Journal
PARASITOLOGY
Volume 141, Issue 7, Pages 875-879Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0031182013002321
Keywords
Teladorsagia circumcinta; immunoglobulin A; parasite; immunology; sheep; Modelling
Categories
Funding
- EU
- Wellcome Trust [WT091717MA]
Ask authors/readers for more resources
Immunoglobulin A (IgA) activity has been associated with reduced growth and fecundity of Teladorsagia circumcincta. IgA is active at the site of infection in the abomasal mucus. However, while IgA activity in abomasal mucus is not easily measured in live animals without invasive methods, IgA activity can be readily detected in the plasma, making it a potentially valuable tool in diagnosis and control. We used a Bayesian statistical analysis to quantify the relationship between mucosal and plasma IgA in sheep deliberately infected with T. circumcincta. The transfer of IgA depends on mucosal IgA activity as well as its interaction with worm number and size; together these account for over 80% of the variation in plasma IgA activity. By quantifying the impact of mucosal IgA and worm number and size on plasma IgA, we provide a tool that can allow more meaningful interpretation of plasma IgA measurements and aid the development of efficient control programmes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available