4.8 Article

Macrolactonization of Peptide Thioesters Catalyzed by Imidazole and Its Application in the Synthesis of Kahalalide B and Analogues

Journal

ORGANIC LETTERS
Volume 12, Issue 10, Pages 2250-2253

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100596p

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Funding

  1. Florida, Executive Officer of the Governor's Office of Tourism, Trade and Economic Development, National Science Foundation [RAH CHE 0455072, 1P41GM079590, 1P41GM081261, U54HG03916-MLSCN]

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The macrolactonization of peptide thioester to yield cyclic depsipeptides was developed using imidazole as a catalyst. This strategy was applied to the synthesis of kahalalide B and its analogues.

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