Review
Geriatrics & Gerontology
Jinyang Zhuang, Jie Jia
Summary: This article reviews the research progress of respiratory muscle strength training (RMST) in Parkinson's disease (PD) rehabilitation, providing new insights into the management of respiratory-related impairments in people with PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Meng-Xi Zhou, Qin Wang, Yin Lin, Qian Xu, Li Wu, Ya-Jing Chen, Yu-Han Jiang, Qing He, Lei Zhao, You-Rong Dong, Jian-Ren Liu, Wei Chen
Summary: This study found that ocular movements are impaired in newly diagnosed, drug-naive PD patients, and these changes could be indicators for disease progression in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Thiago da Silva Rocha Paz, Vera Lucia Santos de Britto, Bruna Yamaguchi, Vera Lucia Israel, Alessandra Swarowsky, Clynton Lourenco Correa
Summary: Handgrip strength is correlated with motor impairment in Parkinson's disease, particularly in the group with freezing of gait. The study also revealed clinical profile differences in motor symptoms between freezers and nonfreezers with PD.
Review
Neurosciences
Romina Gollan, Moritz Ernst, Emma Lieker, Julia Caro-Valenzuela, Ina Monsef, Antje Dresen, Mandy Roheger, Nicole Skoetz, Elke Kalbe, Ann-Kristin Folkerts
Summary: This study aimed to analyze the effects of resistance training (RT) on motor and non-motor outcomes in Parkinson's disease (PD) patients compared to other structured physical interventions. The results showed that RT had positive effects on muscle strength, motor impairment, mobility and balance, quality of life, and depression in PD patients. However, it was not superior to other physically active interventions.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Lidia Castillo-Mariqueo, M. Jose Perez-Garcia, Lydia Gimenez-Llort
Summary: The study on the 3xTg-AD mouse model reveals significant functional impairments in gait and exploratory activity in patients with Alzheimer's disease, which worsen with disease severity and aging. This indicates the potential for using the ICF framework in rehabilitation and understanding of functional decline in AD patients.
Article
Chemistry, Multidisciplinary
Yu Li, Junyi Yin, Shuoyan Liu, Bing Xue, Cyrus Shokoohi, Gang Ge, Menglei Hu, Tenghuan Li, Xue Tao, Zhi Rao, Fanye Meng, Hongfeng Shi, Xiaoqiang Ji, Peyman Servati, Xiao Xiao, Jun Chen
Summary: A multimodal sensor glove was developed to quantify the severity of Parkinson's disease symptoms in patients' hands and assess the hands' multifunctionality. Various algorithms were used to analyze the signals, accurately identify and classify tremor signals, and achieve consistency with clinical observations. The glove can be applied to rehabilitation treatments and improve hand recovery efficiency.
Article
Neurosciences
Alex I. Wiesman, Peter W. A. Donhauser, Clotilde Degroot, Sabrina Diab, Shanna Kousaie, Edward A. Fon, Denise Klein, Sylvain Baillet
Summary: Difficulty producing intelligible speech is a debilitating symptom of Parkinson's disease. This study uses task-free magnetoencephalography to evaluate speech impairments and identify affected brain systems in patients with PD. The findings suggest that speech impairment ratings in PD are related to motor and cognitive impairments, and are influenced by aberrant activity in the left inferior frontal cortex.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Marlene Alonso-Juarez, Robert Fekete, Jose Fidel Baizabal-Carvallo
Summary: Lower limb weakness and allied abnormal sensations are common in patients with Parkinson's disease (PD). However, there is a dissociation between perceived weakness and objective muscle strength in the lower limbs. These abnormal sensations are mostly related to gait freezing, but a causal association is questionable.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Clinical Neurology
Tais Galdencio do Nascimento, Rebecca Peixoto Paes-Silva, Marcella Campos Lima da Luz, Poliana Coelho Cabral, Gleyce Kelly de Araujo Bezerra, Andressa Caroline Burgos Gomes
Summary: This study evaluated the association of phase angle (PA) with clinical and nutritional aspects in patients with Parkinson's disease (PD) treated in an outpatient clinic. The results showed that most individuals had reduced PA, and only age was associated with this result.
NEUROLOGICAL SCIENCES
(2022)
Article
Immunology
Dongdong Zhang, Sheng Li, Liyan Hou, Lu Jing, Zhengzheng Ruan, Bingjie Peng, Xiaomeng Zhang, Jau-Shyong Hong, Jie Zhao, Qingshan Wang
Summary: This study investigated the role of microglia in cognitive deficits in a rotenone-induced mouse PD model. The findings suggest that microglial activation contributes to cognitive impairments via neuroinflammation, oxidative stress, and apoptosis, providing novel insight into the immunopathogenesis of cognitive deficits in PD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Rosie Morris, Douglas N. Martini, Katrina Ramsey, Valerie E. Kelly, Katrijn Smulders, Amie Hiller, Kathryn A. Chung, Shu-Ching Hu, Cyrus P. Zabetian, Kathleen L. Poston, Ignacio F. Mata, Karen L. Edwards, Jodi Lapidus, Brenna Cholerton, Thomas J. Montine, Joseph F. Quinn, Fay Horak
Summary: The study aimed to investigate differences in gait and balance impairments in Parkinson's disease patients with and without GBA variants (mutation carriers and E326K polymorphism) and explore the direct and indirect effects of GBA status on gait, balance, and cognition. The results showed that the GBA variant group had more impaired gait and balance, and cognition mediated the impact of GBA status on gait and balance.
NPJ PARKINSONS DISEASE
(2022)
Article
Geriatrics & Gerontology
Yan Qu, Tingting Zhang, Yunyan Duo, Liling Chen, Xiaohong Li
Summary: This study aims to investigate the value of the Parkinson's KinetiGraph (PKG) in identifying and quantitatively assessing motor complications in the Chinese PD population and its correlation with clinical assessments. The study found that PKG has a significant correlation with clinical assessment, high sensitivity, and high specificity, providing an objective and quantitative method for identifying and assessing motor complications in Parkinson's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Environmental Sciences
Adam Pennell, Nicole Yee, Carmen Conforti, Katienne Yau, Ali Brian
Summary: The study investigated multidimensional standing long jump performance outcomes in youth with visual impairments, finding substandard performance and predictive assessment scores. Interestingly, few hypothesized variables were found to significantly impact standing long jump performance in this population, suggesting potential unique factors influencing muscular fitness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Jaap N. E. Bakers, Leonard H. van den Berg, Toju G. Ajeks, Maxine J. Holleman, Jill Verhoeven, Anita Beelen, Johanna M. A. Visser-Meily, Ruben P. A. van Eijk
Summary: The study found excellent test-retest reliability of the portable fixed dynamometer (PFD) in patients with MND and healthy controls, reducing examiner-induced ceiling effects and extending the range of muscle strength measurements.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Baijayanta Maiti, Kerri S. Rawson, Aaron B. Tanenbaum, Jonathan M. Koller, Abraham Z. Snyder, Meghan C. Campbell, Gammon M. Earhart, Joel S. Perlmutter
Summary: The study found that Parkinson's disease patients have significantly altered functional connectivity between the vermis and sensorimotor cortex, which is correlated with subsequent impairment in specific domains of gait. These results indicate the potential of altered vermal functional connectivity as a novel imaging biomarker for gait impairment in Parkinson's disease.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Sophie E. Waller, Laura Williams, Adrian Y. S. Lee, Ming-Wei Lin, Elizabeth McCusker, Hugo Morales-Briceno, Victor S. C. Fung
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Angela Vratsistas-Curto, Aron Downie, Annie McCluskey, Catherine Sherrington
Summary: This study investigated the trajectories of motor arm function recovery in stroke patients during inpatient rehabilitation. Four distinct patterns of recovery were identified, and factors associated with each pattern were explored.
ANNALS OF MEDICINE
(2023)
Article
Surgery
Sarah M. Manewell, Sarah J. Aitken, Vanessa L. Nube, Anna M. Crawford, Maria I. Constantino, Stephen M. Twigg, Hylton B. Menz, Catherine Sherrington, Serene S. Paul
Summary: This study aimed to determine the incidence of minor and major amputation among inpatients with diabetes-related foot ulceration (DFU) over 4 years, and to investigate the factors associated with these amputations. The results showed that the incidence of minor amputation during the patient's index DFU-related admission was 28%, while the incidence of major amputation was 6%. Minor amputation was associated with requiring revascularisation, while major amputation was associated with more comorbidities and receiving care for a mental health condition.
ANZ JOURNAL OF SURGERY
(2023)
Article
Public, Environmental & Occupational Health
Liam Johnson, Gavin Williams, Catherine Sherrington, Kavya Pilli, Sakina Chagpar, Aylish Auchettl, Jack Beard, Renee Gill, Gabrielle Vassallo, Nick Rushworth, Sean Tweedy, Grahame Simpson, Adam Scheinberg, Kelly Clanchy, Anne Tiedemann, Leanne Hassett
Summary: In 2020, the World Health Organization released global physical activity guidelines for individuals with disabilities, but there is a lack of specific evidence for people with traumatic brain injury (TBI). This study aimed to identify direct evidence of the effects of physical activity on health outcomes for individuals with moderate-to-severe TBI to inform clinical practice guidelines.
Review
Sport Sciences
Juliana S. Oliveira, Stephen Gilbert, Marina B. Pinheiro, Anne Tiedemann, Liane Brito Macedo, Laisa Maia, Wing Kwok, Leanne Hassett, Catherine Sherrington
Summary: This study conducted a systematic review and meta-analysis to examine the effects of sport on health among individuals aged 60 and above. The results suggest that participation in sport can improve cardiorespiratory fitness, physical function, mental health, and reduce fat mass in older people. However, the effects of sport on overall physical activity participation, strength, balance, lean mass, and bone mineral density remain uncertain.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Rehabilitation
Marina B. Pinheiro, Leanne Hassett, Catherine Sherrington, Alison Hayes, Maayken van den Berg, Richard Lindley, Maria Crotty, Sakina Chagpar, Daniel Treacy, Heather Weber, Nicola Fairhall, Siobhan Wong, Annie McCluskey, Leanne Togher, Katharine Scrivener, Kirsten Howard
Summary: This study evaluated the cost-effectiveness of adding a tailored digitally enabled exercise intervention to usual care in improving mobility, showing that the intervention saved costs and was more effective for mobility and quality-adjusted life years compared to usual care. Decision makers willing to pay AU$50,000 per meaningful improvement in mobility or quality-adjusted life year gained had a high probability of the intervention being cost-effective.
CLINICAL REHABILITATION
(2023)
Article
Clinical Neurology
Matthew Silsby, Alessandro F. Fois, Con Yiannikas, Karl Ng, Matthew C. Kiernan, Victor S. C. Fung, Steve Vucic
Summary: This study aimed to evaluate tremor in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and test the hypothesis that tremor occurs due to mistimed peripheral inputs affecting central motor processing, as established in other demyelinating neuropathies. Additionally, the tremor stability index (TSI) was calculated to assess the variability of CIDP-related tremor compared to other tremor disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Heidi Gilchrist, Abby Haynes, Juliana S. Oliveira, Anne Grunseit, Catherine Sherrington, Adrian Bauman, Roberta Shepherd, Anne Tiedemann
Summary: Exercise targeting balance and strength has been proven to prevent falls in older age. The Successful AGEing yoga trial is the first large randomized controlled trial to assess the impact of yoga on falls in people aged >= 60 years. A realist process evaluation was conducted, revealing that the mind-body connection created by relaxation, breathing, and yoga enhances participant engagement and satisfaction, with mindfulness and embodiment playing important roles.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)
Article
Medicine, Research & Experimental
Nisha Aravind, Daniel Treacy, Sakina Chagpar, Lisa A. Harvey, Joanne V. Glinsky, Catherine Sherrington, Leanne M. Hassett
Summary: This study aims to explore the feasibility of implementing digital devices into physiotherapy practice and assess the impact on patient outcomes. It includes an implementation phase to introduce the devices and a subsequent trial phase to evaluate the effects on inpatients' rehabilitation progress.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Nutrition & Dietetics
C. Thogersen-Ntoumani, M. Kritz, A. Grunseit, J. Chau, M. Ahmadi, A. Holtermann, A. Koster, C. Tudor-Locke, N. Johnson, C. Sherrington, S. Paudel, C. Maher, E. Stamatakis
Summary: This study examined the barriers and enablers of Vigorous Intermittent Lifestyle Physical Activity (VILPA) among physically inactive adults. The barriers include physical limitations, perceptions of aging, need for knowledge, environmental constraints, perceptions of effort and energy, and fear. The enablers include convenience, reframing physical activity as purposeful movement, use of prompts and reminders, normalization of taking the active option, gamification, sense of achievement, health improvements, identity fit, and changing from effortful deliberation to habitual action.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Review
Health Care Sciences & Services
Belinda Y. Wang, Catherine Sherrington, Nicola Fairhall, Wing S. Kwok, Zoe A. Michaleff, Anne Tiedemann, Geraldine Wallbank, Marina B. Pinheiro
Summary: Exercise can prevent falls, and targeting interventions to people with higher fall rates may have a greater impact on the population. By prospectively measuring the fall rate of the control group, it was found that exercise reduced falls more in trials with higher fall rates. Therefore, targeting interventions to those with a history of more falls may be more efficient.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
M. Ben, J. V. Glinsky, J. Chu, A. I. Spooren, S. Roberts, L. W. Chen, S. Denis, M. Lorusso, V. Jorgensen, E. J. Gollan, J. Agostinello, C. C. M. Van Laake-Geelen, C. Lincoln, J. M. Stolwijk, C. Bell, S. Paddison, D. Rainey, K. Tranter, J. Ilha, K. Oostra, C. Sherrington, L. A. Harvey
Summary: This study aims to describe the intervention provided in a large multi-centre randomised controlled trial called the SCI-MT Trial. The paper focuses on the rationale and principles of Motor Training for people with spinal cord injuries, and provides a detailed description of the intervention based on the TIDieR checklist.
Article
Clinical Neurology
Lisa A. Harvey, Joanne V. Glinsky, Jackie Chu, Robert D. Herbert, Hueiming Liu, Stephen Jan, Laurent Billot, Giorgio Scivoletto, Annemie I. Spooren, Henk A. Seelen, Marsha Ben, Keira Tranter, Lydia W. Chen, Donna Rainey, Christine Rimmer, Vivien Jorgensen, Fernanda Di Natal, Sophie Denis, Emilie J. Gollan, Federica Tamburella, Jacqui Agostinello, Charlotte M. van Laake-Geelen, Chris Bell, Claire Lincoln, Janneke M. Stolwijk, Jessica van der Lede, Sue Paddison, Kristine Oostra, Ian D. Cameron, Gerard Weber, Catherine Sherrington, Andrew K. Nunn, Emma-Leigh Synnott, Euan McCaughey, Jasbeer Kaur, Sachin Shetty
Summary: This study is a multi-centre randomised controlled trial aiming to determine whether intensive motor training for 10 weeks enhances neurological recovery in individuals with recent spinal cord injury (SCI). The trial will take place in 15 spinal injury units across Australia, Scotland, England, Italy, Netherlands, Norway, and Belgium. Two hundred and twenty participants with recent SCI will be randomised to receive either usual care plus intensive motor training or usual care alone, with various outcomes measured at 10 weeks and 6 months.
Article
Health Care Sciences & Services
Heidi Gilchrist, Abby Haynes, Juliana S. Oliveira, Catherine Sherrington, Lana Clementson, Janetta Glenn, June Jones, Romina Sesto, Anne Tiedemann
Summary: This research examines the challenges and opportunities faced by yoga instructors when transitioning to online teleyoga classes, specifically in the delivery of the SAGE yoga programme. Four main concerns were identified: safety risks, changes in interpersonal dynamics, maintaining mind-body connection, and difficulties with technology. The instructors implemented eight modifications to address these challenges, including individual participant interviews, improved verbal instructions, increased focus on interoception, and IT support. These strategies can enhance engagement and adherence to teleyoga for older adults and can be applied to other telehealth classes.
Article
Health Care Sciences & Services
Abby Haynes, Kirsten Howard, Liam Johnson, Gavin Williams, Kelly Clanchy, Sean Tweedy, Adam Scheinberg, Sakina Chagpar, Belinda Wang, Gabrielle Vassallo, Rhys Ashpole, Catherine Sherrington, Leanne Hassett
Summary: This study successfully developed a discrete choice experiment survey tool through discussions and interviews with patients with moderate-to-severe traumatic brain injury. The tool aimed to understand the preferences for physical activity among these patients and improve the World Health Organization guidelines for physical activity in traumatic brain injury. The formative co-development process significantly improved the relevance and comprehensibility of the survey tool.
PATIENT-PATIENT CENTERED OUTCOMES RESEARCH
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)