Article
Multidisciplinary Sciences
Shuai Yan, Dong Wang, Junrui Zhang, Xiaojin Mo, Yu Feng, Liling Duan, Deyu Liu, Fan Li, Yongchun Dao, Ting Zhang, Wei Hu, Zheng Feng, Bin Zheng
Summary: The study in east Gansu province of China found that the prevalence of echinococcosis is associated with gender, age, and education level. The cross-sectional survey and prevalence surveillance both showed fluctuating rates of infection over different years.
SCIENTIFIC REPORTS
(2021)
Article
Parasitology
Li-Ying Wang, Min Qin, Laurent Gavotte, Wei-Ping Wu, Xixi Cheng, Jia-Xi Lei, Jun Yan, Roger Frutos
Summary: This study identified differences in risk factors for echinococcosis cases in Qinghai-Tibet Plateau and non-Qinghai-Tibet Plateau areas, including demographic characteristics and lifestyle factors. Therefore, tailored control techniques should be established based on the specific epidemic areas to improve echinococcosis prevention efforts.
PARASITES & VECTORS
(2022)
Article
Infectious Diseases
Wei He, Li-Ying Wang, Wen-Jie Yu, Guang-Jia Zhang, Bo Zhong, Sha Liao, Qi Wang, Rui-Rui Li, Liu Yang, Ren-Xin Yao, Yang Liu, Zeli Danba, Sheng-Chao Qin, Shi-An Wang, Yan-Xia Wang, Yan Huang, Qian Wang
Summary: The study investigated the prevalence and spatial distribution characteristics of human echinococcosis at the township level in Sichuan Province, China, revealing a spatial clustering of the disease. The high-high concentration areas were primarily located in some townships in the northwest of Sichuan Province, while the low-low concentration areas were predominantly located in some townships in the southeast of the province. The findings suggest that precise prevention and control strategies should be formulated for the clusters, specifically targeting the high-high clusters at the township level.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Multidisciplinary Sciences
Ling Chen, Xuefeng Fu, Peng Tian, Qing Li, Dan Lei, Zhangli Peng, Quanxian Liu, Nana Li, Jianyong Zhang, Peng Xu, Hong Zhang
Summary: The study found an increasing trend of tuberculosis cases in northern Guizhou Province, particularly rifampicin-resistant and concurrent extrapulmonary tuberculosis cases. Retreated patients had the highest odds of RR-TB, while patients aged 21-40 and certain demographic groups were more likely to have specific types of tuberculosis.
SCIENTIFIC REPORTS
(2021)
Article
Medical Informatics
Yongfeng Yang, Yangdan Cairang, Tian'an Jiang, Jianhua Zhou, Li Zhang, Baowen Qi, Shumei Ma, Lina Tang, Dong Xu, Lingdai Bu, Rui Bu, Xiang Jing, Hui Wang, Zubang Zhou, Cheng Zhao, Baoming Luo, Liwen Liu, Jianqin Guo, Yuzhen Nima, Guoyong Hua, Zengcheng Wa, Yuying Zhang, Guoyi Zhou, Wen Jiang, Changcheng Wang, Yang De, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Fangyi Liu, Jianping Dou, Hui Feng, Chong Wu, Ruifang Wang, Jie Hu, Qi Yang, Yanchun Luo, Jiapeng Wu, Haining Fan, Ping Liang, Jie Yu
Summary: This study aimed to develop a deep convolutional neural network (DCNN) model based on ultrasonography to identify and classify liver lesions, including echinococcosis. The results showed that the DCNN model demonstrated high accuracy and robustness in diagnosing echinococcosis and its types.
LANCET DIGITAL HEALTH
(2023)
Article
Multidisciplinary Sciences
Daren Zhao, Huiwu Zhang, Qing Cao, Zhiyi Wang, Sizhang He, Minghua Zhou, Ruihua Zhang
Summary: This study compared the ARIMA, GM(1,1), and LSTM models for tuberculosis case predictions in mainland China and found that the LSTM model performed the best.
Article
Parasitology
Tian Ma, Qian Wang, Mengmeng Hao, Chuizhao Xue, Xu Wang, Shuai Han, Qian Wang, Jiangshan Zhao, Xiao Ma, Xianglin Wu, Xiaofeng Jiang, Lei Cao, Yaming Yang, Yu Feng, Quzhen Gongsang, Juergen Scheffran, Liqun Fang, Richard James Maude, Canjun Zheng, Fangyu Ding, Weiping Wu, Dong Jiang
Summary: This study used the national echinococcosis survey data from 2012 to 2016 to investigate the spatial prevalence, demographic characteristics, and risk factors of cystic and alveolar echinococcosis in China. The results showed that female gender, older age, occupation as a herdsman or religious worker, and illiteracy were identified as risk factors for both types of echinococcosis. The prevalence of the diseases varied geographically, with high endemicity observed in the Tibetan Plateau region. Various environmental, biological, and social factors were found to be associated with the diseases. The findings will contribute to the development of targeted prevention measures and disease control strategies.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Ye-Sheng Wang, Wen-Long Zhu, Tao Li, Wei Chen, Wei-Bing Wang
Summary: The study analyzed data from 1997 to 2018 and found a significant decline in newly notified cases of tuberculosis in China overall, especially in the eastern and central regions. However, tuberculosis in western China remains a pressing public health emergency that requires urgent attention. Effective prevention and control strategies are needed for regions with high disease burdens and those with increasing or stable numbers of newly notified and smear-positive cases of tuberculosis.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Orthopedics
Laihong Yang, Pahati Tuxunjiang, Wenya Liu, Hui Guo
Summary: This study retrospectively analyzed the clinical manifestations, laboratory tests, radiological findings, and treatment of 44 patients with vertebral and pelvic echinococcosis. The results showed that bone echinococcosis is relatively rare but can cause severe symptoms and high recurrence rates. Therefore, the possibility of bone echinococcosis should be considered for patients with vertebral and pelvic destruction, especially among herdsmen in endemic regions.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Medicine, General & Internal
Dong-Mei Wang, Qi An, Qing Yang, Yi Liao, Yao Jian
Summary: This study analyzed the epidemiological characteristics, common sites, and drug resistance profiles of osteoarticular tuberculosis (TB) infections in southwest China. The results showed that osteoarticular TB mainly affected middle-aged and young men with poor nutritional status, and cases from ethnic minority areas accounted for a large proportion. Spinal TB was prone to occur in the lumbar and thoracic vertebrae, while joint TB was prone to occur in the lower limb joints. Over the past 9 years, there has been an increasing trend in the number of TB cases, and drug resistance has also increased.
FRONTIERS IN MEDICINE
(2023)
Article
Environmental Sciences
Shanhua Sun, Qinxue Chang, Junyu He, Xianyu Wei, Hailong Sun, Yuanyong Xu, Ricardo J. Soares Magalhaes, Yuming Guo, Zhuang Cui, Wenyi Zhang
Summary: This study aimed to explore the impact of air pollutants and meteorological factors on tuberculosis (TB) in Beijing and provide novel insights for public health managers to formulate control strategies. The study found significant associations between NO2, wind speed, temperature, humidity, ozone, and TB cases, but no significant associations with PM2.5, SO2, and sunshine duration.
ENVIRONMENTAL RESEARCH
(2023)
Article
Infectious Diseases
Liying Wang, Qian Wang, Huixia Cai, Hu Wang, Yan Huang, Yu Feng, Xuefei Bai, Min Qin, Sylvie Manguin, Laurent Gavotte, Weiping Wu, Roger Frutos
Summary: Human echinococcosis is a global issue but is most prevalent in China, especially in western regions like the Tibetan Plateau. Dogs are key hosts for Echinococcus, making it crucial to monitor the presence of the worms in dogs for disease control. Different detection kits are used in China, but their efficacy, particularly in terms of sensitivity and specificity, needs further improvement for effective echinococcosis management.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Ling Chen, Xiaodan Wang, Xudong Jia, Yuanbo Lan, Haibo Yi, Xiaomin Wang, Peng Xu
Summary: China, as one of the top countries with high tuberculosis burden, has seen the overall incidence of TB declining. However, in economically less developed areas, such as the one studied here, the burden of TB is increasing.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Yang Gao, Wei Wang, Chuang Lyu, Xin-Yu Wei, Yu Chen, Quan Zhao, Zhi-Guang Ran, You-Qing Xia
Summary: This study conducted a systematic review and meta-analysis of echinococcosis in sheep in China, estimating a combined prevalence of 30.9% from 1983 to 2020. The prevalence varied by region and age, with higher infection rates in certain geographic and climatic conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Geography, Physical
Dong Shijie, Xin Liangjie, Li Shengfa, Xie Hualin, Zhao Yuluan, Wang Xue, Li Xiubin, Song Hengfei, Lu Yahan
Summary: Urbanization and industrialization in China have led to the marginalization of arable land in hilly and mountainous regions, with the abandonment of terraces becoming widespread. The extent of terrace abandonment is higher in the southern regions and lower in the northern regions. The main driving factors of terrace abandonment include rural labor migration, agricultural mechanization level, irrigation conditions, and transportation conditions for cultivation. Targeted measures should be taken to alleviate terrace abandonment based on the specific conditions of each area.
JOURNAL OF GEOGRAPHICAL SCIENCES
(2023)
Review
Immunology
Fei-Yue Li, Xun-Ya Hou, Hong-Zhuan Tan, Gail M. Williams, Darren J. Gray, Catherine A. Gordon, Johanna Kurscheid, Archie C. A. Clements, Yue-Sheng Li, Donald P. McManus
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Donald P. McManus
Article
Biochemistry & Molecular Biology
Hong You, Johannes U. Mayer, Rebecca L. Johnston, Haran Sivakumaran, Shiwanthi Ranasinghe, Vanessa Rivera, Olga Kondrashova, Lambros T. Koufariotis, Xiaofeng Du, Patrick Driguez, Juliet D. French, Nicola Waddell, Mary G. Duke, Wannaporn Ittiprasert, Victoria H. Mann, Paul J. Brindley, Malcolm K. Jones, Donald P. McManus
Summary: CRISPR/Cas9-mediated genome editing has shown great potential for genetic modification of helminth parasites, as demonstrated by successful gene knock-in in Schistosoma mansoni eggs. This study confirmed the utility of CRISPR/Cas9 for functional genomics in schistosomes through combining CRISPR/Cas9 with single-stranded oligodeoxynucleotides (ssODNs).
Article
Infectious Diseases
Baoping Guo, Zhuangzhi Zhang, Yongzhong Guo, Gang Guo, Haiyan Wang, Jianjun Ma, Ronggui Chen, Xueting Zheng, Jianling Bao, Li He, Tian Wang, Wenjing Qi, Mengxiao Tian, Junwei Wang, Canlin Zhou, Patrick Giraudoux, Christopher G. Marston, Donald P. McManus, Wenbao Zhang, Jun Li
Summary: The study analyzed the Alveolar Echinococcosis (AE) cases in Yili Prefecture, Xinjiang Autonomous Region, China and found that the high-altitude mountainous areas are important for disease transmission, with higher incidence rates among Mongolian and Kazak ethnic groups.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Review
Microbiology
Madeleine J. Rogers, Donald P. McManus, Stephen Muhi, Catherine A. Gordon
Summary: Parasitic neglected tropical diseases affect over one billion people worldwide, especially those in low-socioeconomic areas. The lack of infrastructure and sensitive, affordable diagnostic methods hinder disease management programs. Membrane technology offers a solution for simplifying sample storage and diagnostic procedures, although cost remains a barrier for accessibility in endemic regions. New, simple, rapid, accurate, and cost-effective immunological procedures and nucleic acid diagnostics protocols are necessary for progressing control efforts towards elimination of these diseases.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Review
Immunology
Donald P. McManus
Summary: Schistosomiasis is a widespread disease in developing countries that poses a threat to public health with no preventive measures currently available. Vaccine research is crucial in addressing this issue.
Review
Biochemistry & Molecular Biology
Adebayo J. Molehin, Donald P. McManus, Hong You
Summary: Schistosomiasis, a neglected tropical parasitic disease caused by human blood flukes, lacks an available vaccine despite being ranked as one of the top 10 urgently needed vaccines by Science. This review highlights the current progress of schistosomiasis vaccines under clinical development and emphasizes the need for revolutionary and effective vaccine pipeline utilizing cutting-edge technologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Geoffrey N. Gobert, Donald P. McManus, Geoff McMullan, Christopher J. Creevey, Jack Carson, Malcolm K. Jones, Sujeevi S. K. Nawaratna, Kosala G. Weerakoon, Hong You
Summary: This study used FISH and microbial profiling techniques to demonstrate for the first time the presence of bacteria on the epithelial surfaces of adult schistosomes, which differ from the host blood and bile. These schistosome surface-associated bacteria are considered an important component of the host-parasite interaction.
Review
Microbiology
Hong You, Malcolm K. Jones, Catherine A. Gordon, Alexa E. Arganda, Pengfei Cai, Harry Al-Wassiti, Colin W. Pouton, Donald P. McManus
Summary: Despite long-term efforts, developing effective vaccines against parasitic infections has been challenging due to the complexity of parasite life cycles and their interactions with hosts. Traditional vaccine platforms have proven unsuitable for many parasitic diseases. A new wave of research using mRNA vaccines is anticipated to advance the prevention of parasitic infections.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Infectious Diseases
Allen G. Ross, Donald A. Harn, Delia Chy, Marianette Inobaya, Jerric R. Guevarra, Lisa Shollenberger, Yuesheng Li, Donald P. McManus, Darren J. Gray, Gail M. Williams
Summary: This study demonstrates the effectiveness of a bovine vaccine in reducing human schistosome infection. Bovine vaccination significantly decreased the rate of human infection, and the best outcome was achieved when combined with snail mollusciciding.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Multidisciplinary Sciences
Nalini Kaushalya Jayakody, Poornima Lakshini Kumbukgahadeniya, Anjana Silva, Nuwan Darshana Wickramasinghe, Susiji Wickramasinghe, Donald Peter McManus, Kosala Gayan Weerakoon
Summary: Human intestinal nematode infections are a global public health issue, especially in developing countries where there is a shortage of experienced laboratory staff and diagnostic technologies. Molecular methods, such as nucleic acid amplification, have increased the sensitivity of detection for these infections. However, the absence of a gold standard test limits current diagnosis and control efforts.
Article
Medicine, Research & Experimental
Qin Li, Jing Xu, Shi-Zhu Li, Juerg Utzinger, Donald P. McManus, Xiao-Nong Zhou
Summary: The World Bank Loan Project (WBLP) in China significantly contributed to the prevention, control, and elimination of schistosomiasis, with positive impacts on management mechanism reform, technological innovation, and epidemiological changes. The project played a crucial role in enhancing schistosomiasis control and shaping the response towards its elimination in China, offering valuable experiences for similar efforts elsewhere.
Review
Infectious Diseases
Oyime Poise Aula, Donald P. McManus, Malcolm K. Jones, Catherine A. Gordon
Summary: Schistosomiasis remains a major issue in Africa, with 800 million people at risk of infection and current control strategies primarily relying on praziquantel treatment. More effective control and elimination strategies are needed to address the disease.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Medicine, Research & Experimental
Yangyue Ni, Zhipeng Xu, Chen Li, Yuxiao Zhu, Ran Liu, Fan Zhang, Hao Chang, Maining Li, Liang Sheng, Zhong Li, Min Hou, Lin Chen, Hong You, Donald P. McManus, Wei Hu, Yinong Duan, Yu Liu, Minjun Ji
Summary: The study revealed the association between decreased miR-802 and impaired lipid metabolism in Schistosoma japonicum infected mice. Decreased miR-802 promoted the activation of the AMPK pathway, leading to reduced hepatic lipogenesis. Schistosome-derived soluble egg antigens interacted with CD36 on hepatocytes to inhibit miR-802 and attenuate lipogenesis.
Review
Biochemistry & Molecular Biology
Xiaofeng Du, Donald P. McManus, Juliet D. French, Malcolm K. Jones, Hong You
Summary: The main challenges in using CRISPR/Cas9 for parasitic worms lie in enhancing gene mutation efficiency and addressing issues related to host passage to ensure survival of mutated parasites. Strategies developed for CRISPR/Cas9 studies on other organisms may help overcome these obstacles, and utilizing CRISPR/Cas9-mediated gene drive could offer a novel approach for controlling parasitic worms.
