Article
Chemistry, Multidisciplinary
Yuqiang Hu, Zhen Zhang, Wei Zhang, Minghao Hu, Xianjin Xiao, Tongbo Wu
Summary: DNA-functionalized gold nanoparticles are a versatile bionanomaterial for biomedical and clinical diagnosis. This study reveals that the performance of DNAzyme in cleaving substrate is closely related to its length, which only occurs at the interfaces of DNA-functionalized gold nanoparticles. The causes of this phenomenon, such as non-specific adsorption, electrostatic repulsion, and steric hindrance, are systematically investigated. Based on this improved understanding, a highly sensitive and specific amplifiable biosensor for detecting human apurinic/apyrimidinic endonuclease 1 is successfully developed.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Laura Zanetti-Polzi, Patrick Charchar, Irene Yarovsky, Stefano Corni
Summary: Through theoretical investigation, we have revealed the impact of peptide-ligand environment on the pH-responsive fluorescence of gold nanoclusters. Our findings show that subtle changes in the hexapeptide sequence can significantly alter the pH response of the clusters, providing insights into the underlying mechanism.
Article
Biophysics
Zhuang Hu, Rui Zhang, Shiying Xu, Jiwei Wang, Xianjun Li, Jianshe Hu, Aikebaier Reheman
Summary: In this study, a stimuli-responsive polypeptide nano-delivery system was developed for various stimuli response in the tumor microenvironment. The introduction of hydrophobic elements greatly improved the self-assembly performance of polypeptides, leading to enhanced drug loading and encapsulation rate of nanoparticles. The nanoparticles achieved targeted aggregation in tumor tissues and exhibited good safety in vivo without toxicity and side effects on normal bodies during treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Analytical
Joanna Xiuzhu Xu, Md Siddik Alom, Nicholas C. Fitzkee
Summary: An effective intensity-based reference using N-15 tryptophan as an external reference for H-1-N-15 2D NMR experiments is presented in this study to quantify competitive protein adsorption onto nanoparticle surfaces. The referencing system validated the binding capacity of single protein onto gold NPs and accurately quantified signals from protein mixtures. The proposed Trp reference enables the monitoring of competitive adsorption of different proteins in situ and in real time, highlighting the importance of studying protein-NP interactions in protein mixtures using H-1-N-15 2D NMR techniques.
ANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Rafael Leonardo C. G. da Silva, Karina de Oliveira Goncalves, Lilia Coronato Courrol, Luciano Caseli
Summary: The study investigated the application of gold nanoparticles containing 5-ALA in cancer therapy, using Langmuir monolayers as a simplified model for cell membranes, and found strong interactions between the functionalized gold nanoparticles and phospholipids.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yingying Zhong, Xian Wang, Ruyan Zha, Chen Wang, Huijuan Zhang, Yanying Wang, Chunya Li
Summary: The study utilized a novel aptasensor to achieve simultaneous detection of CEA and CA153 tumor markers, demonstrating excellent sensitivity and accuracy. Experimental results showed a high consistency between the aptasensor's detection of CEA and CA153 in serum samples and the traditional ELISA method, indicating promising clinical application prospects.
Article
Chemistry, Physical
Xiaohui Mao, Diling Yang, Lei Xie, Qi Liu, Tian Tang, Hao Zhang, Hongbo Zeng
Summary: This study characterized Pickering emulsions formed by bilayer oleic acid-coated Fe3O4 nanoparticles under different pH values, revealing that W/O and O/W emulsions formed at different pH values are stabilized by unique mechanisms, involving steric barrier formation and electrostatic repulsion, respectively. Increasing maximum loading force and dwelling time enhances the confinement of particles and aggregates at the oil/water interface, providing useful insights into the stabilization mechanisms of Pickering emulsions with stimuli-responsive particles.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Palash Mondal, Jeffery L. Yarger
Summary: A colorimetric assay using functionalized silver nanoparticles has been developed for simultaneous detection of Zn2+ and Hcy. The assay showed excellent selectivity and sensitivity, and can be easily distinguished by color change.
Article
Materials Science, Multidisciplinary
Shumaila Islam, Adil Alshoaibi
Summary: pH evaluation is necessary in various fields of life, and can be used in environmental monitoring, agriculture, and food science research. A zincite-supported silica-anatase nanocomposite (ZSAC) is synthesized using the sol-gel method for pH sensing applications. The nanocomposite exhibits a broad pH range, fast response characteristics, and shows potential for opto-chemical sensing applications.
Article
Chemistry, Medicinal
Sejal Chauhan, Krunal Patel, Poonam Jain, Ashok Kumar Jangid, Sunita Patel, Kanakaraju Medicherla, Kajal Limbad, Chetan Mehta, Hitesh Kulhari
Summary: A matrix metalloproteinase 1 (MMP1) responsive nanoparticle system for delivering the anticancer drug 5-fluorouracil (5Fu) was developed. The system showed advantages of targeted drug release and reduced distribution to healthy tissues, leading to improved anticancer activity and promising CT imaging results.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2022)
Article
Materials Science, Multidisciplinary
Xiao-Bin Mang, Lian-Qi Yao
Summary: Functionalized gold nanoparticles (GNPs) were studied for their nanostructure using X-ray diffraction (XRD). The presence of ligands and co-ligands was found to induce long-range ordered packing style with temperature change.
Article
Chemistry, Multidisciplinary
Atul Kumar Tiwari, Hari Prakash Yadav, Munesh Kumar Gupta, Roger J. J. Narayan, Prem C. C. Pandey
Summary: A highly fluorescent, sensitive, and selective fluorometric assay for detecting Hg2+ ions was developed using vancomycin functionalized and polyethyleneimine stabilized gold nanoparticles (PEI-f-AuNPs@Van). The gold nanoparticles exhibited strong fluorescence properties with excitation and emission wavelengths of 320 nm and 418 nm, respectively. The detection limit for Hg2+ ion was determined to be 0.988 nM within a linear range, while in natural environmental samples it was 12.5 nM. The designed probe showed high selectivity for mercury (II) cations among other divalent cations.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ryan D. Mellor, Andreas G. Schatzlein, Ijeoma F. Uchegbu
Summary: In this study, clustered ultrasmall (sub-5 nm) AuNP constructs were synthesized for in vivo Raman diagnostic monitoring, showing potential suitability for non-invasive detection and monitoring while being able to disaggregate into smaller particles under physiological conditions.
Article
Chemistry, Multidisciplinary
Glenn A. O. Cremers, Bas J. H. M. Rosier, Ab Meijs, Nicholas B. Tito, Sander M. J. van Duijnhoven, Hans van Eenennaam, Lorenzo Albertazzi, Tom F. A. de Greef
Summary: The study investigated the tunable design parameters of antibody-functionalized DNA nanostructures binding to therapeutically relevant receptors, revealing key insights into receptor binding efficiency governed mainly by nanostructure size and DNA handle location.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Kai-Jen Chuang, Meng-Ru Dong, Purnima Laishram, Gui-Bing Hong
Summary: A colorimetric method based on sodium nitrite-functionalized gold nanoparticles was developed for the detection of acenaphthene and naphthalene. The method showed a linear relationship between the analyte concentration range of 0.1-10 ppm and had a limit of detection of 0.046 ppm for acenaphthene and 0.0015 ppm for naphthalene. The recovery rate for actual samples was found to be within the range of 98.4-103.0%. In selective and anti-interference tests, the presence of cations and anions had minimal impact on the detection of the analyte. This study provides an effective colorimetric method for detecting the presence of acenaphthene and naphthalene in real water samples with a high recovery rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Katriann Arja, Robert Selegard, Marketa Paloncyova, Mathieu Linares, Mikael Lindgren, Patrick Norman, Daniel Aili, K. Peter R. Nilsson
Summary: This study reports on the chiro-optical properties and architectural arrangement of optoelectronic materials generated through self-assembly of oligothiophene-porphyrin derivatives and synthetic peptides. The materials exhibit a three-dimensional ordered helical structure and optical activity, making them promising for bioelectronic applications.
Article
Materials Science, Multidisciplinary
Isabelle Matthiesen, Michael Jury, Fatemeh Rasti Boroojeni, Saskia L. Ludwig, Muriel Holzreuter, Sebastian Buchmann, Andrea Aman Trager, Robert Selegard, Thomas E. Winkler, Daniel Aili, Anna Herland
Summary: Astrocytes play a crucial role in the central nervous system, contributing to synaptic development and maintenance, neurotransmitter recycling, and the function of the blood-brain barrier. This study investigates the interactions between neuroblastoma and glioblastoma cell lines and human fetal primary astrocytes using a hyaluronan-based hydrogel system. The study reveals that fetal primary astrocytes have stronger interactions with the hyaluronan-based gels compared to the cell lines, especially when cell-adhesion peptides are conjugated to the hydrogel backbone. Bioprinted astrocytes using functionalized hyaluronan show extensive protrusions and connections between neighboring cells. Tailored and optimized hydrogels that mimic the extracellular matrix and are compatible with astrocytes can aid in the development of advanced tissue and disease models of the central nervous system.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Dheemahi Rao, Ashalatha Indiradevi Kamalasanan Pillai, Magnus Garbrecht, Bivas Saha
Summary: Traditional computation based on von Neumann architecture is limited in terms of time and energy consumption due to data transfer between storage and processing units. It is also inefficient in solving unstructured, probabilistic, and real-time problems. To overcome these challenges, a new brain-inspired neuromorphic computational architecture is required. This study presents CMOS-compatible scandium nitride (ScN) optoelectronic synaptic devices that exhibit both inhibitory and excitatory biological synaptic activities, simulating functionalities like learning-forgetting and logic-gate operations. This work paves the way for practical neuromorphic applications using group-III epitaxial semiconducting nitride materials with inhibitory and excitatory optoelectronic synaptic functionalities.
ADVANCED ELECTRONIC MATERIALS
(2023)
Article
Engineering, Biomedical
Olof Eskilson, Elisa Zattarin, Linn Berglund, Kristiina Oksman, Kristina Hanna, Jonathan Rakar, Petter Sivler, Marten Skog, Ivana Rinklake, Rozalin Shamasha, Zeljana Sotra, Annika Starkenberg, Magnus Oden, Emanuel Wiman, Hazem Khalaf, Torbjorn Bengtsson, Johan P. E. Junker, Robert Selegard, Emma M. Bjork, Daniel Aili
Summary: The skin is the largest organ of the human body, and wounds can have severe consequences, such as morbidity and mortality. Infections in wounds are common and can delay healing and lead to sepsis. This study presents a novel strategy for pH sensing in wound dressings made from bacterial nanocellulose, which can facilitate early detection of infection. The pH-responsive nanocomposites showed excellent properties as wound dressings and could be used for encapsulation and release of bioactive compounds for the treatment of difficult-to-heal wounds, promoting the development of innovative wound care materials.
MATERIALS TODAY BIO
(2023)
Article
Physics, Applied
Krishna Chand Maurya, Vincenzo Caligiuri, Ashalatha Indiradevi Kamalasanan Pillai, Magnus Garbrecht, Roman Krahne, Bivas Saha
Summary: Ferrell and Berreman modes are absorption resonances in thin metal films and polar-dielectric media that arise from radiative bulk plasmon-polariton and phonon-polariton excitations. They provide a unique pathway for light-matter interactions.
APPLIED PHYSICS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Andrea Trager, Sajjad Naeimipour, Michael Jury, Robert Selegard, Daniel Aili
Summary: Bioprinting of hydrogel-based bioinks containing cellulose oxalate nanofibrils allows for the fabrication of complex, cell-laden 3D structures with high viability. Theseshear thinning bioinks can be easily extruded through the printing nozzle and retain the shape of the printed structure. The hydrogels show good biocompatibility and can be cross-linked after printing for long-term stability, making them suitable for producing complex geometries that support cell growth.
Article
Biochemistry & Molecular Biology
Linn Berglund, Paula Squinca, Yagmur Bas, Elisa Zattarin, Daniel Aili, Jonathan Rakar, Johan Junker, Annika Starkenberg, Mattia Diamanti, Petter Sivler, Marten Skog, Kristiina Oksman
Summary: This study explores the self-assembly of nanocellulose into bio-based hydrogels via hydrogen bonding. Different methods of separating and assembling nanocellulose from wood are compared, and it is found that the vacuum-assisted filtration method produces the most promising wound dressing material.
Article
Chemistry, Analytical
Chi Xiao, Georgina Ross, Michel W. F. Nielen, Jens Eriksson, Gert IJ. Salentijn, Wing Cheung Mak
Summary: Food allergies are immune responses to allergenic compounds in food and drinks. The increased consumption of plant-based milks has raised concerns about cross-contamination of allergenic plant proteins during food manufacturing. A portable smartphone iSPR biosensor was developed for on-site detection of hazelnut protein in plant-based milks, showing similar performance to a conventional benchtop SPR system.
Article
Multidisciplinary Sciences
Emanuel Wiman, Elisa Zattarin, Daniel Aili, Torbjorn Bengtsson, Robert Selegard, Hazem Khalaf
Summary: Bacterial resistance to antibiotics is a major global health issue. Few novel antimicrobial agents have been developed, despite the increasing need. Antimicrobial peptides have shown promise in vitro, but limitations exist. Researchers have designed and synthesized lipopeptides with enhanced antimicrobial activity against gram-positive and gram-negative bacteria. These lipopeptides effectively inhibit bacteria by disrupting their cell membranes. Combination with antibiotics further enhances their effects. Additional experiments are needed to validate their efficacy in vivo.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yagmur Bas, Linn Berglund, Totte Niittyla, Elisa Zattarin, Daniel Aili, Zeljana Sotra, Ivana Rinklake, Johan Junker, Jonathan Rakar, Kristiina Oksman
Summary: This study demonstrates a straightforward processing route for obtaining nanofibril hydrogels from different wood species for potential use as wound dressings. Softwood shows the best mechanical properties and biocompatibility.
Meeting Abstract
Cell & Tissue Engineering
Wasihun Bekele Kebede, Elisa Zattarin, Zeljana Sotra, Annika Starkenberg, Jonathan Rakar, Robert Slegard, Daniel Aili, Emanuel Wiman, Sneha Kollenchery Ramanath, Johan P. E. Junker
TISSUE ENGINEERING PART A
(2023)
Meeting Abstract
Cell & Tissue Engineering
Rozalin Shamasha, Sneha Kollenchery Ramanathan, Annika Starkenberg, Gunnar Kratz, Jonathan Rakar, Daniel Aili, Johan P. E. Junker
TISSUE ENGINEERING PART A
(2023)
