immune cells, with limited studies on amniotic fluid, cord blood, and fetal membranes. HLA-G was reported to regulate inflammation, inhibit immune cell cytotoxicity, and trophoblast invasion.
Article
Biochemical Research Methods
Yue Shen, Jerry M. Parks, Jeremy C. Smith
Summary: The HLA-Clus package provides a clustering method for HLA Class I alleles based on their 3D structural similarity. It can be used in HLA functional studies and disease association studies.
BMC BIOINFORMATICS
(2023)
Article
Immunology
Ya-Yu Tsai, Chenxu Qu, Joseph D. Bonner, Rebeca Sanz-Pamplona, Sidney S. Lindsey, Marilena Melas, Kevin J. Mcdonnell, Gregory E. Idos, Christopher P. Walker, Kevin K. Tsang, Diane M. Da Silva, Ferran Moratalla-Navarro, Asaf Maoz, Hedy S. Rennert, W. Martin Kast, Joel K. Greenson, Victor Moreno, Gad Rennert, Stephen B. Gruber, Stephanie L. Schmit
Summary: The diversity at HLA loci is associated with the risk of developing colorectal cancer, and increased heterozygosity at these loci may reduce the odds of developing CRC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gemma Palomar, Katarzyna Dudek, Magdalena Migalska, J. W. Arntzen, G. Francesco Ficetola, Dusan Jelic, Elizabeth Jockusch, Inigo Martinez-Solano, Masatoshi Matsunami, H. Bradley Shaffer, Judit Voros, Bruce Waldman, Ben Wielstra, Wieslaw Babik
Summary: The study found a positive correlation between MHC-I diversity and the diversity of two APGs (TAP1 and TAP2) in salamanders, supporting their coevolution. However, no consistent effect was detected for the other three APGs (PSMB8, PSMB9, and TAPBP). This suggests that while coevolution occurs in salamanders, it does not limit the expansion of the MHC-I gene family.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Guan K. Tay, Halima Alnaqbi, Sarah Chehadeh, Braulio Peramo, Farah Mustafa, Tahir A. Rizvi, Bassam H. Mahboub, Maimunah Uddin, Nawal Alkaabi, Eman Alefishat, Herbert F. Jelinek, Habiba Alsafar
Summary: This study found that certain Human Leucocyte Antigen (HLA) alleles are associated with the severity of COVID-19. These alleles may influence the susceptibility to SARS-CoV-2 infection. The study supports the potential use of HLA testing in prioritizing public healthcare interventions for COVID-19 patients at risk and providing personalized immunotherapeutic targets.
Article
Medicine, General & Internal
Natalia Alves Cortelette, Nayana De Oliveira Souza, Lilian Cataldi-Rodrigues, Connie Arthur, Sean R. Stowell, Marcelo Dias-Baruffi, Daniela Amorim Melgaco Guimaraes, Lorena Rocha Ayres, Joao Alexandre Tres Pancoto
Summary: This study investigated the polymorphisms and expressions of human leukocyte antigen-G (HLA-G), galectin-1 (Gal-1), and interleukin-10 (IL-10) in people living with HIV (PLHIV). The results suggest that high expression of soluble HLA-G and IL-10 or Gal-1 may be associated with the development of comorbidities in PLHIV.
Article
Oncology
Min Jong Song, Suk Ii Jang, Hyon Jee Yoon, Eun Young Ki, Joon Mo Lee, Soo Young Hur
Summary: The study found that HLA-G expression was present in 81.8% of ovarian cancers but not in benign ovarian tumors, while classical HLA class I antigen expression was down-regulated in 75.8% of ovarian cancers and only in 10% of benign tumors. The abnormal expression of HLA-G and down-regulation of classical HLA class I antigen in ovarian cancer may contribute to cancer cells evading the host's immune system.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2021)
Review
Oncology
Natalia Aptsiauri, Federico Garrido
Summary: HLA class I molecules play a crucial role in tumor recognition and T cell-mediated elimination, and loss of tumor HLA class I expression reduces antigen presentation and facilitates cancer immune evasion. This review summarizes the current advances in understanding the mechanisms of MHC/HLA class I alterations during tumor progression and highlights the importance of detecting and correcting tumor HLA expression absence to improve immunotherapy protocols.
CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Jun Gan, Xing-Hong Di, Zi-Yi Yan, Yang-Fan Gao, Hui-Hui Xu
Summary: This study found that HLA-G 3'UTR polymorphisms may influence the peripheral sHLA-G plasma level in patients and play a key role in the susceptibility and prognosis of cervical cancer. sHLA-G may represent a novel plasma biomarker for the prognosis and potential therapeutic target of cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Valentina Ferrari, Antonino Lo Cascio, Alessia Melacarne, Nina Tanaskovi, Alessandro M. Mozzarelli, Luca Tiraboschi, Michela Lizier, Marta Salvi, Daniele Braga, Francesca Algieri, Giuseppe Penna, Maria Rescigno
Summary: Recent research has shown that the gut microbiota plays a significant role in the clinical response to immune check-point inhibitors for solid tumors. Metabolites released by bacteria can enhance the expression of HLA class I molecules on cancer cells, leading to increased sensitivity to immune cells and improved tumor clearance.
Article
Oncology
Ila J. Datar, Sacha C. Hauc, Shruti Desai, Nicole Gianino, Brian Henick, Yuting Liu, Kostas Syrigos, David L. Rimm, Paula Kavathas, Soldano Ferrone, Kurt A. Schalper
Summary: This study analyzed the distribution, immune contexture, and clinical significance of HLA class-I and -II subunits in NSCLC. The results revealed frequent and differential defects in HLA protein subunit expression in NSCLCs, associated with distinct tumor microenvironment composition and patient survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Marlieke L. M. Jongsma, Antonius A. de Waard, Matthijs Raaben, Tao Zhang, Birol Cabukusta, Rene Platzer, Vincent A. Blomen, Anastasia Xagara, Tamara Verkerk, Sophie Bliss, Xiangrui Kong, Carolin Gerke, Lennert Janssen, Elmer Stickel, Stephanie Holst, Rosina Plomp, Arend Mulder, Soldano Ferrone, Frans H. J. Claas, Mirjam H. M. Heemskerk, Marieke Griffioen, Anne Halenius, Hermen Overkleeft, Johannes B. Huppa, Manfred Wuhrer, Thijn R. Brummelkamp, Jacques Neefjes, Robbert M. Spaapen
Summary: HLA class I glycoproteins play a crucial role in driving immune responses by presenting antigens, but tumors and pathogens often exploit this process for immune evasion. Through genome-wide screens, it was discovered that the cell surface glycosphingolipid repertoire determines effective HLA-I antigen presentation. Inhibition of GSL synthesis may represent a potential therapeutic target in cancer, infection, and autoimmunity, offering a promising avenue for immune modulation.
Review
Oncology
Josefa A. Rodriguez
Article
Multidisciplinary Sciences
Andres Julian Gutierrez-Escobar, Gina Mendez-Callejas, Orlando Acevedo, Maria Mercedes Bravo
Article
Plant Sciences
Esperanza Trujillo, Ricardo Sanchez, Maria Mercedes Bravo
ACTA BIOLOGICA COLOMBIANA
(2018)
Article
Microbiology
Cosmeri Rizzato, Javier Torres, Elena Kasamatsu, Margarita Camorlinga-Ponce, Maria Mercedes Bravo, Federico Canzian, Ikuko Kato
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Andres J. Gutierrez-Escobar, Maria M. Bravo, Orlando Acevedo, Steffen Backert
Article
Oncology
Lourdes Flores-Luna, Maria Mercedes Bravo, Elena Kasamatsu, Eduardo Cesar Lazcano Ponce, Teresa Martinez, Javier Torres, Margarita Camorlinga-Ponce, Ikuko Kato
CANCER EPIDEMIOLOGY
(2020)
Article
Oncology
Federico Canzian, Cosmeri Rizzato, Ofure Obazee, Angelika Stein, Lourdes Flores-Luna, Margarita Camorlinga-Ponce, Alfonso Mendez-Tenorio, Jorge Vivas, Esperanza Trujillo, Hyejong Jang, Wei Chen, Elena Kasamatsu, Maria Mercedes Bravo, Javier Torres, Nubia Munoz, Ikuko Kato
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Cosmeri Rizzato, Javier Torres, Ofure Obazee, Margarita Camorlinga-Ponce, Esperanza Trujillo, Angelika Stein, Alfonso Mendez-Tenorio, Maria Mercedes Bravo, Federico Canzian, Ikuko Kato
SCIENTIFIC REPORTS
(2020)
Review
Oncology
Andres Rincon-Riveros, Liliana Lopez, E. Victoria Villegas, Josefa Antonia Rodriguez
Summary: Extracellular vesicles, such as exosomes, have the potential to serve as biomarkers for cancer development, impacting various aspects of tumor progression and immune regulation.
Review
Biochemistry & Molecular Biology
Andres Rincon-Riveros, Duvan Morales, Josefa Antonia Rodriguez, Victoria E. Villegas, Liliana Lopez-Kleine
Summary: Noncoding RNAs play key roles in gene expression regulation by interacting with other biological molecules, and computational biology can enhance our understanding of these interactions. Experimental findings drive advancements in computational methods, which in turn provide new insights for experimental validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Alix A. Guevara-Tique, Roberto C. Torres, Maria M. Bravo, Luis G. Carvajal Carmona, Maria M. Echeverry de Polanco, Mabel E. Bohorquez, Javier Torres
Summary: H. pylori in Colombia has evolved into subpopulations with self identity ancestry, demonstrating advanced adaptation to mixed Colombian groups. Recombination plays a more important role than punctual mutations in the genome diversity of H. pylori.
Article
Oncology
Paula Daniela Morales-Suarez, Wendy Johana Montero-Ovalle, Paula Juliana Pardo-Sanabria, Juan Camilo Cuestas-Castaneda, Yenifer Yamile Segura-Moreno, Marcela Nunez-Lemus, Maria Carolina Sanabria-Salas, Rodolfo Varela-Ramirez, Martha Lucia Serrano
Summary: Prostate cancer is the most common cancer in men in Colombia, posing a significant public health issue. A study was conducted to enhance students' understanding of biology concepts and cancer perceptions through the social appropriation of knowledge strategy. The intervention resulted in improved comprehension and awareness of the subject matter, highlighting the importance of linking school and scientific knowledge to real-world problems.
JOURNAL OF CANCER EDUCATION
(2023)
Article
Biochemistry & Molecular Biology
Andres Rincon-Riveros, Josefa Antonia Rodriguez, Victoria E. Villegas, Liliana Lopez-Kleine
Summary: This study identified two commonly deregulated miRNAs in exosomes from healthy individuals and cancer patients, which had implications for functional processes through the examination of their target genes.
Review
Oncology
Wendy Montero-Ovallea, Maria Carolina Sanabria-Salasa, Martha Lucia Serranoa
Summary: SPOP, as a component of ubiquitin ligase E3 cullin-3 RING-box1 complex, is involved in ubiquitination and proteasomal degradation of biomolecules, and its alterations are associated with the development of various types of cancer.
REVISTA COLOMBIANA DE CANCEROLOGIA
(2021)
Article
Oncology
Hector Javier Ardila, Maria Carolina Sanabria-Salas, Ximena Meneses, Rafael Rios, Antonio Huertas-Salgado, Martha Lucia Serrano
MOLECULAR AND CLINICAL ONCOLOGY
(2019)