期刊
ORGANIC LETTERS
卷 16, 期 24, 页码 6484-6487出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol503345h
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-
资金
- Procter & Gamble Pharmaceuticals, Mason, OH
The oxidation of primary amines using a stoichiometric quantity of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (1) in CH(2)Cl(2)pyridine solvent at room temperature or at gentle reflux affords nitriles in good yield under mild conditions. The mechanism of the oxidation, which has been investigated computationally, involves a hydride transfer from the amine to the oxygen atom of 1 as the rate-limiting step.
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