Article
Orthopedics
K. S. M. Reed, V. Ulici, C. Kim, S. Chubinskaya, R. F. Loeser, D. H. Phanstiel
Summary: Treatment of normal human articular chondrocytes with fibronectin fragments can recapitulate key aspects of the osteoarthritis chondrocyte phenotype, showing promising potential for future osteoarthritis studies, especially considering its compatibility with genomics and genome-editing techniques.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Engineering, Biomedical
Anamarija Rogina, Maja Pusic, Lucija Stefan, Alan Ivkovic, Inga Urlic, Marica Ivankovic, Hrvoje Ivankovic
Summary: Chitosan-based materials are recognized as suitable microenvironments for chondrocyte adhesion, proliferation, and differentiation, while utilizing nasal chondrocytes to culture articular cartilage has emerged as a promising novel strategy for cartilage regeneration. The study indicates that improving chitosan bioactivity can enhance its interactions with fibronectin, thus promoting cartilage regeneration.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Endocrinology & Metabolism
Dylan J. J. Ritter, Dharmendra Choudhary, Gokhan Unlu, Ela W. W. Knapik
Summary: This study reveals that Rgp1 plays a crucial role in craniofacial cartilage development and the secretion of collagen II. Loss of Rgp1 leads to altered movement of Rab6a(+) vesicular compartments and activation of an Arf4b-mediated stress response in chondrocytes, resulting in cell death.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Allison Mixon, Ahmed Suparno Bahar-Moni, Tanvir R. Faisal
Summary: Matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) subsequently damaging cartilage and altering biomechanical properties. Individually, MMP-1 and MMP-9 have minimal effect on cartilage micromechanical properties, but synergistically the two enzymes digest ECM components and result in a greater degradative effect.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Zhongrun Yuan, Sa Liu, Wenjing Song, Ying Liu, Gangyuan Bi, Renjian Xie, Li Ren
Summary: Galactose has been found to promote chondrogenesis and cartilage matrix formation, which suggests its potential for cartilage repair and regeneration.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Virology
Elisa X. Y. Lim, Julie A. A. Webster, Penny A. A. Rudd, Lara J. J. Herrero
Summary: This study used RNA sequencing to analyze the gene expression profiles of Ross River virus (RRV)-infected chondrocytes and bystander chondrocytes. The results showed similarities and differences in gene expression between infected and uninfected cells, indicating the importance of selecting therapeutic targets that minimize adverse effects on neighboring uninfected cells.
Article
Integrative & Complementary Medicine
Zhen Li, Zhenyue Chen, Jiayi Chen, Zhutong Liu, Zehui Li, He Sun, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
Summary: This study found that monotropein (MON), the main active ingredient of Morinda officinalis F.C. How, has therapeutic effects on chondrocytes and a mouse model of OA. It alleviates OA progression by inhibiting cartilage matrix degradation, apoptosis, and pyroptosis of chondrocytes through NF-kappa B pathway inactivation. MON shows promise as an alternative treatment for OA.
Review
Cell Biology
Caleb J. Dalton, Christopher A. Lemmon
Summary: The extracellular matrix fibronectin plays a crucial role in tissue structure and cell signal transduction. It assembles into viscoelastic fibrils that bind various growth factors and cytokines, influencing ECM assembly during development and in disease states. Fibronectin fibrils have unique mechanical properties and interact with other ECM proteins and growth factors to transmit mechanobiology signaling events.
Article
Orthopedics
Zhimin Wu, Ying Wang, Guoqiang Yan, Chengai Wu
Summary: Eugenol has been shown to have anti-inflammatory, antioxidant, and antiapoptotic effects in multiple systems and organs of the human body. This study demonstrates its therapeutic potential for osteoarthritis (OA) by protecting cartilage and subchondral bone, inhibiting inflammatory molecules, and blocking IL-1β-induced signaling pathways.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Brandon Y. H. Chan, Andrej Roczkowsky, Woo Jung Cho, Mathieu Poirier, Consolato Sergi, Vic Keschrumrus, Jared M. Churko, Henk Granzier, Richard Schulz
Summary: The study found that MMP inhibitors can protect against DXR cardiotoxicity by reducing cardiac dysfunction and left ventricular remodelling, preventing myocardial fibrosis. This suggests that MMP inhibitors may be a potential prophylactic strategy to prevent heart injury during chemotherapy.
CARDIOVASCULAR RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shintaro Yamazaki, Ryoko Hirayama, Yayoi Ikeda, Sachiko Iseki, Tetsuya Yoda, Masa-Aki Ikeda
Summary: Engineered cartilage tissue from MSCs can generate bone through ECO. Comparing HA and collagen hydrogels, HA exhibited superior potential for bone formation with vascularization and bone marrow development.
Review
Medicine, Research & Experimental
Mentor Sopjani, Rifat Morina, Valdet Uka, Nguyen Thi Xuan, Miribane Dermaku-Sopjani
Summary: JAK2 acts as a crucial intracellular signaling effector in various cytokine receptor pathways. Research focus has been on understanding the molecular mechanisms of JAK2 activation, regulation, and its pleiotropic signaling roles, as well as its involvement in different diseases/conditions. Recent advances in studying the molecular regulatory mechanisms of JAK2 signaling provide insights for developing alternative therapeutic strategies for JAK2-mediated diseases.
CURRENT MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Wojdas, Klaudia Dabkowska, Kornelia Kuznik-Trocha, Grzegorz Wisowski, Iwona Lachor-Motyka, Katarzyna Komosinska-Vassev, Krystyna Olczyk, Katarzyna Winsz-Szczotka
Summary: This study assessed the effects of ETA therapy on ECM metabolism in JIA patients. The results showed that GAGs and TAS concentrations were significantly lower in patients with aggressive JIA, while MMP-1 and MMP-3 levels were significantly higher. Anti-cytokine therapy did not normalize any of the assessed parameters.
Article
Environmental Sciences
Fang-Fang Yu, Juan Zuo, Xiaoli Fu, Ming-Hui Gao, Lei Sun, Shui-Yuan Yu, Zhiyuan Li, Guo-Yu Zhou, Yue Ba
Summary: This study identified the role of the Hippo signaling pathway in extracellular matrix degradation of chondrocytes induced by fluoride exposure. The fluoride exposure significantly decreased the viability of ATDC5 cells, induced oxidative stress, inhibited the activity of the Hippo pathway, and led to cartilage matrix degradation. These findings suggest a potential mechanism behind fluoride-induced bone injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Rheumatology
Jeong-In Yang, Jang-Soo Chun
Summary: Regnase-1 is specifically upregulated in chondrocytes stimulated with OA-associated catabolic factors among the RNases. It suppresses cartilage destruction by modulating the expression of matrix-degrading enzymes in chondrocytes, potentially functioning as a chondro-protective effector molecule during OA pathogenesis.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Orthopedics
Lei Ding, Biagio Zampogna, Sebastiano Vasta, Kee Woong Jang, Francesca De Caro, James A. Martin, Annunziato Amendola
AMERICAN JOURNAL OF SPORTS MEDICINE
(2015)
Review
Orthopedics
Francesca De Caro, Salvatore Bisicchia, Annunziato Amendola, Lei Ding
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2015)
Article
Acoustics
Kee W. Jang, Dongrim Seol, Lei Ding, Tae-Hong Lim, Joseph A. Frank, James A. Martin
ULTRASOUND IN MEDICINE AND BIOLOGY
(2018)
Article
Rheumatology
Dongrim Seol, Daniel J. McCabe, Hyeonghun Choe, Hongjun Zheng, Yin Yu, Keewoong Jang, Morgan W. Walter, Abigail D. Lehman, Lei Ding, Joseph A. Buckwalter, James A. Martin
ARTHRITIS AND RHEUMATISM
(2012)
Article
Biology
Jason M. Graham, Bruce P. Ayati, Lei Ding, Prem S. Ramakrishnan, James A. Martin
Article
Cell Biology
D. Guo, L. Ding, G. A. Homandberg
INFLAMMATION RESEARCH
(2009)
Article
Orthopedics
Lei Ding, Danping Guo, Gene A. Homandberg, Joseph A. Buckwalter, James A. Martin
JOURNAL OF ORTHOPAEDIC RESEARCH
(2014)
Article
Orthopedics
L. Ding, D. Guo, G. A. Homandberg
OSTEOARTHRITIS AND CARTILAGE
(2008)
Article
Acoustics
Kee W. Jang, Lei Ding, Dongrim Seol, Tae-Hong Lim, Joseph A. Buckwalter, James A. Martin
ULTRASOUND IN MEDICINE AND BIOLOGY
(2014)
Article
Orthopedics
Lei Ding, Annunziato Amendola, Brian Wolf, Matthew Bollier, John Albright, Quanming Wang, Minchen Wu, Xue Wang, Haiyan Song, Douglas Pedersen, James Martin
Article
Orthopedics
Lei Ding, Cheng Zhou, Hongjun Zheng, Quanming Wang, Haiyan Song, Joseph A. Buckwalter, James A. Martin
Summary: The study aimed to investigate the response of migrating chondrogenic progenitor cells (CPCs) from mechanically injured articular cartilage to proinflammatory damage-associated-molecular-patterns (DAMPs). The results showed that CPCs were more sensitive than non-CPCs in response to DAMPs, especially MTDs, indicating their critical role in early posttraumatic osteoarthritis development.
Article
Medicine, Research & Experimental
Liuliu Xiong, Meng Cui, Ziye Zhou, Minchen Wu, Quanming Wang, Haiyan Song, Lei Ding
Summary: Sequential digestion of human articular cartilage with pronase E and collagenase IA resulted in higher chondrocyte yield and viability compared to digestion with collagenase II alone or combined with pronase E. Chondrocytes isolated with this method could be maintained in monolayer cultures for at least 2 passages with unchanged morphology.