Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zhiqiang Feng, Jingang An, Yang He, Yi Zhang
Summary: This study compared the clinical characteristics of patients with medication-related osteonecrosis of the jaw (MRONJ) and osteoporosis versus malignancy. The results showed differences between the osteoporosis and malignancy groups in terms of incubation periods, cumulative doses of bisphosphonates, and the proportion of patients receiving antiangiogenic agents. However, the two groups had similar surgical treatment outcomes.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Medicine, General & Internal
George Adrian Ciobanu, Laurentiu Mogoanta, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Ionela Elisabeta Staicu, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Razvan Mercut, Elena Claudia Sin, Sanda Mihaela Popescu
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of bisphosphonate treatment in cancer patients, and its etiology is not fully understood. This study aimed to investigate the clinical and histopathological characteristics of osteonecrosis and its connection to bisphosphonates in cancer patients who underwent surgical treatment for MRONJ. The study included 51 patients who were analyzed for demographic, clinical, and imaging data. Surgical treatment involved removing the necrotic bone and analyzing the obtained fragments histopathologically. MRONJ was predominantly found in the posterior regions of the mandible, triggered by tooth extraction or periapical/periodontal infections. Histopathological examination revealed specific features of osteonecrosis, including the absence of bone cells, an inflammatory infiltrate, and the presence of bacterial colonies. Thorough dental monitoring could reduce the incidence of osteonecrosis and its complications in cancer patients receiving zoledronic acid.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Brendan W. Wu, Kevin C. Lee, Steven Halepas, Vasiliki Karlis
Summary: This study examined 26 clinical trials on osteonecrosis of the jaw, finding that 50% were completed and 69% of completed trials were published. Predictors of trial completion and publication of results were identified, with no significant increase in completion and publication rates observed with industry sponsorship, larger enrollment sizes, or multi-center involvement.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biology
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J. Campagna, Nicholas A. Lentini, Eric C. Sung, Samantha Chiang, Yi-Ling Lin, Frank H. Ebetino, Varghese John, Shuting Sun, Charles E. McKenna, Ichiro Nishimura
Summary: This study presents a novel method to elucidate the pathological mechanism of BRONJ and demonstrates the potential of HMDP-DNV as an effective therapy. The results show that the intra-oral application of HMDP-DNV can selectively remove legacy N-BP from the jawbone and accelerate wound healing and bone socket healing, while attenuating osteonecrosis development. Single cell RNA sequencing reveals the resolution of chronic inflammation by increasing the expression of anti-inflammatory signature genes. This research suggests that BRONJ pathology is related to N-BP levels in jawbones.
Article
Multidisciplinary Sciences
Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Souichi Yanamoto, Shunsuke Sawada, Yuka Kojima, Madoka Funahara, Hiroshi Iwai, Masahiro Umeda, Toshiyuki Saito
Summary: Tooth extraction is not a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving bone-modifying agents (BMAs), but rather helps reduce the risk of MRONJ development. Infected teeth and longer duration of BMA administration are independent risk factors for MRONJ.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, HyeJin Lee, Hyo-Jung Lee
Summary: The presence of periodontal disease significantly increases the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients, even without tooth extraction. Therefore, patients taking bisphosphonates should actively manage and treat periodontal diseases.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Infectious Diseases
D. Kizub, I. Ghali, R. Sabouni, J. E. Bourkadi, K. Bennani, R. El Aouad, K. E. Dooley
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2012)
Article
Oncology
Darya A. Kizub, Sachin Naik, Ayokunle A. Abogan, Debanjan Pain, Stephen Sammut, Lawrence N. Shulman, Yehoda M. Martei
Summary: This study evaluated access to and affordability of treatment regimens based on the 2019 WHO Essential Medicines List (EML) for the top 10 most common cancers in Kenya, Uganda, and Rwanda. The findings showed that all cancer treatment regimens were unaffordable for patients paying out-of-pocket, and some novel essential targeted agents were not included on the countries' essential medicines lists and were unaffordable for governments through universal healthcare coverage purchasing.
Article
Oncology
Margaret Raber, Ruth Rechis, Denise M. LaRue, Thy T. Ho-Pham, Katherine Oestman, Michael T. Walsh, Darya Kizub, Hilary Ma, Esperanza Galvan, Hui Zhao, Jennifer Gonzalez, Xiudong Lei, Jingfan Hu, Karen Basen-Engquist
Summary: This study aimed to identify opportunities to increase cancer survivor utilization of healthy eating and active living interventions in Acres Homes, Houston. The study found high rates of co-occurrent cardiometabolic disease among Acres Homes survivors and explored their preferences for relevant programming.
CANCER CAUSES & CONTROL
(2023)
Article
Oncology
Darya Kizub, Cathyryne K. Manner, Katy Graef, Bello Abubakar, Jackson Orem, Folakemi Odedina, Mojisola Christianah Adeyeye, Gertrude Nakigudde, Kassa Ayalew, Chitkala Kalidas, Herbert Kim Lyerly, Thea Norman, Lola Fashoyin-Aje, Jamie Freedman, Jennifer Dent, Bill Cance, Julie Gralow
Summary: Patients of African ancestry are underrepresented in cancer clinical trials, despite experiencing high mortality rates. A satellite session was held to discuss the perspectives and priorities of stakeholders in bringing early-stage cancer trials to Africa, resulting in agreed-upon action steps.
JCO GLOBAL ONCOLOGY
(2022)
Article
Oncology
Kevin Diao, Dorothy C. Lombe, Catherine K. Mwaba, Juliana Wu, Darya A. Kizub, Carrie A. Cameron, Elizabeth Y. Chiao, Susan C. Msadabwe, Lilie L. Lin
Summary: The virtual clinical research training program for Zambian clinical oncology fellows led to improvement in academic self-efficacy domains, formation of mentorship groups, and development of research protocols, demonstrating the feasibility of implementing a virtual model.
JCO GLOBAL ONCOLOGY
(2022)
Article
Oncology
Nicoleta Antone, Darya Kizub, Julie Gralow, Jo Anne Zujewski, Allison Dvaladze
Summary: The study explored the experiences and priorities of breast cancer civil society organizations in Eastern Europe and Central Asia, highlighting the important role of survivor- and oncologist-led organizations in raising awareness, providing patient support, and advocating for early detection and treatment. Key facilitators of advocacy efforts included effective partnerships with physicians, like-minded organizations, and policymakers to improve access to educational resources and catalyze policy change.
JCO GLOBAL ONCOLOGY
(2021)
Article
Health Policy & Services
Stefan Baral, Darya Kizub, Nicole Franck Masenior, Alena Peryskina, Julie Stachowiak, Mark Stibich, Vladimir Moguilny, Chris Beyrer
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2010)