Mn Inhibits GSH Synthesis via Downregulation of Neuronal EAAC1 and Astrocytic xCT to Cause Oxidative Damage in the Striatum of Mice

Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model

(2017) Bo-Kyung Park et al.   JOURNAL OF MEDICINAL FOOD

The role of system Xc − in methamphetamine-induced dopaminergic neurotoxicity in mice

(2017) Duy-Khanh Dang et al.   NEUROCHEMISTRY INTERNATIONAL

Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema

(2016) Tina Sehm et al.   Oncotarget

N-acetylcysteineamide protects against manganese-induced toxicity in SHSY5Y cell line

(2015) Yasaswi Maddirala et al.   BRAIN RESEARCH

The autophagic- lysosomal pathway determines the fate of glial cells under manganese- induced oxidative stress conditions

(2015) RM Gorojod et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of SystemXc−Transporter Attenuates Autoimmune Inflammatory Demyelination

(2015) Kirsten S. Evonuk et al.   JOURNAL OF IMMUNOLOGY

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

(2015) Ikuko Miyazaki et al.   JOURNAL OF NEUROCHEMISTRY

Manganese homeostasis in the nervous system

(2015) Pan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1)

(2015) Koji Aoyama et al.   MOLECULES

ER stress and ER stress-mediated apoptosis are involved in manganese-induced neurotoxicity in the rat striatum in vivo

(2015) Ting Wang et al.   NEUROTOXICOLOGY

Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features

(2015) Gunnar Kwakye et al.   International Journal of Environmental Research and Public Health

Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphoma

(2014) Lu Dai et al.   Journal of Hematology & Oncology

Melatonin Inhibits Manganese-Induced Motor Dysfunction and Neuronal Loss in Mice: Involvement of Oxidative Stress and Dopaminergic Neurodegeneration

(2014) Yu Deng et al.   MOLECULAR NEUROBIOLOGY

Minocycline Increases the Activity of Superoxide Dismutase and Reduces the Concentration of Nitric Oxide, Hydrogen Peroxide and Mitochondrial Malondialdehyde in Manganese Treated Drosophila melanogaster

(2014) Marylú Mora et al.   NEUROCHEMICAL RESEARCH

Exploring Cross-Talk Between Oxidative Damage and Excitotoxicity and the Effects of Riluzole in the Rat Cortex After Exposure to Methylmercury

(2014) Yu Deng et al.   NEUROTOXICITY RESEARCH

Cysteine Transport through Excitatory Amino Acid Transporter 3 (EAAT3)

(2014) Spencer D. Watts et al.   PLoS One

Kaempferol attenuates the glutamate-induced oxidative stress in mouse-derived hippocampal neuronal HT22 cells

(2014) Eun-Ju Yang et al.   Food & Function

Role of astrocytes in manganese mediated neurotoxicity

(2013) Marta Sidoryk-Wegrzynowicz et al.   BMC Pharmacology & Toxicology

Non-Cell Autonomous Influence of the Astrocyte System xc− on Hypoglycaemic Neuronal Cell Death

(2012) Nicole A Jackman et al.   ASN Neuro

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II ‘knock-in’ mice

(2012) K. Kollmann et al.   BRAIN

The role of amino acid transporters in GSH synthesis in the blood–brain barrier and central nervous system

(2012) Cesar Valdovinos-Flores et al.   NEUROCHEMISTRY INTERNATIONAL

Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance

(2011) Laurence Had-Aissouni   AMINO ACIDS

The Effect of Intracellular Amino Acids on GSH Production by High-cell-density Cultivation of Saccharomyces cerevisiae

(2011) Miaomiao Wang et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells

(2011) Maqusood Ahamed et al.   TOXICOLOGY

Effects of arsenite on glutamate metabolism in primary cultured astrocytes

(2011) Fenghong Zhao et al.   TOXICOLOGY IN VITRO

Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study

(2011) H N Noristani et al.   Cell Death & Disease

Detection of reactive oxygen species (ROS) by the oxidant-sensing probe 2′,7′-dichlorodihydrofluorescein diacetate in the cyanobacterium Anabaena variabilis PCC 7937

(2010) Rajesh P. Rastogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Manganese and Parkinson’s Disease: A Critical Review and New Findings

(2010) Tomás R. Guilarte   ENVIRONMENTAL HEALTH PERSPECTIVES

Development of a serum-free supplement for primary neuron culture reveals the interplay of selenium and vitamin E in neuronal survival

(2010) Stephan Roth et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Biomarkers of manganese intoxication

(2010) Wei Zheng et al.   NEUROTOXICOLOGY

The protective effect of riluzole on manganese caused disruption of glutamate–glutamine cycle in rats

(2009) Yu Deng et al.   BRAIN RESEARCH

Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum

(2009) Bin Xu et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Antioxidants prevent the cytotoxicity of manganese in RBE4 cells

(2008) A.P. Marreilha dos Santos et al.   BRAIN RESEARCH

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats

(2007) M. Morello et al.   NEUROTOXICOLOGY