Opioid-Induced Constipation: Challenges and Therapeutic Opportunities

Opioid Prescriptions for Chronic Pain and Overdose

(2013) Kate M. Dunn   ANNALS OF INTERNAL MEDICINE

The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health

(2010) B. S. Wong et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Validation of a Bowel Function Diary for Assessing Opioid-Induced Constipation

(2010) Michael Camilleri et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee

(2010) Marc Afilalo et al.   CLINICAL DRUG INVESTIGATION

Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic non-cancer pain: tapentadol, a step toward a solution?

(2010) Keith A. Candiotti et al.   CURRENT MEDICAL RESEARCH AND OPINION

Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation

(2010) Cornelius E. J. Sloots et al.   DIGESTIVE DISEASES AND SCIENCES

Tapentadol and its two mechanisms of action: Is there a new pharmacological class of centrally-acting analgesics on the horizon?

(2010) Hans G. Kress   EUROPEAN JOURNAL OF PAIN

Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

(2010) Robert Buynak et al.   EXPERT OPINION ON PHARMACOTHERAPY

906 A Phase 3, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Lubiprostone for the Treatment of Opioid-Induced Bowel Dysfunction in Patients With Chronic, Non-Cancer Pain

(2010) Byron L. Cryer et al.   GASTROENTEROLOGY

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain

(2010) A. Sandner-Kiesling et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Long-Term Safety and Efficacy of Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules, a Novel Formulation Containing Morphine and Sequestered Naltrexone, in Patients with Chronic, Moderate to Severe Pain

(2010) Lynn R. Webster et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain

(2010) a. k. tuteja et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A Flood of Opioids, a Rising Tide of Deaths

(2010) Susan Okie   NEW ENGLAND JOURNAL OF MEDICINE

Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats

(2010) Lucy A. Bee et al.   PAIN

Clinical Guidelines for the Use of Chronic Opioid Therapy in Chronic Noncancer Pain

(2009) Roger Chou et al.   JOURNAL OF PAIN

Pharmacogenetics of low dose clonidine in irritable bowel syndrome

(2009) m. camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Validation of the Bowel Function Index to detect clinically meaningful changes in opioid-induced constipation

(2009) A. M. Rentz et al.   JOURNAL OF MEDICAL ECONOMICS

A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation

(2008) Winfried Meissner et al.   EUROPEAN JOURNAL OF PAIN

Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain

(2008) Dana Vondrackova et al.   JOURNAL OF PAIN

Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness

(2008) Jay Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE

OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines

(2008) W. Zhang et al.   OSTEOARTHRITIS AND CARTILAGE

Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain

(2008) Lynn Webster et al.   PAIN

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE

Efficacy and Safety of Mu-Opioid Antagonists in the Treatment of Opioid-Induced Bowel Dysfunction: Systematic Review and Meta-analysis of Randomized Controlled Trials

(2007) Ewan McNicol et al.   PAIN MEDICINE