Article
Chemistry, Multidisciplinary
A. Ziyaei Halimehjani, B. Breit
Summary: A rhodium-catalyzed hydrothiolation reaction of terminal allenes with thioacids has been developed for the synthesis of chiral branched allylic thioesters. The reaction exhibits excellent regio- and enantioselectivity and is applicable to the diastereoselective synthesis of thioesters from Fmoc-protected aminothioacids.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Lei Cao, Xing-Ping Zhang, Ming-Sheng Xie, Hai-Ming Guo
Summary: A CuI-catalyzed C-N coupling reaction between 3-bromoDMAP and L-prolinamides was carried out under 80°C for 12-16 hours, where the structure of prolinamide exerted an accelerating effect on the Ullmann type reaction. This reaction was utilized for the construction of chiral 3-amino DMAP catalysts. Moreover, enantioenriched DMAP analogue C8 was applied in an asymmetric Black rearrangement of 2-benzofuranylcarbonates, leading to the formation of 3,3-disubstituted benzofuran-2-ones with up to 96% yield and 97% ee.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Salik Abdullah, Swastika Ganguly
Summary: The search for novel, physiologically active imidazoles is an exciting research topic for medicinal chemists. Imidazole, a five-membered aromatic heterocycle, is present in both natural and synthesized compounds. Current anticancer drugs have limitations such as toxicity and limited efficacy, highlighting the need for new chemotherapeutic agents. Imidazole development as a reliable and safer alternative to anticancer treatment is gaining attention, with potential targets including tubulin/microtubule polymerization inhibition and changes in DNA structure and function, VEGF, topoisomerase, kinases, histone deacetylases, and other proteins involved in gene expression.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yu Zai, Xinping Xi, Zhuming Ye, Chengbang Ma, Mei Zhou, Xiaoling Chen, Shirley W. I. Siu, Tianbao Chen, Lei Wang, Hang Fai Kwok
Summary: Temporin-PF (TPF) was identified as a peptide effective against Gram-positive bacteria but not Gram-negative bacteria. MD simulation showed that the peptides could form oligomers, but substitution of Trp/D-Trp enhanced inter-peptide interaction and eliminated overall biological activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniela Carlisi, Marianna Lauricella, Antonella D'Anneo, Anna De Blasio, Adriana Celesia, Giovanni Pratelli, Antonietta Notaro, Giuseppe Calvaruso, Michela Giuliano, Sonia Emanuele
Summary: The sesquiterpene lactone parthenolide (PN) and its analogues have significant potential in cancer therapy, inducing various forms of cell death and targeting cancer stem cells.
Review
Chemistry, Physical
Shujie Liang, Hong Deng, Zhi Zhou, Wai-Yeung Wong
Summary: This article summarizes important synthesis strategies of Graphdiyne (GDY) and GDY-based materials, elaborates on modifications to regulate the structure and properties of GDY, and highlights recent achievements in energy and environmental applications in photocatalysis. Furthermore, the challenges and potential developments of GDY in catalytic research are discussed.
Article
Microbiology
Soren Planckaert, Benoit Deflandre, Anne-Mare De Vries, Maarten Ameye, Jose C. Martins, Kris Audenaert, Sebastien Rigali, Bart Devreese
Summary: The discovery of new rotihibin analogues in Streptomyces scabies, a major pathogen causing common scab disease, provides insights into their herbicidal activity and potential biotechnological production. Through genomic analysis, a cryptic biosynthetic gene cluster was identified, leading to a better understanding of the mechanism behind targeting the plant TORK pathway. The existence of other variants in plant-associated Streptomyces strains raises new questions about the function of this lipopeptide.
MICROBIOLOGY SPECTRUM
(2021)
Article
Chemistry, Medicinal
Ana R. Araujo, Vania I. B. Castro, Rui L. Reis, Ricardo A. Pires
Summary: This study investigated the impact of four monosaccharides on the pathological features mediated by Aβ in Alzheimer's disease, revealing that GlcN6S and GlcN6P can reduce neuronal cell death, cell membrane damage, acetylcholinesterase activity, insulin resistance, and inflammation levels associated with Aβ.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Geriatrics & Gerontology
Shanshan Lu, Yiwei Li, Qiang Shen, Wanli Zhang, Xiaofan Gu, Mingliang Ma, Yiming Li, Liuqiang Zhang, Xuan Liu, Xiongwen Zhang
Summary: Carnosol and its analogues exhibited anticachexia effects mainly by inhibiting TNF-alpha/NF-kappa B pathway and decreasing muscle and adipose tissue loss. CS and its analogues might be promising drug candidates for the treatment of cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Michel Boutin, Pamela Lavoie, Margot Beaudon, Georges Kabala Ntumba, Daniel G. G. Bichet, Bruno Maranda, Christiane Auray-Blais
Summary: Fabry disease is an X-linked lysosomal storage disorder characterized by impaired alpha-galactosidase A enzyme activity. The accumulation of undegraded glycosphingolipids, including lyso-Gb(3) and related analogues, is a useful biomarker for screening and longitudinal patient evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Spectroscopy
Tong Shao, Xiaolei Song, Yufeng Jiang, Chenchen Wang, Peng Li, Shihao Sun, Dingzhong Wang, Wei Wei
Summary: In this study, vanillin was found to efficiently catalyze hydrogen peroxide to produce reactive radicals and accelerate the chemiluminescence signal of luminol-hydrogen peroxide. By combining with beta-CD, the chemiluminescence intensity was further enhanced. Based on the catalytic and stabilizing functions, a low-cost, rapid, and simple chemiluminescence sensor was developed for the detection of vanillin.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yingying Du, Bin Huang, Jiajun Zeng, Mingzhong Cai
Summary: The study demonstrates the heterogeneous gold(I)-catalyzed oxidative ring expansion of alkynyl quinols using a benzyldiphenylphosphine-modified MCM-41-immobilized gold(I) complex as the catalyst and 8-methylquinoline N-oxide as the oxidant, resulting in the formation of functionalized tropone derivatives in good to excellent yields. The methodology can also be extended to construct other seven- or six-membered ring systems, such as dibenzotropones, dibenzooxepines, phenanthrenes, and quinolin-2(1H)-ones, with the new heterogeneous gold(I) complex showing recyclability up to eight times without loss of catalytic efficiency.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Organic
Durgesh Gurukkala Valapil, Manasa Kadagathur, Nagula Shankaraiah
Summary: The application of amino acids and small peptides as asymmetric organocatalysts in aldol and conjugate addition reactions has been a significant breakthrough in the past decade. Desired stereoselectivity in these reactions can be achieved through the tunable diversity elements present in amino acids/peptides. The literature is classified based on the use of single amino acids or peptides as catalysts, with detailed information on the design and recent applications of these catalysts.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Adesh Kumar Singh, Rapelly Venkatesh, Vimlesh Kumar Kanaujiya, Varsha Tiwari, Jeyakumar Kandasamy
Summary: An efficient method for the synthesis of C-1 aryl enones from aryl iodides and glycal enones through palladium-catalyzed cross-coupling reactions under ligand-free conditions was developed. This method is applicable to a wide range of aryl iodides with different electron-donating and withdrawing groups, and can be carried out under mild reaction conditions.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Ali Moradi Delfani, Hamzeh Kiyani, Mehdi Zamani
Summary: A series of tetrahydrobenzo[b]pyran derivatives were successfully synthesized through three-component reactions, with high yields and relatively shorter reaction times. The optimal reaction conditions were found to be a water-ethanol solvent system, a reaction temperature of 60(o)C, and a 5 mol% loading of the imidazolium catalyst. This method exhibits operational simplicity, no need for chromatographic purification, and avoidance of hazardous solvents.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yangmei Li, Nina Bionda, Renee Fleeman, Hongjie Wang, Akihiko Ozawa, Richard A. Houghten, Lindsey Shaw
BIOORGANIC & MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Yangmei Li, Margret Cazares, Jinhua Wu, Richard A. Houghten, Laurence Toll, Colette Dooley
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Yangmei Li, Nina Bionda, Austin Yongye, Phaedra Geer, Maciej Stawikowski, Predrag Cudic, Karina Martinez, Richard A. Houghten
Article
Chemistry, Applied
Yangmei Li, Austin Yongye, Marc Giulianotti, Karina Martinez-Mayorga, Yongping Yu, Richard A. Houghten
JOURNAL OF COMBINATORIAL CHEMISTRY
(2009)
Article
Chemistry, Organic
Kendall G. Byler, Yangmei Li, Richard A. Houghten, Karina Martinez-Mayorga
ORGANIC & BIOMOLECULAR CHEMISTRY
(2013)
Article
Chemistry, Organic
Yangmei Li, Marc Giulianotti, Richard A. Houghten
TETRAHEDRON LETTERS
(2009)
Article
Chemistry, Organic
Yangmei Li, Marc Giulianotti, Richard A. Houghten
TETRAHEDRON LETTERS
(2010)
Article
Chemistry, Organic
Yangmei Li, Marc Giulianotti, Richard A. Houghten
TETRAHEDRON LETTERS
(2011)
Article
Chemistry, Applied
Yangmei Li, Colette T. Dooley, Jaime A. Misler, Ginamarie Debevec, Marc A. Giulianotti, Margaret E. Cazares, Laura Maida, Richard A. Houghten
ACS COMBINATORIAL SCIENCE
(2012)
Article
Biochemistry & Molecular Biology
Rachel M. Sammons, Nicole A. Perry, Yangmei Li, Eun Jeong Cho, Andrea Piserchio, Diana P. Zamora-Olivares, Ranajeet Ghose, Tamer S. Kaoud, Ginamarie Debevec, Chandra Bartholomeusz, Vsevolod V. Gurevich, Tina M. Iverson, Marc Giulianotti, Richard A. Houghten, Kevin N. Dalby
ACS CHEMICAL BIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Sam Groom, Nina K. Blum, Alexandra E. Conibear, Alexander Disney, Rob Hill, Stephen M. Husbands, Yangmei Li, Lawrence Toll, Andrea Kliewer, Stefan Schulz, Graeme Henderson, Eamonn Kelly, Chris P. Bailey
Summary: This study confirmed that Compound 1 is a G protein-biased mu agonist that can induce substantial rapid receptor desensitisation in mammalian neurons. However, contrary to previous assumptions, the desensitisation effect of Compound 1 is dependent on G protein-coupled receptor kinase (GRK).
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Organic
Kimberly Perry, Binglin Sui, Yangmei Li
Summary: The revival of peptide-based drugs has increased the demand for large-scale synthesis, leading to the successful synthesis of a pentapeptide POSS-thioester with high yield and purity using mercapto-functionalized POSS as a soluble support. This method offers a promising way for the scale-up chemical synthesis of peptide thioesters, peptides, peptide amides, cyclic peptides, and even proteins.
TETRAHEDRON LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Yangmei Li, Shainnel O. Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A. Houghten, Jay P. McLaughlin
Summary: Peptide-based opioid ligands are potential candidates for developing safer and more effective analgesics. In this study, a cyclic pentapeptide library was screened and a novel cyclic peptide, CycloAnt, was identified. CycloAnt exhibited dose- and time-dependent antinociception mediated by MOR and showed lower adverse effects and dependence compared to morphine.
Review
Pharmacology & Pharmacy
Abraham Madariaga-Mazon, Andres F. Marmolejo-Valencia, Yangmei Li, Lawrence Toll, Richard A. Houghten, Karina Martinez-Mayorga
DRUG DISCOVERY TODAY
(2017)
