Journal
ORGANIC LETTERS
Volume 16, Issue 24, Pages 6484-6487Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol503345h
Keywords
-
Categories
Funding
- Procter & Gamble Pharmaceuticals, Mason, OH
Ask authors/readers for more resources
The oxidation of primary amines using a stoichiometric quantity of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (1) in CH(2)Cl(2)pyridine solvent at room temperature or at gentle reflux affords nitriles in good yield under mild conditions. The mechanism of the oxidation, which has been investigated computationally, involves a hydride transfer from the amine to the oxygen atom of 1 as the rate-limiting step.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available