Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine

The inhibition of the kynurenine pathway prevents behavioral disturbances and oxidative stress in the brain of adult rats subjected to an animal model of schizophrenia

(2018) Gislaine Z. Réus et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Increasing UCP2 expression and decreasing NOX1/4 expression maintain chondrocyte phenotype by reducing reactive oxygen species production

(2017) Yansong Miao et al.   Oncotarget

Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival

(2016) Colin J. Barnstable et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Uncoupling protein 2 in the glial response to stress: implications for neuroprotection

(2016) ColinJ Barnstable et al.   Neural Regeneration Research

Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis

(2015) Veronica De Simone et al.   Oncotarget

Mitochondrial uncoupling protein 2 protects splenocytes from oxidative stress-induced apoptosis during pathogen activation

(2013) Ting Cao et al.   CELLULAR IMMUNOLOGY

Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy

(2013) Linda Holtman et al.   EPILEPSIA

Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures

(2013) Kristina A. Simeone et al.   EXPERIMENTAL NEUROLOGY

Stat3 mediates LIF-induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

(2013) Daniel W. Lapp et al.   GLIA

Kinase AKT controls innate immune cell development and function

(2013) Yan Zhang et al.   IMMUNOLOGY

Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation

(2013) Ming Lu et al.   NEUROBIOLOGY OF AGING

High-frequency stimulation of the hippocampus protects against seizure activity and hippocampal neuronal apoptosis induced by kainic acid administration in macaques

(2013) N. Chen et al.   NEUROSCIENCE

Oxidative Stress and Mitogen-Activated Protein Kinase Pathways Involved in Cadmium-Induced BRL 3A Cell Apoptosis

(2013) Zhang Yiran et al.   Oxidative Medicine and Cellular Longevity

Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons

(2013) Maria I. Morte et al.   TOXICOLOGY IN VITRO

The Role of Uncoupling Proteins in Diabetes Mellitus

(2013) Jing Liu et al.   Journal of Diabetes Research

The Neuroprotection of Hydrogen Sulfide Against MPTP-Induced Dopaminergic Neuron Degeneration Involves Uncoupling Protein 2 Rather Than ATP-Sensitive Potassium Channels

(2012) Ming Lu et al.   ANTIOXIDANTS & REDOX SIGNALING

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

(2012) Lei Ma et al.   BRAIN RESEARCH

Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus

(2012) Yao-Chung Chuang et al.   Journal of Neuroinflammation

Urokinase-Type Plasminogen Activator Receptor Modulates Epileptogenesis in Mouse Model of Temporal Lobe Epilepsy

(2012) Xavier Ekolle Ndode-Ekane et al.   MOLECULAR NEUROBIOLOGY

A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's Disease model

(2012) Rafique Islam et al.   NEUROBIOLOGY OF DISEASE

UCP2 Inhibits ROS-Mediated Apoptosis in A549 under Hypoxic Conditions

(2012) Sanming Deng et al.   PLoS One

Overexpression of Mitochondrial Uncoupling Protein 2 Inhibits Inflammatory Cytokines and Activates Cell Survival Factors after Cerebral Ischemia

(2012) Bryan Haines et al.   PLoS One

Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior

(2012) Julia Simon-Areces et al.   PLoS One

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Uncoupling Protein 2 Negatively Regulates Mitochondrial Reactive Oxygen Species Generation and Induces Phosphatase-Mediated Anti-Inflammatory Response in Experimental Visceral Leishmaniasis

(2011) W. Basu Ball et al.   JOURNAL OF IMMUNOLOGY

Expression of Mitochondrial Uncoupling Protein UCP2 in the Brain of Rats after Hippocampal Injury Inflicted by Kainic Acid

(2010) D. S. Lebedev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus

(2010) Telma Luciana Furtado Gouveia et al.   EPILEPSY & BEHAVIOR

Deletion of Mitochondrial Uncoupling Protein-2 Increases Ischemic Brain Damage after Transient Focal Ischemia by Altering Gene Expression Patterns and Enhancing Inflammatory Cytokines

(2010) Bryan A Haines et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice

(2008) Eun-Joo Shin et al.   CELLULAR SIGNALLING

The renin-angiotensin system is upregulated in the cortex and hippocampus of patients with temporal lobe epilepsy related to mesial temporal sclerosis

(2008) Gustavo Adolfo Argañaraz et al.   EPILEPSIA

UCP2 protects hypothalamic cells from TNF-α-induced damage

(2008) Giovanna R. Degasperi et al.   FEBS LETTERS

Overexpression of UCP2 Protects Thalamic Neurons following Global Ischemia in the Mouse

(2008) Tomas Deierborg Olsson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice

(2008) Fatiha Moukdar et al.   JOURNAL OF LIPID RESEARCH

Kinin B1 receptors facilitate the development of temporal lobe epilepsy in mice

(2007) J.A. Silva et al.   INTERNATIONAL IMMUNOPHARMACOLOGY