Article
Endocrinology & Metabolism
Ji Hyun Lee, JooYong Park, Jung Hee Kim, Ji-Yeob Choi, Hyung Jin Choi, Eu Jeong Ku, A. Ram Hong, Chan Soo Shin, Nam H. Cho
Summary: This Korean prospective cohort study found that decreasing waist circumference and lean muscle mass loss were significant risk factors for hip bone loss in both men and women. Other factors may have sex-specific or age-specific effects on hip bone loss. None of the genetic factors tested were associated with hip bone loss after multiple testing adjustments, indicating that modifiable factors may play a larger role in determining bone health.
Article
Agriculture, Multidisciplinary
Kathryn M. McRae, Sue M. Cooper, John C. McEwan, Rayna Anderson, Wendy E. Bain, Hayley J. Baird, Ken G. Dodds, Shannon M. Clarke, Natalie K. Pickering, Geoff Holmes
Summary: This study investigates the genetic variability in the New Zealand sheep population for economically important skin traits. The research confirms that suitable lamb skins for high-value shoe leather can be bred, although these traits are polygenic and moderately to highly heritable.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Endocrinology & Metabolism
Melody Kasher, Maxim B. Freidin, Frances Mk Williams, Stacey S. Cherny, Ida Malkin, Gregory Livshits
Summary: This study investigated the genetic association between rheumatoid arthritis (RA) and osteoporosis (OP), and found evidence of pleiotropy. Shared genetic variants associated with both RA and OP were identified.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Genetics & Heredity
Valentin Hivert, Naomi R. Wray, Peter M. Visscher
Summary: The Falconer ShinyApp is a user-friendly web tool that demonstrates how gene action and allele frequencies at causal loci affect genetic variance and complex traits, as well as the relationship between SNP effect size estimated from GWAS and the variation the SNP generates in the population. It also shows that within and between locus interactions usually do not lead to a large amount of nonadditive variance relative to additive variance, and therefore do not explain individual differences in a population.
Review
Endocrinology & Metabolism
Erika Kague, Carolina Medina-Gomez, Simeon A. Boyadjiev, Fernando Rivadeneira
Summary: The genetic overlap between osteoporosis and craniosynostosis provides valuable insights into molecular mechanisms and potential therapeutic approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yanyu Xiao, Jingjing Wang, Jiaqi Li, Peijing Zhang, Jingyu Li, Yincong Zhou, Qing Zhou, Ming Chen, Xin Sheng, Zhihong Liu, Xiaoping Han, Guoji Guo
Summary: Understanding the mechanism of genetic associations with human phenotypes is complicated by cellular heterogeneity and linkage disequilibrium. The authors propose an analytical framework, Huatuo, to decode the genetic variation of gene regulation at both cell-type and single-nucleotide levels.
NATURE COMMUNICATIONS
(2023)
Review
Biotechnology & Applied Microbiology
Jayesh J. Ahire, Vikram Kumar, Alka Rohilla
Summary: This article provides a comprehensive understanding of osteoporosis, including its causes, effects on bone density, and the role played by genetic pathways and gut flora. It investigates the link between gut flora and osteoporosis through animal and human experiments. Additionally, it speculates on possible developments in osteoporosis prevention and therapy.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biology
Jennifer A. Fortunato, Ryan L. Earley
Summary: Understanding the factors underlying behavioural variance is crucial in predicting behavioural response to selection and evolution. Behavioural variation can change across ontogeny, with varying contributions of genetics and environment across ages. This study investigated variation in aggression among individuals and genotypes across development stages. Results showed that aggression was repeatable and heritable only in juveniles, and the changes in aggression between juvenile and adult stages varied significantly among individuals and genotypes. These findings suggest that juvenile aggression is more likely to evolve rapidly through natural selection and that the trajectory of behavioural change across lifespan has evolutionary potential. Determining when genetic variation explains behavioural variation can enhance our understanding of key life-history stages for strong evolutionary response.
Article
Pharmacology & Pharmacy
S. Khijmatgar, S. Panda, R. Biagi, M. Rovati, L. Colletti, F. Goker, A. Greco Lucchina, C. Mortellaro, M. Del Fabbro
Summary: Optical Coherence Tomography (OCT) is a non-invasive imaging technique that can produce cross-sectional images of biological tissues, allowing three-dimensional reconstruction and analysis. This study aimed to evaluate whether OCT can differentiate tissues with different bone density and composition by measuring the depth of light penetration in porcine and rat bone samples.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Xing-Hao Yu, Rong-Rong Cao, Yi-Qun Yang, Lei Zhang, Shu-Feng Lei, Fei-Yan Deng
Summary: The study revealed that various serum metabolites have causal effects on estimated bone mineral density and fracture risk, and some metabolites have independent effects on osteoporosis that are not influenced by other confounders. Additionally, multiple metabolic pathways involved in bone metabolism were identified in the analysis.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Psychiatry
Hanxin Zhang, Atif Khan, Steven A. Kushner, Andrey Rzhetsky
Summary: Schizophrenia is a leading cause of disability worldwide, and its etiology involves genetic and environmental factors. This study utilized unique data sources and mathematical models to estimate the contributions of genetic and environmental factors to schizophrenia risk, finding that environmental factors are an important source of explanatory variance.
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: Bone mineral density (BMD) loss shows greater variability at shorter testing intervals, but this variability diminishes over longer intervals. Using reports of rapid BMD loss as an indication for antifracture medication initiation may not be accurate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Summary: This study examined medication adherence in women with osteoporosis before and after a fracture. The results show that many women experience a decline in medication adherence after a fracture, which is paradoxical to expectations. Fracture on therapy represents an important opportunity for clinicians to emphasize treatment adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Bingxin Zhao, Tengfei Li, Yue Yang, Xifeng Wang, Tianyou Luo, Yue Shan, Ziliang Zhu, Di Xiong, Mads E. Hauberg, Jaroslav Bendl, John F. Fullard, Panagiotis Roussos, Yun Li, Jason L. Stein, Hongtu Zhu
Summary: The study identified common genetic variants influencing white matter microstructure and detected multiple associated loci, some of which were related to brain diseases. Additionally, genetic correlations were observed between white matter microstructure and a wide range of complex traits and diseases.
Article
Medicine, Research & Experimental
Jin He, Hua Xie, Chengyuan Yan, Yawen Sun, Zhonghua Xu, Xing Zhang
Summary: The study revealed that the VKORC1 gene polymorphism rs9923231 increased the risk of osteoporosis, especially among the elderly. Additionally, the genotypes of rs9923231 were associated with low body mass index and T-score. It is suggested that further large, well-designed studies are needed to confirm these findings.
ARCHIVES OF MEDICAL RESEARCH
(2021)