Review
Biochemistry & Molecular Biology
Ana Bogut, Bojan Stojanovic, Marina Jovanovic, Milica Dimitrijevic Stojanovic, Nevena Gajovic, Bojana S. Stojanovic, Goran Balovic, Milan Jovanovic, Aleksandar Lazovic, Milos Mirovic, Milena Jurisevic, Ivan Jovanovic, Violeta Mladenovic
Summary: This review provides a comprehensive overview of the multifaceted role of Galectin-1 in Pancreatic Ductal Adenocarcinoma (PDAC), including its contributions to tumor stroma remodeling, angiogenesis, metabolic reprogramming, and potential implications for therapeutic interventions. The challenges associated with targeting Galectin-1 are discussed, and the promising prospects of Gal-1 inhibition, including the utilization of nanotechnology and theranostics, are highlighted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yang Wu, Chun Zhang, Kuirong Jiang, Jens Werner, Alexandr V. Bazhin, Jan G. D'Haese
Summary: PDAC progression is influenced by PSCs, which through interactions with PCCs and other stroma cells, establish a tumor microenvironment that promotes tumor growth, metastasis, and chemoresistance. Targeting stroma has emerged as a promising strategy for PDAC therapy, with several novel strategies proposed to intervene in this complex crosstalk.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Roman Bubin, Romans Uljanovs, Ilze Strumfa
Summary: The discovery of cancer stem cells (CSCs) in leukemia has led to active research on stemness in neoplastic tissues. CSCs are a subpopulation of malignant cells with unique properties, including a dedifferentiated state, self-renewal, pluripotency, resistance to therapy, epigenetic alterations, and higher tumorigenicity. CSCs have been confirmed in various malignancies, including pancreatic ductal adenocarcinoma, which has a poor prognosis. This review aims to summarize the current knowledge on the markers and molecular features of CSCs in pancreatic ductal adenocarcinoma and the therapeutic options for their elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
George Sharbeen, Joshua A. McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R. Cox, Brooke A. Pereira, Jessica L. Chitty, Sigrid K. Fey, Arafath K. Najumudeen, Andrew D. Campbell, Owen J. Sansom, Rosa Mistica C. Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J. Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti Apte, Thomas P. Davis, Jennifer P. Morton, Koroush S. Haghighi, Jorjina Kasparian, Benjamin J. McLean, Yordanos F. Setargew, Phoebe A. Phillips
Summary: High expression of SLC7A11 in human PDAC tumor stroma, independently prognostic of poorer overall survival. The study demonstrates that PDAC-derived CAFs are highly dependent on SLC7A11 for cystine uptake and glutathione synthesis. Inhibition of SLC7A11 decreases CAF proliferation, reduces their resistance to oxidative stress, and inhibits their ability to support PDAC cell growth.
Article
Oncology
A. Allam Mohamed, Andreas Thomsen, Marie Follo, Costantinos Zamboglou, Peter Bronsert, Hanan Mostafa, Aber Amen, Mohamed Mekawy, Anca L. Grosu, Thomas B. Brunner
Summary: The study investigates the role of FAK in pancreatic cancer and suggests that pharmacological inhibition of FAK could be a novel therapeutic strategy, demonstrating a potential radiosensitization effect in pancreatic cancer.
STRAHLENTHERAPIE UND ONKOLOGIE
(2021)
Review
Biochemistry & Molecular Biology
Milica Dimitrijevic Stojanovic, Bojan Stojanovic, Ivan Radosavljevic, Vojin Kovacevic, Ivan Jovanovic, Bojana S. Stojanovic, Nikola Prodanovic, Vesna Stankovic, Miodrag Jocic, Marina Jovanovic
Summary: This review comprehensively examines the role of Galectin-3 in pancreatic ductal adenocarcinoma (PDAC), including its expression, interaction with immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. The prognostic significance of serum levels of Galectin-3 and its potential utilization as a biomarker are also discussed. Additionally, the review critically analyzes the inhibitors of Galectin-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments.
Article
Biochemistry & Molecular Biology
Maria Mortoglou, Francesc Miralles, Elif Damla Arisan, Alwyn Dart, Stipo Jurcevic, Sigrun Lange, Pinar Uysal-Onganer
Summary: This study investigated the role of miR-21 in cancer stem cells (CSCs) and its association with the aggressiveness of PDAC. Knockout of miR-21 resulted in reversed expressions of CSC markers and suppressed cellular invasion and proliferation. These findings suggest that miR-21 is involved in the stemness of PDAC cells, may play roles in mesenchymal transition, and serves as a novel functional biomarker for PDAC aggressiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Michelle R. Goulart, Jennifer Watt, Imran Siddiqui, Rita T. Lawlor, Ahmet Imrali, Christine Hughes, Amina Saad, Joanne ChinAleong, Chris Hurt, Catrin Cox, Roberto Salvia, Alberto Mantovani, Tatjana Crnogorac-Jurcevic, Somnath Mukherjee, Aldo Scarpa, Paola Allavena, Hemant M. Kocher
Summary: PTX3 is a potential stromal-derived biomarker for PDAC, with higher sensitivity and specificity for detection, and can impact its secretion and evolution by modulating PSC activity through ATRA. These research findings are expected to be further validated in clinical trials.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liwei Cao, Chen Huang, Daniel Cui Zhou, Yingwei Hu, T. Mamie Lih, Sara R. Savage, Karsten Krug, David J. Clark, Michael Schnaubelt, Lijun Chen, Felipe da Veiga Leprevost, Rodrigo Vargas Eguez, Weiming Yang, Jianbo Pan, Bo Wen, Yongchao Dou, Wen Jiang, Yuxing Liao, Zhiao Shi, Nadezhda Terekhanova, Song Cao, Rita Jui-Hsien Lu, Yize Li, Ruiyang Liu, Houxiang Zhu, Peter Ronning, Yige Wu, Matthew A. Wyczalkowski, Hariharan Easwaran, Ludmila Danilova, Arvind Singh Mer, Seungyeul Yoo, Joshua M. Wang, Wenke Liu, Benjamin Haibe-Kains, Mathangi Thiagarajan, Scott D. Jewell, Galen Hostetter, Chelsea J. Newton, Qing Kay Li, Michael H. Roehr, David Fenyo, Pei Wang, Alexey Nesvizhskii, D. R. Mani, Gilbert S. Omenn, Emily S. Boja, Mehdi Mesri, Ana Robles, Henry Rodriguez, Oliver F. Bathe, Daniel W. Chan, Ralph H. Hruban, Li Ding, Bing Zhang, Hui Zhang
Summary: This study conducted comprehensive proteogenomic analysis of PDAC to understand the molecular alterations that drive oncogenesis. Multiple analyses were performed on tissues from patients, providing valuable resources for early detection and identification of therapeutic targets.
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Review
Cell Biology
Jian Yang, Ying Liu, Shi Liu
Summary: Of all pancreatic cancer cases, pancreatic ductal adenocarcinoma (PDAC) accounts for approximately 90% and is characterized by its high invasiveness and metastatic potential. Epithelial-mesenchymal transition (EMT) is a crucial process for cancer cell invasion and spread, and it is influenced by cellular behaviors and the tumor microenvironment. Autophagy, a target of cancer therapy, has been found to have a dual and contradictory role in EMT-mediated PDAC invasion.
CELL DEATH & DISEASE
(2023)
Article
Materials Science, Biomaterials
Jing Zhao, Yun Zhu, Zhuojin Li, Jiawei Liang, Yin Zhang, Siqi Zhou, Yixuan Zhang, Zhiwen Fan, Yonghua Shen, Yifeng Liu, Feng Zhang, Shanshan Shen, Guifang Xu, Lei Wang, Ying Lv, Shu Zhang, Xiaoping Zou
Summary: This study developed a self-biomimetic drug delivery system, PF@PCCEs, to deliver the antifibrotic drug PF precisely to fibrotic premetastatic organs, successfully inhibiting the liver metastasis of PDAC by intervening in the suitable niche for circulating tumor cell colonization in the premetastatic liver.
BIOMATERIALS SCIENCE
(2022)
Review
Oncology
Eleonora Lai, Pina Ziranu, Dario Spanu, Marco Dubois, Andrea Pretta, Simona Tolu, Silvia Camera, Nicole Liscia, Stefano Mariani, Mara Persano, Marco Migliari, Clelia Donisi, Laura Demurtas, Valeria Pusceddu, Marco Puzzoni, Mario Scartozzi
Summary: Despite ongoing research, there is still insufficient data on BRCA1/2-mutant PDAC, and more understanding is needed on the specific landscape of PDAC with BRCA mutations.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Tatsuya Kometani, Koki Kamo, Taketomo Kido, Nobuyoshi Hiraoka, Taku Chibazakura, Kenji Unno, Keisuke Sekine
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a serious and chemotherapy-resistant disease. We established a co-culture system using PDAC patient-derived cancer cells and stellate cells from human induced pluripotent stem cells to mimic the tumor microenvironment (TME) of PDAC. This system successfully demonstrated the interaction between cancer cells and stellate cells and replicated some features of PDAC in vitro. Furthermore, the co-culture system showed potential for drug treatment testing in vitro.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Xiao-Feng Xue, Wei Deng, Shao-Xuan Qu, Xiao-Yue Hong, Renfu Shao
Article
Oncology
Ye Zhang, Xiaofeng Xue, Xiaoqian Zhao, Lei Qin, Yu Shen, Huiqiang Dou, Jialin Sun, Tong Wang, Da-Qing Yang
Article
Evolutionary Biology
Wei-Ning Li, Renfu Shao, Qi Zhang, Wei Deng, Xiao-Feng Xue
Article
Zoology
Wei-Ning Li, Xiao-Feng Xue
ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2019)
Article
Entomology
Qi Zhang, Xiao-Feng Xue
INTERNATIONAL JOURNAL OF ACAROLOGY
(2019)
Article
Hematology
Huiying Han, Gao Fan, Sha Song, Yunxin Jiang, Chen'ao Qian, Weimin Zhang, Qi Su, Xiaofeng Xue, Wenzhuo Zhuang, Bingzong Li
Summary: The study demonstrates that piRNA-30473 plays an oncogenic role in promoting the aggressive phenotype of DLBCL, and its depletion can reduce proliferation and induce cell cycle arrest. Through regulating m6A RNA methylation, the piRNA-30473/WTAP/HK2 axis contributes to the progression of DLBCL.
Article
Cardiac & Cardiovascular Systems
Lin Ling, Tingting Feng, Xiaofeng Xue, Zicheng Ling
Summary: The study investigated the main causes, risk factors, and prognosis of patients hospitalized with syncope. High-risk factors for cardiogenic syncope include age >= 60, male gender, hypertension, palpitation, troponin T-positive, abnormal ECG, CHD family history, and syncope-related trauma. Age, hypertension, troponin T-positive, abnormal ECG, and CHD history were associated with the prognosis of syncope, with older age and positive troponin T being strongly related to prognosis.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yue Yin, Liang-Fei Yao, Yue Hu, Zi-Kai Shao, Xiao-Yue Hong, Paul D. N. Hebert, Xiao-Feng Xue
Summary: This study establishes a DNA barcode reference library for eriophyoid mites, providing coverage for a significant proportion of known species. The barcode analysis reveals clear barcode gaps between species, enabling effective species identification. The study also shows that eriophyoid mites exhibit high host specificity and that the host-mite networks are highly modular. These findings highlight the importance of DNA barcoding in advancing our understanding of eriophyoid mite diversity and their host interactions.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Evolutionary Biology
Xin-Chao Ban, Zi-Kai Shao, Li-Jun Wu, Jing-Tao Sun, Xiao-Feng Xue
Summary: Arachnida is a diverse class in Arthropoda, and the monophyly of ten orders is confirmed while the monophyly of Acari and Arachnida is rejected. Highly rearranged mitochondrial genomes are found in mites, indicating their exceptional diversification. Arachnid orders have ancient origins and significantly diversified since the Cretaceous.
Article
Entomology
Yue Yin, Yi-Wen Lu, Xin-Yu Liu, Xiao-Feng Xue
Summary: In this study, morphological and molecular approaches were used to delimitate species in the Calvittacus genus, resulting in the discovery of a new species. The new species, Calvittacus spectabilus sp. nov., is distributed in the Oriental Region and does not cause apparent symptoms to the host plant.
Article
Entomology
Qi-Qi Hu, Xin-Yue Yu, Xiao-Feng Xue, Xiao-Yue Hong, Jian-Ping Zhang, Jing-Tao Sun
Summary: This study found that spider mites cannot locate suitable host plants from a long distance by volatile odours, but they can use a combination of olfactory and gustatory senses to select suitable host plants at a short distance. The similarity in perceiving suitable host plants among spider mite species is highly correlated with their phylogenetic relationships.
Article
Ecology
Ni Li, Jing-Tao Sun, Yue Yin, Xiao-Yue Hong, Xiao-Feng Xue
Summary: This study examined the effects of environmental drivers and host plants on the diversity of herbivorous eriophyoid mites, and found that temperate regions have the highest species richness and endemism. Environmental variables and host plants indirectly influenced mite diversity through complex interactions.
JOURNAL OF BIOGEOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Xiao-Feng Xue, Liang-Fei Yao, Yue Yin, Qing Liu, Ni Li, Ary A. Hoffmann, Jing-Tao Sun, Xiao-Yue Hong
Summary: The superfamily Eriophyoidea includes a large number of small phytophagous mites with over 5000 named species. The evolutionary diversification of these mites is mainly influenced by host plants.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2023)
Article
Entomology
Ke-Xin Hao, Parisa Lotfollahi, Xiao-Feng Xue
Summary: This study describes three new species of eriophyid mites from the temperate region of China, namely Scolotosus ehretus sp. nov., Neotegonotus ulmchangus sp. nov., and Leipothrix ventricosis sp. nov. These mites inhabit the lower leaf surface of their host plants without causing apparent symptoms. Eriophyid mites are predominantly found in temperate regions worldwide, with south and southwest China being hotspots for species diversity and endemism.
Article
Mathematical & Computational Biology
Xiaohong Qiao, Xiaofeng Xue, Jianjun Niu, Lixin Ren, Huifeng Yang
Summary: In elderly patients with femoral neck fracture (FNF) undergoing joint replacement, poor nutritional status and low serum albumin levels are associated with postoperative mortality risk. Malnutrition increases the risk of death. Age, as well as factors such as serum albumin levels, hemoglobin, and nutritional status, are also related to postoperative mortality in elderly FNF patients.
JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS
(2021)