Article
Endocrinology & Metabolism
Louis de Mestier, Frederique Savagner, Hedia Brixi, Christine Do Cao, Sophie Dominguez-Tinajero, Guillaume Roquin, Bernard Goichot, Olivia Hentic, Olivier Dubreuil, Vincent Hautefeuille, Thomas Walter, Guillaume Cadiot
Summary: This study compared the diagnostic performances of three biomarkers in midgut NETs and found that Ou5HIAA and p5HIAA could be used as more convenient alternatives to 24u5HIAA. These two markers were significantly correlated with clinical features such as carcinoid syndrome, carcinoid heart disease, and liver metastatic involvement greater than 30%.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Takeshi Tanaka, Masahiko Mori, Masato Tashiro, Koichi Izumikawa
Summary: Plasma 5-HIAA is identified as a biomarker for the severity of ARDS and is a strong predictor for mortality rate, highlighting the importance of evaluating vascular leakage levels in ARDS treatment.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Taymeyah Al-Toubah, Brian Morse, Jonathan Strosberg
Summary: The CAPTEM regimen shows significant activity in high-grade small bowel NETs, but is less effective in patients with low/intermediate-grade tumors.
Article
Endocrinology & Metabolism
Elisa Lenotti, Andrea Alberti, Francesca Spada, Vito Amoroso, Patrick Maisonneuve, Salvatore Grisanti, Alice Baggi, Susanna Bianchi, Nicola Fazio, Alfredo Berruti
Summary: This study retrospectively evaluated the outcomes of patients with metastatic lung NET treated with first line SSAs in two Italian reference Institutions from 2014 to 2019. The results showed that the long PFS and OS obtained suggest that SSAs could be effective as a first line approach in managing patients with progressive, metastatic pulmonary NET.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Clemence Delhomme, Thomas Walter, Dimitri Arangalage, Gaspard Suc, Olivia Hentic, Agnes Cachier, Soleiman Alkhoder, Laurent Francois, Catherine Lombard-Bohas, Bernard Iung, Philippe Ruszniewski, Louis de Mestier
Summary: Carcinoid heart disease (CHD) is a major complication of carcinoid syndrome (CS) associated with metastatic small intestine neuroendocrine tumors (NETs). The formation of fibrous plaques involving the right side of the heart is mainly caused by vasoactive hormones secreted by NETs, particularly serotonin. Diagnosis of CHD can be delayed as patients are often asymptomatic despite severe heart valve involvement. Treatment of CHD requires a multidisciplinary approach, including antitumor treatment, control of CS, and surgical valve replacement in severe cases.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Electrochemistry
Sonia Sam, Goldamol S. Pallam, K. Girish Kumar
Summary: In this report, the first voltammetric sensor for simultaneous determination of neuroendocrine tumour biomarkers 5-Hydroxy indole acetic acid (HIAA) and Vannillyl mandelic acid (VMA) is presented. A glassy carbon electrode modified with a copolymer of taurine and glutamic acid was used to detect the analytes. The combined effect of the two conducting polymers showed significant voltammetric response for the biomarkers. Calibration measurements were conducted using a fast and feasible square wave voltammetric technique. The voltammetric sensor achieved detection limits as low as 4.19 x 10(-8) M (HIAA) and 6.16 x 10(-8) M (VMA) with tolerable interference from coexisting species. Additionally, spike recovery analysis of the analytes in artificial urine samples showed adequate recovery values, demonstrating the reliability of the sensor.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2023)
Article
Medicine, Research & Experimental
Mfon Ewang-Emukowhate, Krithika Subramaniam, Francis Lam, Aimee Hayes, Dalvinder Mandair, Christos Toumpanakis, Ashley Grossman, Devaki Nair, Martyn Caplin
Summary: This study assessed the application of 5-hydroxyindole acetic acid as a biochemical marker of neuroendocrine tumours in plasma and serum. The results showed that plasma and serum 5-hydroxyindole acetic acid had similar sensitivity and specificity compared to the urinary assay. Therefore, plasma and serum samples can be interchangeably used for this testing.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Tim Meyer, Martyn Caplin, Mohid S. Khan, Christos Toumpanakis, Shishir Shetty, John K. Ramage, Aude Houchard, Kate Higgs, Tahir Shah
Summary: CALM-NET was a phase IV exploratory study conducted in the UK to evaluate if the presence of circulating tumour cells (CTCs) at baseline could predict symptomatic response in patients with midgut neuroendocrine tumours (NETs) treated with lanreotide autogel (LAN). The study found that patients without baseline CTCs may be more likely to achieve a symptomatic response following LAN treatment, and there was a correlation between plasma 5-HIAA and urinary 5-HIAA during LAN treatment.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Seung Lee, Sang-Mi Kim, Ja-Hyun Jang, Hyung-Doo Park, Soo-Youn Lee
Summary: The study found that the increased ratio of 5-hydroxyindoleacetic acid to serotonin may serve as a surrogate marker for VAKI, reflecting acute oxidative stress and inflammation.
Article
Oncology
Jace P. Landry, Brianne A. Voros, Robert A. Ramirez, J. Philip Boudreaux, Eugene A. Woltering, Ramcharan Thiagarajan
Summary: The study evaluated the metastatic potential of appendiceal neuroendocrine tumors (ANETs) < 2 cm diameter and found that smaller tumors had metastatic capability. Factors like patient age, tumor characteristics were associated with metastatic diseases. Appendectomy alone was deemed sufficient for most ANETs patients, regardless of tumor size.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Microbiology
Fang Li, Liuyiqi Jiang, Shuming Pan, Shaowei Jiang, Yiwen Fan, Chao Jiang, Chengjin Gao, Yuxin Leng
Summary: This study demonstrates that modulation of the microbiome and metabolism can effectively prevent intestinal damage induced by IAH, with 5-HIAA identified as a potential metabolic marker for IAH and sepsis.
Review
Psychiatry
Anna La Salvia, Alberto Portigliatti Pomeri, Irene Persano, Elena Trevisi, Elena Parlagreco, Nicoletta Colombi, Maria Pia Brizzi, Rocco Luigi Picci, Francesco Oliva
Summary: Neuroendocrine tumors (NETs) are rare and malignant neoplasms with the potential to produce metabolically active substances, resulting in clinical syndromes. Psychiatric disorders among NET patients are often overlooked and have received little research attention, highlighting the need for detailed psychiatric evaluation, especially in those with carcinoid syndrome (CS) and symptoms suggestive of psychiatric involvement.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Kenneth P. Seastedt, George A. Alyateem, Karthik Pittala, Seth M. Steinberg, David S. Schrump, Lynnette K. Nieman, Chuong D. Hoang
Summary: This study analyzed the outcomes of lung neuroendocrine tumors associated with Cushing syndrome and found that these tumors have higher nodal metastasis, higher recurrence rates, and shorter disease-free survival compared to quiescent bronchopulmonary carcinoid tumors. However, many patients still experienced favorable outcomes, indicating that a lung-sparing approach could be sufficient. These results suggest that the hormone physiology may play a more important role than the carcinoid biologic factors in determining prognosis.
Article
Oncology
Yue Cheng, Lowell Anthony, Chris Delcher, Daniela C. Moga, Aman Chauhan, Bin Huang, Val Adams
Summary: This study evaluated the real-world utilization of long-acting release (LAR) and immediate-release (IR) in patients with neuroendocrine tumors (NETs). The results showed that a significant percentage of LAR prescriptions exceeded the recommended maximum dose, while a small percentage of LAR prescriptions had preceding IR use. Furthermore, patients with NETs or carcinoid syndrome (CS) were more likely to experience dose escalation compared to patients with an unknown diagnosis.
Article
Oncology
Yue Cheng, Lowell Anthony, Chris Delcher, Daniela C. Moga, Aman Chauhan, Bin Huang, Val Adams
Summary: This study evaluates the real-world utilization of octreotide long-acting release (LAR) and immediate-release (IR) in the treatment of neuroendocrine tumors (NETs). It found that dosing above the label-maximum dose of LAR is common and IR rescue dosing is underutilized. Patients with NETs or carcinoid syndrome (CS) are more likely to experience dose escalations and have a higher proportion of IR use before dose escalation compared to those with an unknown diagnosis.
Article
Cell Biology
John P. Lee, Yin P. Hung, Thomas M. O'Dorisio, James R. Howe, Jason L. Hornick, Andrew M. Bellizzi
Article
Radiology, Nuclear Medicine & Medical Imaging
Yusuf Menda, Thomas M. O'Dorisio, James R. Howe, Michael Schultz, Joseph S. Dillon, David Dick, G. Leonard Watkins, Timothy Ginader, David L. Bushnell, John J. Sunderland, Gideon K. D. Zamba, Michael Graham, M. Sue O'Dorisio
JOURNAL OF NUCLEAR MEDICINE
(2017)
Article
Medicine, General & Internal
J. Strosberg, G. El-Haddad, E. Wolin, A. Hendifar, J. Yao, B. Chasen, E. Mittra, P. L. Kunz, M. H. Kulke, H. Jacene, D. Bushnell, T. M. O'Dorisio, R. P. Baum, H. R. Kulkarni, M. Caplin, R. Lebtahi, T. Hobday, E. Delpassand, E. Van Cutsem, A. Benson, R. Srirajaskanthan, M. Pavel, J. Mora, J. Berlin, E. Grande, N. Reed, E. Seregni, K. Oberg, M. Lopera Sierra, P. Santoro, T. Thevenet, J. L. Erion, P. Ruszniewski, D. Kwekkeboom, E. Krenning
NEW ENGLAND JOURNAL OF MEDICINE
(2017)
Article
Gastroenterology & Hepatology
Allen B. Choi, Jessica E. Maxwell, Kendall J. Keck, Andrew J. Bellizzi, Joseph S. Dillon, Thomas M. O'Dorisio, James R. Howe
Article
Gastroenterology & Hepatology
Jonathan R. Strosberg, Thorvardur R. Halfdanarson, Andrew M. Bellizzi, Jennifer A. Chan, Joseph S. Dillon, Anthony P. Heaney, Pamela L. Kunz, Thomas M. O'Dorisio, Riad Salem, Eva Segelov, James R. Howe, Rodney F. Pommier, Kari Brendtro, Mohammad A. Bashir, Simron Singh, Michael C. Soulen, Laura Tang, Jerome S. Zacks, James C. Yao, Emily K. Bergsland
Article
Gastroenterology & Hepatology
Nancy Sharma, Boris G. Naraev, Eric G. Engelman, M. Bridget Zimmerman, David L. Bushnell, Thomas M. O'Dorisio, M. Sue O'Dorisio, Yusuf Menda, Jan Mueller-Brand, James R. Howe, Thorvardur R. Halfdanarson
Article
Surgery
Kendall J. Keck, Jessica E. Maxwell, Yusuf Menda, Andrew Bellizzi, Joseph Dillon, Thomas M. O'Dorisio, James R. Howe
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark T. Madsen, Yusuf Menda, Thomas M. O'Dorisio, M. Sue O'Dorisio
Article
Surgery
Kendall J. Keck, Patrick Breheny, Terry A. Braun, Benjamin Darbro, Guiying Li, Joseph S. Dillon, Andrew M. Bellizzi, Thomas M. O'Dorisio, James R. Howe
Article
Anatomy & Morphology
Thomas W. Czeczok, Kristen M. Stashek, Jessica E. Maxwell, Thomas M. O'Dorisio, James R. Howe, Jason L. Hornick, Andrew M. Bellizzi
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2018)
Article
Oncology
Kendall J. Keck, Jessica E. Maxwell, Alan F. Utria, Andrew M. Bellizzi, Joseph S. Dillon, Thomas M. O'Dorisio, James R. Howe
ANNALS OF SURGICAL ONCOLOGY
(2018)
Article
Medicine, Research & Experimental
Shaikamjad Umesalma, Courtney A. Kaemmer, Jordan L. Kohlmeyer, Blake Letney, Angela M. Schab, Jacqueline A. Reilly, Ryan M. Sheehy, Jussara Hagen, Nitija Tiwari, Fenghuang Zhan, Mariah R. Leidinger, Thomas M. O'Dorisio, Joseph Dillon, Ronald A. Merrill, David K. Meyerholz, Abbey L. Perl, Bart J. Brown, Terry A. Braun, Aaron T. Scott, Timothy Ginader, Agshin F. Taghiyev, Gideon K. Zamba, James R. Howe, Stefan Strack, Andrew M. Bellizzi, Goutham Narla, Benjamin W. Darbro, Frederick W. Quelle, Dawn E. Quelle
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Oncology
Aaron T. Scott, Daniel Pelletier, Jessica E. Maxwell, Scott K. Sherman, Kendall J. Keck, Guiying Li, Joseph S. Dillon, Thomas M. O'Dorisio, Andrew M. Bellizzi, James R. Howe
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Kendall J. Keck, Allen Choi, Jessica E. Maxwell, Guiying Li, Thomas M. O'Dorisio, Patrick Breheny, Andrew M. Bellizzi, James R. Howe
ANNALS OF SURGICAL ONCOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mohammadali Hamiditabar, Muzammil Ali, Joseph Roys, Edward M. Wolin, Thomas M. O'Dorisio, David Ranganathan, Izabela Tworowska, Jonathan R. Strosberg, Ebrahim S. Delpassand
CLINICAL NUCLEAR MEDICINE
(2017)