Article
Immunology
Helena Biasizzo, Barbara Soba, Frosina Ilovski, Matevz Harlander, Matej Lukin, Olga Blatnik, Matjaz Turel, Matevz Srpcic, Izidor Kern, Bojana Beovic
Summary: This article reports a case of human Dirofilaria repens infection in Slovenia, where the patient had both pleural and subcutaneous manifestations. This case demonstrates the multisystemic clinical course of a severe symptomatic parasitic infection.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Parasitology
Yeong-Seok Goh, Hye-Min Kim, Badriah Alkathiri, Hong Suh Chang, Young Min Yoon, Seung-Hun Lee, Kyung-Mee Park
Summary: We report two cases of ectopic dirofilariasis caused by Dirofilaria immitis in dogs, one involving subconjunctival involvement and the other involving subcutaneous localization. The species was confirmed using molecular methods. This is the first report of subconjunctival ectopic dirofilariasis caused by D. immitis in Korea, which is of significant importance.
PARASITOLOGY INTERNATIONAL
(2023)
Article
Microbiology
Beata Rymgayllo-Jankowska, Marta Ziaja-Soltys, Beata Flis, Anna Bogucka-Kocka, Tomasz Zarnowski
Summary: We report a case of a 60-year-old man who had a subcutaneous nodule on his left upper eyelid. The patient had multiple mosquito bites during work trips to Ukraine. Histopathological examination suggested infestation of Dirofilaria repens in the nodule isolated during surgery. Ophthalmologists should be aware of unusual presentations of parasitic infections in the ocular adnexa.
Article
Parasitology
E. Napoli, R. Panarese, F. La Russa, I Cambera, J. A. Mendoza-Roldan, D. Otranto, E. Brianti
Summary: The potential involvement of Culicoides spp. in the transmission of Dirofilaria spp. as well as the blood-meal source was investigated. The detection of D. immitis and D. repens DNA in Culicoides midges suggests their potential role in the epidemiology of these filarial nematodes.
Article
Parasitology
Alisher Safarov, Firuza Akramova, Djalaliddin Azimov, Andrei D. Mihalca, Angela M. Ionica
Summary: The study in the Republic of Uzbekistan found a wide distribution of zoonotic filarioid D. repens in domestic dogs and four species of wildlife hosts, raising awareness of the public health risks associated with this parasite.
PARASITOLOGY RESEARCH
(2021)
Review
Veterinary Sciences
Sergio Villanueva-Saz, Maria Victoria Martinez, Sandra Alsina, Antonio Fernandez, Alex Gomez, Maite Verde, Hector Ruiz, Delia Lacasta, Alaa Aldin Alnassan, Michele Trotta, Andres Yzuel, Diana Marteles
Summary: This article reports the first detection of D. repens in cats in Spain, confirmed by PCR testing. A review of the current status of feline subcutaneous dirofilariosis in Europe is also provided, highlighting the need for future investigations on the role of cats in the transmission of this disease.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Microbiology
Faten A. M. Abo-Aziza, Seham H. M. Hendawy, Hend H. A. M. Abdullah, Amira El Namaky, Younes Laidoudi, Oleg Mediannikov
Summary: Equine filariosis (EF) caused by nematode species is a neglected vector-borne disease. This study investigated the occurrence and immune response of EF in horses and donkeys in Egypt. Results revealed the presence of three different filaroid species, and different immune response types were identified. Control measures are urgently needed to prevent the spread of EF.
Article
Surgery
T. V. Aswathi, L. S. Sreelesh, T. M. Sheeja Rajan, G. N. Geethu
Summary: Human subcutaneous dirofilariasis is a rare zoonotic infection caused by worms of the genus Dirofilaria. This case presented with itching, erythematous wheals, and swelling, with ultrasound examination revealing a hypoechoic lesion with internal tubular serpiginous structure.
INDIAN JOURNAL OF SURGERY
(2021)
Article
Parasitology
Beata Szostakowska, Agnieszka Cwiklowska, Luiza Marek-Jozefowicz, Artur Czaplewski, Dariusz Grzanka, Natalia Kulawiak-Wasielak, Malgorzata Sulima
Summary: Dirofilariasis is an emerging zoonotic disease caused by nematodes of the genus Dirofilaria, with dogs as main hosts and mosquitoes as vectors. Human is usually an accidental host, but with the recent expansion of Dirofilaria species in Europe, species identification in diagnostics is important for atypical courses of infection.
PARASITOLOGY INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Brian Webster, Ying Xiong, Peirong Hu, Darong Wu, Leah Alabanza, Rimas J. Orentas, Boro Dropulic, Dina Schneider
Summary: Restricting the timing and magnitude of CAR expression can be functionally beneficial, whereas constitutive CAR activation may lead to exhaustion. A self-driving CAR system has been created to regulate its own function based on the presence of a CD19 antigen engaged by the CAR itself.
Article
Multidisciplinary Sciences
John P. Gleeson, Namit Chaudhary, Katherine C. Fein, Rose Doerfler, Patricia Hredzak-Showalter, Kathryn A. Whitehead
Summary: Breast milk contains cells that are beneficial for infant development, but little is known about these cells. This study characterized the cells in mature breast milk from healthy donors and identified the main cell population as epithelial cells, with several subpopulations including previously unidentified ones. These findings provide insights into the potential applications of breast milk cells in maternal and infant medicine.
Article
Multidisciplinary Sciences
Zhaoqi Shu, Minghe Fan, Bo Tu, Zhiheng Tang, Haojie Wang, Haimeng Li, Hengchao Li, Meng Yuan, Jingru Bai, Sihan Huo, Lina Wang, Wei-Guo Zhu, Wei Wang, Xiaoyun Liu, Shaokun Shu, Ying Zhao
Summary: Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment is crucial for tumor development, and the Lin28b/let-7 pathway plays a key role in modulating the expression of Wnt5a in tumor epithelium and cancer-associated fibroblasts.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Lianne Kok, David Masopust, Ton N. Schumacher
Summary: CD8(+) tissue resident memory T cells are crucial for immune defence against pathogens and malignancies. While it was previously believed that these cells formed locally within inflamed tissue, emerging evidence suggests the existence of circulating T-RM cell precursors. This review discusses the formation of T-RM cells and the signals within the lymphoid compartment that influence their lineage decisions.
NATURE REVIEWS IMMUNOLOGY
(2022)
Review
Microbiology
Emily Speranza
Summary: Although virus-host interactions are typically studied in vitro in a single cell type, it is important to consider the complexity of the tissue environment in order to truly understand infection dynamics. Immune cells, non-immune cells, and extracellular matrix components all play a role in shaping the host response to viruses. This review highlights methods for studying virus-host interactions in the infection microenvironment.
NATURE MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sabrina Summer, Eva Rossmanith, Markus Pasztorek, Constantin Fiedler, Marion Groeger, Sabine Rauscher, Viktoria Weber, Michael B. Fischer
Summary: Mesenchymal stem cells play a crucial role in supporting endothelial cells during tissue regeneration and new vessel formation. By co-culturing these cells in a specific microenvironment, complex vascular networks can be formed. Under dynamic flow conditions, mesenchymal stem cells can bind to damaged endothelial cells, potentially aiding in the healing process.
Correction
Parasitology
Irene Ajonina-Ekoti, Dieudonne Ndjonka, Manchang Kingsley Tanyi, Meike Wilbertz, Abuelhassan Elshazly Younis, Djafsia Boursou, Marc Andre Kurosinski, Raphael Eberle, Kai Lueersen, Markus Perbandt, Minka Breloer, Norbert W. Brattig, Eva Liebau
Article
Biochemistry & Molecular Biology
Emmanuela M. Anandarajah, Dana Ditgen, Jan Hansmann, Klaus D. Erttmann, Eva Liebau, Norbert W. Brattig
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2016)
Article
Genetics & Heredity
Vicky L. Hunt, Isheng J. Tsai, Avril Coghlan, Adam J. Reid, Nancy Holroyd, Bernardo J. Foth, Alan Tracey', James A. Cotton', Eleanor J. Stanley, Helen Beasley, Hayley M. Bennett, Karen Brooks, Bhavana Harsha, Rei Kajitani, Arpita Kulkarni, Dorothee Harbecke, Eiji Nagayasu, Sarah Nichol, Yoshitoshi Ogura, Michael A. Quail, Nadine Randle, Dong Xia, Norbert W. Brattig, Hanns Soblik, Diogo M. Ribeiro, Alejandro Sanchez-Flores, Tetsuya Hayashi, Takehiko Itoh, Dee R. Denver, Warwick Grant, Jonathan D. Stoltzfus, James B. Lok, Haruhiko Murayama, Jonathan Wastling, Adrian Streit, Taisei Kikuchi, Mark Viney, Matthew Berriman
Article
Infectious Diseases
Marco Albonico, Soren L. Becker, Peter Odermatt, Andrea Angheben, Mariella Anselmi, Arancha Amor, Beatrice Barda, Dora Buonfrate, Philip Cooper, Laurent Getaz, Jennifer Keiser, Virak Khieu, Antonio Montresor, Jose Munoz, Ana Requena-Mendez, Lorenzo Savioli, Richard Speare, Peter Steinmann, Lisette van Lieshout, Jurg Utzinger, Zeno Bisoffi
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Infectious Diseases
Djafsia Boursou, Dieudonne Ndjonka, Albert Eisenbarth, Kingsley Manchang, Archille Paguem, Nancy Ngwafu Ngwasiri, Jacqueline Dikti Vildina, Babette Abanda, Ralf Krumkamp, Silke van Hoorn, Alfons Renz, Mbunkah Daniel Achukwi, Eva Liebau, Norbert W. Brattig
BMC INFECTIOUS DISEASES
(2018)
Article
Parasitology
Norbert W. Brattig, Marcel Tanner, Robert Bergquist, Jurg Utzinger
Summary: The conference convened 120 researchers from over 20 countries to discuss the impact of environmental changes on infectious disease dynamics, with particular emphasis on food-, vector- and water-borne diseases. Speakers were encouraged to turn their talks into stand-alone manuscripts, resulting in a unique collection of 13 articles that highlight potential actions for preventing and mitigating the impact of environmental change on infectious diseases.
Review
Parasitology
Norbert W. Brattig, Robert A. Cheke, Rolf Garms
Summary: This review summarizes over a century of research on onchocerciasis, also known as river blindness, and its control. It discusses the history, milestones, current state, and future perspectives of the disease, highlighting successful control and elimination efforts in certain countries. It contributes to a deeper comprehension of this tissue-dwelling filaria disease and may aid in efforts to control and eliminate other filarial infections.
Article
Parasitology
Norbert W. Brattig, Robert Bergquist, Men-Bao Qian, Xiao-Nong Zhou, Juerg Utzinger
Article
Microbiology
Ngwafu Nancy Ngwasiri, Norbert W. Brattig, Dieudonne Ndjonka, Eva Liebau, Archile Paguem, Dustin Leusder, Manchang Tanyi Kingsley, Albert Eisenbarth, Alfons Renz, Achukwi Mbunkah Daniel
Summary: The study identified an O. ochengi galectin gene, confirmed its immunogenicity, and found a high degree of identity between O. ochengi and O. volvulus galectin, with similar immune reactivity. These results suggest the suitability of the cattle O. ochengi model for O. volvulus infection research.
Correction
Microbiology
Ngwafu Nancy Ngwasiri, Norbert W. Brattig, Dieudonne Ndjonka, Eva Liebau, Archile Paguem, Dustin Leusder, Manchang Tanyi Kingsley, Albert Eisenbarth, Alfons Renz, Achukwi Mbunkah Daniel
Review
Parasitology
Giovanni Benelli, Marion Wassermann, Norbert W. Brattig
Summary: Taeniosis/cysticercosis and echinococcosis are neglected zoonotic helminth infections with high disease burden caused by tapeworms. Arthropods play a key role in the spread of taeniid eggs in the environment, potentially infecting new hosts through direct ingestion of insects or contaminated food and water. Further research is needed to develop guidelines and actions to prevent taeniid infections worldwide.
VETERINARY PARASITOLOGY
(2021)
Article
Parasitology
Banchob Sripa, Lydia Leonardo, Sung-Jong Hong, Akira Ito, Norbert W. Brattig
Article
Parasitology
Norbert W. Brattig, Andrea Graf, Akuto Konou, Giovanni Casagrande, Jurg Utzinger, Lukas Meier
Summary: This article introduces the history and development of the international journal Acta Tropica, highlighting its importance in the fields of tropical medicine and parasitology. The number of publications in this journal has steadily increased in recent years, and its research scope has expanded to include emerging and re-emerging infectious diseases, non-communicable diseases, and environmental and climate change. Acta Tropica embraces interdisciplinary research to address global health issues and sustainable development.
Article
Parasitology
Andrea Graf, Akuto A. Konou, Lukas Meier, Norbert W. Brattig, Juerg Utzinger
Summary: Acta Tropica, established in 1944, has evolved over the years and become increasingly globally anchored, contributing not only to SDG 3 but also to SDG 17. In recent years, the journal has focused more on infectious diseases research and public health, with a particular emphasis on the health issues of low-and middle-income countries.
Article
Parasitology
Robert Bergquist, Norbert W. Brattig, Moses J. Chimbari, Jakob Zinsstag, Jurg Utzinger