Morphine-Induced Constipation Develops With Increased Aquaporin-3 Expression in the Colon via Increased Serotonin Secretion

Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract

(2014) Risako Kon et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of Aquaporin-3 Water Channel in the Colon Induces Diarrhea

(2012) Nobutomo Ikarashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Opioid-Induced Constipation: Challenges and Therapeutic Opportunities

(2011) Michael Camilleri   AMERICAN JOURNAL OF GASTROENTEROLOGY

The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages

(2011) Nobutomo Ikarashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of Magnesium Sulphate Administration on Aquaporin 3 in Rat Gastrointestinal Tract

(2011) Nobutomo Ikarashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect

(2011) Nobutomo Ikarashi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis

(2011) Yan J. Jiang et al.   EXPERIMENTAL DERMATOLOGY

Fluoxetine inhibits the extracellular signal regulated kinase pathway and suppresses growth of cancer cells

(2010) Andrzej Stepulak et al.   CANCER BIOLOGY & THERAPY

The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites

(2010) Tsuyoshi Waku et al.   EMBO JOURNAL

Anti-mitogenic and apoptotic effects of 5-HT1B receptor antagonist on HT29 colorectal cancer cell line

(2010) Ramin Ataee et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A mechanism by which the osmotic laxative magnesium sulphate increases the intestinal aquaporin 3 expression in HT-29 cells

(2010) Nobutomo Ikarashi et al.   LIFE SCIENCES

The management of constipation in palliative care: clinical practice recommendations

(2008) PJ Larkin et al.   PALLIATIVE MEDICINE