An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System

Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide

(2018) Congkuo Du et al.   ANTIOXIDANTS & REDOX SIGNALING

The interaction between XBP1 and eNOS contributes to endothelial cell migration

(2018) Junyao Yang et al.   EXPERIMENTAL CELL RESEARCH

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK

(2018) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nitric oxide signalling in cardiovascular health and disease

(2018) Charlotte Farah et al.   Nature Reviews Cardiology

Hydrogen sulfide mediates athero-protection against oxidative stress via S-sulfhydration

(2018) Sau Ha Cheung et al.   PLoS One

Novel H 2 S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure

(2018) Dan Wu et al.   Redox Biology

Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis

(2017) Gandhi T. K. Boopathy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen Sulfide Preserves Endothelial Nitric Oxide Synthase Function by Inhibiting Proline-Rich Kinase 2: Implications for Cardiomyocyte Survival and Cardioprotection

(2017) Sofia-Iris Bibli et al.   MOLECULAR PHARMACOLOGY

New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS

(2017) Bo Tan et al.   Scientific Reports

Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway

(2016) Yu Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Colorimetric Determination of Sulfide in Microsamples

(2016) Shogo SUGAHARA et al.   ANALYTICAL SCIENCES

Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide–Nitric Oxide Hybrid Molecule

(2016) Qingxun Hu et al.   ANTIOXIDANTS & REDOX SIGNALING

Additive cardioprotection by pharmacological postconditioning with hydrogen sulfide and nitric oxide donors in mouse heart: S-sulfhydration vs. S-nitrosylation

(2016) Junhui Sun et al.   CARDIOVASCULAR RESEARCH

Sodium Sulfide Attenuates Ischemic-Induced Heart Failure by Enhancing Proteasomal Function in an Nrf2-Dependent MannerCLINICAL PERSPECTIVE

(2016) Yuuki Shimizu et al.   Circulation-Heart Failure

Cystathionine β-synthase regulates endothelial function via protein S-sulfhydration

(2016) Sounik Saha et al.   FASEB JOURNAL

Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway

(2016) Dan Wu et al.   Oxidative Medicine and Cellular Longevity

Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137

(2016) Qutuba G. Karwi et al.   PHARMACOLOGICAL RESEARCH

S- Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

(2016) Katalin Módis et al.   PHARMACOLOGICAL RESEARCH

Cystathionine γ-lyase is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesis

(2016) J. C. van den Born et al.   Scientific Reports

Hydrogen Sulfide Regulates Krüppel‐Like Factor 5 Transcription Activity via Specificity Protein 1 S‐Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy

(2016) Guoliang Meng et al.   Journal of the American Heart Association

Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure

(2016) Erminia Donnarumma et al.   Journal of the American Heart Association

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

(2016) E. Doka et al.   Science Advances

Quantitative Persulfide Site Identification (qPerS-SID) Reveals Protein Targets of H2S Releasing Donors in Mammalian Cells

(2016) Sebastian Longen et al.   Scientific Reports

S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and HypertrophyNovelty and Significance

(2015) Tomoya Irie et al.   CIRCULATION RESEARCH

Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling

(2015) Rajesh K. Mistry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia

(2015) Shera Lilyanna et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enhanced nitric oxide bioavailability in coronary arteries prevents the onset of heart failure in rats with myocardial infarction

(2015) Gisele K. Couto et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction via the suppression of endoplasmic reticulum stress

(2015) Larry A. Barr et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes

(2015) Dan Wu et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential

(2015) Madhav Lavu et al.   CLINICAL SCIENCE

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

(2015) Mirjam Eberhardt et al.   Nature Communications

Sulfhydration of p66Shc at Cysteine59 Mediates the Antioxidant Effect of Hydrogen Sulfide

(2014) Zhi-Zhong Xie et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitrite Therapy Improves Left Ventricular Function During Heart Failure via Restoration of Nitric Oxide–Mediated Cytoprotective Signaling

(2014) Shashi Bhushan et al.   CIRCULATION RESEARCH

S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair

(2014) K. Zhao et al.   EMBO REPORTS

Hydrogen Sulfide and Endothelium-Dependent Vasorelaxation

(2014) Jerzy Bełtowski et al.   MOLECULES

Hydrogen sulfide and nitric oxide interactions in inflammation

(2014) Maria Letizia Lo Faro et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent

(2014) A. L. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The coordination of S-sulfhydration, S-nitrosylation, and phosphorylation of endothelial nitric oxide synthase by hydrogen sulfide

(2014) Z. Altaany et al.   Science Signaling

Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide

(2014) Miriam M. Cortese-Krott et al.   Redox Biology

Persulfide Reactivity in the Detection of Protein S-Sulfhydration

(2013) Jia Pan et al.   ACS Chemical Biology

Detection of Protein S-Sulfhydration by a Tag-Switch Technique

(2013) Dehui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

H2S Is an Endothelium-Derived Hyperpolarizing Factor

(2013) Guanghua Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

S-Propargyl-Cysteine, a Novel Water-Soluble Modulator of Endogenous Hydrogen Sulfide, Promotes Angiogenesis Through Activation of Signal Transducer and Activator of Transcription 3

(2013) Juntao Kan et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide Prevents Heart Failure Development via Inhibition of Renin Release from Mast Cells in Isoproterenol-Treated Rats

(2013) Yi-Hong Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Enzymology of H2S Biogenesis, Decay and Signaling

(2013) Omer Kabil et al.   ANTIOXIDANTS & REDOX SIGNALING

Thioredoxin 1 Is Essential for Sodium Sulfide–Mediated Cardioprotection in the Setting of Heart Failure

(2013) Chad K. Nicholson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

(2013) Antonia Asimakopoulou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles

(2013) Lauren Howitt et al.   CARDIOVASCULAR RESEARCH

H 2 S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase

(2013) Kazuhisa Kondo et al.   CIRCULATION

Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis

(2013) David J. Polhemus et al.   Circulation-Heart Failure

Crosstalk between hydrogen sulfide and nitric oxide in endothelial cells

(2013) Zaid Altaany et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cardioprotection of H2S by downregulating iNOS and upregulating HO-1 expression in mice with CVB3-induced myocarditis

(2013) Wang Hua et al.   LIFE SCIENCES

Hydrogen Sulfide Stimulates Ischemic Vascular Remodeling Through Nitric Oxide Synthase and Nitrite Reduction Activity Regulating Hypoxia‐Inducible Factor‐1α and Vascular Endothelial Growth Factor–Dependent Angiogenesis

(2013) Shyamal C. Bir et al.   Journal of the American Heart Association

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

VEGFR2 Functions As an H2S-Targeting Receptor Protein Kinase with Its Novel Cys1045–Cys1024 Disulfide Bond Serving As a Specific Molecular Switch for Hydrogen Sulfide Actions in Vascular Endothelial Cells

(2012) Bei-Bei Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide increases nitric oxide production with calcium-dependent activation of endothelial nitric oxide synthase in endothelial cells

(2012) Michiya Kida et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols

(2012) Milos R. Filipovic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

(2012) C. Coletta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Heart Function by Endogenous Gaseous Mediators—Crosstalk Between Nitric Oxide and Hydrogen Sulfide

(2011) Qian-Chen Yong et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

(2011) Matthew Whiteman et al.   CLINICAL SCIENCE

Nitric oxide synthase inhibition abrogates hydrogen sulfide-induced cardioprotection in mice

(2011) Bhavesh Sojitra et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Selective fluorescent probes for live-cell monitoring of sulphide

(2011) Yong Qian et al.   Nature Communications

Hydrogen Sulfide Increases Nitric Oxide Production from Endothelial Cells by an Akt-Dependent Mechanism

(2011) Benjamin L. Predmore et al.   Frontiers in Physiology

Hydrogen sulfide: its production, release and functions

(2010) Hideo Kimura   AMINO ACIDS

Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity

(2010) Mariarosaria Bucci et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hydrogen sulfide interacts with nitric oxide in the heart: possible involvement of nitroxyl

(2010) Q.-C. Yong et al.   CARDIOVASCULAR RESEARCH

The hypothesis of the main role of H2S in coupled sulphide-nitroso signalling pathway

(2010) A. Bertova et al.   GENERAL PHYSIOLOGY AND BIOPHYSICS

Gaseotransmitters: New Frontiers for Translational Science

(2010) C. Szabo   Science Translational Medicine

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Subtle interplay of endogenous bioactive gases (NO, CO and H2S) in inflammation

(2009) Hyun-Ock Pae et al.   ARCHIVES OF PHARMACAL RESEARCH

Hydrogen sulfide induces nitric oxide release from nitrite

(2009) Loris Grossi   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability?

(2009) Matthew Whiteman et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting angiogenesis to restore the microcirculation after reperfused MI

(2009) Anja M. van der Laan et al.   Nature Reviews Cardiology

Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation — a tale of three gases!

(2009) Ling Li et al.   PHARMACOLOGY & THERAPEUTICS

Hydrogen sulfide is an endogenous stimulator of angiogenesis

(2009) A. Papapetropoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning

(2008) Qian Chen Yong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

(2008) Julie Furne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

3-Mercaptopyruvate Sulfurtransferase Produces Hydrogen Sulfide and Bound Sulfane Sulfur in the Brain

(2008) Norihiro Shibuya et al.   ANTIOXIDANTS & REDOX SIGNALING

A Source of Hydrogen Sulfide and a Mechanism of Its Release in the Brain

(2008) Mari Ishigami et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S

(2008) Qingxiang Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CysteineS-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation

(2008) Yi-Yun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen sulfide decreases adenosine triphosphate levels in aortic rings and leads to vasorelaxation via metabolic inhibition

(2008) Levente Kiss et al.   LIFE SCIENCES

S-Nitrosylation of β-Arrestin Regulates β-Adrenergic Receptor Trafficking

(2008) Kentaro Ozawa et al.   MOLECULAR CELL

H2S and HS− donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells

(2008) Karol Ondrias et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE