Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 58, Issue 7, Pages 1054-1057Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.116.180984
Keywords
neuroendocrine; PET/CT; Ga-68-DOTATOC; neuroendocrine tumor; unknown primary
Funding
- NIH [1R01CA167632, 1P50CA174521-01A1]
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Localization of the site of the unknown primary tumor is critical for surgical treatment of patients presenting with neuroendocrine tumor (NET) with metastases. Methods: Forty patients with metastatic NET and unknown primary site underwent Ga-68-DOTATOC PET/CT in a single-site prospective study. The Ga-68-DOTATOC PET/CT was considered true-positive if the positive primary site was confirmed by histology or follow-up imaging. The scan was considered false-positive if no primary lesion was found corresponding to the Ga-68-DOTATOC-positive site. All negative scans for primary tumor were considered false-negative. A scan was classified unconfirmed if Ga-68-DOTATOC PET/CT suggested a primary, however, no histology was obtained and imaging follow-up was not confirmatory. Results: The true-positive, false-positive, false-negative, and unconfirmed rates for unknown primary tumor were 38%, 7%, 50%, and 5%, respectively. Conclusion: Ga-68-DOTATOC PET/CT is an effective modality in the localization of unknown primary in patients with metastatic NET.
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