Article
Veterinary Sciences
Nur Nasuha Hafidi, Jaclyn Swan, Pierre Faou, Rohan Lowe, Harinda Rajapaksha, Callum Cairns, Michael Stear, Travis Beddoe
Summary: Teladorsagia circumcincta is a major gastrointestinal parasite in the livestock industry in temperate regions worldwide, with its excretory-secretory molecules potentially playing critical roles in modulating host immune responses. Among these molecules, Tci-gal-1 protein interacts with host proteins to provide new insights into host-parasite interactions and potential control strategies.
VETERINARY SCIENCES
(2021)
Article
Parasitology
Tara Perez-Hernandez, Yolanda Corripio-Miyar, Julia N. Hernandez, Cynthia Machin, Yania Paz-Sanchez, Adam D. Hayward, Harry W. Wright, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet, Jorge F. Gonzalez
Summary: This study investigated the enhancement of resistance to gastrointestinal nematode infection in CHB lambs by immunizing them with a T. circumcincta prototype recombinant vaccine after weaning. The results showed that vaccinated CHB lambs had better protection against infection, with reduced egg shedding, lower worm burden, and altered immune response compared to unvaccinated control lambs.
VETERINARY PARASITOLOGY
(2022)
Article
Multidisciplinary Sciences
A. M. Ahbara, M. Rouatbi, M. Gharbi, M. Rekik, A. Haile, B. Rischkowsky, J. M. Mwacharo
Summary: The study revealed that traditionally managed indigenous sheep have evolved multiple strategies to combat gastrointestinal nematode infections, including enhancing resistance and developing defense mechanisms. Through molecular research, multiple potential genetic mechanisms were discovered, which contribute to understanding the resistance and developmental stability of these sheep.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Jalal Aliabadi, Ehsan Rakhshandehroo, Azadeh Yektaseresht
Summary: This study demonstrated that the indirect ELISA method using ES content can effectively distinguish T. circumcincta infected sheep with high specificity. Immunogenic fractions with specific molecular weights were detected in the somatic content and excretory/secretory material using western blot analysis.
BMC VETERINARY RESEARCH
(2021)
Article
Infectious Diseases
Gaetan-Romain Joliat, Sebastiao N. Martins-Filho, Simon Haefliger, Nicolas Demartines, Nermin Halkic, Ismail Labgaa, Christine Sempoux
Summary: This study analyzed the prognostic value of PD-L1 expression in tissue samples of patients with AE undergoing surgery. It found that patients with lower PD-L1 expression had better disease-free survival. These findings highlight the potential importance of PD-L1 in AE and the role of immune checkpoint blockade as a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Immunology
Anne C. S. Ramos, Luciana M. Oliveira, Yvanna L. D. C. O. Santos, Marlon C. S. Dantas, Cristiani I. B. Walker, Ana M. C. Faria, Lilian L. Bueno, Silvio S. Dolabella, Ricardo T. Fujiwara
Summary: This systematic review aimed to investigate the role of Immunoglobulin-A (IgA) as a mediator of protective immunity against gastrointestinal helminths. The results showed consistent associations between higher IgA levels and lower parasitological parameters in mice, rats, and sheep. However, the role of IgA in other host species remained uncertain, highlighting the need for further research.
IMMUNOLOGY LETTERS
(2022)
Article
Parasitology
Katarzyna Donskow-Lysoniewska, Marta Maruszewska-Cheruiyot, Katarzyna Krawczak-Wojcik, Jorge F. Gonzalez, Julia N. Hernandez, Michael J. Stear
Summary: The nematode's galectin competes with host galectin and inhibits mast cell degranulation, which is an important mechanism for the establishment and survival of gastrointestinal nematodes.
VETERINARY PARASITOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Kate J. Flay, Fraser I. Hill, Daniela Hernandez Muguiro
Summary: Infection with Haemonchus contortus parasites is a significant cause of anaemia in sheep, especially those raised in warm, high rainfall environments. This review examines the different stages and severity of haemonchosis, highlighting the various factors that influence the clinical symptoms.
Article
Biochemistry & Molecular Biology
Lauren E. Fuess, Jesse N. Weber, Stijn den Haan, Natalie C. Steinel, Kum Chuan Shim, Daniel Bolnick
Summary: The vertebrate immunity system consists of constitutive and inducible defenses, influenced by selective pressure from parasites and pathogens, leading to variations in immune responses across populations. Through a natural host-parasite model system, it was found that populations adapt to parasites through constitutive differences, shared inducible responses, and divergent inducible responses. Gene expression analysis showed limited divergence in constitutive immune defense expression, strong conserved inducible responses to parasites, and some immune-related genes with divergent inducible responses that may contribute to infection success or failure.
Article
Microbiology
Matthew A. Jackson, Claire Pearson, Nicholas E. Ilott, Kelsey E. Huus, Ahmed N. Hegazy, Jonathan Webber, B. Brett Finlay, Andrew J. Macpherson, Fiona Powrie, Lilian H. Lam
Summary: The study presents a detailed IgA-Seq protocol to accurately isolate IgA-bound taxa from intestinal samples and demonstrates the effectiveness of novel probability-based scores in accurately quantifying taxon-level IgA binding using simulated and experimental data. These methods improve the generation and interpretation of IgA-Seq datasets and have the potential to be applied to study other immunoglobulins and sample types.
Review
Microbiology
Maura Rojas-Pirela, Lisvaneth Medina, Maria Veronica Rojas, Ana Isabel Liempi, Christian Castillo, Elizabeth Perez-Perez, Jesus Guerrero-Munoz, Sebastian Araneda, Ulrike Kemmerling
Summary: Apicomplexans are pathogenic protists that cause various diseases in humans and animals, particularly impacting pregnant women. The exact pathogenic mechanisms of these diseases, which may have adverse effects during pregnancy, are still not fully understood.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Cynthia Machin, Yolanda Corripio-Miyar, Julia N. Hernandez, Tara Perez-Hernandez, Adam D. Hayward, Harry W. Wright, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet, Jorge F. Gonzalez
Summary: A recombinant sub-unit vaccine for Teladorsagia circumcincta showed protective effects in a susceptible sheep breed by enhancing antigen-specific antibodies and cellular immune responses. In a more resistant sheep breed, the vaccine did not significantly impact parasitological parameters, but may have had an effect through increasing mucosal T cell activation. These findings could be useful for improving the current vaccine prototype.
VETERINARY RESEARCH
(2021)
Article
Evolutionary Biology
Lauren E. Fuess, Daniel Bolnick
Summary: The risk and severity of pathogen infections depend on host immune function, which can vary between host populations or individuals. Recent studies have focused on population divergence in immunity using whole-tissue transcriptomics. However, this method cannot distinguish between evolved differences in gene regulation within cells and changes in cell composition. In this study, we used single-cell transcriptomic approaches to document the microevolution of immune system structure in three-spined stickleback fish. We identified significant variation in immune cell abundance and expression profiles among different populations and demonstrated how this information can enhance the interpretation of traditional transcriptomic data.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Immunology
Veronica Calonga-Solis, Leonardo M. Amorim, Ticiana D. J. Farias, Maria Luiza Petzl-Erler, Danielle Malheiros, Danillo G. Augusto
Summary: The study indicates that pemphigus foliaceus (PF) is an autoimmune blistering skin disease, and genetic variants within genes involved in B-cell development and antibody production confer differential susceptibility to endemic PF. These findings suggest potential candidates for functional studies to further understand the impact of immunoglobulin gene rearrangement on diseases.
Article
Genetics & Heredity
Yunus Arzik, Mehmet Kizilaslan, Stephen N. White, Lindsay M. W. Piel, Mehmet Ulas Cinar
Summary: This study used genome-wide association studies to identify candidate genes related to gastrointestinal parasite resistance in Akkaraman sheep, providing valuable insights for animal breeding programs.
Article
Infectious Diseases
Jason A. Galvis, Chris M. Jones, Joaquin M. Prada, Cesar A. Corzo, Gustavo Machado
Summary: Limited understanding of swine disease transmission dynamics hinders disease prevention and control efforts, making it crucial to develop forecasting systems. Three epidemiological models were compared to predict PEDV outbreaks, with a multi-model approach showing promising results in reducing disease spread and improving pig production systems' resilience.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Jason A. Galvis, Cesar A. Corzo, Joaquin M. Prada, Gustavo Machado
Summary: This study investigated the impact of different farm types and transmission routes on the spread of PRRSV, developed an epidemiological model to evaluate vaccination strategies, and found that local transmission played a significant role in sow farms infections, while animal movements were crucial in nursery farms infections.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Parasitology
Saeid Nikbin, Fazel Almasi, Dalal Alenizi, Caitlin Jenvey, Sarah Sloan, Sarah Preston, David Piedrafita, Nicholas Jonsson, Michael Stear
Summary: Bayesian modeling was used to estimate the heritability of egg counts of Nematodirus battus, a serious threat to young lambs. The results showed that there was no convincing evidence of heritability in the variation of egg counts, making selective breeding for resistance difficult.
Article
Biochemistry & Molecular Biology
Maja Machcinska, Magdalena Kierasinska, Martyna Michniowska, Marta Maruszewska-Cheruiyot, Ludmila Szewczak, Rafal Rola, Anna Karlinska, Michael Stear, Katarzyna Donskow-Lysoniewska
Summary: Altered regulatory T cell function is associated with multiple sclerosis. In this study, we investigated T cell phenotypes in patients with relapsing-remitting MS (RRMS) at an early stage of the disease. We found that the expression of PD-1 and GITR on CD4+ and CD8+ regulatory T cells was decreased in RRMS patients, while the levels of proinflammatory cytokines were increased. These findings suggest that a deficiency in PD-1 and GITR immune checkpoints on Tregs may contribute to impaired T cell control in RRMS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Sonia Natalie Mitchell, Andrew Lahiff, Nathan Cummings, Jonathan Hollocombe, Bram Boskamp, Ryan Field, Dennis Reddyhoff, Kristian Zarebski, Antony Wilson, Bruno Viola, Martin Burke, Blair Archibald, Paul Bessell, Richard Blackwell, Lisa A. A. Boden, Alys Brett, Sam Brett, Ruth Dundas, Jessica Enright, Alejandra N. N. Gonzalez-Beltran, Claire Harris, Ian Hinder, Christopher David Hughes, Martin Knight, Vino Mano, Ciaran McMonagle, Dominic Mellor, Sibylle Mohr, Glenn Marion, Louise Matthews, Iain J. J. McKendrick, Christopher Mark Pooley, Thibaud Porphyre, Aaron Reeves, Edward Townsend, Robert Turner, Jeremy Walton, Richard Reeve
Summary: Modern epidemiological analyses rely on access to and use of data, but the rapidly evolving nature of data and the imprecise identification of data use present challenges. This article introduces a data pipeline tool that allows for the annotation of data during analysis and the tracing of scientific outputs back to primary data, enhancing transparency and trust in decision-making.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Emma Taylor, Elsa Gladys Aguilar-Ancori, Ashley C. Banyard, Isis Abel, Clara Mantini-Briggs, Charles L. Briggs, Carolina Carrillo, Cesar M. Gavidia, Ricardo Castillo-Neyra, Alejandro D. Parola, Fredy E. Villena, Joaquin M. Prada, Brett W. Petersen, Nestor Falcon Perez, Cesar Cabezas Sanchez, Moises Sihuincha, Daniel G. Streicker, Ciro Maguina Vargas, Ana Maria Navarro Vela, Marco A. N. Vigilato, Hui Wen Fan, Rodney Willoughby, Daniel L. Horton, Sergio E. Recuenco
Summary: The Amazonian Tropical Bites Research Initiative (ATBRI) has been established to unify the control methods for neglected zoonotic diseases related to animal bites across Latin America, and provide evidence for policy-making.
INTERNATIONAL HEALTH
(2023)
Article
Parasitology
Katarzyna Donskow-Lysoniewska, Marta Maruszewska-Cheruiyot, Katarzyna Krawczak-Wojcik, Jorge F. Gonzalez, Julia N. Hernandez, Michael J. Stear
Summary: The nematode's galectin competes with host galectin and inhibits mast cell degranulation, which is an important mechanism for the establishment and survival of gastrointestinal nematodes.
VETERINARY PARASITOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcinska, Katarzyna Donskow-Lysoniewska
Summary: There has been little interaction between parasitologists and oncologists historically, although some helminth infections may predispose to tumor development. Recent research suggests that both tumors and parasites suppress the immune response to increase their chances of survival. They both exploit the TGF beta signaling pathway to modulate the immune response for their own benefit.
Review
Biochemistry & Molecular Biology
Michael Stear, Sarah Preston, David Piedrafita, Katarzyna Donskow-Lysoniewska
Summary: Nematode infection is a significant threat to human, domestic animal, and wildlife health. Resistance to infection varies among individuals, largely due to genetic variation in the immune response. Both host and nematode-derived factors play a role in regulating the immune response. However, the specific mechanisms underlying these interactions and the variation in immunomodulation among nematode species remain unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Marta Maruszewska-Cheruiyot, Katarzyna Krawczak-Wojcik, Martyna Michniowska, Michael James Stear, Maja Machcinska, Maria Doligalska, Katarzyna Donskow-Lysoniewska
Summary: Parasitic nematode infection has a significant influence on growth factors related to angiogenesis in autoimmune disorders. This study evaluated the impact of infection with the nematode Heligmosomoides polygyrus on the production of growth factors in murine autoimmune models. The findings suggest that parasitic infection can modify the levels of angiogenic factors and induce remodeling of vessels in the brain.
Article
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Ludmila Szewczak, Katarzyna Krawczak-Wojcik, Magdalena Kierasinska, Michael Stear, Katarzyna Donskow-Lysoniewska
Summary: The study evaluated the excretory-secretory proteins produced by H. polygyrus L4 stage nematodes that developed in a colitic milieu. Unique proteins were identified in the secretome of H. polygyrus L4 females and males that developed during colitis, which may be responsible for the therapeutic effects of nematodes in colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Fazel Almasi, Michael J. Stear, Majid Khansefid, Hien Nguyen, Aniruddha Desai, Jennie E. Pryce
Summary: This study aimed to estimate the repeatability and heritability of traits related to grazing and rumination activities and their correlations with other traits. The results showed that the repeatability of grazing traits was high, indicating that wearable sensors and SVM methods are reliable for recording sheep activities on pasture and have potential applications in selective breeding.
FRONTIERS IN ANIMAL SCIENCE
(2023)
Article
Veterinary Sciences
Michael Laurence Zini Lise, Jo Widdicombe, Claudia Ribeiro Zini Lise, Stefan Vilges de Oliveira, Eduardo Pacheco de Caldas, Mahbod Entezami, Joaquin M. Prada, Nilton Ghiotti, Rosangela Rodrigues E Silva, Katherina A. Vizcaychipi, Victor Del Rio Vilas
Summary: This study used two national databases in Brazil to describe the registered cases and mortality from echinococcosis from 1995 to 2016. The study found that although echinococcosis exists in Brazil, it is often underreported due to the lack of mandatory notification of cases. There was great variability in mortality rates between states, indicating possible differences in the quality of healthcare received by patients and highlighting the need to expand the compulsory notification of the disease across the country.
VETERINARY SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
F. Almasi, H. Nguyen, D. Heydarian, R. Sohi, S. Nikbin, C. J. Jenvey, E. Halliwell, E. N. Ponnampalam, A. Desai, M. Jois, M. J. Stear
Summary: This study investigates the distributions and variation of grazing behavior in 147 Merino lambs. The results show that different behaviors can be best described by different statistical distributions. The findings enhance our understanding of grazing behavior and provide a more appropriate approach to analyze the causes of variation in grazing behavior.
ANIMAL PRODUCTION SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Rajneet Sohi, Fazel Almasi, Hien Nguyen, Alexandra Carroll, Jason Trompf, Maneka Weerasinghe, Aidin Bervan, Boris Godoy, Awais Ahmed, Michael J. Stear, Aniruddha Desai, Markandeya Jois
Summary: The time of parturition in pregnant ewes can be predicted using wearable sensors and machine learning algorithms, providing necessary time for farm managers to take care of high-risk ewes during lambing. This knowledge could significantly improve sheep productivity and reduce lamb mortality rates.
ANIMAL PRODUCTION SCIENCE
(2022)
