Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols

Short and Sweet:D-Glucose toL-Glucose andL-Glucuronic Acid

(2013) R. Fernando Martínez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3-Hydroxyazetidine Carboxylic Acids: Non-Proteinogenic Amino Acids for Medicinal Chemists

(2013) Andreas F. G. Glawar et al.   ChemMedChem

Pharmacological Chaperones as Therapeutics for Lysosomal Storage Diseases

(2013) Robert E. Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Eight Stereoisomers of Pochonicine: Nanomolar Inhibition of β-N-Acetylhexosaminidases

(2013) Jian-She Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

An approach to 8 stereoisomers of homonojirimycin from d-glucose via kinetic & thermodynamic azido-γ-lactones

(2013) Andreas F. G. Glawar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition

(2012) Andreas F. G. Glawar et al.   CHEMISTRY-A EUROPEAN JOURNAL

PUGNAc treatment leads to an unusual accumulation of free oligosaccharides in CHO cells

(2012) A. Mehdy et al.   JOURNAL OF BIOCHEMISTRY

Glycosidase Inhibition by All 10 Stereoisomeric 2,5-Dideoxy-2,5-iminohexitols Prepared from the Enantiomers of Glucuronolactone

(2012) Benjamin J. Ayers et al.   JOURNAL OF ORGANIC CHEMISTRY

Pharmacological chaperones for human  -N-acetylgalactosaminidase

(2012) N. E. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iminosugars as therapeutic agents: recent advances and promising trends

(2011) Robert J Nash et al.   Future Medicinal Chemistry

2-Acetamido-N-benzyl-1,4-imino-1,2,4-trideoxy-L-xylitol (N-benzyl-L-XYLNAc)

(2010) Sarah. F. Jenkinson et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

β-N-Acetylhexosaminidase: What's in a name…?

(2010) Kristýna Slámová et al.   BIOTECHNOLOGY ADVANCES

Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors

(2010) J.S. Shane Rountree et al.   COMPTES RENDUS CHIMIE

Lysosomal storage of oligosaccharide and glycosphingolipid in imino sugar treated cells

(2010) Stephanie D. Boomkamp et al.   GLYCOCONJUGATE JOURNAL

An α-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain

(2010) Atsushi Kato et al.   Phytochemistry Letters

Synthesis of 2-acetamido-1,2-dideoxy-d-galacto-nojirimycin [DGJNAc] from d-glucuronolactone: the first sub-micromolar inhibitor of α-N-acetylgalactosaminidases

(2010) Daniel Best et al.   TETRAHEDRON LETTERS

Pochonicine, a polyhydroxylated pyrrolizidine alkaloid from fungus Pochonia suchlasporia var. suchlasporia TAMA 87 as a potent β-N-acetylglucosaminidase inhibitor

(2009) Hirokazu Usuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

GlcNAc-Thiazoline conformations

(2009) Spencer Knapp et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Serum proteomic profile of cutaneous malignant melanoma and relation to cancer progression: Association to tumor derived alpha-N-acetylgalactosaminidase activity

(2009) Marilena Greco et al.   CANCER LETTERS

Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease

(2009) J. S. Shane Rountree et al.   ChemMedChem

Gem-diamine 1-N-iminosugars as versatile glycomimetics: synthesis, biological activity and therapeutic potential

(2009) Yoshio Nishimura   JOURNAL OF ANTIBIOTICS

Large scale synthesis of the acetonides of l-glucuronolactone and of l-glucose: easy access to l-sugar chirons

(2009) Alexander C. Weymouth-Wilson et al.   TETRAHEDRON LETTERS

Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-d-lyxitol [a potent competitive inhibitor of α-d-galactosidase] and of 1,4-dideoxy-1,4-imino-l-lyxitol [a weak competitive inhibitor of α-d-galactosidase] inhibit naringinase, an α-l-rhamnosidase competitively

(2009) Thomas B. Mercer et al.   TETRAHEDRON-ASYMMETRY

Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases

(2008) Yasuhiro Minami et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A convenient approach toward the synthesis of enantiopure isomers of DMDP and ADMDP

(2008) En-Lun Tsou et al.   TETRAHEDRON

High yield protection of alcohols, including tertiary and base sensitive alcohols, as benzhydryl ethers by heating with diphenyldiazomethane in the absence of any other reagent

(2008) Daniel Best et al.   TETRAHEDRON LETTERS