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Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw

OSTEOPOROSIS INTERNATIONAL (2013)

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OSTEOPOROSIS INTERNATIONAL

Volume 24, Issue 2, Pages 731-733

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SPRINGER LONDON LTD

DOI: 10.1007/s00198-012-1918-9

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Is teriparatide therapy effective for medication-related osteonecrosis of the jaw? A systematic review and meta-analysis

L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos

Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.

OSTEOPOROSIS INTERNATIONAL (2021)

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Article Pharmacology & Pharmacy

Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-Related Osteonecrosis of the Jaw

Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong

Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Multidisciplinary Sciences

Relationship between drug holiday of the antiresorptive agents and surgical outcome of medication-related osteonecrosis of the jaw in osteoporosis patients

Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda

Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.

SCIENTIFIC REPORTS (2022)

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Article Multidisciplinary Sciences

Preventive effect of teriparatide on medication-related osteonecrosis of the jaw in rats

Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park

Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.

SCIENTIFIC REPORTS (2023)

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Article Dentistry, Oral Surgery & Medicine

Management of medication-related osteonecrosis of jaw: Comparison between icariin and teriparatide in a rat model

Jie Liu, Nikos Mattheos, Chuanxi Deng, Cheng Su, Zekun Wang, Nanyu Luo, Hua Tang

Summary: Icariin benefits MRONJ by improving soft tissue wound area and empty bone lacuna ratio, while teriparatide activates RANKL expression and reduces bone necrosis area and empty lacuna ratio. These findings suggest potential therapeutic benefits for patients with MRONJ.

JOURNAL OF PERIODONTOLOGY (2021)

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Article Pharmacology & Pharmacy

Teriparatide for the Treatment of Medication-Related Osteonecrosis of the Jaw

Kirti Chopra, Namrita Malhan

Summary: MRONJ is a painful and intractable disease of the jaw with no established effective treatment, however, teriparatide may play an important role in the treatment with good efficacy.

AMERICAN JOURNAL OF THERAPEUTICS (2021)

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Article Multidisciplinary Sciences

Effectiveness of surgery and hyperbaric oxygen for antiresorptive agent-related osteonecrosis of the jaw: A subgroup analysis by disease stage

Takuma Watanabe, Keita Asai, Shizuko Fukuhara, Ryuji Uozumi, Kazuhisa Bessho

Summary: This study evaluated the variables associated with treatment outcomes in patients with ARONJ at a single center, finding that surgery and HBO therapy were effective treatment approaches for both stage 2 and 3 ARONJ. Extensive surgery was more effective in healing than conservative surgery for stage 2 ARONJ, while >= 46 sessions of HBO therapy was less associated with healing in the same stage.

PLOS ONE (2021)

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Article Medicine, General & Internal

Risk Factors for Medication-Related Osteonecrosis of the Jaw-A Binomial Analysis of Data of Cancer Patients from Craiova and Constanta Treated with Zoledronic Acid

George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu

Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Oncology

Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307)

Darya A. Kizub, Jieling Miao, Mark M. Schubert, Alexander H. G. Paterson, Mark Clemons, Elizabeth C. Dees, James N. Ingle, Carla I. Falkson, William E. Barlow, Gabriel N. Hortobagyi, Julie R. Gralow

Summary: Bisphosphonates reduce bone metastases in postmenopausal women with early-stage breast cancer but carry the risk of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Implementation of prevention guidelines can lower the incidence of BRONJ.

SUPPORTIVE CARE IN CANCER (2021)

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Article Medicine, General & Internal

Rat Calvaria Model Mimicking the Intraoral Lesion of Medication-Related Osteonecrosis in the Jaw: A Preliminary Test

Yesel Kim, Jeong-Kui Ku

Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Cell Biology

Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw

Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang

Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Ozonated oil effect for prevention of medication-related osteonecrosis of the jaw (MRONJ) in rats undergoing zoledronic acid therapy

C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins

Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.

CLINICAL ORAL INVESTIGATIONS (2021)

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Article Biology

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inerthydroxymethylene diphosphonate

Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J. Campagna, Nicholas A. Lentini, Eric C. Sung, Samantha Chiang, Yi-Ling Lin, Frank H. Ebetino, Varghese John, Shuting Sun, Charles E. McKenna, Ichiro Nishimura

Summary: This study presents a novel method to elucidate the pathological mechanism of BRONJ and demonstrates the potential of HMDP-DNV as an effective therapy. The results show that the intra-oral application of HMDP-DNV can selectively remove legacy N-BP from the jawbone and accelerate wound healing and bone socket healing, while attenuating osteonecrosis development. Single cell RNA sequencing reveals the resolution of chronic inflammation by increasing the expression of anti-inflammatory signature genes. This research suggests that BRONJ pathology is related to N-BP levels in jawbones.

ELIFE (2022)

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Article Multidisciplinary Sciences

Relationship between tooth extraction and development of medication-related osteonecrosis of the jaw in cancer patients

Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Souichi Yanamoto, Shunsuke Sawada, Yuka Kojima, Madoka Funahara, Hiroshi Iwai, Masahiro Umeda, Toshiyuki Saito

Summary: Tooth extraction is not a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving bone-modifying agents (BMAs), but rather helps reduce the risk of MRONJ development. Infected teeth and longer duration of BMA administration are independent risk factors for MRONJ.

SCIENTIFIC REPORTS (2021)

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Article Chemistry, Medicinal

Interactive Associations between PPAR & gamma; and PPARGC1A and Bisphosphonate-Related Osteonecrosis of the Jaw in Patients with Osteoporosis

Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak

Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.

PHARMACEUTICALS (2023)

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Antimalarials exert a cardioprotective effect in lupus patients: Insights from the Spanish Society of Rheumatology Lupus Register (RELESSER) analysis of factors associated with heart failure

Inigo Rua-Figueroa, David Rua-Figueroa, Natalia Perez-Veiga, Ana M. Anzola, Maria Galindo-Izquierdo, Jaime Calvo-Alen, Antonio Fernandez-Nebro, Clara Sanguesa, Raul Menor-Almagro, Eva Tomero, Natividad del Val, Esther Uriarte-Isazelaya, Ricardo Blanco, Jose L. Andreu, Alina Boteanu, Javier Narvaez, Tatiana Cobo, Cristina Bohorquez, Carlos Montilla, Esteban Salas, Francisco J. Toyos, Jose A. Bernal, Eva Salgado, Mercedes Freire, Antonio J. Mas, Lorena Exposito, Jose A. Hernandez-Beriain, Oihane Ibarguengoitia, Maria L. Velloso-Feijoo, Nuria Lozano-Rivas, Gemma Bonilla, Mireia Moreno, Inmaculada Jimenez, Victor Quevedo-Vila, Angela Pecondon, Elena Aurrecoechea, Elia Valls, Coral Mourino, Tomas Vazquez-Rodriguez, Jose M. Pego-Reigosa

Summary: Chronic heart failure is a common complication in patients with systemic lupus erythematosus (SLE), and treatment with antimalarials may have a cardioprotective effect.

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Summary: This study aims to describe the methods of the Spanish Registry of patients with idiopathic inflammatory myopathy (IIM) and analyze the evolution and clinical management of the patient cohort. The registry collects comprehensive data including demographic, clinical, and laboratory variables, complications, and comorbidities. It is expected to provide a reliable source of data for future analysis.

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Lack of response to teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw

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