Editorial Material
Cell Biology
Christabel N. Hikaambo, Natalia Shakela, John G. Woodland, Kathryn J. Wicht, Kelly Chibale
Summary: Zoonotic and related infections pose a significant health threat to Africa, the world's second-most populous continent. Despite the challenges faced by drug discovery scientists, recent progress in identifying potential medicines across diverse disease areas brings optimism and indicates African-led scientific initiatives are making progress.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Jayantee Kalita, Abhilasha Tripathi, Ruchi Shukla, Usha K. Misra, Sunil Kumar
Summary: This study investigates the expression of TNF alpha, IL6, and caspase-3 in patients with tuberculous meningitis (TBM) and compares these biomarkers between patients with and without tuberculoma. The findings suggest that TNF alpha and IL6 are upregulated in patients with tuberculoma but downregulated in patients without tuberculoma. The expression of TNF alpha is positively correlated with caspase-3, and higher expression of TNF alpha and caspase-3 is associated with patient mortality.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Prisca Lagardere, Romain Mustiere, Nadia Amanzougaghene, Sebastien Hutter, Marion Casanova, Jean-Francois Franetich, Shahin Tajeri, Aurelie Malzert-Freon, Sophie Corvaisier, Nadine Azas, Patrice Vanelle, Pierre Verhaeghe, Nicolas Primas, Dominique Mazier, Nicolas Masurier, Vincent Lisowski
Summary: The need for new compounds effective against multiple stages of Plasmodium falciparum development is urgent due to the increasing number of strains resistant to current treatments. In this study, 25 new 4-amino-substituted analogues based on Gamhepathiopine were synthesized and evaluated on both erythrocytic and hepatic stages of the parasite. A promising compound, N2-(tert-butyl)-N [4]-(3-(dimethylamino)propyl)-6-(p-tolyl)thieno[3,2-d]pyrimidine-2,4-diamine, showed improved physicochemical properties, intestinal permeability, and microsomal stability compared to Gamhepathiopine, while maintaining good anti-plasmodial activity on the erythrocytic and hepatic stages of Plasmodium falciparum and P. berghei.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Daniel J. Weiss, Amelia Bertozzi-Villa, Susan F. Rumisha, Punam Amratia, Rohan Arambepola, Katherine E. Battle, Ewan Cameron, Elisabeth Chestnutt, Harry S. Gibson, Joseph Harris, Suzanne Keddie, Justin J. Millar, Jennifer Rozier, Tasmin L. Symons, Camilo Vargas-Ruiz, Simon I. Hay, David L. Smith, Pedro L. Alonso, Abdisalan M. Noor, Samir Bhatt, Peter W. Gething
Summary: This study evaluated the impact of disruptions to malaria control on malaria incidence and mortality in Africa. Findings show that reductions in access to effective antimalarial drug treatment and insecticide-treated net coverage could lead to increased malaria burden, potentially doubling malaria mortality in 2020.
LANCET INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Adeola Y. Olukosi, Olusola Ajibaye, Omowunmi Omoniwa, Olusola Oresanya, Aina O. Oluwagbemiga, Chinazo Ujuju, Michael Ekholuenetale, Kolawole Maxwell, Colin J. Sutherland, James K. Tibenderana, Khalid B. Beshir
Summary: A rapid surveillance study was conducted in Ebonyi and Osun states in Nigeria to assess the suitability of sulfadoxine/pyrimethamine (SP) as perennial malaria chemoprevention (PMC). The study revealed that both states are suitable for SP-PMC implementation, and it has been implemented in Osun since 2022. Continuous monitoring of the 540E mutation is necessary to ensure the effectiveness of SP chemoprevention in Nigeria.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Microbiology
Gabriel Luiz Costa, Denise Anete Madureira Alvarenga, Anna Caroline Campos Aguiar, Jaime Louzada, Dhelio Batista Pereira, Tatiana Flavia De Oliveira, Antonio Augusto Fonseca Junior, Luzia Helena Carvalho, Cristiana Ferreira Alves De Brito, Tais Nobrega De Sousa
Summary: This study evaluated the performance of droplet digital PCR (ddPCR) in detecting Plasmodium DNA in saliva samples of individuals exposed to malaria transmission in the Brazilian Amazon region. The results showed that ddPCR had higher sensitivity in detecting malaria parasites in blood and swabs compared to traditional qPCR methods, and it was able to detect more mixed infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Damian Madan, Rafael Rivera, Corrie Ortega, Justin C. Touchon, Corinna Kimball, Geert-Jan Van Gemert, Wouter Graumans, Stephanie Matsuura, Sean S. Parghi, David Bell, Teun Bousema, Chris Drakeley, Katharine A. Collins, Thomas R. Burkot
Summary: This study demonstrates that measuring spermatozoa quantity in female Anopheles mosquitoes is an effective approach to assess mosquito age, which can improve vector control strategies for mosquito-borne diseases.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jessica N. McCaffery, Douglas Nace, Camelia Herman, Balwan Singh, Eric Mukomena Sompwe, Papy Mandoko Nkoli, Dieudonne Mumba Ngoyi, Gauthier Mesia Kahunu, Eric S. Halsey, Eric Rogier
Summary: A study conducted in the Democratic Republic of the Congo found a low prevalence of pfhrp2 and pfhrp3 gene deletions in blood samples from patients with Plasmodium falciparum infection. Single deletions of pfhrp2 and pfhrp3 were sporadically observed in the study sites, while dual deletions were not found. The use of HRP2-based RDTs still appears to be appropriate for these locations in DRC.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Ellie Sherrard-Smith, Peter Winskill, Arran Hamlet, Corine Ngufor, Raphael N'Guessan, Moussa W. Guelbeogo, Antoine Sanou, Rebecca K. Nash, Alexander Hill, Emma L. Russell, Mark Woodbridge, Patrick Tungu, Mara D. Kont, Tom Mclean, Christen Fornadel, Jason H. Richardson, Martin J. Donnelly, Sarah G. Staedke, Samuel Gonahasa, Natascha Protopopoff, Mark Rowland, Thomas S. Churcher
Summary: The study aimed at comparing the public health impact and cost-effectiveness of different malaria prevention measures through the use of mathematical modeling and empirical data, highlighting the importance of selecting vector control interventions based on local conditions and budget.
LANCET PLANETARY HEALTH
(2022)
Article
Multidisciplinary Sciences
Paulina Tindana, Rosemonde Guissou, Oladimeji Akeem Bolarinwa, Fatoumata Tou, Freek de Haan, Mehul Dhorda, Arjen M. Dondorp, Chanaki Amaratunga, Olugbenga Ayodeji Mokuolu, Jean Bosco Ouedraogo, Phaik Yeong Cheah
Summary: This paper presents an analysis of stakeholders' perspectives regarding key ethical considerations to be considered in the deployment of triple artemisinin-based combination therapies (TACTs) in Africa. Engagement with stakeholders and addressing ethical issues will be crucial for potential deployment of TACTs in Africa.
Article
Multidisciplinary Sciences
Camelia Herman, Colleen M. Leonard, Perpetua Uhomoibhi, Mark Maire, Delynn Moss, Uwem Inyang, Ado Abubakar, Abiodun Ogunniyi, Nwando Mba, Stacie M. Greby, McPaul I. Okoye, Nnaemeka C. Iriemenam, Ibrahim Maikore, Laura Steinhardt, Eric Rogier
Summary: In a nationwide HIV survey conducted in Nigeria in 2018, blood samples were collected from children aged 0-14 years and analyzed for the presence of Plasmodium antigens, DNA, and antibodies. The study found that children in Nigeria have widespread exposure to Pm, but lower rates of exposure to Po and Pv.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Immunology
Mitchell N. Lefebvre, John T. Harty
Summary: The new research shows that gamma delta T cells recognize Plasmodium-infected erythrocytes through the interaction of the T cell antigen receptor with the phosphoantigen sensor BTN3A1 and subsequently destroy infected cells either by secreting cytotoxic molecules or through antibody-dependent phagocytosis.
Article
Parasitology
Abel Cruz Camacho, Edo Kiper, Sonia Oren, Nir Zaharoni, Netta Nir, Noam Soffer, Yael Noy, Bar Ben David, Anna Rivkin, Ron Rotkopf, Dan Michael, Teresa G. Carvalho, Neta Regev-Rudzki
Summary: A high-throughput RT-qPCR platform was developed to investigate gene expression changes of Plasmodium falciparum during its lifecycle in the human host. The study found that the antimalarial drug dihydroartemisinin and choline significantly altered gene expression patterns and developmental rate of the parasites. In addition, lactate and kynurenic acid were identified as potential regulators of sexual differentiation in malaria parasites. This research expands our understanding of gene expression changes during sexual differentiation.
PARASITES & VECTORS
(2023)
Article
Microbiology
Brittany N. Araj, Bruce Swihart, Robert Morrison, Patricia Gonzales Hurtado, Andrew Teo, Almahamoudou Mahamar, Oumar Attaher, Bacary S. Diarra, Santara Gaoussou, Djibrilla Issiaka, Alassane Dicko, Patrick E. Duffy, Michal Fried
Summary: The study utilized proteomic analyses of PfEMP1 from clinical parasite isolates collected from Malian children to identify targets of immunity. Peptide-specific antibody responses in children were examined, and it was found that high antibody levels to specific PfEMP1 domains correlated with decreased parasite burden in future infections. These findings suggest that certain PfEMP1 domains play a role in protective immunity against malaria.
Article
Medicine, General & Internal
Mudsser Azam, Kirti Upmanyu, Ratan Gupta, Karugatharayil Sasi Sruthy, Monika Matlani, Deepali Savargaonkar, Ruchi Singh
Summary: Loop-mediated isothermal amplification (LAMP) based malaria diagnostic assays are crucial for strengthened surveillance in low-resource settings. The developed two-tube LAMP assay demonstrated high sensitivity and specificity for detecting P. vivax and P. falciparum infections, with comparable results to commercial kits and superior performance in detecting co-infections.
Article
Biochemistry & Molecular Biology
Babita Aneja, Mohammad Irfan, Md. Imtaiyaz Hassan, Amresh Prakash, Umesh Yadava, Constantin G. Daniliuc, Md. Zafaryab, M. Moshahid A. Rizvi, Amir Azam, Mohammad Abid
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2016)
Article
Biotechnology & Applied Microbiology
Asgar Ali, Syed Jafar Mehdi, Krishnan Hajela, Sundeep Singh Saluja, Pramod Kumar Mishra, Aga Syed Sameer, M. Moshahid Alam Rizvi
Article
Chemistry, Applied
Neha Mallick, Mohammed Anwar, Mohammed Asfer, Syed Hassan Mehdi, Mohammed Moshahid Alam Rizvi, Amulya Kumar Panda, Sushama Talegaonkar, Farhan Jalees Ahmad
CARBOHYDRATE POLYMERS
(2016)
Article
Environmental Sciences
Shahanshah Khan, Jawahar Singh Adhikari, Moshahid Alam Rizvi, Nabo Kumar Chaudhury
ENVIRONMENTAL TOXICOLOGY
(2017)
Article
Biochemistry & Molecular Biology
M. Asad Khan, Khursheed Alam, Kiran Dixit, M. Moshahid A. Rizvi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Biochemistry & Molecular Biology
Md. Asad Khan, Md. Zafaryab, Syed Hassan Mehdi, Irfan Ahmad, M. Moshahid A. Rizvi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Review
Chemistry, Medicinal
Wasim Akhtar, Mohemmed Faraz Khan, Garima Verma, M. Shaquiquzzaman, M. A. Rizvi, Syed Hassan Mehdi, Mymoona Akhter, M. Mumtaz Alam
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Md. Asad Khan, Md. Zafaryab, Syed Hassan Mehdi, Javed Quadri, M. Moshahid A. Rizvi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Article
Chemistry, Physical
Md. Mushtaque, Fernando Avecilla, Subhash S. Pingale, Kirtee M. Kamble, Zafar Yab, Mohammad Moshahid Alam Rizvi
JOURNAL OF MOLECULAR LIQUIDS
(2017)
Article
Chemistry, Physical
Md. Mushtaque, Fernando Avecilla, Zubair Bin Hafeez, Meriyam Jahan, Md. Shahzad Khan, M. Moshahid A. Rizvi, Mohd. Shahid Khan, Anurag Srivastava, Anwesha Mallik, Saurabh Verma
JOURNAL OF MOLECULAR STRUCTURE
(2017)
Article
Chemistry, Physical
Md Mushtaque, Fernando Avecilla, Ashanul Haque, Ahmad Perwez, Md Shahzad Khan, M. Moshahid Alam Rizvi
JOURNAL OF MOLECULAR STRUCTURE
(2017)
Article
Toxicology
Mohemmed Faraz Khan, Mohammad Mumtaz Alam, Garima Verma, Wasim Akhtar, Moshahid Alam Rizvi, Asif Ali, Mymoona Akhter, Mohammad Shaquiquzzaman
TOXICOLOGY MECHANISMS AND METHODS
(2017)
Article
Toxicology
Mohemmed Faraz Khan, Mohammad Mumtaz Alam, Garima Verma, Wasim Akhtar, Moshahid Alam Rizvi, Asif Ali, Mymoona Akhter, Mohammad Shaquiquzzaman
TOXICOLOGY MECHANISMS AND METHODS
(2017)
Review
Biochemistry & Molecular Biology
Md. Asad Khan, Khursheed Alam, Md. Zafaryab, M. Moshahid A. Rizvi
Article
Toxicology
Shahanshah Khan, Sandeep Choudhary, Arun Kumar, Akanchha Mani Tripathi, Amit Alok, Jawahar Singh Adhikari, Moshahid Alam Rizvi, Nabo Kumar Chaudhury
TOXICOLOGY REPORTS
(2016)
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)
