Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure

Building Proficient Enzymes with Foldamer Prostheses

(2014) Clemens Mayer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Backbone modification of a polypeptide drug alters duration of action in vivo

(2014) Ross W Cheloha et al.   NATURE BIOTECHNOLOGY

Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation

(2014) George A. Lengyel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Semisynthesis of Peptoid–Protein Hybrids by Chemical Ligation at Serine

(2014) Paul M. Levine et al.   ORGANIC LETTERS

Folding thermodynamics of protein-like oligomers with heterogeneous backbones

(2014) Zachary E. Reinert et al.   Chemical Science

n→π* Interactions of Amides and Thioamides: Implications for Protein Stability

(2013) Robert W. Newberry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein-like Tertiary Folding Behavior from Heterogeneous Backbones

(2013) Zachary E. Reinert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Introduction of Cyclically Constrained γ-Residues Stabilizes an α-Peptide Hairpin in Aqueous Solution

(2013) George A. Lengyel et al.   ORGANIC LETTERS

A PEG-Based Oligomer as a Backbone Replacement for Surface-Exposed Loops in a Protein Tertiary Structure

(2012) Zachary E. Reinert et al.   CHEMBIOCHEM

Extending Foldamer Design beyond α-Helix Mimicry: α/β-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling

(2012) Holly S. Haase et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design Strategies for the Sequence-Based Mimicry of Side-Chain Display in Protein β-Sheets by α/β-Peptides

(2012) George A. Lengyel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Protein-Folding Problem, 50 Years On

(2012) K. A. Dill et al.   SCIENCE

Protein Side-Chain Translocation MutagenesisviaIncorporation of Peptoid Residues

(2011) Byoung-Chul Lee et al.   ACS Chemical Biology

α/β-Peptide foldamers: state of the art

(2011) Ludwig K. A. Pilsl et al.   AMINO ACIDS

Synthesis of a Biologically Active Triazole-Containing Analogue of Cystatin A Through Successive Peptidomimetic Alkyne-Azide Ligations

(2011) Ibai E. Valverde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic foldamers

(2011) Gilles Guichard et al.   CHEMICAL COMMUNICATIONS

Peptidic foldamers: ramping up diversity

(2011) Tamás A. Martinek et al.   CHEMICAL SOCIETY REVIEWS

Peptide and peptoid foldamers in medicinal chemistry

(2011) W Seth Horne   Expert Opinion on Drug Discovery

Hairpin Folding Behavior of Mixed α/β-Peptides in Aqueous Solution

(2011) George A. Lengyel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein conformational dynamics in the mechanism of HIV-1 protease catalysis

(2011) V. Y. Torbeev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioamides as Fluorescence Quenching Probes: Minimalist Chromophores To Monitor Protein Dynamics

(2010) Jacob M. Goldberg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection and Analysis of Chimeric Tertiary Structures by Backbone Thioester Exchange: Packing of an α Helix against an α/β-Peptide Helix

(2009) Joshua L. Price et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins

(2009) Jianmin Gao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evaluating  -turn mimics as  -sheet folding nucleators

(2009) A. A. Fuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

(2009) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis, folding, and structure of the β-turn mimic modified B1 domain of streptococcal protein G

(2009) Benoit Odaert et al.   PROTEIN SCIENCE

Exploring β-Sheet Structure and Interactions with Chemical Model Systems

(2008) James S. Nowick   ACCOUNTS OF CHEMICAL RESEARCH

Sequence-Based Design of α/β-Peptide Foldamers That Mimic BH3 Domains

(2008) W. Seth Horne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Effect of a Trans-Locked Gly−Pro Alkene Isostere on Collagen Triple Helix Stability

(2008) Nan Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Artificial Chemokines: Combining Chemistry and Molecular Biology for the Elucidation of Interleukin-8 Functionality

(2008) Ralf David et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Toward β-Amino Acid Proteins:  Design, Synthesis, and Characterization of a Fifteen Kilodalton β-Peptide Tetramer

(2008) E. James Petersson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

X-ray Structure of Snow Flea Antifreeze Protein Determined by Racemic Crystallization of Synthetic Protein Enantiomers

(2008) Brad L. Pentelute et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly

(2008) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An experimental survey of the transition between two-state and downhill protein folding scenarios

(2008) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA